Month: February 2023

An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis was written by Komm, Barry S.;Chines, Arkadi A.. And the article was included in Maturitas in 2012.Formula: C24H23ClO2 This article mentions the following:

Several selective estrogen receptor modulators are in clin. development for postmenopausal osteoporosis. Bazedoxifene has shown significant reductions in vertebral and non-vertebral (in higher-risk women) fracture risk, with no evidence of breast or endometrial stimulation. Lasofoxifene has demonstrated significant reductions in vertebral and non-vertebral fracture risk, but has been associated with endometrial/uterine effects. Both selective estrogen receptor modulators were generally safe and well tolerated but have been associated with some “class effects” (e.g., hot flushes, venous thromboembolic events). A tissue selective estrogen complex partnering bazedoxifene with conjugated estrogens is under clin. investigation for the treatment of menopausal symptoms and osteoporosis prevention. Future directions in selective estrogen receptor modulator research include ospemifene and RAD 1901. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Formula: C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva was written by Li, Rongfeng;Yu, Huahua;Yue, Yang;Liu, Song;Xing, Rong’e;Chen, Xiaolin;Li, Pengcheng. And the article was included in Chinese Journal of Oceanology and Limnology in 2017.Recommanded Product: 10030-85-0 This article mentions the following:

Sea cucumber is a traditional nutritional food and medicinal resource with many bioactive components in China. Holothuria fuscogliva is a big sea cucumber with a rich of bioactive polysaccharides. To investigate the bioactivities of the polysaccharides from sea cucumber H. fuscogliva, we prepared the sulfated polysaccharides (HfP) from sea cucumber H. fuscogliva using a protease hydrolysis method. Antioxidant activities of HfP were investigated, including hydroxyl radical scavenging activity and superoxide radical scavenging activity. And, the anticoagulant activities of HfP were studied, including the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT). The average mol. weight was 1 867.1 Da, with a sulfate content of 20.7%. In addition, the molar ratio of monosaccharide composition of HfP was Man: Rha: Glc A: Glc: Gal: Xyl: Fuc=0.083 6: 0.437: 0.134: 0: 1.182: 0.748: 1. It had a strong antioxidant activity, the hydroxyl and superoxide radical scavenging activity EC 50 of HfP was 3.74 and 0.037 mg/mL, resp. It also showed a good anticoagulant activity in our study. The APTT of HfP was much higher than that of heparin sodium, and the PT and TT of HfP was close to that of heparin sodium at a low concentration Therefore, HfP shows a good antioxidant and anticoagulant activity and it may become a potential candidate of the natural antioxidant and anticoagulant and will have a good application future in health product or medicine industry. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Recommanded Product: 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH was written by Cheng, Ying-Ni;Wu, Hsyueh-Liang;Wu, Ping-Yu;Shen, Ying-Ying;Uang, Biing-Jiun. And the article was included in Chemistry – An Asian Journal in 2012.Synthetic Route of C8H9ClO This article mentions the following:

An effective catalytic system that imparts high enantioselectivity has been disclosed for the synthesis of optically active alcs., which may undergo further chem. transformations. The enantioselective alkylation of aldehydes with dialkylzincs to afford the corresponding optically active alcs. with excellent enantioselectvities has been achieved in the presence of 0.1-0.5 mol % of the camphor-derived chiral ligand (-)-2-exo-morpholinoisobornane-10-thiol (MITH) at room temperature or at 0°. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Synthetic Route of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photopolymer resins for luminescent three-dimensional printing was written by Wang, Fei;Chong, Yiting;Wang, Fu Ke;He, Chaobin. And the article was included in Journal of Applied Polymer Science in 2017.Application of 4074-88-8 This article mentions the following:

Liquid resins based three-dimensional (3D) printing techniques such as stereolithog. (SLA) and digital light processing (DLP) show higher resolution and accuracy than other printing techniques, but their applications were impeded by the limited materials selection and lack of functions. We here reported the preparation of luminescent resins for DLP-based 3D printing. Homogeneous dispersion of the fluorescent dyes was achieved by small acrylate mols. screening, and the cure depth studies was used to optimize both resin composition and printing parameters setting. In addition, we showed that the optical anal. of absorption and emission spectra is an important tool to reduce the complex mutual-interference of the light absorption of dye, photoinitiator and photo-absorber in the printable resin. We also developed the mater batch technique to tune the emitting colors in the whole visible range, together with white emitting. By using the developed resins, different 3D structures with different emitting colors were successfully printed by DLP technique. These results will further widen the applications of the liquid resins-based 3D printing techniques, and these luminescent resins show highly potential applications in education, lighting, UV converters, and so on. © 2017 Wiley Periodicals, Inc.J. Appl. Polym. Sci. 2017, 134, 44988. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Harnessing light to create functional, three-dimensional polymeric materials: multitasking initiation systems as the critical key to success was written by Tomal, Wiktoria;Krok, Dominika;Chachaj-Brekiesz, Anna;Lepcio, Petr;Ortyl, Joanna. And the article was included in Additive Manufacturing in 2021.Recommanded Product: 4074-88-8 This article mentions the following:

Nowadays, the lack of suitable photoinitiators (PI) and photoinitiating systems (PISs) represents the utmost challenge in 3D-VAT printing. High photoinitiating efficiency is needed for example in the presence of nanofillers such as carbon nanotubes (CNTs) which absorb and scatter light. Many prominent PISs contains iodonium salt as an initiator and a second component as a photosensitizer. This study addresses the high demand for innovative PISs with improved photoinitiating efficiency by a complete cycle of research: from the synthesis of new biphenyl derivatives, through their employment as photosensitizers of iodonium salt for light-induced cationic, free-radical, and hybrid polymerization processes, to the representative application in 3D printing processes such as digital light processing (DLP) or laser printing. The ultimate performance of the newly synthesized compounds was tested by preparing 3D-printable photosensitive nanocomposite resins filled with CNTs as a nanoscale filler. Their photopolymerization kinetics as well as the effect of the CNT concentration on the crosslinking were analyzed via real-time FTIR and photo-rheol. The printouts were observed with optical microscopy and SEM. In addition, the key printing parameters were determined, i.e. E_c (critical energy to initiate polymerization) and D_p (penetration depth of curing light). Our results evidence the capability of the synthesized compounds to take part in the photoinitiating systems of complex and demanding 3D printing applications. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Isolation, characterization and prediction of biological activity of two new fatty esters and a phenol from the heartwood of Pterocarpus Marsupium Roxb was written by Katiyar, Deepti;Singh, Vijender;Ali, Mohammed. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2017.Application of 69393-72-2 This article mentions the following:

Objective: The current investigation involves the isolation, characterization and prediction of biol. activity spectra of the phytoconstituents from the ethanolic extract of the heartwood of Pterocarpus marsupium roxb. (Fabaceae). Methods: The heartwood (3 kg) was extracted in alc. by cold maceration for 21 d and the compounds were isolated by column chromatog. The compounds thus isolated were characterised and their structures were elucidated by using assorted spectral data anal., i.e., IR radiation spectroscopy (IR), proton NMR (¹HNMR), carbon thirteen NMR (¹C³ NMR) and direct anal. in real time mass spectrometry (DART-MS). PASS (prediction of activity spectra for substances) computer program was used to predict the biol. activity spectra of the isolated compounds Results: Phytochem. investigation of ethanolic extract of the heartwood of Pterocarpus marsupium led to isolate two fatty esters and a phenolic compound characterised as n-octanyl n-octadeca-9,12-dienoate (n-octanyl linoleiate, 1), n-dodecanyl n-octadeca-9,12-dienoate (n-dodecanyl linoleiate, 2) and 2, 3-dioxymethylene phenol (3). These phytoconstituents are reported for first time in the heartwood of Pterocarpus marsupium Roxb. The in silico profiling of these phytoconstituents exhibited their broad spectra of biol. activity. Compounds (1) and (2) showed their maximum activity as All-trans-retinyl-palmitate hydrolase inhibitor, anti eczematic, lipid metabolism regulator, etc. and compound (3) was found to be active as membrane integrity agonist, aspulvinone dimethylallyl transferases inhibitor, carminative, neurotransmitter uptake inhibitor, etc. Conclusion: These isolated phytoconstituents can be used as the marker compounds to establish the identity, quality and purity of the drug. The results of PASS prediction shall be very useful for establishing these phytoconstituents as active pharmacol. moieties. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application of 69393-72-2).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 69393-72-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists was written by Okano, Masahiko;Mito, Jun;Maruyama, Yasufumi;Masuda, Hirofumi;Niwa, Tomoko;Nakagawa, Shin-ichiro;Nakamura, Yoshitaka;Matsuura, Akira. And the article was included in Bioorganic & Medicinal Chemistry in 2009.SDS of cas: 155975-19-2 This article mentions the following:

Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1 R,2 S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the μ, δ, and κ opioid receptors. Mol. modeling clarified the structural factors contributing to the high affinity and selectivity of (1 R,2 S)-17. In the experiment, the researchers used many compounds, for example, tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2SDS of cas: 155975-19-2).

tert-Butyl ((1R,2R)-2-hydroxycyclohexyl)carbamate (cas: 155975-19-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 155975-19-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Acceptorless dehydrogenation of primary alcohols to carboxylic acids by self-supported NHC-Ru single-site catalysts was written by Yin, Shenxiang;Zheng, Qingshu;Chen, Jie;Tu, Tao. And the article was included in Journal of Catalysis in 2022.Product Details of 873-76-7 This article mentions the following:

The acceptorless dehydrogenation of diverse aromatic and aliphatic primary alcs. to corresponding carboxylic acids was accomplished by self-supported NHC-Ru single-site catalysts under mild reaction conditions. Besides broad substrates with excellent activity, selectivity and good tolerance to sensitive functional groups, the solid single-site catalyst could be recovered and reused for more than 20 runs without deactivation. Remarkably, up to 1.8 x 10⁴ turnover numbers could be achieved by this newly developed sustainable protocol in gram scale at low catalyst loading, highlighting its potential in industry. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Product Details of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, physical properties and application of a series of new polyoxometalate-based ionic liquids was written by Martinetto, Yohan;Basset, Salome;Pegot, Bruce;Roch-Marchal, Catherine;Camerel, Franck;Jeftic, Jelena;Cottyn-Boitte, Betty;Magnier, Emmanuel;Floquet, Sebastien. And the article was included in Molecules in 2021.Product Details of 1122-71-0 This article mentions the following:

This paper deals with the preparation and the characterization of four new ionic liquids resulting from the pairing of various polyoxotungstates or polyoxomolybdates with the cation trihexyltetradecylphosphonium. The phys. properties measured by different techniques evidence that the viscosity and the rheol. behaviors of such POM-based ionic liquids, POM-ILs, strongly depend on the nature of the POM, especially its charge. Playing on the nature of the POM, we can indeed obtain Newtonian liquids or some much more viscous materials exhibiting characteristics of resins or pseudo-plastics. In a second part of this study, the potentialities of using such materials both as solvent and catalyst for the oxidation of a series of alcs. are presented as proof of concept. This part highlights great differences in strength and selectivity as a function of the POM-IL used. Furthermore, a very simple way to recycle the catalyst is also presented. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Product Details of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology was written by Mills, Carolyn E.;Waltmann, Curt;Archer, Andre G.;Kennedy, Nolan W.;Abrahamson, Charlotte H.;Jackson, Alexander D.;Roth, Eric W.;Shirman, Sasha;Jewett, Michael C.;Mangan, Niall M.;Olvera de la Cruz, Monica;Tullman-Ercek, Danielle. And the article was included in Nature Communications in 2022.Safety of 1,2-Propanediol This article mentions the following:

Abstract: Engineering subcellular organization in microbes shows great promise in addressing bottlenecks in metabolic engineering efforts; however, rules guiding selection of an organization strategy or platform are lacking. Here, we study compartment morphol. as a factor in mediating encapsulated pathway performance. Using the 1,2-propanediol utilization microcompartment (Pdu MCP) system from Salmonella enterica serovar Typhimurium LT2, we find that we can shift the morphol. of this protein nanoreactor from polyhedral to tubular by removing vertex protein PduN. Anal. of the metabolic function between these Pdu microtubes (MTs) shows that they provide a diffusional barrier capable of shielding the cytosol from a toxic pathway intermediate, similar to native MCPs. However, kinetic modeling suggests that the different surface area to volume ratios of MCP and MT structures alters encapsulated pathway performance. Finally, we report a microscopy-based assay that permits rapid assessment of Pdu MT formation to enable future engineering efforts on these structures. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts