Month: December 2022

Ertas, Merve published the artcileSynthesis and characterization of conducting copolymers of succinic acid bis-(4-pyrrol-1-yl-phenyl) ester and their electrochromic properties, Computed Properties of 23351-09-9, the publication is Synthetic Metals (2004), 143(1), 49-58, database is CAplus.

A new dipyrrolyl monomer was synthesized via the reaction between 4-pyrrol-1-yl phenol and butanedioyl dichloride. The electrochem. behavior of this monomer, succinic acid bis(4-pyrrol-1-yl-phenyl) ester (SM) was studied. Homopolymerization was achieved by chem. and constant current electrolysis methods. Copolymerization of SM with thiophene was performed by constant potential electrolysis in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB) and dichloromethane-TBAFB, solvent-electrolyte couples. The chem. structure was investigated by NMR spectroscopy and Fourier-transform IR spectroscopy. Thermal analyses were studied by differential scanning calorimetry and thermal gravimetry anal. The morphologies of the films were examined by SEM. Conductivities of the samples were measured using a four-probe technique. Moreover, the spectroelectrochem. and electrochromic properties of SM/thiophene copolymer were investigated using a UV-visible spectrophotometer and colorimetry.

Synthetic Metals published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Computed Properties of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Di Meo, Chiara published the artcilePolyaspartamide-Doxorubicin Conjugate as Potential Prodrug for Anticancer Therapy, Related Products of alcohols-buliding-blocks, the publication is Pharmaceutical Research (2015), 32(5), 1557-1569, database is CAplus and MEDLINE.

The purpose of this study was to synthesize a new polymeric prodrug based on α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-d,l-aspartamide copolymer bearing amine groups in the side chain (PHEA-EDA), covalently linked to the anticancer drug doxorubicin and to test its potential application in anticancer therapy. The drug was previously derivatized with a biocompatible and hydrophilic linker, leading to a doxorubicin derivative highly reactive with amino groups of PHEA-EDA. The PHEA-EDA-DOXO prodrug was characterized in terms of chem. stability. The pharmacokinetics, biodistribution and cytotoxicity of the product was investigated in vitro and in vivo on human breast cancer MCF-7 and T47D cell lines and NOD-SCID mice bearing a MCF-7 human breast carcinoma xenograft. Data collected were compared to those obtained using free doxorubicin. The final polymeric product is water soluble and easily hydrolysable in vivo, due to the presence of ester and amide bonds along the spacer between the drug and the polymeric backbone. In vitro tests showed a retarded cytotoxic effect on tumor cells, whereas a significant improvement of the in vivo antitumor activity of PHEA-EDA-DOXO and a survival advantage of the treated NOD-SCID mice was evidenced, compared to that of free doxorubicin. The features of the PHEA-EDA-DOXO provide a potential protection of the drug from the plasmatic enzymic degradation and clearance, an improvement of the blood pharmacokinetic parameters and a suitable body biodistribution. The data collected support the promising rationale of the proposed macromol. prodrug PHEA-EDA-DOXO for further potential development and application in the treatment of solid cancer diseases.

Pharmaceutical Research published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dhabaria, Avantika published the artcileA High-Efficiency Cellular Extraction System for Biological Proteomics, Computed Properties of 85618-21-9, the publication is Journal of Proteome Research (2015), 14(8), 3403-3408, database is CAplus and MEDLINE.

Recent developments in quant. high-resolution mass spectrometry have led to significant improvements in the sensitivity and specificity of the biochem. analyses of cellular reactions, protein-protein interactions, and small-mol.-drug discovery. These approaches depend on cellular proteome extraction that preserves native protein activities. Here, we systematically analyzed mech. methods of cell lysis and phys. protein extraction to identify those that maximize the extraction of cellular proteins while minimizing their denaturation. Cells were mech. disrupted using Potter-Elvehjem homogenization, probe- or adaptive-focused acoustic sonication, and were in the presence of various detergents, including polyoxyethylene ethers and esters, glycosides, and zwitterions. Using fluorescence spectroscopy, biochem. assays, and mass spectrometry proteomics, we identified the combination of adaptive focused acoustic (AFA) sonication in the presence of a binary poloxamer-based mixture of octyl-β-glucoside and Pluronic F-127 to maximize the depth and yield of the proteome extraction while maintaining native protein activity. This binary poloxamer extraction system allowed for native proteome extraction comparable in coverage to the proteomes extracted using denaturing SDS or guanidine-containing buffers, including the efficient extraction of all major cellular organelles. This high-efficiency cellular extraction system should prove useful for a variety of cell biochem. studies, including structural and functional proteomics.

Journal of Proteome Research published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Computed Properties of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jin, Tong-yin published the artcileTheoretical studies on mechanism and kinetics of the hydrogen-abstraction reaction of CF₃CH₂CH₂OH with OH radical, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Computational & Theoretical Chemistry (2013), 63-75, database is CAplus.

The hydrogen abstraction reaction of CF₃CH₂CH₂OH + OH has been studied theor. by dual-level direct dynamics method. The required potential energy surface information for the kinetic calculation was obtained at the MCG3-MPWB//M06-2X/aug-cc-pVDZ level. Five stable conformers of CF₃CH₂CH₂OH have been located. For each conformer, there are three potential H-abstraction sites (Cα, Cβ and -OH), and some of the H atoms can be abstracted by more than one abstraction channel due to the different attack orientations of the incoming OH radical. As a result, 31 distinct H abstraction channels have been identified for the reaction. The individual rate constants for each H abstraction channel were calculated by the improved canonical transition-state theory with small curvature tunneling correction (ICVT/SCT), and the overall rate constant was evaluated by the Boltzmann distribution function. It is shown that the calculated rate constant is in good agreement with the available exptl. data at 298 K, and exhibits neg. temperature dependence with 200-350 K. H-abstraction from the α site dominates the reaction at low temperatures, while the contributions from the β and OH abstractions should be taken into account as temperature increases. The fitted four-parameter expressions within 200-1000 K for the overall rate constants as well as the rate constants from the α, β and OH abstractions were given to provide good estimation for future laboratory investigations. In addition, because of the lack of available exptl. data for the product radicals involved in the reactions, their enthalpies of the formation (ΔH_f,298°) were predicted via isodesmic reaction at the MCG3-MPWB//M06-2X/aug-cc-pVDZ level.

Computational & Theoretical Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Noh, Chanho published the artcileHighly stable aqueous organometallic redox flow batteries using cobalt triisopropanolamine and iron triisopropanolamine complexes, Recommanded Product: Triisopropanolamine, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2021), 126966, database is CAplus.

Two metal-organic complexes consisting of new triisopropanolamine (TiPA) ligand and two transition cobalt (Co) and iron (Fe) metals (Co(TiPA) and Fe(TiPA)) are suggested and used as redox couple for redox flow battery (RFB) with potassium hydroxide (KOH) electrolyte. The redox reactivity of Co(TiPA) and Fe(TiPA) adopting TiPA ligand is measured and their reaction mechanism is compared with that of complexes containing triethanolamine (TEA) ligand (Co(TEA) and Fe(TEA)) that are conventionally considered. According to evaluations, the reaction rate of all complexes is controlled by their diffusion rate. In a comparison of the complexes, that of TEA complexes is faster than that of TiPA complexes. This means that the viscosity of TEA complexes is lower than that of TiPA complexes. However, regarding the stability in KOH, the stability of TiPA complexes is much better than that of TEA complexes, enabling the stable redox reactions over a long period. Considering the reduction potential of complexes and their stabilization constant, TiPA complexes have a higher stabilization constant than TEA complexes because the redox reaction of TiPA complexes is stably performed, whereas the Fe ions of Fe(TEA) are precipitated for charging process and the preciptation induces irreversible reaction in KOH. This is confirmed by the solidified Fe atoms observed onto carbon felt after RFB test. When the performance of RFB using Co(TiPA) and Fe(TiPA) is measured, its capacity retention is well maintained for 100 cycle (298 h), while this RFB shows superior energy efficiency (77% at 40 mA cm^-2) and power d. (81.3 mW cm^-2 at 160 mA cm^-2).

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Noh, Chanho published the artcileOptimization of iron and cobalt based organometallic redox couples for long-term stable operation of aqueous organometallic redox flow batteries, Product Details of C9H21NO3, the publication is Journal of Power Sources (2021), 229799, database is CAplus.

The optimal electrolyte condition for iron (Fe) and cobalt (Co) coordinated with Triisopropanolamine (TiPA) and 3-[Bis(2-hydroxyethyl)amino]-2-hydroxypropanesulfonic acid (DIPSO) is suggested for aqueous organometallic redox flow batteries (AMORFBs), while best combination for improving its long-term stability is determined Co(TiPA) is optimal catholyte due to excellent redox reactivity and stability, while such benefits are proved by the comparison of formation constant which is proportional to the strength of coordination bonds within metal complex. That of Co(TiPA) is 10.8 times higher than that of Co(DIPSO) that is a competitor for catholyte. Regarding anolyte, Fe(DIPSO) formed by 1:1.5 mol ratio of Fe ion to DIPSO ligand is more stable than Fe(TiPA) that is a competitor for anolyte. The stability is exptl. verified by linear sweep voltamogram. According to the measurements, In Fe(DIPSO), potential required for the solidification of Fe ions, which causes the performance degradation of AMORFB, is placed more neg. than that required in Fe(TiPA). This indicates the when Fe(DIPSO) is used, the stable cut-off voltage range for AMORFB tests is extended with its performance improvement. Furthermore, since the solidified Fe further acts as catalyst for undesirable hydrogen evolution reaction, retarding the solidification of Fe ions enhances the performance and stability of AMORFB. In in-situ AMORFB cell tests performed to validify the electrochem. evaluations of metal complexes, the stability of AMORFB using Co(TiPA) and Fe(DIPSO) is best. Regarding its performance, charge capacity is high as 15.5 Ah L^-1, while its capacity loss rate is low as 0.018 Ah L^-1cyc^-1 for 100 cycles.

Journal of Power Sources published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Go, Su Yong published the artcileA Unified Synthetic Strategy to Introduce Heteroatoms via Electrochemical Functionalization of Alkyl Organoboron Reagents, SDS of cas: 597-52-4, the publication is Journal of the American Chemical Society (2022), 144(20), 9149-9160, database is CAplus and MEDLINE.

Based on systematic electrochem. anal., an integrated synthetic platform of C(sp³)-based organoboron compounds was established for the introduction of heteroatoms. The electrochem. mediated bond-forming strategy is highly effective for the functionalization of sp³-hybridized C atoms with significant steric hindrance. Also, virtually all the nonmetallic heteroatoms could be used as reaction partners using one unified protocol. The observed reactivity stems from the two consecutive single-electron oxidations of the substrate, which eventually generates an extremely reactive carbocation as the key intermediate. The detailed reaction profile could be elucidated through multifaceted electrochem. studies. Ultimately, a new dimension in the activation strategies for organoboron compounds was accomplished through the electrochem. driven reaction development.

Journal of the American Chemical Society published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, SDS of cas: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wei, Bing published the artcileChanges in Th1/Th2-producing cytokines during acute exacerbation chronic obstructive pulmonary disease, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Journal of International Medical Research (2018), 46(9), 3890-3902, database is CAplus and MEDLINE.

This study aimed to explore cytokine serum levels and the ratio of type 1 T helper (Th1)/Th2 cells in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). A total 245 patients diagnosed with AECOPD and 193 patients who progressed to stable COPD after the initiation of treatment in hospital were selected, while a further 50 healthy individuals served as controls. All patients with COPD were diagnosed using Global Initiative for Chronic Obstructive Lung Disease criteria. Serum concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-4, IL-10, IL-17, and Ig (Ig)E were measured using enzyme-linked immunosorbent assays. AECOPD patients had higher levels of IL-2, IFN-γ, IL-4, IL-10, IL-17, and IgE than those with stable COPD or controls. Intriguingly, the ratios of Th1/Th2 and IL-17/IgE were lower in AECOPD patients compared with the other two groups. These data suggest that AECOPD patients produce more IgE and have more differentiated Th2 cells than other groups. Ur findings suggest that an imbalance of circulating CD4⁺ T cell subsets correlates with AECOPD, and that a shift of Th1/Th2 and IL-17/IgE ratios may be caused by increased Th2 cell production

Journal of International Medical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C14H18BNO2, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huffman, Benjamin J. published the artcileStereodivergent Attached-Ring Synthesis via Non-Covalent Interactions: A Short Formal Synthesis of Merrilactone A, Formula: C9H22OSi, the publication is Angewandte Chemie, International Edition (2022), 61(3), e202114514, database is CAplus and MEDLINE.

A strategy to control the diastereoselectivity of bond formation at a prochiral attached-ring bridgehead was reported. An unusual stereodivergent Michael reaction relied on basic vs. Lewis acidic conditions and non-covalent interactions to control re- vs. si- facial selectivity en route to fully substituted attached-rings. This divergency reflected differential engagement of one rotational isomer of the attached-ring system. The successful synthesis of an erythro subtarget diastereomer ultimately leads to a short formal synthesis of merrilactone A.

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Formula: C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, Zhenting published the artcileHierarchical Ti3C2Tx@BPA@PCL for flexible polyurethane foam capable of anti-compression, self-extinguishing and flame-retardant, Quality Control of 80-09-1, the publication is Journal of Colloid and Interface Science (2022), 208-220, database is CAplus and MEDLINE.

It is of great importance to fabricate flexible polyurethane foam (FPUF) with superior mech. properties and flame retardancy for practical applications. Herein, organosilicon and Ph phosphorus compounds were synthesized and grafted on the surface of Ti₃C₂T_x (Ti₃C₂T_x@BPA@PCL) via in-situ polymerization Then, the FPUF composites were fabricated, combining intrinsic flame retardancy (9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide-diethanolamine: DH-DOPO) (addition amount: 20 wt%) and Ti₃C₂T_x@BPA@PCL (addition amount: 4 wt%). Attributed to the rigid structure of Ti₃C₂T_x@BPA@PCL, the tensile strength and compression strength of FPUF showed 24.0% and 253% increase, resp. In addition, anti-fatigue properties of FPUF composites during the cyclical test were dramatically enhanced. In contrast to pure FPUF, 36.1% and 44.0% reductions in peak heat release rate (pHRR) and total heat release (THR) were achieved for the FPUF containing Ti₃C₂T_x@BPA@PCL and DH-DOPO, the production rate of carbon dioxide (CO₂) and carbon oxide (CO) also decreased by 40.3% and 52.1%, resp. FPUF4 showed self-extinguishing behavior, and passed the vertical burning test (VBT). This work provides a facile approach to preparing high-performance FPUF with enhanced mech. property and flame retardancy.

Journal of Colloid and Interface Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C2H4ClNO, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts