Month: December 2022

3,7-Dioxaazelaamides as ionophores for lithium ion selective liquid membrane electrodes was written by Metzger, Erich;Aeschimann, Roland;Egli, Martin;Suter, Gaby;Dohner, Rene;Ammann, Daniel;Dobler, Max;Simon, Wilhelm. And the article was included in Helvetica Chimica Acta in 1986.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Neutral lipophilic dioxaazelaamides I (R = H, Me, CMe₂; R¹ = H, Me, Et; R² = H, Me, Bu) were prepared and incorporated in lipophilic liquid membranes. Li⁺-Na⁺ selectivities of these were ≤80; the membranes allow reliable measurements of Li⁺ in blood serum within the clin. concentration range. The structure of the LiSCN complex with I (R = H; R¹ = R² = Me) was determined by x-ray crystallog. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Category: alcohols-buliding-blocks).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of pharmacophores containing a prolinate core using a multicomponent 1,3-dipolar cycloaddition of azomethine ylides was written by Selva, Elisabet;Castello, Luis M.;Mancebo-Aracil, Juan;Selva, Veronica;Najera, Carmen;Foubelo, Francisco;Sansano, Jose M.. And the article was included in Tetrahedron in 2017.Application of 65-22-5 The following contents are mentioned in the article:

Synthesis of pharmacophores containing a prolinate core, e.g. I, II, III and IV via silver acetate catalyzed multicomponent 1,3-dipolar cycloaddition reaction of heterocyclic aldehydes, amino esters and dipolarophiles was described. The preference of each tested amino esters toward different dipolarophiles was discussed. At the end, a selective reduction of an ester group allowed the preparation of dideoxiazanucleoside derivative V. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Influence of molecular structure on transparency of powder coating in synthesis of polyester was written by Pan, Cong-yi;Liu, Liang;Luo, Qing;Wang, Wei-yue;Li, Yong. And the article was included in Xiandai Tuliao Yu Tuzhuang in 2017.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

From the perspective of the raw materials of synthetic polyester resin, curing agent, leveling agent and so on were added to the resin synthesized by different monomers. After melt-extrusion, blending, grinding and sieving, spray it on the glass mirror plate to detect the impact of different synthetic monomer on transparency of coating film. At the same time, the acid value, crystallinity and other indicators of polyester resins were also tested to determine their impact on the transparency of polyester powder coating. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Category: alcohols-buliding-blocks).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Manganese-Catalyzed Dual-Deoxygenative Coupling of Primary Alcohols with 2-Arylethanols was written by Wang, Yujie;Shao, Zhihui;Zhang, Kun;Liu, Qiang. And the article was included in Angewandte Chemie, International Edition in 2018.Synthetic Route of C10H22O The following contents are mentioned in the article:

Reported herein is a general and efficient dual-deoxygenative coupling of primary alcs. with 2-arylethanols catalyzed by a well-defined Mn/PNP pincer complex. This reaction is the first example of the catalytic dual-deoxygenation of alcs. using a non-noble-metal catalyst. Both deoxygenative homocoupling of 2-arylethanols (17 examples) and their deoxygenative cross-coupling with other primary alcs. (20 examples) proceeded smoothly to form the corresponding alkenes by a dehydrogenation and deformylation reaction sequence. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Synthetic Route of C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Structural Aspects of N-Triflylphosphoramides and Their Calcium Salts-Highly Acidic and Effective Bronsted Acids was written by Rueping, Magnus;Nachtsheim, Boris J.;Koenigs, Rene M.;Ieawsuwan, Winai. And the article was included in Chemistry – A European Journal in 2010.Reference of 851615-07-1 The following contents are mentioned in the article:

Recently, 1,1′-bi-2-naphthol (BINOL)-based N-triflylphosphoramides emerged as a new class of potent Bronsted acid catalysts. In this paper we describe the efficient synthesis of various BINOL-based N-triflylphosphoramides, e.g. I [Ar = 1-naphthyl, 2-naphthyl, Ph, etc.], and their calcium salts. Furthermore, X-ray crystal structure anal. combined with energy-dispersive X-ray spectroscopy (EDX) measurements confirmed that the synthesized chiral N-triflylphosphoramides are highly acidic metal-free catalysts. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Reference of 851615-07-1).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 851615-07-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A copper-catalysed one-pot hydroboration/azidation/cycloaddition reaction of alkynes was written by Zimba, Hamilton C.;Baldassari, Lucas L.;Moro, Angelica V.. And the article was included in Organic & Biomolecular Chemistry in 2022.Computed Properties of C37H74NO8P The following contents are mentioned in the article:

Reported study on the development of a catalytic one-pot process, showing the challenges and advantages encountered all over the way. At the end, developed a regioselective, environmentally friendly and operationally simple method to explore the reactivity of functionalized propargylic alkynes through three copper-catalyzed reactions in a single reaction vessel. The sequence consisted of a hydroboration, azidation, and 1,3-dipolar cycloaddition and led to the regioselective formation of vinyl 1,2,3-triazoles in good yields. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Computed Properties of C37H74NO8P).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C37H74NO8P

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anticancer activity of novel 3-azaxanthenes was written by Kibardina, Lyudmila K.;Trifonov, Alexey V.;Dobrynin, Alexey B.;Pudovik, Michail A.;Burilov, Alexander R.;Voloshina, Alexandra D.;Strelnik, Anna G.;Gazizov, Almir S.. And the article was included in Mendeleev Communications in 2021.SDS of cas: 65-22-5 The following contents are mentioned in the article:

Novel 3-azaxanthenes have been synthesized via acid-catalyzed one-pot Friedel-Crafts reaction of pyridoxal/pyridoxal-5-phosphate with naphthols followed by dehydration of the intermediate bis(2-hydroxyaryl)-(pyridin-4-yl)methane derivatives The cytotoxicity of the obtained 3-azaxanthenes against M-HeLa and HuTu-80 tumor cell lines is comparable to that of tamoxifen, whereas the cytotoxicity against normal cell line is absent in the tested concentratons range, which makes this class of compounds interesting for further studies. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Total Synthesis of Paeoveitol was written by Xu, Lun;Liu, Fengyi;Xu, Li-Wen;Gao, Ziwei;Zhao, Yu-Ming. And the article was included in Organic Letters in 2016.HPLC of Formula: 52010-89-6 The following contents are mentioned in the article:

A four-step total synthesis of paeoveitol (I), a recently disclosed norditerpene natural product from Paeonia vetchii, is reported. This highly concise synthetic route was guided by biosynthetic considerations and enabled by an unusual intermol. ortho-quinone methide [4 + 2]-cycloaddition reaction, which proceeded with excellent regio- and diastereoselectivity. D. functional theory (DFT) calculations point to a crucial intermol. hydrogen bond and π-π stacking interaction that govern selectivity in this process. This study involved multiple reactions and reactants, such as 2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6HPLC of Formula: 52010-89-6).

2,5-Dihydroxy-4-methylbenzaldehyde (cas: 52010-89-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 52010-89-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles was written by Kritchenkov, Andreii S.;Kurasova, Margarita N.;Godzishevskaya, Anastasia A.;Mitrofanova, Elizaveta S.;Egorov, Anton R.;Yagafarov, Niyaz Z.;Ballesteros Meza, Moises J.;Tskhovrebov, Alexander G.;Artemjev, Alexey A.;Andrusenko, Elena V.;Khrustalev, Victor N.. And the article was included in Mendeleev Communications in 2021.Reference of 65-22-5 The following contents are mentioned in the article:

The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-mol.-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate mol. weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Direct Synthesis of Mono-α-arylated Ketones from Alcohols and Olefins via Ni-Catalyzed Oxidative Cross-Coupling was written by Yang, Peng-Fei;Shu, Wei. And the article was included in Organic Letters in 2020.Computed Properties of C10H22O The following contents are mentioned in the article:

Controlled synthesis of α-monoarylated ketones is significant yet challenging due to the site-selectivity issues and nonproductive overarylation reactions. Herein, we reported the direct synthesis of α-arylated ketones enabled by Ni-catalyzed dehydrogenative cross-coupling reaction cascade between alcs. and olefins. The use of readily available and cost-effective alcs. and olefins provides a straightforward access to monoarylated ketones in good yields with exclusive selectivity without using any advanced synthetic intermediates. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Computed Properties of C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts