Month: December 2022

Moubri, K. published the artcileDiscovery of a recombinant Babesia canis supernatant antigen that protects dogs against virulent challenge infection, Category: alcohols-buliding-blocks, the publication is Veterinary Parasitology (2018), 21-29, database is CAplus and MEDLINE.

Soluble parasite antigens (SPA) in supernatants of in vitro cultures of Babesia canis can be used to vaccinate dogs against virulent B. canis infection. The moment that immunity becomes apparent coincides with the appearance of antibodies against SPA in the serum of the vaccinated animals. This so-called vaccination-challenge serum (VC-serum) was used to precipitate antigens from B. canis culture supernatants in agarose gels. This antigen preparation was then used to analyze the reactivity of sera from vaccinated dogs on western blots showed that the first appearance of antibody reactivity against a protein that migrated at the 39 kDa position in SDS-PAGE gels was associated with the moment vaccinated dogs started to recover from a virulent challenge infection. In addition, pulse-chase experiments revealed that a 39-40 kDa doublet was released into the supernatant of B. canis cultures starting 15 min after the chase. This doublet was specifically precipitated by VC-serum, thus corroborating that the 39-40 kDa doublet in SPA preparations was of parasite origin. Partial amino acid sequencing allowed the discovery of the gene that encoded the 39-40 kDa doublet (canine Babesia antigen; CBA). The full-length gene was cloned and expressed in E. coli. The recombinant CBA protein (rCBA) was recognized by VC-serum, and antibodies against rCBA precipitated the 39 kDa antigen of SPA preparations and of merozoites of B. canis. In addition, anti-rCBA serum reacted with the surface of B. canis merozoites (but not with B. rossi merozoites) in immunofluorescence. Vaccination of dogs with rCBA induced antibodies against rCBA, which recognized B. canis merozoites. Vaccinated dogs were protected against virulent challenge infection by limiting parasite proliferation. As a result, the development of clin. signs was prevented and the animals self-cured. In contrast, six out of seven non-vaccinated control dogs developed relatively high parasitemia and serious clin. signs associated with poor tissue perfusion. This antigen can be used to replace the SPA antigen in the conventional B. canis vaccines, which eliminates the need for dog blood and serum for vaccine production

Veterinary Parasitology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bold, Christian P. published the artcileStudies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2021), 23(6), 2238-2242, database is CAplus and MEDLINE.

Studies are described toward the synthesis of an oxazole-based analog I of (-)-zampanolide. Construction of (-)-dactylolide analog 22 was achieved via alc. II and acid III through esterification and Horner-Wadsworth-Emmons (HWE)-based macrocyclization; however, attempts to attach (Z,E)-sorbamide to I proved unsuccessful. The C(8)-C(9) double bond of the macrocycle was prone to migration into conjugation with the oxazole ring, which may generally limit the usefulness of zampanolide analogs with aromatic moieties as tetrahydropyran replacements.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ishii, Fumio published the artcileOxidation of hydroquinone and catechols with aqueous sodium hypochlorite under phase-transfer catalysis, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Synthesis (1980), 706-8, database is CAplus.

Hydroquinones I (R = H, Me, Me₃C, tert-octyl, Ph, 4-MeC₆H₄, EtCMe₂; R¹, R³ = H, Me; R² = H, Me₃C, EtCMe₂, tert-octyl; RR¹ = CH:CHCH:CH) and II (R⁴ = H, Me₃C) were treated with 10% NaOCl in the presence of Bu₄N⁺.HSO₄^– to give 14-91% III and 91-92% IV, resp.

Synthesis published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jayakrishnan, S. S. published the artcileDrug utilization pattern in paediatric peritonitis, Quality Control of 23828-92-4, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2020), 9(10), 2159-2174, database is CAplus.

Peritonitis is defined as inflammation of a portion or all of the parietal and visceral peritoneum. In peritonitis, an infection can rapidly spread into the blood (sepsis) and then to other organs, carrying the risk of multiple organ failure and if left untreated death will occur. The objective of the study was to determine the drug utilization pattern of peritonitis among paediatric population. It was a Descriptive study for a period o6 mo with 115 patients. All paediatric patients diagnosed clin. with peritonitis reporting to the Department of Paediatric Surgery for undergoing treatment. A written informed consent was taken in a prescribed format from the patient/caregiver diagnosed with peritonitis. Patient who met the inclusion criteria were enrolled for the study. All the information relevant to the study was collected from case records and direct interview with the patient / caregiver by the help of a physician. In the study, majority of patients (43.5%) were in the age group of 7-10 years and were males. The drugs were classified into 9 classes, depending on the therapeutic indications. Majority of patients were given drugs belonging to Antibiotics in class I (100%), followed by Antiulcers in class -IV (97.4%). Drugs belonging to class- VI Antiemetics (18.3%) were the least used in the study population. Other categories of drugs in the study population included class – II used as Analgesics and Antipyretics (93.9%), class – VIII as Vitamins (45.2%), class – IX i.e, Miscellaneous drugs (32.2%), class V as Laxatives (29.6%), class VII (27.8%) used as Antiasthmatics and Antispasmodics class III (26.1%). The study is concluded by the demog. and drug utilization pattern in paediatric peritonitis. Drug utilization evaluation played a key role in helping health care system to understand, interrupt and improve the prescribing, administration and use of medications.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wada, Masanori published the artcileReactions of 1,8-Dimethoxy-9-phenylxanthen-9-ol in the Presence of an Acid, and Its Basicity, SDS of cas: 596-38-3, the publication is Bulletin of the Chemical Society of Japan (1999), 72(4), 779-785, database is CAplus.

In the presence of a catalytic amount of acid, the title xanthenol (1) reacted in acetone to give 1,8-dimethoxy-9-phenylxanthen-9-ylmethyl Me ketone. Analogous reactions were observed for Et Me ketone and acetophenone, but not for di-Et ketone. Propanal and butanal also reacted to give 2-(1,8-dimethoxy-9-phenylxanthen-9-yl)propanal and 2-(1,8-dimethoxy-9-phenylxanthen-9-yl)butanal, resp. In hot primary and secondary alcs.,1 was reduced to give 1,8-dimethoxy-9-phenylxanthene. 1 also reacted with methoxybenzenes, phenol, and N-alkylanilines to give 9-aryl-1,8-dimethoxy-9-phenylxanthenes. The basicity of 1, or the stability of the carbenium ion (pK_R⁺ = -0.81), was measured in hydrochloric acid and compared with those of related 9-arylxanthen-9-ols, such as 1,8-dimethoxy-9-(2,6-dimethoxyphenyl)xanthen-9-ol (1.14), 9-(2,6-dimethoxyphenyl)xanthen-9-ol (4.80) (8), and 9-phenylxanthen-9-ol (0.75). The drastic differences in the reactivities and the basicity between 1 and 8 were attributed to a steric effect rather than an electronic effect.

Bulletin of the Chemical Society of Japan published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C4H6O3, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Taniguchi, Ikuo published the artcilePiperazine-immobilized polymeric membranes for CO₂ capture: mechanism of preferential CO₂ permeation, HPLC of Formula: 622-40-2, the publication is Polymer Journal (Tokyo, Japan) (2021), 53(1), 129-136, database is CAplus.

Amines are incorporated into various membranes to improve their CO₂ separation performance. With amine-containing polymeric membranes, gas transport properties are often enhanced under humidity, where CO₂ migrates through the membranes in the form of bicarbonate ions. Piperazine (Pz) and its derivatives are known to catalyze the conversion of CO₂ to bicarbonate ions and have been used in liquid amine scrubbing technol. Piperazines were immobilized in poly(vinyl alc.) (PVA), and the resulting polymeric membranes showed high CO₂ separation performance over H₂ and CH₄. The gas transport properties were dependent on the chem. structure of the amines. In particular, 3-(1-piperazinyl)-1,2-propanediol (PzPD)-containing polymeric membranes gave excellent CO₂ separation performance, and the CO₂ permeability and CO₂ selectivity over CH₄ were 1060 Barrer and 370, resp., at 50°C and 90% relative humidity with a transmembrane CO₂ pressure of 11 kPa. The interaction between PzPD and CO₂ was quant. studied by inverse-gate decoupling ¹³C NMR spectroscopy. CO₂ interacted with the secondary amino group on the Pz ring to form a carbamate, which was readily hydrolyzed to produce bicarbonate ions. The hydroxyl group on the C2 carbon of PzPD facilitated the interaction between CO₂ and the amine through hydrogen bonding, resulting in enhanced diffusivity of CO₂ in the membranes.

Polymer Journal (Tokyo, Japan) published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C9H10O3S, HPLC of Formula: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Saito, Akinori published the artcileHydrosilane-assisted formation of metal nanoparticles on graphene oxide, Category: alcohols-buliding-blocks, the publication is Bulletin of the Chemical Society of Japan (2016), 89(1), 67-73, database is CAplus.

Metal nanoparticles were formed on graphene oxide by a deposition process with hydrosilane, giving thin layer metal-graphene oxide (metal/GO) composites. The particle size and catalytic activity could be controlled by varying the hydrosilane amount Hydrosilane prevented the aggregation of GO layers by surface functionalization via silane coupling reaction. The metal/GO composites were evaluated as catalysts in hydrosilane oxidation

Bulletin of the Chemical Society of Japan published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grabosch, Carsten published the artcileA dual Click’ strategy for the fabrication of bioselective, glycosylated self-assembled monolayers as glycocalyx models, Quality Control of 96345-79-8, the publication is Organic & Biomolecular Chemistry (2013), 11(24), 4006-4015, database is CAplus and MEDLINE.

Solid surfaces decorated with specific saccharide patterns can serve as a model for the chem. and structurally highly complex glycocalyx of eukaryotic cells. Here we present an approach based on self-assembled monolayers on gold, which are built up in a three-step manner to provide a solid basis, a biorepulsive oligoethylene glycol part, and a specific glycoside terminus, e.g. I, in a modular way. Of the different reaction sequences, the one with two consecutive click reactions’ (the copper(I)-catalyzed 1,3-dipolar cycloaddition of alkynes with azides and the thiourea-bridging of isothiocyanates with amines) directly on SAM’ results in the densest layers, as demonstrated by IR absorption reflection spectroscopy and ellipsometry. As a real life’ test, the surfaces obtained this way were used for bacterial adhesion experiments Here the biorepulsivity of the middle part of the SAMs as well as specific binding to the carbohydrate termini could be clearly demonstrated.

Organic & Biomolecular Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Haraguchi, Kazutoshi published the artcileNew Aqueous Solutions with Lower Viscosities than Water, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Bulletin of the Chemical Society of Japan (2021), 94(4), 1185-1191, database is CAplus.

Liquid water exhibits many anomalous phys. properties because of its unique structure and hydrogen bonding networks, which were mostly uncovered at the beginning of the 20th century. Because of its interesting properties and microstructures under various conditions and in aqueous solutions, understanding the behavior of water is important, but remains scientifically challenging. Regarding the viscosity of aqueous solutions, despite the discovery 147 years ago that very small amounts of certain salts decrease the viscosity of water slightly, there has been no significant progress to date. Herein, we report new aqueous solutions, with low additive fractions and much lower viscosities than pure water, which exhibit unique viscosity-composition curves. The findings should spark renewed interest in scientific research on water, which may greatly impact numerous industries.

Bulletin of the Chemical Society of Japan published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boggu, Pulla Reddy published the artcileDiscovery of benzimidazole analogs as a novel interleukin-5 inhibitors, COA of Formula: C4H11NO, the publication is European Journal of Medicinal Chemistry (2019), 111574pp., database is CAplus and MEDLINE.

A series of novel ((hydroxyalkyl)aminomethyl)benzimidazole analogs I [n = 1, 2, 3, 4; R = H, tert-Bu, Ph, etc.; R¹ = H, cyclohexyl, 4-pyridinylmethyl, etc.] and II [R² = Ph, 4-methoxyphenyl, benzyl, 4-methoxybenzyl] were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, compound I [n = 1, R = Et, R¹ = H] (94.3% inhibition at 30 μM, IC₅₀ = 3.5 μM, cLogP = 4.132) and compound I [n = 1, R = cyclohexylemthyl, R¹ = H] (94.7% inhibition at 30 μM, IC₅₀ = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon played an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of compounds I [n = 1; R = Et, cyclohexylmethyl; R¹ = H] with normal B lymphoblasts revealed that they had no significant effects on cell viability.

European Journal of Medicinal Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts