Month: November 2022

In 2019,Advanced Synthesis & Catalysis included an article by Oh, Hyunseok; Park, Areum; Jeong, Kyu-Sung; Han, Soo Bong; Lee, Hyuk. COA of Formula: C6H12O. The article was titled 《Copper-Catalyzed 1,2-Bistrifluoromethylation of Terminal Alkenes》. The information in the text is summarized as follows:

The catalytic 1,2-bistrifluoromethylations of alkenes catalyzed by Copper (Cu) have been reported. Two CF3 sources have been used, namely Umemoto’s reagent and (trifluoromethyl)trimethylsilane (TMSCF3). Each reagent plays a unique role during this transformation; Umemoto’s reagent generates CF3 radicals, while TMSCF3 is used to form CF3 anions. Copper (I) bromide (CuBr) exhibited the best catalytic activity for this reaction. CuBr oxidizes the alkyl radical, which is produced by the addition of CF3 radical to the alkenes R(CH2)nCH2=CH2 (Ar = 4-acetamidophenoxy, 3-methylphenoxy, phthalimido, (4-methylbenzene)sulfonamido, 4-formylphenoxy, etc.; n = 1, 2, 3, 4) to the corresponding alkyl cation, which then reacts with the CF3 anion from TMSCF3 to produce the desired products R(CH2)nCH(CF3)CH2CF3. This reaction tolerates a diverse set of substrates bearing functional groups such as amides, esters, ethers, ketones, protected amines, tertiary amines, and phthalimides, hence making this transformation to be widely applicable to a wide variety of substrates. After reading the article, we found that the author used 5-Hexen-1-ol(cas: 821-41-0COA of Formula: C6H12O)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.COA of Formula: C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemistry – A European Journal included an article by Zheng, Lu; Zhan, Yulin; Ye, Lin; Zheng, Dan; Wang, Ying; Zhang, Kun; Jiang, Hua. SDS of cas: 126456-43-7. The article was titled 《Chiral Induction and Remote Chiral Communication in Quinoline Oligoamide Foldamers for Determination of Enantiomeric Excess and Absolute Configuration of Chiral Amines and Their Derivatives》. The information in the text is summarized as follows:

Two pentameric foldamers, Q5 (I) and Q5C-S (II), containing a C-F bond were synthesized based on quinoline oligamide foldamers for the measurement of enantiomeric excess and for the determination of absolute configuration of chiral amines, diamines, amino alcs., and α-amino acid esters. Chiral induction of Q5 was triggered in situ when the chiral analytes reacted with the C-F bond in Q5 by a N-nucleophilic substitution reaction, leading to a linear correlation between the CD amplitude at the region of quinoline chromophores and the ee values of the chiral analytes, which can be used for the ee determination of chiral analytes. Furthermore, the CD intensity of Q5C-S containing a chiral motif at its C-terminus enhances via remote, favorable chiral communication when the chiral induction was triggered in situ by chiral analytes at the N-terminus matches the original helicity of Q5C-S, but decreases via remote, conflicted chiral communication when the chiral induction is triggered in situ by chiral mols. at the N-terminus mismatches the original one. The system can thus be used for determination of the absolute configuration of chiral analytes, given that the chirality of the chiral motif at the C-terminus of Q5C-S is known. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7SDS of cas: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.SDS of cas: 126456-43-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Membrane Science included an article by Shi, Xiansong; Xiao, Ankang; Zhang, Chenxu; Wang, Yong. Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde. The article was titled 《Growing covalent organic frameworks on porous substrates for molecule-sieving membranes with pores tunable from ultra- to nanofiltration》. The information in the text is summarized as follows:

Crystalline imine-based covalent organic frameworks (COFs) have attracted great interest as next-generation water treatment materials owning to their numerous merits. The construction of COF layers with tunable pore sizes ranging from meso- to micropores, which can significantly broaden the membrane selectivity from ultra- (UF) to nanofiltration (NF), has remained unexplored. Herein, we demonstrate the controllable solvothermal synthesis of COF layers with adjustable pore sizes on anodic aluminum oxide (AAO) substrates. With rising synthesis duration the modulation on pore sizes of AAO supports can be achieved till the formation of continuous COF layers, leading to a gradually enhanced selectivity. Importantly, the synthesized microporous COFs shrink the pore sizes of AAO substrates and provide addnl. nanochannels for water transporting, eventuating in a ∼2-9 times higher permeance than other reported UF membranes with comparable rejections. Once forming continuous COF layers, more rigid selectivities based on COF inherent nanochannels (∼1.83 nm) can be realized with capacities of removing dyes from water or organic solvent. This work provides a facile methodol. to construct COF-based membranes with broadly tunable separation performance, recommending the membranes for removing targeted mols. including proteins, nanoparticles, and dyes. In the experiment, the researchers used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeFor acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Bulletin of Materials Science included an article by Dang, Le Hang; Huynh, Ngoc Trinh; Pham, Ngoc Oanh; Nguyen, Cong Truc; Vu, Minh Thanh; Dinh, Van Thoai; Le, Van Thu; Tran, Ngoc Quyen. COA of Formula: C3H9NO. The article was titled 《Injectable nanocurcumin-dispersed gelatin-pluronic nanocomposite hydrogel platform for burn wound treatment》. The information in the text is summarized as follows:

To utilize the potent pharmaceutical properties of curcumin (Cur) and gelatin-based materials in tissue regeneration, we fabricated a thermosensitive nanocomposite hydrogel based on pluronic-grafted gelatin (PG) and nanocurcumin (nCur) to enhance burn healing. In this method, the amphiphilic PG played a role as a surfactant to prepare and protect nanosized Cur particles, which could overcome the poor dissolution of the phytochem. The synthesized PG was identified by 1H NMR. Depending on the amount of Cur, size distribution of the dispersed nCur ranged from 1.5 ± 0.5 to 16 ± 3.2 nm as observed using transmission electron microscopy and dynamic light scattering. The nCur-dispersed PG solution formed nCur-PG nanocomposite hydrogel on warming up to 35oC. Release profile indicated sustainable release of Cur from the injectable platform. Fibroblast cells were well proliferated on the nanocomposite hydrogel. The nCur-PG enhanced the healing process of second-degree burn wound. These results showed potential applications of the biomaterial in tissue regeneration. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6COA of Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Medicinal Chemistry Research included an article by Khan, Ayesha; Khan, Ajmal; Farooq, Umar; Taha, Muhammad; Shah, Syed Adnan Ali; Halim, Sobia Ahsan; Akram, Arfa; Khan, Mohammed Ziauddin; Jan, Abdul Khaliq; Al-Harrasi, Ahmed. Quality Control of 3,5-Dihydroxybenzaldehyde. The article was titled 《Oxindole-based chalcones: synthesis and their activity against glycation of proteins》. The information in the text is summarized as follows:

Diabetes mellitus, a metabolic disorder, is characterized by a substantial hyperglycemia. Prevalence of hyperglycemia for longer period of time can cause nonenzymic condensation of sugar in blood with amino group of protein and give rise to advanced glycation end products (AGEs). AGEs play a major role in the onset of late diabetic complications including diabetic retinopathy, nephropathy, neuropathy and cardiovascular diseases. There is a need to establish potential therapeutic regimens that can effectively inhibit the formation of AGEs. To this end a series of novel oxindole-based chalcones have been investigated for their antiglycation potential. Analogs 1 (IC50 = 155.22 ± 2.98 μM), 3 (IC50 = 195.95 ± 0.43 μM), 4 (IC50 = 289.47 ± 2.47 μM), 5 (IC50 = 222.44 ± 4.03 μM), 7 (IC50 = 251.27 ± 2.80 μM), and 20 (224.23 ± 1.93 μM) showed potent inhibitory activity against glycation compared to the reference Rutin (IC50 = 294.5 ± 1.5 μM). These results reveal that multiple hydroxyl substituents and their position on the aromatic ring play a key role in inhibitory effect due to their hydrogen bonding potential. The study also reveals the influence of substituents on the binding capabilities and in turn inhibitory potential of different analogs.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Enzymatic degradation of fluorinated Poly(ε-caprolactone) (PCL) block copolymer films with improved hydrophobicity》 were Liu, Qun; Wang, Haipeng; Chen, Lei; Li, Wulong; Zong, Yakun; Sun, Yi; Li, Zhanxiong. And the article was published in Polymer Degradation and Stability in 2019. COA of Formula: C6H15NO The author mentioned the following in the article:

Fluorinated Poly(ε-caprolactone) (PCL) block copolymers PCL-PTFOA(2 h), PCL-PTFOA(4 h), PCL-PTFOA(6 h), PCL-PTFOA(8 h) were prepared via esterification by using poly(1H,1H,2H,2H-perfluorooctylacrylate) (PTFOA) with different mol. weights as reactants. It was found that PCL-PTFOA(6 h) and PCL-PTFOA(8 h) possessed the similar mol. weight via GPC anal. PCL and fluorinated PCL block copolymers films were prepared by solution casting method. The structure and properties of film surface of the fluorinated PCL block copolymers were analyzed by energy dispersive X-ray spectrometer (EDS), scanning electron microscope (SEM), Differential scanning calorimetry (DSC), water contact angles (WCAs) and the surface free energy. The results showed that the fluorinated PCL films possessed improved hydrophobicity because of the microphase separation between fluoropolymer chain and PCL chain. The enzymic degradation of PCL, PCL-PTFOA(2 h), PCL-PTFOA(4 h) and PCL-PTFOA(6 h) films were performed at 37 °C in a phosphate buffer solution (PBS, 0.1 M, with a pH of 7.2-7.4) with lipase and analyzed by weight loss, SEM and EDS. It was found that the introduction of fluorine-containing segment reduced the rate of enzymic degradation of the copolymer film in the early period, while increased the finally weight loss rate with a prolonged time. In addition, the enzymic degradation rate of PCL-PTFOA(2 h) film and PCL-PTFOA(4 h) film was faster than that of PCL-PTFOA(6 h) film. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3COA of Formula: C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.COA of Formula: C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Folate-conjugated chitosan-pluronic P123 nanogels: synthesis and characterizations towards dual drug delivery》 were Nguyen, Van Toan; Nguyen, Thi Huong; Dang, Le Hang; Vu-Quang, Hieu; Tran, Ngoc Quyen. And the article was published in Journal of Nanomaterials in 2019. Reference of 4-Aminobutan-1-ol The author mentioned the following in the article:

In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system. 1H-NMR and TGA proved that the fabricating method of CP-FA was successful. Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16.27 ± 2.01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate pos. potential value (39.43 ± 3.45 mV) and the lower critical micelle concentration (0.036 mg/mL). Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer. The high hydrophobicity of the segment induced a great loading efficacy of up to 98.63 ± 0.42 of PTX and 97.82 ± 0.48 of Cur. In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time. The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel. The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5.74 ± 0.23 nM which was higher than that of CP-FA/PTX (IC50 = 8.20 ± 1.41 nM) due to the synergistic effect of both PTX and Cur. Thereby, a dual-drug delivery-system-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Fabrication of Hydrazone-Linked Covalent Organic Frameworks Using Alkyl Amine as Building Block for High Adsorption Capacity of Metal Ions》 were Li, Ya; Wang, Chang; Ma, Shujuan; Zhang, Haiyang; Ou, Junjie; Wei, Yinmao; Ye, Mingliang. And the article was published in ACS Applied Materials & Interfaces in 2019. Electric Literature of C9H6O6 The author mentioned the following in the article:

There are several researches on the preparation and application of hydrazone-linked covalent organic frameworks (COFs), and all of them generally necessitate rigid aromatic amines. Herein, we report a strategy for design and synthesis of COF with flexible alkyl amine as a building block and intramol. hydrogen bonding as a knot in the network. The proof-of-concept design was demonstrated by exploring 1,3,5-triformylphloroglucinol and oxalyldihydrazide (ODH) as precursors to synthesize a novel COF material (TpODH), in which different organic building units are combined through hydrazone bonds to form two-dimensional porous frameworks. It should be pointed that irreversible enol-to-keto tautomerism and intramol. N-H···O=C hydrogen bonding of TpODH would enhance the crystallinity and chem. stability, leading to large sp. surface area of 835 m2 g-1. However, another COF synthesized with 1,3,5-triformylbenzene and ODH exhibited less crystallinity and low special surface area (94 m2 g-1). Representatively, the resulting TpODH afforded Cu(II) and Hg(II) capacities of 324 and 1692 mg g-1, resp., which exceeded that of most COFs previously reported. Moreover, the Fourier-transform IR and XPS spectra analyses were taken to demonstrate the adsorption mechanism. These results suggested that the materials could be applied to the removal of metallic ions in the future. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Electric Literature of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Electric Literature of C9H6O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones》 were Taha, Muhammad; Alkadi, Khaled A. A.; Ismail, Nor Hadiani; Imran, Syahrul; Adam, Aishah; Kashif, Syed Muhammad; Shah, Syed Adnan Ali; Jamil, Waqas; Sidiqqui, Salman; Khan, Khalid Mohammed. And the article was published in Arabian Journal of Chemistry in 2019. SDS of cas: 100-83-4 The author mentioned the following in the article:

A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones I [R1 = C5H4N, 4-FC6H4, 2,4-(HO)2C6H3, etc.] was synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involved a 3-step reaction in which a pyridine diamine was converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target mols. after treating them with the appropriate benzohydrazone derivatives The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound I [R1 = 2,4,6-(HO)3C6H2] (140.16 ± 0.36μM) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Ionic liquid as a green solvent for ionothermal synthesis of 2D keto-enamine-linked covalent organic frameworks》 were Dong, Bin; Wang, Wen-Jing; Pan, Wei; Kang, Guo-Jun. And the article was published in Materials Chemistry and Physics in 2019. COA of Formula: C9H6O6 The author mentioned the following in the article:

Covalent organic frameworks (COFs) are usually synthesized under solvothermal conditions in a mixture of high-boiling organic solvents in a sealed system. By using a room temperature ionic liquid (IL) as a solvent, we presented the preparation of two-dimensional (2D) keto-enamine-linked COFs in an open container at ambient pressure. The as-synthesized 2D keto-enamine-linked COFs have ordered open channels and so the IL can be completely removed from the pores to provide the sole formation of crystalline 2D COFs. Not only the imidazolium-based IL acted as both solvent and catalyst, it was also recycled for further use without activity loss. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4COA of Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.COA of Formula: C9H6O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts