Month: November 2022

Name: (4-Bromophenyl)methanolIn 2019 ,《Iridium(I)-Catalyzed C-C and C-N Bond Formation Reactions via the Borrowing Hydrogen Strategy》 was published in Journal of Organic Chemistry. The article was written by Genc, Sertac; Arslan, Burcu; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya. The article contains the following contents:

Iridium(I) complexes having an imidazol-2-ylidene ligand with benzylic wingtips efficiently catalyzed the β-alkylation of secondary alcs. with primary alcs. and acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones through a borrowing hydrogen pathway. The β-alkylated alcs., including cholesterol derivatives, and substituted quinolines were obtained in good yields by using a minute amount of the catalyst with a catalytic amount of NaOH or KOH under the air atm., liberating water (and H2 in the case of quinoline synthesis) as the sole byproduct. Notably, this system demonstrated turnover numbers of 940,000 (for β-alkylation of secondary alcs. with primary alcs. by using down to 0.0001 mol % = 1 ppm of the catalyst) and 9200 (acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones). After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Name: (4-Bromophenyl)methanol)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Name: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateIn 2015 ,《Facile synthesis of fine Zn2SnO4 nanoparticles/graphene composites with superior lithium storage performance》 was published in Journal of Power Sources. The article was written by Wang, Bang-Yong; Wang, Hui-Yuan; Ma, Yin-Long; Zhao, Xiao-Hui; Qi, Wen; Jiang, Qi-Chuan. The article contains the following contents:

Fine Zn2SnO4 nanoparticles are synthesized via a facile hydrothermal route using potassium sodium tartrate as a structure-directing agent for the first time. The average size of the as-prepared nanoparticles is about 8-10 nm. More significantly, based on the effect of the reaction time and the amounts of tartrate on the morphol. evolution of the precursors, a crystal growth mechanism is proposed involving in-situ dissolution-recrystallization accompanied by morphol. and phase change. The Zn2SnO4/graphene (Zn2SnO4/G) nanocomposites are further obtained through the incorporation of graphene sheets under another hydrothermal condition. When evaluated as anode for lithium ion batteries, Zn2SnO4/G nanocomposites deliver a high specific capacity of 745 mAh/g after 100 cycles at 200 mA/g and improved cyclic stability with a capacity of 492 mAh/g after 500 cycles at 500 mA/g. The outstanding electrochem. performance is mainly ascribed to the synergetic effect of fine Zn2SnO4 nanoparticles and graphene nanosheets. Furthermore, our work provides a simple and low-cost synthetic strategy for the controllable fabrication of various structural materials for energy storage. The results came from multiple reactions, including the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Recommanded Product: (4-Bromophenyl)methanolIn 2021 ,《TEMPO-Functionalized Nanoreactors from Bottlebrush Copolymers for the Selective Oxidation of Alcohols in Water》 was published in Journal of Organic Chemistry. The article was written by Wang, Maolin; Xu, Zhenkai; Shi, Yi; Cai, Fang; Qiu, Jiaqi; Yang, Guang; Hua, Zan; Chen, Tao. The article contains the following contents:

Preparation of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-containing nanoreactors by the self-assembly of amphiphilic bottlebrush copolymers was demonstrated. First, a macromonomer having a norbornenyl polymerizable group were prepared by RAFT polymerization of hydrophobic and hydrophilic monomers. The macromonomer were further subjected to ring-opening metathesis polymerization to produce an amphiphilic bottlebrush copolymer. Further, TEMPO, as a catalyst, were introduced into the hydrophobic block through the activated ester strategy. Finally, TEMPO-functionalized polymeric nanoreactors were successfully obtained by self-assembly in water. The nanoreactors exhibited excellent catalytic activities in selective oxidation of alcs. in water. More importantly, the reaction kinetics showed that the turnover frequency was greatly increased compared to that of the similar nanoreactor prepared from liner copolymers under the same conditions. The outstanding catalytic activities of the nanoreactors from bottlebrush copolymers was attributed to the more stable micellar structure using the substrate concentration effect. Work presents a new strategy to fabricate stable nanoreactors, paving the way for highly efficient organic reactions in aqueous solutions In addition to this study using (4-Bromophenyl)methanol, there are many other studies that have used (4-Bromophenyl)methanol(cas: 873-75-6Recommanded Product: (4-Bromophenyl)methanol) was used in this study.

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Recommanded Product: (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

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Quality Control of 3-HydroxybenzaldehydeIn 2022 ,《Design, Synthesis, and Biological Screening for Cytotoxic Activity of Monastrol Analogues》 was published in Polycyclic Aromatic Compounds. The article was written by Asham, Hila; Bohlooli, Shahab; Dostkamel, Donya; Rezvanpoor, Sadaf; Sepehri, Saghi. The article contains the following contents:

A series of 1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives I (Ar = 3-HOC6H4, 4-O2NC6H4, 4-BrC6H5; X = O, S; R = CH3, C2H5) was synthesized through one-pot condensation reaction. Then, they were investigated for in vitro cytotoxic activity. These derivatives showed a good cytotoxic activity against three human cancer cell lines counting MCF-7, HepG-2, and AGS. Among these derivatives, mols. I (Ar = 4-BrC6H5; X = S; R = C2H5) and I (Ar = 3-HOC6H5; X = S; R = CH3) exhibited the highest activity against all cell lines. In vitro cytotoxicity evaluation on all mols. showed that sulfur atom at C2 position, length chain of ester moiety and different substituents on Ph ring positions of tetrahydropyrimidine influenced the antiproliferative activity. Furthermore, according to docking studies a good correlation between exptl. activity and binding affinity was observed In silico studies of mols. showed the participation of hydrophobic interactions and hydrogen bonds with allosteric site Eg5 active site similar to monastrol, Eg5 inhibitor, and co-crystal ligand. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Quality Control of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Quality Control of 3-Hydroxybenzaldehyde

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《One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction》 was written by Loureiro, Daniela R. P.; Soares, Jose X.; Maia, Ana; Silva, Andre M. N.; Rangel, Maria; Azevedo, Carlos M. G.; Hansen, Steffen V.; Ulven, Trond; Pinto, Madalena M. M.; Reis, Salette; Afonso, Carlos M. M.. COA of Formula: C6H7BO3This research focused onxanthone preparation one pot Suzuki coupling. The article conveys some information:

In this communication, the first time a one-pot synthesis of the xanthone scaffold based on a carbonylative Suzuki coupling was reported. Iodophenol and (2-methoxyphenyl)boronic acid were coupled under carbon monoxide, generated from a carbon monoxide surrogate. An exptl. data-based model was built to guide the reaction optimization. The optimized conditions were 1 mol% of a pincer complex as palladium catalyst, 5 equiv of K2CO3 as base, and DMF:water (7 : 3) as solvent. The robustness of the synthetic method, namely in terms of the reactants scope, was also evaluated. This approach provided the xanthone scaffold in high yields and provided a deep insight into the carbonylative Suzuki couplings. The experimental process involved the reaction of 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringCOA of Formula: C6H7BO3

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《Spatiotemporal distribution of Streptococcus agalactiae attenuated vaccine strain YM001 in the intestinal tract of tilapia and its effect on mucosal associated immune cells》 was written by Huang, Ting; Li, Li-Ping; Liu, Yu; Luo, Yong-Ju; Wang, Rui; Tang, Jia-You; Chen, Ming. Synthetic Route of C13H19Br2ClN2O And the article was included in Fish & Shellfish Immunology on April 30 ,2019. The article conveys some information:

In the current study, the tilapia was orally vaccinated by the attenuated Streptococcus agalactiae(S. agalactiae) strain YM001, and the distribution and the pathol. effect of strain YM001 in different intestinal segments of tilapia were evaluated by real-time PCR(qPCR), immunohistochem.(IHC) and histomorphol. The qPCR results showed that the number of bacteria was the highest in the intestinal tracts at 12 h post oral gavage in the YM001 group, then began to decrease sharply and eliminated at 7 d. And the number of bacteria was highest in the foregut, hindgut, and rectum at 12 h, 24 h, and 3 d, resp. IHC indicated that bacteria mainly distributed in the margin epithelium and the goblet cells at 12 h – 24 h, and in the submucosa and muscle layer in the YM001 group in 3 d post gavage, then almost disappeared at 7 d. Histol. examination of intestines post gavage displayed that an inflammation was observed at 7 d in the YM001 group and the intestinal structure was fully recovered at 15 d. and the intestinal structure was fully recovered at 15 d. The attenuated S. agalactiae vaccine strain YM001 could enter the intestinal tissue after oral gavage and had a strong spatial and temporal selectivity in the intestinal tract, which could cause obvious mucosal immune response and mild pathol. reaction, but the pathol. change could be gradually repaired with the extinction of bacteria in the body. In the experiment, the researchers used many compounds, for example, trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Synthetic Route of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Synthetic Route of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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《Two tetranuclear 3d-4f heterometal complexes Mn2Ln2 (Ln = Dy, Gd): synthesis, structure, magnetism, and electrocatalytic reactivity for water oxidation》 was written by Lan, Tian-Xiang; Gao, Wei-Song; Chen, Chang-Neng; Wang, Hui-Sheng; Wang, Mei; Fan, Yu-hua. Computed Properties of C7H9NO2This research focused ontransition metal pyridinyldimethanol bishydroxymethylpyridinylmethylester preparation redox potential magnetism; electrochem oxidation catalyst transition metal pyridinyldimethanol bishydroxymethylpyridinylmethoxymethylester complex; crystal structure transition metal pyridinyldimethanol bishydroxymethylpyridinylmethoxymethylester complex. The article conveys some information:

Two Mn/Ln clusters, [Mn2Ln2(O2CMe)6(pdmH)2L](NO3)·H2O (Ln = Dy (1), Gd (2)), were synthesized and exptl. studied by x-ray crystallog., PXRD, magneto- and electrochem., pdmH2 = 2,6-pyridine dimethanol; LH2 = (6-hydroxymethylpyridin-2-yl)-(6-hydroxymethylpyridin-2-ylmethoxy)methanol. By x-ray anal., the two complexes are isomorphous, both possessing one [MnIIMnIIILnIII2(μ3-O)2]6+ core with four metal atoms in one plane arranged in a butterfly conformation. This is the 1st time that mixed-valent manganese (MnII and MnIII) and LnIII heterometal tetranuclear complexes were isolated and characterized. Magnetic susceptibility measurements reveal that compounds 1 and 2 both display overall weak ferromagnetic exchanges between the metal ions within the clusters. The temperature dependencies of the out-of-phase (χM’) and in-phase (χM’) a.c. susceptibility signals exhibit no significant frequency-dependency for compounds 1 and 2, which suggests that the two complexes may not be SMMs. Electrochem. studies indicate that compounds 1 and 2 can both catalyze water oxidation at a potential of ∼1.70 V with an overpotential of ∼880 mV vs. Normal H electrode, which could be due to a cooperative catalytic effect between the manganese and lanthanide ions. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Computed Properties of C7H9NO2

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Application of 1082066-29-2On October 31, 2019 ,《Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer》 appeared in Bioorganic Chemistry. The author of the article were Skarbek, Charles; Serra, Silvia; Maslah, Hichem; Rascol, Estelle; Labruere, Raphael. The article conveys some information:

This study describes the synthesis of arylboronate-based ROS-responsive prodrugs of doxorubicin and their biol. evaluation as anticancer agents. The determination of the most sensitive cancer type toward arylboronate prodrugs is crucial for further consideration of these mols. in clin. phase. To address this goal, an arylboronate-based profluorescent probe was used to compare the capacity of various cancer cell lines to efficiently convert the precursor into the free fluorophore. On the selected MiaPaCa-2 pancreatic cancer cells, a benzeneboronate prodrug exhibited 67% of the cytotoxicity obtained with the free doxorubicin. The prodrug was also able to induce tumor regression on MiaPaCa-2 pancreatic tumor model in ovo. Using this model, the amount of free doxorubicin liberated from this prodrug into the tumor was equivalent to the quantity measured after direct intratumoral injection of the same concentration of doxorubicin. After reading the article, we found that the author used (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2Application of 1082066-29-2)

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application of 1082066-29-2

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Application of 23828-92-4On March 25, 2020, Zheng, Rui; Tao, Liyuan; Kwong, Joey S. W.; Zhong, Changming; Li, Chengyu; Chen, Shiqi; Sun, Yang; Zhang, Xiaoyu; Shang, Hongcai published an article in Journal of Ethnopharmacology. The article was 《Risk factors associated with the severity of adverse drug reactions by Xiyanping injection: A propensity score-matched analysis》. The article mentions the following:

Xiyanping injection (XYP), extraction of Andrographis paniculate (Andrographis paniculata (Burm. f.) Nees, chuan xin lian), is a Chinese patent medicine approved to treat bronchitis in China. In 2017, safety incidents associated with treatment of XYP began to emerge throughout China. However, the risk factors of severity of adverse reactions by XYP remain uncertain. To determine risk factors for the severity of XYP-associated adverse drug reactions (ADRs). We analyzed a total of 26,317 cases of ADRs linked to the use of XYP injection in the China National Adverse Drug Reaction Monitoring Information System from 2004 to 2017. Data were analyzed with respect to age, gender, ethnicity, previous ADRs, family history of ADRs, dosage specification, medication frequency specification, body weight, route of administration, herb-drug interactions (ribavirin, cefatriaxone, penicillin sodium, ambroxol hydrochloride, clindamycin, cefoxitin sodium, azithromycin, ceftazidime, amoxicillin sodium and clavulanate potassium, levofloxacin, cefazolin sodium pentahydrate, acyclovir) by univariate anal. and multivariate anal. Propensity score matching was used to compare severity of (general or serious) ADRs. We included 24,911 cases of general ADRs and 1406 cases of serious ADRs. Univariate anal. identified age (p < 0.001), body weight (p < 0.001), route of administration (p = 0.008), co-administration of XYP with ribavirin (p = 0.031) as risk factors of severity of ADRs. Multivariate anal. identified XYP + ribavirin combination (p = 0.048) and age (p < 0.001) as the independent risk factors. Upon propensity score matching, the variables were relatively balanced amongst the two groups of patients with general or severe ADRs, and the level of severity in patients who received treatment of XYP + ribavirin increased (p = 0.020). Age and co-administration of ribavirin may be potential risk factors for the severity of XYP-associated ADRs. This reminds us to pay more attention to the safety of elderly medication. Minimizing the herb-drug-interaction effects of XYP and ribavirin is a viable treatment target for healthcare professionals in managing serious ADRs amongst patients receiving XYP injection. The experimental process involved the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Application of 23828-92-4)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Application of 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

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Category: alcohols-buliding-blocksOn October 31, 2009 ,《Iridium complexes of N-heterocyclic carbenes in C-H borylation using energy efficient microwave technology: influence of structure, ligand donor strength and counter ion on catalytic activity》 appeared in Green Chemistry. The author of the article were Rentzsch, Christoph F.; Tosh, Evangeline; Herrmann, Wolfgang A.; Kuehn, Fritz E.. The article conveys some information:

Bridged and unbridged N-heterocyclic carbene (NHC) ligands were metalated with [Ir(COD)Cl]2 to give Ir(I) mono- and biscarbene substituted catalysts [Ir(COD)NHC(Cl)] and [Ir(COD)(NHC)2][X] (X: I, PF6, BF4, CF3COO, OTf). The prepared NHC-complexes were tested in the C-H borylation reaction of aromatic carbons with bis(pinacolato)diboron (B2pin2) and pinacolborane (HBpin). The use of microwave technol. in this study not only facilitates a time efficient screening of a wide range of influences such as ligand σ-donor strength and structural motif as well as the effects of the complex counterion, but also provides an energy efficient heating source. Catalyst (η4-1,5-cyclooctadiene)(1,1′-methyl-3,3′-propylene-diimidazol-2,2′-diylidene)iridium(I) trifluoroacetate (6TFA), which features a chelating NHC ligand, proved to be the most effective catalyst and further studies with this complex in the borylation of mono- and disubstituted benzene derivatives exploring chemo- and regioselectivity were undertaken. In the experimental materials used by the author, we found 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Category: alcohols-buliding-blocks)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Category: alcohols-buliding-blocks

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