Month: November 2022

Product Details of 100-83-4In 2019 ,《Covalent immobilization of Co complex on the surface of SBA-15: Green, novel and efficient catalyst for the oxidation of sulfides and synthesis of polyhydroquinoline derivatives in green condition》 was published in Polyhedron. The article was written by Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Tamoradi, Taiebeh; Ghadermazi, Mohammad. The article contains the following contents:

In this work, a green and novel catalyst was prepared through immobilization of cobalt complex on the surface of mesostructured SBA-15 and characterized by TGA, SEM, FT-IR, EDX, ICP, BET and X-ray mapping anal. methods. This mesostructural material was used as an efficient and green interphase catalyst for the oxidation reactions and synthesis of polyhydroquinoline derivatives All reactions were performed in short times and good yields. Moreover, the prepared catalyst could be used up to six runs without significant degradation in its catalytic activity or cobalt leaching. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Product Details of 100-83-4

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Application In Synthesis of Azetidin-3-ol hydrochlorideIn 2017 ,《Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity》 was published in ACS Chemical Neuroscience. The article was written by Lu, Wenfeng; Liu, Yongqiang; Ma, Haikuo; Zheng, Jiyue; Tian, Sheng; Sun, Zhijian; Luo, Lusong; Li, Jiajun; Zhang, Hongjian; Yang, Zeng-Jie; Zhang, Xiaohu. The article contains the following contents:

Abstract: Medulloblastoma is one of the most prevalent brain tumors in children. Aberrant hedgehog (Hh) pathway signaling is thought to be involved in the initiation and development of medulloblastoma. Vismodegib, the first FDA-approved cancer therapy based on inhibition of aberrant hedgehog signaling, targets smoothened (Smo), a G-protein coupled receptor (GPCR) central to the Hh pathway. Although vismodegib exhibits promising therapeutic efficacy in tumor treatment, concerns have been raised from its nonlinear pharmacokinetic (PK) profiles at high doses partly due to low aqueous solubility Many patients experience adverse events such as muscle spasms and weight loss. In addition, drug resistance often arises among tumor cells during treatment with vismodegib. There is clearly an urgent need to explore novel Smo antagonists with improved potency and efficacy. Through a scaffold hopping strategy, the authors have identified a series of novel tetrahydropyrido[4,3-d]pyrimidine derivatives, which exhibited effective inhibition of Hh signaling. Among them, compound I is three times more potent than vismodegib in the NIH3T3-GRE-Luc reporter gene assay. Compound I has lower m.p. and much greater solubility compared with vismodegib, resulting in linear PK profiles when dosed orally at 10, 30, and 100 mg/kg in rats. Furthermore, compound I showed excellent PK profiles with a 72% oral bioavailability in beagle dogs. Compound I demonstrated overall favorable in vitro safety profiles with respect to CYP isoform and hERG inhibition. Finally, compound I led to significant regression of s.c. tumor generated by primary Ptch1-deficient medulloblastoma cells in SCID mouse. In conclusion, tetrahydropyrido[4,3-d]pyrimidine derivatives represent a novel set of Smo inhibitors that could potentially be utilized to treat medulloblastoma and other Hh pathway related malignancies. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Application In Synthesis of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
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《Exfoliation of layered mixed zirconium 4-sulfophenylphosphonate phenylphosphonates》 was written by Kopecka, Katerina; Melanova, Klara; Benes, Ludvik; Knotek, Petr; Mazur, Michal; Zima, Vitezslav. Safety of 4-Aminobutan-1-olThis research focused onzirconium sulfophenylphosphonate phenylphosphonate preparation intercalation amino alc. The article conveys some information:

Mixed zirconium 4-sulfophenylphosphonate phenylphosphonates with formulas Zr(HO3SC6H4PO3)1.8(C6H5PO3)0.2·2.6H2O, Zr(HO3SC6H4PO3)1.3(C6H5PO3)0.7·2H2O, and Zr(HO3SC6H4PO3)0.7(C6H5PO3)1.3·3.6H2O (generally, ZrSPhP) were intercalated with a series of amino alcs., H2N(CH2)nOH, where n = 2 to 6, and triethylamine. It was found that in the case of amino alcs. the basal spacing of the intercalates increases linearly with n. The intercalates prepared can be exfoliated either by sonication or by the action of high-shear forces. The use of a high-shear force disperser is a more efficient exfoliation method, as it provides lamellas with larger lateral dimensions in a much shorter time. It was found that amino alcs. provide roughly the same results regardless of the length of their carbon chain. As follows from at. force microscopy measurements, triethylamine is the most appropriate exfoliation agent for ZrSPhP as it produces platelets with the largest lateral size and the lowest amount of defects. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Safety of 4-Aminobutan-1-ol

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《Gel chromatographic behavior of mononuclear aromatic hydrocarbons and phenols》 was published in Journal of Chromatography in 1974. These research results belong to Coupek, Jiri; Pokorny, Svatopluk; Pospisil, Jan. Name: 4-Butylbenzene-1,2-diol The article mentions the following:

The gel chromatog. behavior of aromatic hydrocarbons and phenols during elution with THF in columns packed with styrene-divinylbenzene copolymer was investigated. From the elution volumes of 27 aromatic hydrocarbons and 80 phenols, conclusions were drawn about the effects of the types and positions of substituents and of the numbers and positions of phenolic hydroxyl groups on the elution volumes of these compounds in the system under investigation. The effects of the size of the alkyl substituents and of their positions with respect to the hydroxyl group of phenols were determined, and the partial contributions of the alkyl and hydroxyl groups to the elution volumes were calculated Chromatog. results were used for the characterization of the solvatability of phenolic mols. with THF and as the basis of a discussion of problems of the steric hindrance of hydroxyl groups due to neighboring substituents. In addition to this study using 4-Butylbenzene-1,2-diol, there are many other studies that have used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Name: 4-Butylbenzene-1,2-diol) was used in this study.

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Name: 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

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《In-situ layer-by-layer synthesized TpPa-1 COF solid-phase microextraction fiber for detecting sex hormones in serum》 was written by Zheng, Jiating; Huang, Shuyao; Tong, Yuanjun; Wei, Songbo; Chen, Guosheng; Huang, Siming; Ouyang, Gangfeng. Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeThis research focused onTpPa1 COF solid phase microextraction fiber serum sex hormone; testosterone progesterone dehydroepiandrosterone TpPa1 COF; In-situ layer-by-layer synthesis; Sex hormone detection; Solid-phase microextraction; TpPa-1 COFs. The article conveys some information:

The secretion disorder of sex hormones is the source that leads to the occurrence of many diseases such as polycystic ovarian syndrome (PCOS), hyperandrogenism and so on. There exist physiol. changes in human body when slight fluctuations in concentrations of sex hormones happen. Therefore, it′s of great significance for accurate detection of sex hormones in human body. In this work, TpPa-1 COF solid-phase microextraction (SPME) fiber was prepared using high-efficient in-situ synthesis strategy and coupled with HPLC-MS/MS to detect three sex hormones, including Progesterone (P), testosterone (T) and dehydroepiandrosterone (DHEA) in human serum. The thickness of the coating reached 7 μm within 2 h. Under the optimal conditions, the established method presented low limit of detections (LODs, ≤ 0.75 ng/mL), wide linear ranges (0.100-100 ng mL-1) and good reproducibility, and three sex hormones (T, P, DHEA) were successfully detected and quantified in human serum. In conclusion, the established SPME method presented high-efficient fiber preparation and good anal. performances of sex hormone detection, therefore was in great potential for application in clin.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

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《Iron-catalyzed Versatile and Efficient C(sp2)-H Borylation》 was published in Chemistry Letters in 2019. These research results belong to Kamitani, Masahiro; Kusaka, Haruki; Yuge, Hidetaka. Recommanded Product: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The article mentions the following:

The efficient C-H borylation of a variety of aromatic hydrocarbons and heteroarenes has been achieved using an iron complex bearing a quinoline-based PNN pincer ligand. Mechanistic studies revealed the formation of a bis-boryl complex, which plays a crucial role in the catalytic cycle. The methodol. allows the borylation of unactivated arenes using iron catalysts. The experimental process involved the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Recommanded Product: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Recommanded Product: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Alcohol – Wikipedia,
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《Structure Revision of Protoaculeine B, a Post-translationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B》 was written by Irie, Raku; Miyako, Kei; Matsunaga, Satoko; Sakai, Ryuichi; Oikawa, Masato. Computed Properties of C8H19NO2 And the article was included in Journal of Natural Products on April 23 ,2021. The article conveys some information:

The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to the cis-1,3-disubstituted tetrahydro-β-carboline framework. We prepared two truncated model compounds that lack a long-chain polyamine using the one-step Pictet-Spengler reaction of tryptophan and compared their NMR, mass spectra, and chem. reactivity with those of the natural protoaculeine B. The synthetic models reproduced the profiles of the natural product well, which confirmed the appropriateness of the structure revision. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Computed Properties of C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C8H19NO2

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《Thiourea-functional bioreducible poly(amido amine)s in gene delivery》 was written by Elzes, M. Rachel; Si, Guoying; Engbersen, Johan F. J.; Paulusse, Jos M. J.. Formula: C4H11NOThis research focused onthiourea bioreducible polyamido amine gene delivery. The article conveys some information:

Successful gene therapy relies on gene delivery vectors with high transfection efficiency and minimal toxicity. Bioreducible cationic polymers were developed as nonviral gene delivery vectors due to their large capacity to carry genes and highly modular synthesis. Poly(amido amine)s (PAAs) with disulfide linkages along the backbone and varying amounts of thiourea moieties in the side-chains were prepared via Michael-type polyaddition of 1-(4-aminobutyl)-3-(pyridin-3-yl)thiourea to N,N’-cystamine bisacrylamide (CBA). The thiourea-containing PAAs are able to condensate plasmid DNA into nanosized polyplexes with pos. surface charge as determined by dynamic light scattering and zeta-potential measurements. The plasmid DNA is readily liberated from the polyplexes upon exposure to reducing environment, as confirmed by gel electrophoresis after treatment with the reducing agent dithiothreitol. Polyplexes of thiourea-functionalized PAAs show no discernible toxicity and markedly higher transfection efficiencies on COS-7 cells as compared to polyplexes of the frequently applied branched polyethylenimine (PEI, 25 kDa), as well as the PAA analog obtained via polyaddition of 1-amino-4-butanol (ABOL) to CBA (pABOL), at their optimal transfection conditions. The high transfection capacity of the thiourea-functionalized PAAs remains largely unaffected in the presence of 10% serum, while the transfection efficiencies of PEI and pABOL are considerably reduced under these conditions. The results demonstrate the potential of thiourea functionalization of PAAs in enhancing their transfection efficiencies while maintaining minimal toxicities. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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Alcohol – Wikipedia,
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Name: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diolOn October 23, 2017 ,《Molybdenum-Catalyzed Enantioselective Synthesis of Planar-Chiral (η5-Phosphacyclopentadienyl)manganese(I) Complexes and Application in Asymmetric Catalysis》 was published in Organometallics. The article was written by Ogasawara, Masamichi; Tseng, Ya-Yi; Uryu, Mizuho; Ohya, Naoki; Chang, Ninghui; Ishimoto, Hiroto; Arae, Sachie; Takahashi, Tamotsu; Kamikawa, Ken. The article contains the following contents:

Enantioselective desymmetrization of Cs-sym. (η5-2,5-dialkenylphospholyl)(allyldiphenylphosphine)manganese(I) dicarbonyl complexes 1 was realized by Mo-catalyzed asym. ring-closing metathesis (ARCM), and the corresponding bridged planar-chiral phosphacymantrene derivatives 2 were obtained in good yields with excellent enantioselectivity. The enantioselectivity of the ARCM reaction was strongly influenced by the structures of the phospholyl-bound alkenyl groups, and the highest enantioselectivity of up to 99% ee was achieved in the reaction of 1d,e, which possess the 2-methylpropenyl substituents at the 2- and 5-positions of the η5-phospholides. Single-enantiomeric planar-chiral 2d, which was obtained by the recrystallization of the highly enantiomerically enriched ARCM product, can serve as a chiral ligand for the Pd-catalyzed asym. allylic alkylation to show good enantioselectivity in up to 74% ee. The experimental part of the paper was very detailed, including the reaction process of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Name: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol)

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols.Name: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).

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Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetateOn March 1, 2020, Townsend, Jakob M.; Sali, Goksel; Homburg, Hannah B.; Cassidy, Nina T.; Sanders, Megan E.; Fung, Kar-Ming; Andrews, Brian T.; Nudo, Randolph J.; Bohnstedt, Bradley N.; Detamore, Michael S. published an article in Acta Biomaterialia. The article was 《Thiolated bone and tendon tissue particles covalently bound in hydrogels for in vivo calvarial bone regeneration》. The article mentions the following:

Bone regeneration of large cranial defects, potentially including traumatic brain injury (TBI) treatment, presents a major problem with non-crosslinking, clin. available products due to material migration outside the defect. Com. products such as bone cements are permanent and thus not conducive to bone regeneration, and typical com. bioactive materials for bone regeneration do not crosslink. Our previous work demonstrated that non-crosslinking materials may be prone to material migration following surgical placement, and the current study attempted to address these problems by introducing a new hydrogel system where tissue particles are themselves the crosslinker. Specifically, a pentenoate-modified hyaluronic acid (PHA) polymer was covalently linked to thiolated tissue particles of demineralized bone matrix (TDBM) or devitalized tendon (TDVT), thereby forming an interconnected hydrogel matrix for calvarial bone regeneration. All hydrogel precursor solutions exhibited sufficient yield stress for surgical placement and an adequate compressive modulus post-crosslinking. Critical-size calvarial defects were filled with a 4% PHA hydrogel containing 10 or 20% TDBM or TDVT, with the clin. product DBX being employed as the standard of care control for the in vivo study. At 12 wk, micro-computed tomog. anal. demonstrated similar bone regeneration among the exptl. groups, TDBM and TDVT, and the standard of care control DBX. The group with 10% TDBM was therefore identified as an attractive material for potential calvarial defect repair, as it addnl. exhibited a sufficient initial recovery after shearing (i.e., > 80% recovery). Future studies will focus on applying a hydrogel in a rat model for treatment of TBI. Non-crosslinking materials may be prone to material migration from a calvarial bone defect following surgical placement, which is problematic for materials intended for bone regeneration. Unfortunately, typical crosslinking materials such as bone cements are permanent and thus not conducive to bone regeneration, and typical bioactive materials for bone regeneration such as tissue matrix are not crosslinked in com. products. The current study addressed these problems by introducing a new biomaterial where tissue particles are themselves the crosslinker in a hydrogel system. The current study successfully demonstrated a new material based on pentenoate-modified hyaluronic acid with thiolated demineralized bone matrix that is capable of rapid crosslinking, with desirable paste-like rheol. of the precursor material for surgical placement, and with bone regeneration comparable to a com. available standard-of-care product. Such a material may hold promise for a single-surgery treatment of severe traumatic brain injury (TBI) following hemicraniectomy. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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