Month: November 2022

《A functionalized magnetic covalent organic framework for sensitive determination of trace neonicotinoid residues in vegetable samples》 was written by Lu, Junyu; Wang, Rui; Luan, Jingyi; Li, Yijun; He, Xiwen; Chen, Langxing; Zhang, Yukui. Electric Literature of C9H6O6 And the article was included in Journal of Chromatography A in 2020. The article conveys some information:

A functionalized magnetic covalent organic framework containing the nitro groups (Fe3O4@COF-(NO2)2) with core-shell structure was synthesized for magnetic solid phase extraction (MSPE) of six neonicotinoid insecticides residue in vegetable samples. The structure of Fe3O4@COF-(NO2)2 was investigated by various characterization techniques. The Fe3O4@COF-(NO2)2 exhibits the excellent thermal and chem. stability, high surface area (254.72 m2 g-1), total pore volume (0.19 cm3 g-1), high magnetic responsivity (27.7 emu g-1), which can be used as an ideal adsorbent for rapid isolation and enrichment of target analytes. A sensitive method was developed by using Fe3O4@COF-(NO2)2-based MSPE coupled with HPLC with UV detection. It offered good linearity within the range of 0.1-30 ng mL-1, low limits of detection (S/N = 3) of 0.02-0.05 ng mL-1. Furthermore, high enrichment factors of 170-250 for six neonicotinoid insecticides were obtained. The applicability of Fe3O4@COF-(NO2)2 is demonstrated for measuring trace neonicotinoid residues in vegetable samples with satisfactory recoveries, which ranged from 77.5 to 110.2%. The results indicated that the Fe3O4@COF-(NO2)2 microspheres offer great potential for efficient extraction of neonicotinoid insecticides from complex samples. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Electric Literature of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Electric Literature of C9H6O6

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《Fiber optic particle plasmon resonance immunosensor for rapid and sensitive detection of methamphetamine based on competitive inhibition》 was written by Chang, Ting-Chou; Chiang, Chang-Yue; Lin, Min-Hsiu; Chen, I-Kuang; Chau, Lai-Kwan; Hsu, Day-Shin; Shieh, Szu-Shan; Kuo, Chin-Jung; Wang, Shau-Chun; Chen, Yung-fou. Electric Literature of C6H15NO And the article was included in Microchemical Journal in 2020. The article conveys some information:

We report the study of methamphetamine (MA) sensing in urine samples using fiber optic particle plasmon resonance (FOPPR) biosensor. This approach is intended for on-site anal. of low-mol.-weight compounds High sensitivity detection of MA at ultra-low concentration is realized by using a competitive inhibition immunoreaction scheme based on the competition of free MA in solution for anti-MA mols. that bind to the bovine serum albumin (BSA)-MA conjugate on the gold nanoparticle surface. With the BSA-MA functionalized sensor fiber, in the presence of a fixed concentration of anti-MA and various concentrations of MA in sample, the change of transmitted light intensity through the sensor fiber relative to that in a buffer solution decreases when the MA concentration increases because of the inhibition effect of MA. Based on this sensing method, the MA-functionalized FOPPR biosensor is capable for determining the concentration of MA with high sensitivity and wide linear dynamic range of 1-1000 ng/mL. The limit of detection for MA is 0.16 ng/mL. In addition, the MA functionalized FOPPR biosensor can detect MA in diluted human urine samples without nonspecific adsorption interference.6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO) was used in this study.

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

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Alcohol – Wikipedia,
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《Synthesis of an oligomeric thickener for supercritical carbon dioxide and its properties》 was written by Zhou, Ming; Tu, Hongjun; He, Yinglan; Peng, Pengao; Liao, Mao; Zhang, Jinfeng; Xu, Xiaoxia; He, Wanying; Zhao, Yaxiong; Guo, Xiao. COA of Formula: C3H9NO2 And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

The applications of supercritical CO2 as a solvent are limited by its very low viscosity. A four-armed oligomeric CO2 thickener containing fluorine 1,6-bis(1,3-perfluorooctanoic acid biester-2-Urea)Hexane (BPFAUH) was synthesized with 2-amino-1,3-propanediol, (Boc)2D, pentadecafluorooctanoic acid, thionyl chloride, hexamethylene-1,6-diisocyanate (HMDI) as crude materials by using amino protection, esterification, deprotection, and nucleophilic addition reaction. and characterized using FTIR, 13C NMR and elemental anal. TG anal. showed that the oligomeric thickener was thermally stable below 473.15 K. Its solubility in CO2 correlated well with the pressure. The viscosity of the system increased with increasing thickener concentration, but the viscosity of the thickener decreased with increasing temperature and shear rate. The system viscosity reached 19.2 mPa·s, a 480-fold increase compared to the initial viscosity, when 2.0 wt% thickener was added; this increase greatly exceeds that of other reported thickeners. The CO2-philic fluorocarbon groups promoted the solubility of the thickener; while intra-mol. thickener crosslinking occurred via O···H bonds. Thus, the mol. with four fluorocarbon groups and two urea groups formed a network structure to achieve superstrong CO2-thickening ability. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H9NO2

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《Deorphanization of an odorant receptor revealed new bioactive components for green mirid bug Apolygus lucorum (Hemiptera: Miridae)》 was written by Khashaveh, Adel; An, Xingkui; Shan, Shuang; Xiao, Yong; Wang, Qi; Wang, Shanning; Li, Zibo; Geng, Ting; Gu, Shaohua; Zhang, Yongjun. Application In Synthesis of 5-Hexen-1-ol And the article was included in Pest Management Science in 2020. The article conveys some information:

BACKGROUND : The Apolygus lucorum is one of the most destructive insect pests in China with a wide range of host plants. Interaction of A. lucorum with surrounding environment heavily relies on chem. communication. Deorphanization of receptors involved in odors detection elevates our understanding of the olfactory system of this pest and may help to develop a chem. ecol.-based control strategy. RESULTS : AlucOR80, an odorant receptor (OR) in A. lucorum was newly cloned. Gene expression anal. showed that this receptor was mainly expressed in the antennae and head of both sexes but with a male bias. The Xenopus oocytes heterologous expression system coupled with the two-electrode voltage-clamp (TEVC) recording revealed that AlucOR80 was tuned to 21 selected compounds Furthermore, electroantennogram (EAG) tests confirmed that all 21 ligands of AlucOR80 were electrophysiol. active in antennae of both sexes. Behavioral trials in a three-cage olfactometer indicated that 16 compounds were behaviorally active, amongst which, 12 components were attractants and four components were repellents for adults of both sexes. Bu butyrate and Di-Me disulfide (DMDS) were the strongest attractive and repellent compounds, resp. Importantly, we found the repellency of 1, 8-Cineole, S-(-)-cis-Verbenol and (1S)-(1)-beta-Pinene against adults of A. lucorum. CONCLUSION : Although AlucOR80 is a general OR, may play important role in the olfactory perception of A. lucorum. Screening of AlucOR80 ligands by behavioral assay provided valuable insights by which olfactory-based management approaches could be developed by utilizing the behaviorally active components as attractants or repellents. © 2019 Society of Chem. Industry The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Application In Synthesis of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application In Synthesis of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
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《Macrocycle synthesis strategy based on step-wise “”adding and reacting”” three components enables screening of large combinatorial libraries》 was written by Mothukuri, Ganesh K.; Kale, Sangram S.; Stenbratt, Carl L.; Zorzi, Alessandro; Vesin, Jonathan; Bortoli Chapalay, Julien; Deyle, Kaycie; Turcatti, Gerardo; Cendron, Laura; Angelini, Alessandro; Heinis, Christian. Recommanded Product: 4-Aminobutan-1-ol And the article was included in Chemical Science in 2020. The article conveys some information:

Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three building blocks are coupled sequentially in efficient alkylation reactions that eliminate the need for product purification We demonstrate the power of the approach by combinatorially reacting 15 bromoacetamide-activated tripeptides, 42 amines, and 6 bis-electrophile cyclization linkers to generate a 3780-compound library with minimal effort. Screening against thrombin yielded a potent and selective inhibitor (Ki = 4.2 ± 0.8 nM) that efficiently blocked blood coagulation in human plasma. Structure-activity relationship and X-ray crystallog. anal. revealed that two of the three building blocks acted synergistically and underscored the importance of combinatorial screening in macrocycle development. The three-component library synthesis approach is general and offers a promising avenue to generate macrocycle ligands to other targets. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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Alcohol – Wikipedia,
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Cadena-Cruz, Jose Eduardo; Guaman-Ortiz, Luis M.; Romero-Benavides, Juan Carlos; Bailon-Moscoso, Natalia; Murillo-Sotomayor, Kevin E.; Ortiz-Guaman, Nadia V.; Heredia-Moya, Jorge published their research in BMC Chemistry in 2021. The article was titled 《Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities》.SDS of cas: 100-83-4 The article contains the following contents:

The 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives I (R = Ph, 3,4-dihydroxyphenyl, 2-nitrophenyl, etc.) were synthesized by a three-component reaction of 3-methyl-1-phenyl-5-pyrazolone with various benzaldehydes RCHO catalyzed by sodium acetate at room temperature The structures of all synthesized compounds were characterized by physicochem. properties and spectral means (IR and NMR) and evaluated for their radical scavenging activity by DPPH assay and tested in vitro on colorectal RKO carcinoma cells in order to determine their cytotoxic properties. All 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives I were synthesized in high to excellent yield, and pure products were isolated by simple filtration. All compounds have good radical scavenging activity, and half of them are more active than ascorbic acid used as standard Several derivatives proved to be cytotoxic in the RKO cell line. In particular, compound I (R = 3,4-dihydroxyphenyl) proved to be a very potent scavenger with an IC50 of 6.2 ± 0.6μM and exhibited an IC50 of 9.9 ± 1.1μM against RKO cell. Autophagy proteins were activated as a survival mechanism, whereas the predominant pathway of death was p53-mediated apoptosis. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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Alcohol – Wikipedia,
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Gulati, Anmol; Yeung, Charles S.; Lapointe, Blair; Kattar, Solomon D.; Gunaydin, Hakan; Scott, Jack D.; Childers, Kaleen K.; Methot, Joey L.; Simov, Vladimir; Kurukulasuriya, Ravi; Pio, Barbara; Morriello, Greg J.; Liu, Ping; Tang, Haiqun; Neelamkavil, Santhosh; Wood, Harold B.; Rada, Vanessa L.; Ardolino, Michael J.; Yan, Xin Cindy; Palte, Rachel; Otte, Karin; Faltus, Robert; Woodhouse, Janice; Hegde, Laxminarayan G.; Ciaccio, Paul; Minnihan, Ellen C.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.; Ellis, J. Michael published their research in RSC Medicinal Chemistry in 2021. The article was titled 《Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors》.Computed Properties of C3H8ClNO The article contains the following contents:

The discovery of potent, kinome selective, brain penetrant LRRK2 inhibitors is the focus of extensive research seeking new, disease-modifying treatments for Parkinson′s disease (PD). Herein, we describe the discovery and evolution of a picolinamide-derived lead series. Our initial optimization efforts aimed at improving the potency and CLK2 off-target selectivity of compound 1 by modifying the heteroaryl C-H hinge and linker regions. This resulted in compound 12 which advanced deep into our research operating plan (ROP) before heteroaryl aniline metabolite 14 was characterized as Ames mutagenic, halting its progression. Strategic modifications to our ROP were made to enable early de-risking of putative aniline metabolites or hydrolysis products for mutagenicity in Ames. This led to the discovery of 3,5-diaminopyridine 15 and 4,6-diaminopyrimidine 16 as low risk for mutagenicity (defined by a 3-strain Ames neg. result). Anal. of key matched mol. pairs 17 and 18 led to the prioritization of the 3,5-diaminopyridine sub-series for further optimization due to enhanced rodent brain penetration. These efforts culminated in the discovery of Et trifluoromethyl pyrazole 23 with excellent LRRK2 potency and expanded selectivity vs. off-target CLK2. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
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He, Junhua; Wu, Xuehui; Zhou, Yue; Chen, Jiahui published their research in Journal of Food Biochemistry in 2021. The article was titled 《Effects of different preheat treatments on volatile compounds of camellia (Camellia oleifera Abel.) seed oil and formation mechanism of key aroma compounds》.Computed Properties of C6H7NO The article contains the following contents:

In this study, volatile compounds of camellia seed oil (CSO) prepared by different preheat treatments (microwave, frying, roasting, and steaming) were identified by headspace solid-phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME/GC-MS). A total of 107 volatile compounds were identified in CSO samples, including aldehydes (16), alcs. (6), ketones (3), heterocyclic compounds (26), esters (23), hydrocarbons (15), and others (17). Among them, untreated CSO is mainly hydrocarbons, roasting and steaming CSO are mainly aldehydes and alcs., while microwave and roasting CSO are dominated by aldehydes and heterocyclic compounds Fourteen volatile compounds with high relative odor activity value (ROAV ≥ 1) were selected as key aroma compounds (KACs). Principal Component Anal. (PCA) and Cluster Anal. (CA) were performed on 14 KACs, which determined that there were 3, 3, 3, 7, and 6 characteristic aroma compounds (CACs) in untreated, microwaved, frying, roasting, and steaming CSO. Addnl., the potential formation pathways and mechanism of KACs were discussed. Flavor is an important factor for consumers to choose edible oils, and it is also one of the indicators of oil quality. Different flavors of CSO can cater to the needs of different consumers. CSO manufactories can choose different preheat treatments to produce CSO with various flavors to meet different customer’s need. CSO with new flavor can extend its market share and increase its value.3-Pyridinemethanol(cas: 100-55-0Computed Properties of C6H7NO) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C6H7NO

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Pang, Yue-Hong; Huang, Yu-Ying; Shen, Xiao-Fang; Wang, Yi-Ying published their research in Analytica Chimica Acta in 2021. The article was titled 《Electro-enhanced solid-phase microextraction with covalent organic framework modified stainless steel fiber for efficient adsorption of bisphenol A》.COA of Formula: C9H6O6 The article contains the following contents:

In this work, electro-enhanced solid-phase microextraction (EE-SPME) and covalent organic framework (COF) were adopted to improve the extraction efficiency. A conductive COF synthesized of 2,6-diaminoanthraquinone (DQ) and 1,3,5-triformylphloroglucinol (TP) was in situ bonded to the stainless steel wire via facile solution-phase approach and used as the EE-SPME fiber coating to preconc. a typical endocrine disruptor bisphenol A (BPA). Compared with conventional SPME, the DQTP bonded fiber coupled with EE-SPME device exhibited higher extraction efficiency and achieved extraction equilibrium within 10 min. The proposed approach based on EE-SPME and gas chromatog. coupled with flame ionization detector gave a linear range of 0.05-10μg mL-1 and detection limit of 3μg L-1 (S/N = 3) with good precision (<6.7%) and reproducibility (<7.1%) spiked with 0.1, 0.5, 1.0μg mL-1 BPA. Quant. determination of BPA in extracts of food packagings (mineral water bottles, milk boxes and milk tea cups) was achieved with recoveries from 88.6 to 118.0%.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4COA of Formula: C9H6O6) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.COA of Formula: C9H6O6For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

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Zhou, Zijun; Tan, Yuqi; Shen, Xiang; Ivlev, Sergei; Meggers, Eric published an article in 2021. The article was titled 《Catalytic enantioselective synthesis of β-amino alcohols by nitrene insertion》, and you may find the article in Science China: Chemistry.Electric Literature of C9H11NO The information in the text is summarized as follows:

Herein, a general intramol. C(sp3)-H nitrene insertion method for the synthesis of chiral oxazolidin-2-ones as precursors of chiral β-amino alcs was reported. Specifically, the ring-closing C(sp3)-H amination of N-benzoyloxycarbamates with 2 mol% of a chiral ruthenium catalyst provides cyclic carbamates in up to 99% yield and with up to 99% ee. The method was applicable to benzylic, allylic, and propargylic C-H bonds and can even be applied to completely non-activated C (sp3)-H bonds, although with somewhat reduced yields and stereoselectivities. The obtained cyclic carbamates was subsequently be hydrolyzed to obtain chiral β-amino alcs. The method was very practical as the catalyst was easily synthesized on a gram scale and was recycled after the reaction for further use. The synthetic value of the new method was demonstrated with the asym. synthesis of a chiral oxazolidin-2-one as intermediate for the synthesis of the natural product aurantioclavine and chiral β-amino alcs. that are intermediates for the synthesis of chiral amino acids, indane-derived chiral Box-ligands, and the natural products dihydrohamacanthin A and dragmacidin A. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Electric Literature of C9H11NO)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts