Month: November 2022

《Light-induced enzyme deactivation as a new tool to prevent cross reactions in multistep enzyme cascades》 was published in Chemie Ingenieur Technik in 2020. These research results belong to Gerlach, T.; Drepper, T.; Rother, D.. Quality Control of 3-Hydroxybenzaldehyde The article mentions the following:

To eliminate cross reactivity in one-pot reaction systems, enzymes prone to side reactivities are combined with produce reactive oxygen species upon irradiation The enzyme fusions can be added to the corresponding reaction step enabling the catalyst activity to be switched off selectively. Here, an enzyme cascade starting from 3-hydroxy benzaldehyde and pyruvate to a trisubstituted tetrahydroisoquinoline has been chosen as a test system. CA> The first cascade step encompasses a carboligation conducted by the pyruvate decarboxylase variant E469G/W543H from Acetobacter pasteurianus (ApPDC E469G/W54m). Afterwards a reductive amination occurs, mediated by the Chromobacterium violaceum transaminase (Cv2025). This cascade is a suitable target as in a one-pot reaction approach across reactivity occurs. The ApPDC E469G/W543H was genetically linked to a photosensitizer, the singlet oxygen photosensitizing protein (SOPP3). After illumination with blue light (450 nm), the relative activity of SOPP3-ApPDC E469G/W543H could be reducedto 10% (Fig. A). The Cv2025 was inactivated simply by illuminating the cofactor of the transaminase pyridoxal 5-phosphate and could also be inactivated to 10% residual activity (Fig.B). As both inactivation, steps still need 30-120 min to reach the goal, the light-inactivation setups are current target to optimization. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Quality Control of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Quality Control of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
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《Ultralight covalent organic framework/graphene aerogels with hierarchical porosity》 was written by Li, Changxia; Yang, Jin; Pachfule, Pradip; Li, Shuang; Ye, Meng-Yang; Schmidt, Johannes; Thomas, Arne. COA of Formula: C9H6O6 And the article was included in Nature Communications in 2020. The article conveys some information:

The fabrication of macroscopic objects from covalent organic frameworks (COFs) is challenging but of great significance to fully exploit their chem. functionality and porosity. Herein, COF/reduced graphene oxide (rGO) aerogels synthesized by a hydrothermal approach are presented. The COFs grow in situ along the surface of the 2D graphene sheets, which are stacked in a 3D fashion, forming an ultralight aerogel with a hierarchical porous structure after freeze-drying, which can be compressed and expanded several times without breaking. The COF/rGO aerogels show excellent absorption capacity (uptake of >200 g organic solvent/g aerogel), which can be used for removal of various organic liquids from water. Moreover, as active material of supercapacitor devices, the aerogel delivers a high capacitance of 269 F g-1 at 0.5 A g-1 and cycling stability over 5000 cycles. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4COA of Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.COA of Formula: C9H6O6For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
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《Perylene-diimide-based n-type semiconductors with enhanced air and temperature stable photoconductor and transistor properties》 was written by Yuen, Jonathan D.; Pozdin, Vladimir A.; Young, Ashlyn T.; Turner, Brendan L.; Giles, Ian D.; Naciri, Jawad; Trammell, Scott A.; Charles, Paul T.; Stenger, David A.; Daniele, Michael A.. SDS of cas: 4048-33-3 And the article was included in Dyes and Pigments in 2020. The article conveys some information:

We report the synthesis and characterization of highly air and temperature stable, solution-processed, n-type organic semiconductors: a perylene-diimide monomer and a perylene-diimide-based pendant polymer. When integrated into a transistor structure, both materials possess pure n-type transport with mobility as high as 10-5 cm2 V-1 s-1 for the polymer. The organic semiconductors exhibit good photoconductor properties, with photocurrent to dark current ratios of up to 103 for the monomer, despite its lower FET mobility. The differences in transistor and photoconductor properties suggest different applications for each material. Both materials can be processed in air, and their transport properties have good air stability, improving with annealing even up to 200 °C in air. It is notable that such air-stable photoconductivity and transport properties have rarely been reported for n-type organic semiconductors before, as most n-type organic semiconductors are not stable in air. Hence, these materials may have potential in a wide range of applications. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.SDS of cas: 4048-33-3

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Alcohol – Wikipedia,
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Wang, Hui-Sheng; Zhang, Ke; Wang, Jia; Hu, Zhao-Bo; Zhang, Zaichao; Song, You; Zhang, Yi-Quan published their research in Inorganic Chemistry in 2021. The article was titled 《Influence of the Different Types of Auxiliary Noncarboxylate Organic Ligands on the Topologies and Magnetic Relaxation Behavior of Zn-Dy Heterometallic Single Molecule Magnets》.Related Products of 1195-59-1 The article contains the following contents:

The authors 1st synthesized a Zn-Dy complex, [Zn6Dy2(L)6(tea)2(MeOH)2]·6MeOH·8H2O (H2L = N-3-methoxysalicylidene-2-amino-3-hydroxypyridine, teaH3 = triethanolamine, 1), by employing H2L, anhydrous ZnCl2, and Dy(NO3)3·5H2O reacting with auxiliary ligand teaH3 in the mixture of MeOH and DMF. When teaH3 and MeOH in the reaction system of 1 were replaced by the auxiliary ligand 2,6-pyridinedimethanol (pdmH2) and the solvent MeCN, another Zn-Dy complex, [Zn4Dy4(L)6(pdm)2(pdmH)4]·10MeCN·5H2O (2), was obtained. The crystal structure of 1 can be seen as a dimer of two Zn3DyIII units. However, for 2, four DyIII form a zigzag arrangement, and each of its terminals linked two ZnII ions. Although the structural topologies of 1 and 2 are different, the coordination geometries of DyIII are all triangular dodecahedron (TDD-8). The difference is that the continuous shape measure (CShM) values of DyIII in 1 are larger than the corresponding values in 2. Magnetic studies revealed that the diluted sample 1@Y exhibits two magnetic relaxation processes, while 2 exhibits a single relaxation process. Ab initio calculations indicated that, in the crystal lattice of 1, two complexes exhibiting slightly different CShM values of DyIII result in the double relaxation behavior of 1@Y. However, for 2, one of two DyIII fragments possesses a fast quantum tunneling of magnetization (QTM), resulting in its magnetic process presented at T < 1.8 K, so 2 exhibits single relaxation behavior. Theor. calculations also clearly indicated that the weak ligation at equatorial sites of DyIII in 1 and 2 ensure that 1@Y and 2 possess SMM behavior, although the coordination geometry of DyIII (TDD-8) in 1 and 2 severely deviates from the ideal polyhedron and its axial symmetry is low. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bera, Srikrishna; Mao, Runze; Hu, Xile published their research in Nature Chemistry in 2021. The article was titled 《Enantioselective C(sp3)-C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis》.Category: alcohols-buliding-blocks The article contains the following contents:

Cross-coupling of two alkyl fragments is an efficient method to produce organic mols. rich in sp3-hybridized carbon centers, which are attractive candidate compounds in drug discovery. Enantioselective C(sp3)-C(sp3) coupling is challenging, especially of alkyl electrophiles without an activating group (aryl, vinyl, carbonyl). Here, we report a strategy based on nickel hydride addition to internal olefins followed by nickel-catalyzed alkyl-alkyl coupling. This strategy enables the enantioselective cross-coupling of non-activated alkyl halides with alkenyl boronates to produce chiral alkyl boronates. Employing readily available and stable olefins as pro-chiral nucleophiles, the coupling proceeds under mild conditions and exhibits broad scope and high functional-group tolerance. Applications for the functionalization of natural products and drug mols., as well as the synthesis of chiral building blocks and a key intermediate to (S)-(+)-pregabalin, are demonstrated. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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Lu, Tian-Qi; Wang, Xue-Tao; Cheng, Lan-Tao; Chen, Cheng; Shi, Haiyan; Zheng, Jun; Zheng, Xiu-Ying published an article in 2021. The article was titled 《Soft Metal-Organic Frameworks Based on {Na@Ln6} as a Secondary Building Unit Featuring a Magnetocaloric Effect and Fluorescent Sensing for Cyclohexane and Fe3+》, and you may find the article in Crystal Growth & Design.COA of Formula: C7H9NO2 The information in the text is summarized as follows:

Two series of cluster-based Ln-metal-organic frameworks (MOFs) {[Na@Ln8(EDTA)6(H2O)22]·ClO4·xH2O}n (x ≈ 28, Ln = Gd 1, Ln = Eu 2) and {[Na@Ln9(EDTA)6(H2O)27]·(ClO4)4·xH2O}n (x ≈ 26, Ln = Gd 3, Ln = Eu 4) were prepared by ethylene diamine tetraacetic acid (H4EDTA) to control the hydrolysis of lanthanide ions to form cluster-based secondary building blocks and hydrated metal ions as linkers. Structural anal. showed that all four compounds were formed by using {Na@Ln6} as the node and hydrated [Ln(H2O)5]3+ ion as the linker. Compounds 1-2 and 3-4 featured a two-dimensional (2D) layered structure and a three-dimensional (3D) frame structure, resp. Magnetic studies showed that compounds 1 and 3 displayed a considerable magnetocaloric effect with magnetic entropy values of 32.8 and 33.3 J kg-1 K-1, resp., at low temperature and high field. The magnetic entropy changes of 3 did not increase greatly with the increase of the dimension due to the similar weak magnetic interactions and similar magnetic densities of compounds 1 and 3. Luminescence studies showed that compounds 2 and 4 had a good recognition effect on the cyclohexane mol., and 4 displayed excellent sensitive sensing and a detection effect on Fe3+ ions in MeOH based on the high-sensitivity fluorescence quenching phenomenon. In the experiment, the researchers used many compounds, for example, 2,6-Pyridinedimethanol(cas: 1195-59-1COA of Formula: C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C7H9NO2

Referemce:
Alcohol – Wikipedia,
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Nallagonda, Rajender; Karimov, Rashad R. published an article in 2021. The article was titled 《Copper-Catalyzed Regio- and Diastereoselective Additions of Boron-Stabilized Carbanions to Heteroarenium Salts: Synthesis of Azaheterocycles Containing Contiguous Stereocenters》, and you may find the article in ACS Catalysis.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

Nucleophilic addition of diborylalkyl reagents to N-alkyl or N-acylpyridinium and related heteroarenium salts has been developed as a key step for the synthesis of nonaromatic nitrogen heterocycles that contain contiguous stereogenic centers. Derivatization of the dihydropyridine products for the synthesis of tetrahydropyridines and piperidines have also been described. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Category: alcohols-buliding-blocks)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Category: alcohols-buliding-blocks Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kuranaga, Takefumi; Tamura, Miho; Ikeda, Hiroaki; Terada, Sakahiro; Nakagawa, Yusuke; Kakeya, Hideaki published an article in 2021. The article was titled 《Identification and Total Synthesis of an Unstable Anticancer Macrolide Presaccharothriolide Z Produced by Saccharothrix sp. A1506》, and you may find the article in Organic Letters.Quality Control of 3,5-Dihydroxybenzaldehyde The information in the text is summarized as follows:

Saccharothriolides A-F are 10-membered microbial macrolides proposed to be generated from their precursors presaccharothriolides X-Z. Previously, we isolated presaccharothriolide X, and its unique natural prodrug-like properties have intrigued us. However, the other congeners were not detected. Herein, we detected presaccharothriolide Z using our highly sensitive labeling reagent. Moreover, chem. synthesis of presaccharothriolide Z, the first total synthesis of saccharothriolide-class macrolides, was achieved, and the structure and biol. activity of presaccharothriolide Z were determined In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lagerspets, Emi; Abba, Donatella; Sharratt, Joseph; Eronen, Aleksi; Repo, Timo published an article in 2022. The article was titled 《Water tolerant base free Copper (I) catalyst for the selective aerobic oxidation of primary alcohols》, and you may find the article in Molecular Catalysis.Quality Control of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

Authors report here a base free copper(I) catalyst for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to their corresponding lactones or lactols. In the presence of the in situ generated Cu(I)-catalyst with 2,2′-dipyridylamine (dpa) as a ligand and 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO) as a persistent radical, the oxidation reaction proceeds under true aerobic conditions, at ambient temperature, utilizing air as the oxidant and without added base. High catalytic activity without over oxidation was achieved for numerous primary alcs. (aliphatic, allylic, benzylic and diols) with different substitution patterns. The catalyst’s stability is unique among reported Cu(I)-catalysts. It is not moisture or air sensitive, and is capable of e.g. oxidizing aliphatic and benzyl alcs. in a water/acetonitrile solution in moderate or in quant. yield (> 99%) in 3 h. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Quality Control of 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Valigura, Dusan; Rajnak, Cyril; Titis, Jan; Moncol, Jan; Bienko, Alina; Boca, Roman published an article in Dalton Transactions. The title of the article was 《Unusual slow magnetic relaxation in a mononuclear copper(II) complex》.Related Products of 1195-59-1 The author mentioned the following in the article:

A hexacoordinate Cu(II) complex with the {CuO4O′N} donor set shows an intermol. π-π stacking owing to which a 1D-chain structure is formed. The DC magnetic data at low temperature are consistent with the Curie law. The AC susceptibility shows a field supported slow magnetic relaxation that survives up to 7 K. The relaxation time at T = 2.0 K and BDC = 0.2 T is τ = 0.23 ms and it increases at BDC = 0.6 T to τ = 2.9 ms. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts