Month: November 2022

《Selective uni- and bidirectional homologation of diborylmethane》 was written by Blair, Daniel J.; Tanini, Damiano; Bateman, Joseph M.; Scott, Helen K.; Myers, Eddie L.; Aggarwal, Varinder K.. Recommanded Product: Bis[(pinacolato)boryl]methaneThis research focused onuni bidirectional homologation diborylmethane; bis boronic ester preparation reactivity. The article conveys some information:

Diborylmethane can be homologated uni- and bidirectionally by using enantiomerically pure lithium-stabilized carbenoids to give 1,2- and 1,3-bis(boronic esters), resp., in good yield and with excellent levels of enantio- and diastereoselectivity. The high sensitivity of the transformation to steric hindrance enables the exclusive operation of either manifold, effected through the judicious choice of the type of carbenoid, which can be a sparteine-ligated or a diamine-free lithiated benzoate/carbamate. The scope of the 1,2-bis(boronic esters) so generated is complementary to that encompassed by the asym. diboration of alkenes, in that primary-secondary and primary-tertiary 1,2-bis(boronic esters) can be prepared with equally high levels of selectivity and that functional groups, such as terminal alkynes and alkenes, are tolerated. Methods for forming C2-sym. and non-sym. anti and syn 1,3-bis(boronic esters) are also described and represent a powerful route towards 1,3-functionalized synthetic intermediates. In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Recommanded Product: Bis[(pinacolato)boryl]methane

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Related Products of 20880-92-6On September 30, 2020 ,《An Expedient Method for Kinetically Controlled Acetonide Formation from D-Fructose Induced by Ionic Liquid Catalyst Accompanied with SrCl2·6H2O》 was published in Catalysis Letters. The article was written by Yildirim, Ayhan. The article contains the following contents:

The present work was undertaken to ascertain whether IL-metal salt catalyzed isopropylidenation of D-fructose yield desired acetonides. For the first time, an imidazole based ionic liquid compound accompanied with strontium chloride has been identified as a suitable dual catalyst system for the chemoselective O-isopropylidenation of D-fructose with acetone. In the present protocol, mainly the kinetically controlled less stable cyclic ketal 1,2;4,5-di-O-isopropylidene-β-D-fructopyranose is formed as an initial product with satisfactory yield and without isomerization to the thermodynamically more stable cyclic ketal 2,3;4,5-di-O-isopropylidene-β-D-fructopyranose. Therefore, this protocol is more advantageous compared to other mineral acid catalyzed protocols that require more sensitive reaction conditions. After reading the article, we found that the author used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
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Related Products of 23828-92-4On September 30, 2020 ,《Quality by Design Strategy for Simultaneous HPLC Determination of Bromhexine HCl and Its Metabolite Ambroxol HCl in Dosage Forms and Plasma》 was published in Chromatographia. The article was written by El-Sayed, Heba M.; Hashem, Hisham. The article contains the following contents:

Abstract: The quality by design strategy was applied for the simultaneous chromatog. quantification of a binary mixture of bromhexine HCl and its pharmacol. active metabolite ambroxol HCl in dosage forms as well as in human plasma. In this study, five independent parameters were screened by fractional factorial design to specify the critical ones. The optimal conditions were determined by a response surface methodol. using a central composite design. Response surface methodol. enabled the best separation in minimal run time, as well as, prediction of separation and retention parameters with min. error. Separation and quantitation were carried out on BDS Hypersil C8 (250 × 4.6 mm, 5μm) RP-column at 1.1 mL min-1 flow rate, 25 mM of KH2PO4 (pH 3.5) in aqueous mobile phase, 65% MeOH, 210 nm wavelength of detection and 10μL injection volume After optimization of the chromatog. parameters, validation of the method was achieved according to ICH guidelines. Linearity ranged from 0.195 to 100μg mL-1 ambroxol HCl, and 0.391-100μg mL-1 bromhexine HCl, with R2 values of 0.9998 and 0.9999 and limits of detection of 0.098 and 0.195μg mL-1, resp. Recovery results ranged from 98.06 to 100.18 and 97.88 to 100.68 for bromhexine HCl and ambroxol HCl, resp., with RSD less than 1.80. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Related Products of 23828-92-4) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Related Products of 23828-92-4 Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
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Related Products of 54-17-1On March 31, 2021, Moret, Florian; Delorme, Gael; Clement, Gilles; Grosjean, Claire; Lemaitre-Guillier, Christelle; Trouvelot, Sophie; Adrian, Marielle; Fontaine, Florence published an article in Physiologia Plantarum. The article was 《Esca-affected grapevine leaf metabolome is clone- and vintage-dependent》. The article mentions the following:

Esca is a complex grapevine trunk disease caused by wood-rotting ascomycetes and basidiomycetes and leading to several foliar and wood symptoms. Given that the esca expression can be influenced by several environmental, physiol., and genetic factors, foliar symptoms are inconsistent in incidence and prevalence and may appear 1 yr but not the following. We have previously reported a clone-dependent expression of the disease in cv Chardonnay. Owing to metabolome anal., we could discriminate the metabolite fingerprint of green leaves collected on diseased vines of clones 76 and 95. These clone-dependent fingerprints were year-dependent in intensity and nature. The present work was conducted to determine if the clone-dependent disease expression observed is specific to Chardonnay or if it also occurs in another cultivar. A plot located in the Jura vineyard (France) and planted with both 1004 and 1026 clones of Trousseau, a cultivar highly susceptible to esca, was thus selected and studied during 2017 and 2018. A year-dependent variation of the symptoms expression was first observed and a possible relationship with rainfall is hypothesized and discussed. Moreover, a higher percentage of the clone 1026 vines expressed disease, compared to the 1004 ones, suggesting the higher susceptibility of this clone. Finally, metabolomic analyzes of the remaining green leaves (i.e, without symptom expression) of partial esca-apoplectic vines allowed us to confirm a clone-dependent metabolic response to the disease. The metabolite fingerprints obtained differed in nature and intensity to those previously reported for Chardonnay and also between years. In the experimental materials used by the author, we found rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Related Products of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Related Products of 54-17-1

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Alcohol – Wikipedia,
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Recommanded Product: 63012-03-3On September 1, 2008 ,《Cesium hydroxide-promoted aerobic oxidation of sec-aromatic alcohols》 was published in Tetrahedron Letters. The article was written by Zhang, Weiwei; Liu, Miaochang; Wu, Huayue; Ding, Jinchang; Cheng, Jiang. The article contains the following contents:

A CsOH-promoted aerobic oxidation of sec-aromatic alcs. was developed, using air as a free and clean oxidant, and providing aryl ketones in good to excellent yields.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Recommanded Product: 63012-03-3) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Recommanded Product: 63012-03-3 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
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Safety of (3-Chlorophenyl)(phenyl)methanolOn March 27, 2013, Zhang, Wenxue; Dai, Yisi; Zhu, Haizhen; Zhang, Wei published an article in Tetrahedron Letters. The article was 《One-pot synthesis of indene derivatives by CF3SO3H-promoted reactions of benzylic alcohols and 1,3-dicarbonyl compounds》. The article mentions the following:

An efficient and convenient one-pot synthesis of indene derivatives was achieved in moderate to high yields by the CF3SO3H promoted coupling/cyclization reaction of benzylic alcs. and 1,3-dicarbonyls for the first time. For the reactions of methoxy- or methyl-substituted diarylmethanols with 1,3-dicarbonyls, 2 equiv of CF3SO3H was needed to reach the best results; but for the reactions of methoxy-substituted arylethanols with 1,3-dicarbonyls, 0.6 equiv of CF3SO3H at lower temperatures was capable of promoting the reaction finished. After reading the article, we found that the author used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Safety of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Safety of (3-Chlorophenyl)(phenyl)methanol The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
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Fuentes, Jose A.; Janka, Mesfin E.; Rodgers, Jody; Fontenot, Kevin J.; Buhl, Michael; Slawin, Alexandra M. Z.; Clarke, Matthew L. published their research in Organometallics on December 13 ,2021. The article was titled 《Effect of Ligand Backbone on the Selectivity and Stability of Rhodium Hydroformylation Catalysts Derived from Phospholane-Phosphites》.Recommanded Product: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol The article contains the following contents:

A study on how ligand backbone structure has an impact on selectivity, rate, and catalyst stability of hydroformylation catalysts was prompted by some longer-term stability issues being discovered for a phospholane-phosphite with a [-CH2O-] backbone. Phospholane-phosphite ligands were synthesized. Catalysts made in situ from these ligands and [Rh(acac)(CO)2] gave iso-butanal selectivities up to 75% at 75-105°: the latter being a benchmark for iso-selectivity in reactions conducted at industrially meaningful temperatures A racemic Rh complex of a bidentate phospholane-phosphite from a tropos-biphenol with an extended backbone showed unusually high stability at high temperatures, combined with even better iso-selectivity in propene hydroformylation relative to the original complex. A related ligand with an electron-withdrawing group maintained the unusually high stability and improved activity. Characterization of the precatalysts [RhH(CO)2(L)] was accomplished using in situ HPIR spectroscopy and backed up by d. functional theory calculations (B3PW91-D3 level) and by NMR studies; the latter showed that the variation of the backbone also had a pronounced impact on the precatalyst structure. A key finding is that it is now possible to prepare phospholane-phosphite ligands that deliver high iso-butanal selectivity and that show no signs of degradation after several days even above typical reaction temperatures In one stability test, several kilograms of aldehydes were produced with TOF and selectivity being consistent over several days. In the experiment, the researchers used (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Recommanded Product: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol)

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).Recommanded Product: (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol

Referemce:
Alcohol – Wikipedia,
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In 2020,Dalton Transactions included an article by Sun, Xiaoman; Meng, Fanyu; Su, Qing; Luo, Kexin; Ju, Pengyao; Liu, Ziqian; Li, Xiaodong; Li, Guanghua; Wu, Qiaolin. Recommanded Product: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde. The article was titled 《New catalytically active conjugated microporous polymer bearing ordered salen-Cu and porphyrin moieties for Henry reaction in aqueous solution》. The information in the text is summarized as follows:

A catalytically active conjugated microporous polymer (SP-CMP-Cu) was facilely constructed with condensation polymerization of salen-Cu [salen = N,N’-bis(3-tertbutyl-5-formylsalicylidene) ethylenediamine] and pyrrole. The as-synthesized SP-CMP-Cu was completely characterized by powder X-ray diffraction (PXRD), Fourier transform IR (FT-IR) spectroscopy, thermogravimetric anal. (TGA), XPS, and energy-dispersive X-ray (EDX) anal. The morphol. features of SP-CMP-Cu were revealed by SEM and transmission electron microscopy (TEM). According to N2 adsorption/desorption isotherm, Brunauer-Emmett-Teller (BET) surface area of SP-CMP-Cu was calculated to be 252 m2 g-1 with a total pore volume of 0.178 cm3 g-1. SP-CMP-Cu exhibited an outstanding catalytic performance for Henry reaction in aqueous solutions with excellent conversion and good selectivity. Moreover, SP-CMP-Cu can be reused for up to five consecutive runs without any significant loss in its catalytic efficiency.5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde) was used in this study.

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Recommanded Product: 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

Referemce:
Alcohol – Wikipedia,
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Jadhav, Sandip B.; Chegondi, Rambabu published their research in Organic Letters on December 20 ,2019. The article was titled 《Diastereoselective Desymmetrization of p-Quinamines through Regioselective Ring Opening of Epoxides and Aziridines》.Recommanded Product: (R)-Oxiran-2-ylmethanol The article contains the following contents:

A highly diastereoselective desymmetrization of p-quinamines via regioselective ring opening of epoxides and aziridines under mild conditions has been developed. A chairlike six-membered transition state with minimized 1,3-diaxial interactions explains the relative stereoselectivity of the cyclization reaction. This transition-metal free [3 + 3] annulation reaction provides rapid access to fused bicyclic morpholines and piperazines with a tetrasubstituted carbon center in high yields. In addition, it also allows the synthesis of enantioenriched products by using easily accessible chiral nonracemic epoxides and aziridines. In the experimental materials used by the author, we found (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Recommanded Product: (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Recommanded Product: (R)-Oxiran-2-ylmethanol

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Alcohol – Wikipedia,
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The author of 《Gas-chromatographic analysis of aminothiol radioprotective compounds》 were Lofberg, R. T.. And the article was published in Analytical Letters in 1971. Formula: C5H14ClNS The author mentioned the following in the article:

A gas chromatog. method is described for aminothiols and disulfides. This method is based upon the formation of the trimethylsilyl derivatives and their separation by gas chromatog. The kinetics of the derivative formation were investigated. A synthetic method for C4 to C6 aminothiols is given.5-Aminopentane-1-thiol hydrochloride(cas: 31110-78-8Formula: C5H14ClNS) was used in this study.

5-Aminopentane-1-thiol hydrochloride(cas: 31110-78-8) belongs to thiols. Thiols show many reactions like those of the hydroxyl compounds, such as formation of thioesters and thioethers (sulfides). Toward oxidation, however, they differ profoundly from alcohols: whereas oxidation of an alcohol usually leads to a product in which the oxidation state of a carbon atom has been changed, oxidation of a thiol affects the sulfur atom. Formula: C5H14ClNS

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts