Month: November 2022

The author of 《Design, synthesis and in vitro evaluation of coumarin-imidazo[1,2-a]pyridine derivatives against cancer induced osteoporosisã€?were Sashidhara, Koneni V.; Singh, L. Ravithej; Choudhary, Dharmendra; Arun, Ashutosh; Gupta, Sampa; Adhikary, Sulekha; Palnati, Gopala Reddy; Konwar, Rituraj; Trivedi, Ritu. And the article was published in RSC Advances in . Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde The author mentioned the following in the article:

A series of biol. important 6-(imidazo[1,2-a]pyridin-2-yl)-2H-chromen-2-one derivatives were synthesized by employing the silver(I) catalyzed Groebke-Blackburn-Bienayme multicomponent reaction. The synthesized compounds were tested in a primary calvarial osteoblast cells by alk. phosphatase assay and an alizarin red-S staining assay for their possible osteoprotective properties. Further, the effects of active compounds 6h, 6l, and 6o on the expression of osteogenic genes BMP2, RUNX2, COL1, and OCN were measured by qPCR. Out of three promising compounds, 6l and 6o significantly induced apoptosis in MDA-MB-231 cancer cells via mitochondrial depolarisation without affecting normal cells. In an in vitro co-culture model of bone metastasis, we investigated the ability of coumarin-imidazo[1,2-a]pyridine hybrids to reverse the neg. impact of MDA-MB-231 cancer cells on osteoblast differentiation. The results illustrate the potential of designed hybrids to re-establish the bone homeostasis. These findings demonstrate the significance of newly synthesized hybrids as lead mols., possessing both antiosteoporotic and anticancer properties that can be developed into new therapeutic agents to alleviate osteoporosis and bone metastasis. In the experimental materials used by the author, we found 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Reference of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde

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Tu, Jia-Lin; Liu, Jia-Li; Tang, Wan; Su, Ma; Liu, Feng published an article on February 7 ,2020. The article was titled 《Radical Aza-Cyclization of α-Imino-oxy Acids for Synthesis of Alkene-Containing N-Heterocycles via Dual Cobaloxime and Photoredox Catalysisã€? and you may find the article in Organic Letters.Product Details of 20880-92-6 The information in the text is summarized as follows:

Nitrogen-containing heterocycles are prevalent in both naturally and synthetically bioactive mols. We report herein an unprecedented protocol for radical aza-cyclization of α-imino-oxy acids with pendant alkenes via synergistic photoredox and cobaloxime catalysis. With or without alkenes as the intermol. cross-coupling partners, the transformation provides a variety of corresponding alkene-containing dihydropyrrole products in satisfactory yields. In the presence of external alkenes, the tandem reaction generates E-selective coupling products with excellent chemo- and stereoselectivity. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€? And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

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Zhang, Tao; Luan, Yu-Xin; Lam, Nelson Y. S.; Li, Jiang-Fei; Li, Yue; Ye, Mengchun; Yu, Jin-Quan published their research in Nature Chemistry on December 31 ,2021. The article was titled 《A directive Ni catalyst overrides conventional site selectivity in pyridine C-H alkenylationã€?Application In Synthesis of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The article contains the following contents:

Herein, application of bifunctional N-heterocyclic carbene-ligated Ni-Al catalyst in C3-H alkenylation of pyridines was described. This method overrode the intrinsic C2 and/or C4 selectivity, and provided a series of C3-alkenylated pyridines such as I in 43-99% yields and up to 98:2 C3 selectivity. This method not only allowed a variety of pyridine and heteroarene substrates to be used as the limiting reagent, but was also effective for the late-stage C3 alkenylation of diverse complex pyridine motifs in bioactive mols. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application In Synthesis of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€? And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Application In Synthesis of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

Referemce:
Alcohol – Wikipedia,
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In 2018,Fujiki, Katsumasa; Tanaka, Katsunori published 《Bis[ N , N ‘-(2-indanolyl)]-1,5-diazacyclooctane as Unique Metal Ligand: Self-Assembly of Palladium Nanoparticles and Catalytic Reactivity on C-C Bond Formationã€?Synthesis published the findings.Application of 126456-43-7 The information in the text is summarized as follows:

A previously unreported 1,5-diazacyclooctane-palladium(II) complex was synthesized using bis[ N, N’-(2-indanolyl)]-1,5-diazacyclooctane, which was readily prepared via a novel [4+4] homocyclization of the unsaturated imine intermediate generated from acrolein and 1-amino-2-indanol. Interestingly, the 1,5-diazacyclooctane-palladium(II) complex self-assembled to form palladium nanoparticles. This approach readily provided palladium nanoparticles simply by heating a mixture of palladium(II) acetate and bis[ N, N’-(2-indanolyl)]-1,4-diazacyclooctane in dichloroethane at mild temperatures The 1,5-diazacyclooctane-derivative-palladium nanoparticles were successfully deployed in synthetic applications as a heterogeneous catalyst, facilitating Suzuki coupling and a challenging C-C bond formation via C(sp 3)-H activation under low catalyst loading conditions.(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Application of 126456-43-7) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 126456-43-7

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Cai, Pan; Fan, Hongxian; Cao, Shuo; Qi, Jian; Zhang, Songmei; Li, Gang published 《Electrochemical conversion of corn stover lignin to biomass-based chemicals between Cu/Ni-Mo-Co cathode and Pb/PbO2 anode in alkali solutionã€?Electrochimica Acta published the findings.COA of Formula: C7H6O3 The information in the text is summarized as follows:

In this study, we put forward an effective method of producing renewable chems. from corn stover lignin with electrochem. redox between the Cu/Ni-Mo-Co cathode and Pb/PbO2 anode in sodium hydroxide solution Cyclic voltammetry tests and polarization curves were conducted to research the electrochem. oxidation performance of Pb/PbO2 anode and electrocatalytic hydrogenation of Cu/Ni-Mo-Co in lignin alkali solution Fourier transform IR spectroscopy (FTIR) and high performance liquid chromatog. (HPLC) were used to characterize the functional groups and mol. weight distribution of the lignin residue. By GC-MS anal., it confirmed that there were 24 kinds of compounds in degradation products of alkali corn stover lignin. In addition to this, some com. value chems. including trans-ferulic acid, vanillin, 3-hydroxy-4-methoxyphenyl-ethanone, syringaldehyde, acetosyringone and 4-methoxy-3-methyl-phenol were also observed The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8COA of Formula: C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.COA of Formula: C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Meng, Fei-Fan; Xie, Jia-Hao; Xu, Yun-He; Loh, Teck-Peng published 《Catalytically asymmetric synthesis of 1,3-bis(silyl)propenes via copper-catalyzed double proto-silylations of polar enynesã€?ACS Catalysis published the findings.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

A copper-catalyzed (CuCl2/bpy) double proto-silylations of electron-deficient conjugated enynes RCH:CHCCX (X = CO2Me, CN, COCH2CH2Ph) with silylboronate PhMe2SiBpin to synthesize functional bis(silyl)propenes (E)-RCH(SiMe2Ph)CH:C(SiMe2Ph)CH2X (3; R = aryl, alkyl, thienyl) was developed. Under mild reaction conditions, the silylboronate PhMe2Si-Bpin reacts with the enynes via cascade proto-silylations and yields the corresponding Z-specific bis(silyl)propene products in up to 98% yield and 95% ee. In addition, the use instead of bipyridines chiral enantiopure substituted and annelated 2-pyridyloxazoles resulted in enantioselective synthesis of the compounds (3) was also achieved. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHRâ€? to form imines (R2C=NRâ€?. Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
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In 2018,ACS Catalysis included an article by Ociepa, Michal; Turkowska, Joanna; Gryko, Dorota. Recommanded Product: 27489-62-9. The article was titled 《Redox-Activated Amines in C(sp3)-C(sp) and C(sp3)-C(sp2) Bond Formation Enabled by Metal-Free Photoredox Catalysisã€? The information in the text is summarized as follows:

The amino group represents one of the most prevalent structural motifs in organic chem. Therefore, application of amines as alkylating agents in synthesis is highly compelling. Herein, we present a metal-free photoredox strategy for the formation of C(sp3)-C(sp) and C(sp3)-C(sp2) bonds from redox-activated primary amine derivatives The developed reaction of 2,4,6-triphenylpyridinium salts with alkynyl p-tolylsulfones, leading to functionalized alkynes, is easily scalable and offers broad substrate scope, high chemoselectivity, and mild conditions. Its potential is also highlighted by diversification of complex mol. scaffolds. Addnl., the approach is also suitable for synthesis of (E)-alkenes from vinyl Ph sulfones. Mechanistic studies contribute to the elucidation of unexpected differences in reactivity of primary and secondary alkyl substituted pyridinium salts.trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 27489-62-9

Referemce:
Alcohol – Wikipedia,
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In 2019,Organic Letters included an article by Tong, Chao-Lai; Xu, Xiu-Hua; Qing, Feng-Ling. Quality Control of 5-Hexen-1-ol. The article was titled 《Oxidative Hydro-, Bromo-, and Chloroheptafluoroisopropylation of Unactivated Alkenes with Heptafluoroisopropyl Silverã€? The information in the text is summarized as follows:

Oxidant-induced three-component hydro-, bromo-, and chloroheptafluoroisopropylation of unactivated alkenes are disclosed. In these reactions, the CF(CF3)2 radical was generated from the oxidation of AgCF(CF3)2. Then the addition of this perfluorinated radical to alkenes, followed by hydrogenation, bromination, or chlorination, gave the corresponding difunctionalized CF(CF3)2-containing products in high yields. In the experimental materials used by the author, we found 5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Quality Control of 5-Hexen-1-ol

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Alcohol – Wikipedia,
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In 2019,ACS Catalysis included an article by Corpas, Javier; Quiros, M. Teresa; Mauleon, Pablo; Gomez Arrayas, Ramon; Carretero, Juan C.. Application In Synthesis of 2-Hydroxyphenylboronic acid. The article was titled 《Metal- and Photocatalysis to Gain Regiocontrol and Stereodivergence in Hydroarylations of Unsymmetrical Dialkyl Alkynesã€? The information in the text is summarized as follows:

Herein a regioselective, stereodivergent catalytic hydroarylation of unsym. dialkyl alkynes with arylboronic acids that allows highly selective access to either E- or Z- diastereoisomers of trisubstituted alkenes I (R = 4-tBuC6H4, C6H5, 5-indolyl, etc.) II (R1 = H, Me, iPr, etc.; R2 = Et, Pr, iPr, etc.) is reported. The E-selectivity is achieved through syn-carbopalladation of the Ar-Pd species followed by protodepalladation in which a 2-pyridyl sulfonyl (SO2Py) directing group enables complete control of the regioselectivity. Access to the complementary stereochem. is achieved through a tandem Pd/Ir sequence, which includes hydroarylation and E-Z photoisomerization. Lastly, facile removal of the directing group by reduction, reductive elimination, Julia-Kocienski olefination, or Cu-catalyzed C(sp3)-C(sp2) or C(sp3)-C(sp3) cross coupling, allows for the selective preparation of stereodefined olefins and dienes. In the experimental materials used by the author, we found 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Application In Synthesis of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
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In 2019,ChemistrySelect included an article by Choudhary, Anu; Sharma, Nitika; Sharma, Chandan; Jamwal, Babita; Paul, Satya. Application In Synthesis of 3-Pyridinemethanol. The article was titled 《Synergistic Effect of Cr3+ on Layered Double Hydroxide Supported Cu0 Nanoparticles for the Oxidation of Alcohols and Hydrocarbonsã€? The information in the text is summarized as follows:

Chromium(III)-doped layered double hydroxide supported copper nanoparticles (Cr3+-Cu0/LDH) has been prepared as an efficient and reusable catalyst using simple and versatile synthetic method. Effect of doping of Cr3+ to the layered double hydroxide supported Cu0 nanoparticles was evaluated for the oxidation of alcs. e.g., I and hydrocarbons e.g., II by varying the amount of Cr3+ loading in the catalyst. The catalyst with Cu:Cr ratio = 1:1 afforded highest catalytic activity among the synthesized catalysts towards the oxidation using TBHP (tBuOOH) in aqueous medium. The high activity and selectivity was assigned to the synergistic electronic interaction between copper(0) nanoparticles and chromium(III) ions based on exptl. data and XPS results. Moreover, the high stability of Cu0 and Cr3+ in the catalyst was attributed to the strong metal-support interactions, which make the catalyst recyclable upto five runs. In the experiment, the researchers used 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
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