Month: November 2022

Recommanded Product: 26153-38-8In 2022 ,《Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Proteinã€?was published in Molecules. The article was written by Ruggiero, Dafne; Terracciano, Stefania; Lauro, Gianluigi; Pecoraro, Michela; Franceschelli, Silvia; Bifulco, Giuseppe; Bruno, Ines. The article contains the following contents:

The multidomain BAG3 protein is a member of the BAG (Bcl-2-associated athanogene) family of co-chaperones, involved in a wide range of protein-protein interactions crucial for many key cellular pathways, including autophagy, cytoskeletal dynamics, and apoptosis. Basal expression of BAG3 is elevated in several tumor cell lines, where it promotes cell survival signaling and apoptosis resistance through the interaction with many protein partners. In addition, its role as a key player of several hallmarks of cancer, such as metastasis, angiogenesis, autophagy activation, and apoptosis inhibition, has been established. Due to its involvement in malignant transformation, BAG3 has emerged as a potential and effective biol. target to control multiple cancer-related signaling pathways. Recently, by using a multidisciplinary approach we reported the first synthetic BAG3 modulator interfering with its BAG domain (BD), based on a 2,4-thiazolidinedione scaffold and endowed with significant anti-proliferative activity. Here, a further in silico-driven selection of a 2,4-thiazolidinedione-based compound was performed. Thanks to a straightforward synthesis, relevant binding affinity for the BAG3BD domain, and attractive biol. activities, this novel generation of compounds is of great interest for the development of further BAG3 binders, as well as for the elucidation of the biol. roles of this protein in tumors. Specifically, we found compound 6 as a new BAG3 modulator with a relevant antiproliferative effect on two different cancer cell lines (IC50: A375 = 19.36 μM; HeLa = 18.67 μM).3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A facile synthesis of ZrOx-MnCO3/graphene oxide (GRO) nanocomposites for the oxidation of alcohols using molecular oxygen under base free conditionsã€?was written by Adil, Syed Farooq; Assal, Mohamed E.; Shaik, Mohammed Rafi; Kuniyil, Mufsir; AlOtaibi, Nawaf M.; Khan, Mujeeb; Sharif, Muhammad; Alam, M. Mujah; Al-Warthan, Abdulrahman; Mohammed, Jabair Ali; Sdiqui, Mohammed Rafiq H.; Tahir, Muhammad Nawaz. Recommanded Product: 821-41-0This research focused onzirconium manganese carbonate graphene oxide nanocomposite alc oxidation. The article conveys some information:

Graphene and its nanocomposites are showing excellent potential in improving the catalytic performances of different materials. However, the synthetic protocol and its form, such as graphene oxide (GRO) or highly reduced graphene oxide (HRG), influence the catalytic efficiencies. Here, we present, a facile synthesis of graphene oxide (GRO) and ZrOx-MnCO3-based nanocomposites [(1%)ZrOx-MnCO3/(x%)GRO] and their outcome as an oxidation catalyst for alc. oxidation under mild conditions using O2 as a clean oxidant. The ZrOx-MnCO3/GRO catalyst prepared by incorporating GRO to pre-calcined ZrOx-MnCO3 using ball milling showed remarkable enhancement in the catalytic activities as compared to pristine ZrOx-MnCO3, ZrOx-MnCO3 supported on HRG or ZrOx-MnCO3/GRO prepared by in-situ growth of ZrOx-MnCO3 onto GRO followed by calcination. The catalyst with composition (1%)ZrOx-MnCO3/(1%)GRO exhibited superior specific activity (57.1 mmol/g·h) with complete conversion and >99% selectivity of the product within a short period of time (7 min) and at a relatively lower temperature (100°C). The catalyst could be recycled at least five times with a negligible decrease in efficiency and selectivity. The catalytic study was extended to different aromatic as well as aliphatic alcs. under optimized conditions, which confirmed the efficiency and selectivity of the catalyst. The results came from multiple reactions, including the reaction of 5-Hexen-1-ol(cas: 821-41-0Recommanded Product: 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Recommanded Product: 821-41-0

Referemce:
Alcohol – Wikipedia,
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《Benzoyl cellulose beads in the pure polymeric form as a new powerful sorbent for the chromatographic resolution of racematesã€?was published in Chirality in 1991. These research results belong to Francotte, Eric; Wolf, Romain M.. Category: alcohols-buliding-blocks The article mentions the following:

Cellulose-based stationary phases are known to be very efficient and versatile chiral sorbents for the chromatog. resolution of racemates. Except for microcrystalline cellulose triacetate, basically all other cellulose-based phases are prepared by coating of �0% weight polymer on a wide-pore silica gel used as a carrier. Benzoyl cellulose beads were in the pure polymeric form (without inorganic carrier) from an emulsion of the organic polymer. The new material was characterized fully and used as a chiral stationary phase for the resolution of various classes of racemic compounds such as benzylic alcs. or acetate derivatives of aliphatic alcs. and diols. The structural variety of the separated solutes as well as the irrational influence of the aromatic substituent in different classes of aryl compounds suggest that multiple interaction sites are involved in the complexation, making a prediction of the separation difficult. The benzoyl cellulose beads exhibit a very high loading capacity, which is particularly useful for preparative purposes, as shown for selected examples. The experimental process involved the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Category: alcohols-buliding-blocks)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Palladium-catalyzed coupling reaction of halo heteroaromatic compounds in waterã€?was written by Inoue, Naoki; Sugimoto, Osamu; Tanji, Ken-ichi. Category: alcohols-buliding-blocks And the article was included in Heterocycles on April 13 ,2007. The article conveys some information:

Palladium-catalyzed coupling reaction of π-deficient heteroaromatic halides with terminal alkynes in water was accomplished with excellent to good yields without any side reactions such as hydrolysis. The experimental process involved the reaction of 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Category: alcohols-buliding-blocks)

3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《The effect of solvents on the thermal degradation products of two Amadori derivativesã€?was published in RSC Advances in 2020. These research results belong to Zhang, Shiyi; Li, Rui; Zhang, Yudan; Zhao, Mingqin. Related Products of 20880-92-6 The article mentions the following:

To enrich the flavor additives of the Maillard reaction, two Amadori analogs, N-(1-deoxy-D-fructosyl-1-yl)-L-phenylalanine ester (Derivative 1) and di-O-isopropylidene-2,3:4,5-β-D-fructopyranosyl phenylalanine ester (Derivative 2), were chem. synthesized starting from D-fructose. The samples were reacted at 120 and 180°C for 2 h, and the effects of solvents (water and ethanol) on their degradation products were studied. The analyses of thermogravimetry (TG), derivative thermogravimetry (DTG), differential scanning calorimetry (DSC), and gas chromatog.-mass spectrometry (GC/MS) were used to investigate the thermal behavior and degradation products of the samples. TG-DTG curves show that the Tp values of the samples corresponding to the largest mass-loss rates are 132 and 275°C, resp. The degradation products of Derivative 1 are mainly Ph acetaldehyde and phenylalanine Et ester in water and Et benzoate and benzaldehyde di-Et acetal in ethanol. For Derivative 2, the major degradation products both in water and ethanol are phenylalanine Et ester and diacetonefructose, but the products have different relative contents affected by solvent media. The products of the pyrolysis of the samples at 350°C were analyzed and compared with the degradation compounds obtained in solvent. These results show that organic solvents can greatly influence the degradation pathway and products. Finally, possible mechanisms of the degradation processes are proposed. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€?Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Thiocarbonyl Surrogate via Combination of Sulfur and Chloroform for Thiocarbamide and Oxazolidinethione Constructionã€?was written by Tan, Wei; Wei, Jianpeng; Jiang, Xuefeng. Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olThis research focused onthiourea preparation; amine chloroform sulfur coupling; oxazolidinethione preparation; aminoalc chloroform sulfur coupling. The article conveys some information:

An efficient and practical thiocarbonyl surrogate via combination of sulfur and chloroform has been developed. A variety of thiocarbamides and oxazolidinethiones have been established, including chiral thiourea catalysts and chiral oxazolidinethione auxiliaries with high selectivity. Meanwhile, pesticides Diafenthiuron (an acaricide), ANTU (a rodenticide), and Chloromethiuron (an insecticide) were practically synthesized through this method in gram scale. Dicholorocarbene, as the key intermediate, was further confirmed via a carbene-trapping control experiment After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)â€? RS(O)2â€? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ€?; the products are amides of the corresponding acids.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
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Application of 20880-92-6On March 11, 2022, Guo, Peng; Pang, Xiaobo; Wang, Ke; Su, Pei-Feng; Pan, Qiu-Quan; Han, Guan-Yu; Shen, Qian; Zhao, Zhen-Zhen; Zhang, Wenhua; Shu, Xing-Zhong published an article in Organic Letters. The article was 《Nickel-Catalyzed Reductive Csp3-Ge Coupling of Alkyl Bromides with Chlorogermanesã€? The article mentions the following:

Reductive cross-coupling provides facile access to organogermanes, but it remains largely unexplored. Herein the authors report a Ni-catalyzed reductive Csp3-Ge coupling of alkyl bromides with chlorogermanes. This work established a new method for producing alkylgermanes. The reaction proceeds under very mild conditions and tolerates various functionalities including ether, alc., alkene, nitrile, amine, ester, phosphonates, amides, ketone, and aldehyde. The application of this method to the modification of bioactive mols. is demonstrated. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)â€?Application of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 401797-00-0On November 19, 2021 ,《A Cu-Promoted C-N Coupling of Boron Esters and Diaziridinone. An Approach to Aryl Ureasã€?appeared in Organic Letters. The author of the article were Li, Jing; Wang, Xiaoyu; Wang, Zhanwei; Shi, Yian. The article conveys some information:

A novel Cu-promoted C-N coupling between boron esters and di-tert-butyldiaziridinone was described. A wide variety of aryl ureas were readily obtained under mild conditions with up to 92% yield. In the experiment, the researchers used many compounds, for example, 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0HPLC of Formula: 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.HPLC of Formula: 401797-00-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Didier, Eric; Loubinoux, Bernard; Ramos Tombo, Gerardo M.; Rihs, Grety published an article in Tetrahedron. The title of the article was 《Chemo-enzymatic synthesis of 1,2- and 1,3-amino alcohols and their use in the enantioselective reduction of acetophenone and anti-acetophenone oxime methyl ether with boraneã€?Related Products of 135969-66-3 The author mentioned the following in the article:

New chiral amino alcs. were enantioselectively synthesized using biotransformations as the key steps. Thus, the Bakers yeast reduction of the β-keto ester I gave hydroxy ester II (R = CO2Et) in 34% yield with high enantio- and diastereoselectivity. Saponification of the ester gave acid II (R = CO2H), which was converted to oxazolidinone III by a modified reaction with diphenylphosphorazide. Hydrolysis of III with KOH gave amino alc. II (R = NH2). The new chiral amino alcs. were used as ligand in the enantioselective borane reduction of acetophenone and of the corresponding anti-oxime Me ether. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-2-(Methylamino)cyclopentan-1-ol(cas: 135969-66-3Related Products of 135969-66-3)

(1S,2R)-2-(Methylamino)cyclopentan-1-ol(cas: 135969-66-3) is a member of cyclopentanes. Although cyclopentane itself doesn’t have a single highly favoured conformation, a substituent on the cyclopentane ring can upset the balance of strains thereby favouring either the envelope or the half-chair.Related Products of 135969-66-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Liangzhen; Hussain, Muhammad Ijaz; Deng, Qingfu; Liu, Qing; Feng, Yangyang; Zhang, Xiaohui; Xiong, Yan published an article on January 11 ,2019. The article was titled 《I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation processã€? and you may find the article in Tetrahedron.Reference of (3-Chlorophenyl)(phenyl)methanol The information in the text is summarized as follows:

One-step base promoted strategy for cyanation of α,α-diaryl alcs. has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, resp., up to 99% yield. Moreover, various azides and ethers could also be accessed from their resp. nucleophiles under standard reaction conditions. In addition to this study using (3-Chlorophenyl)(phenyl)methanol, there are many other studies that have used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Reference of (3-Chlorophenyl)(phenyl)methanol) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Reference of (3-Chlorophenyl)(phenyl)methanol Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts