Month: November 2022

《Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds》 was written by Okuda, Yuta; Nagaoka, Masahiro; Yamamoto, Tetsuya. Quality Control of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane And the article was included in ChemCatChem in 2020. The article conveys some information:

The synthesis of primary, secondary, and tertiary alcs. by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02-0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcs. that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Quality Control of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Quality Control of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Chuntian; Sun, Yangyang; Xu, Yangsen; Zhang, Bing; Zhang, Xu; Yu, Lei; Su, Chenliang published their research in ChemSusChem in 2021. The article was titled 《Photoredox-Catalyzed Simultaneous Olefin Hydrogenation and Alcohol Oxidation over Crystalline Porous Polymeric Carbon Nitride》.HPLC of Formula: 100-55-0 The article contains the following contents:

Booming of photocatalytic water splitting technol. (PWST) opens a new avenue for the sustainable synthesis of high-value-added hydrogenated and oxidized fine chems., in which the design of efficient semiconductors for the in-situ and synergistic utilization of photogenerated redox centers are key roles. Herein, a porous polymeric carbon nitride (PPCN) with a crystalline backbone was constructed for visible light-induced photocatalytic hydrogen generation by photoexcited electrons, followed by in-situ utilization for olefin hydrogenation. Simultaneously, various alcs. were selectively transformed to valuable aldehydes or ketones by photoexcited holes. The porosity of PPCN provided it with a large surface area and a short transfer path for photogenerated carriers from the bulk to the surface, and the crystalline structure facilitated photogenerated charge transfer and separation, thus enhancing the overall photocatalytic performance. High reactivity and selectivity, good functionality tolerance, and broad reaction scope were achieved by this concerted photocatalysis system. The results contribute to the development of highly efficient semiconductor photocatalysts and synergistic redox reaction systems based on PWST for high-value-added fine chem. production The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.HPLC of Formula: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Weikang; Huang, Ming; Liu, Jiahao; Huang, Yong-Liang; Lan, Xiao-Bing; Ye, Zongren; Zhao, Cunyuan; Liu, Yan; Ke, Zhuofeng published their research in ACS Catalysis in 2021. The article was titled 《Enhanced Hydride Donation Achieved Molybdenum Catalyzed Direct N-Alkylation of Anilines or Nitroarenes with Alcohols: From Computational Design to Experiment》.COA of Formula: C6H7NO The article contains the following contents:

An example of homogeneous Mo-catalyzed direct N-alkylation of anilines or nitroarenes with alcs. is presented. The DFT aimed design suggested the easily accessible bis-NHC-Mo(0) complex features a strong hydride-donating ability, achieving effective N-alkylation of anilines or challenging nitroarenes with alcs. The enhanced hydride-donating strategy should be useful in designing highly active systems for borrowing hydrogen transformations. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0COA of Formula: C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C6H7NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jahan, Khorshada; Khan, Kaif Rashid; Akhter, Kawsari; Romman, Umme Kulsum Rowzatur; Halim, Ershad published their research in PLoS One in 2021. The article was titled 《A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study》.Related Products of 100-83-4 The article contains the following contents:

A convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) I [R = 3-OH, 2-MeO, 2-Cl, 3-Cl, 2-2ON] derivatives in two steps with moderate to good yield using morpholine as a catalyst was reported. All the structures I were confirmed by their spectral IR, 1H NMR and 13C NMR data. The anti-diabatic activity of all synthesized mols. I was evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies revealed that compounds I [R = 3-OH, 2-MeO, 4-Cl] showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Related Products of 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Shuai; Cui, Jing-Wang; Rao, Cai-Hui; Jia, Meng-Ze; Chen, Yun-Rui; Zhang, Jie published their research in Green Chemistry in 2021. The article was titled 《Boosting activity of molecular oxygen by pyridinium-based photocatalysts for metal-free alcohol oxidation》.SDS of cas: 873-75-6 The article contains the following contents:

An eco-friendly and economical approach for the photocatalytic oxidation of organic inter-mediates by air under mild conditions is highly desirable in green and sustainable chem., where the photogeneration of active oxygen species plays a key role in improving conversion efficiency and selectivity. By using pyridinium derivatives as mol. mediators for electron transfer and energy transfer, the simultaneous activation of O2 from air into superoxide radicals and singlet oxygen species can be achieved, and a photoinduced electron transfer catalytic system for the oxidation of alcs. has been developed. Thus, we have successfully simplified the complicated catalytic system into a single mol. catalyst without any addnl. noble metals and co-catalysts/additives. The current photocatalytic system shows high catalytic efficiency not only for aromatic alcs. but also for aliphatic alcs. that are generally difficult to undergo aerobic oxidation at room temperature under air atm., representing an ideal photocatalytic platform for green and economical organic syntheses. In the experiment, the researchers used many compounds, for example, (4-Bromophenyl)methanol(cas: 873-75-6SDS of cas: 873-75-6)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.SDS of cas: 873-75-6 It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Driessen, Daniel; Biesen, Lukas; Mueller, Thomas J. J. published an article in 2021. The article was titled 《Sequentially Catalyzed Three-Component Masuda-Suzuki-Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion》, and you may find the article in Synlett.Computed Properties of C3H6O2 The information in the text is summarized as follows:

The Masuda-Suzuki-Sonogashira sequence efficiently united in a one-pot fashion, a borylation, an arylation and an alkynylation in the sense of a sequentially Pd-catalyzed three-component reaction to give fluorescent 2-alkynyl-4-(7-azaindol-3-yl)pyrimidines in yields of 24-83%. Time-dependent d.-functional theory calculations supported the electronic structure of the longest wavelength absorption bands, and revealed that this novel consecutive three-component synthesis opened an efficient access to alkynyl meriolins, a novel class of potential inducers of apoptosis. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Yoon Jee; Duraisamy, Kalaiselvi; Jeong, Min-Hye; Park, Sook-Young; Kim, Soonok; Lee, Yookyung; Nguyen, Van Thi; Yu, Nan Hee; Park, Ae Ran; Kim, Jin-Cheol published an article in 2021. The article was titled 《Nematicidal activity of grammicin biosynthesis pathway intermediates in Xylaria grammica KCTC 13121BP against Meloidogyne incognita》, and you may find the article in Molecules.Recommanded Product: 3,5-Dihydroxybenzaldehyde The information in the text is summarized as follows:

Grammicin, a polyketide metabolite produced by the endolichenic fungus Xylaria grammica KCTC 13121BP, shows strong nematicidal activity against Meloidogyne incognita. This study was performed to elucidate the grammicin biosynthesis pathway of X. grammica KCTC 13121BP and to examine the nematicidal activity of the biosynthesis intermediates and derivatives against M. incognita. Two grammicin biosynthesis intermediates were isolated from a T-DNA insertion transformant (strain TR-74) of X. grammica KCTC 13121BP and identified as 2-(hydroxymethyl)cyclohexa-2,5-diene-1,4-dione (compound 1) and 2,5-dihydroxybenzaldehyde (compound 2), which were also reported to be intermediates in the biosynthesis pathway of patulin, an isomer of grammicin. This indicates that the grammicin biosynthesis pathway overlaps almost with that of patulin, except for the last few steps. Among 13 grammicin biosynthesis intermediates and their derivatives (except grammicin), toluquinol caused the highest M. incognita J2 mortality, with an LC50/72 h value of 11.13μg/mL, which is similar to grammicin with an LC50/72 h value of 15.95μg/mL. In tomato pot experiments, the wettable powder type formulations (WP) of toluquinol (17.78μg/mL) and grammicin (17.78μg/mL) also effectively reduced gall formation on the roots of tomato plants with control values of 72.22% and 77.76%, resp., which are much higher than abamectin (16.67%), but lower than fosthiazate (100%). The results suggest that toluquinol can be used directly as a biochem. nematicide or as a lead mol. for the development of new synthetic nematicides for the control of root-knot nematode diseases. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Yue; Liu, Zhengyi; Zou, Peng; Chen, Yali; Chen, Yiyun published an article in 2022. The article was titled 《Hypervalent Iodine Reagents Enable C(sp2)-H Amidation of (Hetero)arenes with Iminophenylacetic Acids》, and you may find the article in Organic Letters.Product Details of 7748-36-9 The information in the text is summarized as follows:

The sulfonamidyl (hetero)arenes synthesis by the C(sp2)-H amidation from bench-stable amidyl-iminophenylacetic acids was reported. The hypervalent iodine reagents covalently activated iminophenylacetic acids for the facile sulfonamidyl radical generation under mild photocatalytic oxidative conditions. Diversified indoles, pyrroles, imidazopyridines and fused arenes underwent the C(sp2)-H amidation with excellent chemoselectivity and regioselectivity. This reaction performed well under neutral aqueous conditions with potential biol. applications. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Sarkar, Nabin; Sahoo, Rajata Kumar; Patro, A. Ganesh; Nembenna, Sharanappa published an article in Polyhedron. The title of the article was 《Aluminum-catalyzed selective hydroboration of carbonyls and dehydrocoupling of alcohols, phenols, amines, thiol, selenol, silanols with HBpin》.HPLC of Formula: 1195-59-1 The author mentioned the following in the article:

A popular N,N’-chelated NacNac analog, i.e., conjugated bis-guanidinate (CBG) stabilized aluminum dihydride LAlH2 [1; L = ArNC(ArNH):NC:(NHAr)NAr, where Ar = 2,6-Et2-C6H3], demonstrates excellent catalytic hydroboration of a wide array of carbonyls with pinacolborane (HBpin) under neat conditions with good tolerance of reducible functional groups such as alkyl, alkene, halide, nitrile, nitro, ester, amide, and heteroaryl. In addition, we investigated complex 1 catalyzed cross-dehydrocoupling (CDC) of alcs., phenols, amines, thiol, selenol, and silanols with HBpin under mild reaction conditions. Furthermore, several control experiments have been performed to understand the mechanisms in hydroboration and CDC reactions. All corresponding catalytic intermediates have been identified and characterized by 1H and 13C{1H} NMR spectroscopic methods. In contrast to several reports on metal-catalyzed hydroboration of carbonyls, this is the second report for the mol. aluminum catalyzed CDC of organic substrates with HBpin. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhou, Bei; Ma, Zhuang; Alenad, Asma M.; Kreyenschulte, Carsten; Bartling, Stephan; Beller, Matthias; Jagadeesh, Rajenahally V. published an article in Green Chemistry. The title of the article was 《Cobalt-catalysed CH-alkylation of indoles with alcohols by borrowing hydrogen methodology》.Quality Control of 3-Pyridinemethanol The author mentioned the following in the article:

A general heterogeneous cobalt-catalyzed CH-alkylation of indoles with alcs. was reported. Utilizing this straightforward borrowing hydrogen methodol., a series of substituted and functionalized indoles were easily coupled with benzylic, heterocyclic, and aliphatic alcs. including methanol to prepare >65 substituted indoles in good to excellent yields. The resulting products represented an interesting class of heterocyclic compounds widely used in organic synthesis and medicinal chem. Key for this synthesis was the use of specific cobalt-nanoparticles supported on N-doped carbon, which were conveniently prepared by the pyrolysis of a templated material generated in-situ by mixing cobalt-nitrate, zinc-nitrate, 2,6-diaminopyridine, and colloidal silica, and subsequent removal of silica. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts