Month: November 2022

Li, Xin; He, Songtao; Song, Qiuling published their research in Organic Letters in 2021. The article was titled 《Diethylzinc-Mediated Radical 1,2-Addition of Alkenes and Alkynes》.Category: alcohols-buliding-blocks The article contains the following contents:

A novel diethylzinc-mediated radical 1,2-addition of perfluoroalkyl iodides to unactivated alkenes and alkynes was presented, which demonstrates a novel way to generate an Et difluoroacetate radical. This method was highly efficient and gives full conversions of the substrates, high yields of the products and negligible byproducts and requires no column chromatog. purifications. The mild conditions enable this protocol to exhibited excellent functional group compatibility. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Feng-Zhi; Shao, Yuan-Guang; Zhang, Zibin; Shen, Yan-Feng; Huang, Xue-Chun; Zhang, Pei-Ling; Li, Shijun published their research in Synthesis in 2021. The article was titled 《Synthesis of Catenanes from a BMP32C10-Based Cryptand Tuned by the Linkage Length of Paraquat Salts》.Quality Control of 5-Hexen-1-ol The article contains the following contents:

A series of catenanes was synthesized through olefin metathesis from a BMP32C10-based cryptand and paraquat guests attached with two terminal alkenes. Distribution of catenane products could be significantly affected by linkage length on paraquat guests. In presence of BMP32C10-based cryptand, paraquat salt with a long linkage facilitates intramol. olefin metathesis to release a [2]catenane as sole catenation product, while use of a paraquat salt with a shorter linkage led to simultaneous generation of [2]-, [3]-, and [4]-catenanes. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Quality Control of 5-Hexen-1-ol)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Quality Control of 5-Hexen-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yucel, Muge; Koc, Altug; Ulgenalp, Ayfer; Akkoc, Gun Deniz; Ceyhan, Metin; Yildiz, Umit Hakan published their research in ACS Sensors in 2021. The article was titled 《PCR-Free Methodology for Detection of Single-Nucleotide Polymorphism with a Cationic Polythiophene Reporter》.Reference of 3-Bromopropan-1-ol The article contains the following contents:

This study presents a nonamplification-based nucleic acid assay for the detection of single-nucleotide polymorphism (SNP) associated with familial Mediterranean fever (FMF) besides polymerase chain reaction (PCR)-based methodologies. The major objective is to show the potential of the proposed assay for rapid screening of FMF in a Mediterranean region of 400 million population. The assay relies on binding difference of specially designed wild and mutant primers to the target genomic DNA, followed by determination of unbound primers by quick titration of a cationic polythiophene reporter. The fluorescent reporter exhibits signal transition from 525 to 580 nm in the presence of unbound primers, and it correlates the binding affinity of label-free primers to the homozygous wild and mutant genomes. As a proof of concept, 26 real samples are studied relying on the ON and OFF fluorescence signals of the cationic polythiophene reporter. The results are analyzed by principal component anal. (PCA), which provides clear separation of healthy and patient individuals. The further anal. by support vector machine (SVM) classification has revealed that our assay converges to 96% overall accuracy. These results support that the PCR-free nucleic acid assay has a significant potential for rapid and cost-effective screening of familial Mediterranean fever. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Ping; Zhang, Baozhong published their research in RSC Advances in 2021. The article was titled 《Sustainable aromatic polyesters with 1,5-disubstituted indole units》.Recommanded Product: 3-Bromopropan-1-ol The article contains the following contents:

This work aims to unravel the impact of disubstitution patterns on the phys. properties and processing characteristics of indole-based aromatic polyesters. A series of hydroxyl-carboxylate (AB-type) monomers with 1,5-disubstituted indole and 3-6 methylene units was conveniently synthesized and used in bulk polycondensation to yield the corresponding polyesters with decent mol. weight These new monomers and polyesters showed enhanced thermal stability compared to the previously reported monomers and polyesters with a 1,3-disubstituted indole structure. According to DSC results, these polyesters showed tunable glass transition temperatures (Tg ∼57-80°C), depending on the length of the aliphatic methylene units. DSC and WAXD measurements revealed that these polymers did not crystallize from melt, but the ones with 3 or 5 methylene units per repeating unit crystallized from solution Finally, we demonstrated that the new polyesters with 1,5-disubstituted indole units could be crosslinked using sustainable aromatic aldehyde, which could further enhance their thermal properties. After reading the article, we found that the author used 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 3-Bromopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vezse, Panna; Benda, Bianka; Fekete, Andras; Golcs, Adam; Toth, Tunde; Huszthy, Peter published an article in 2022. The article was titled 《Covalently Immobilizable Tris(Pyridino)-Crown Ether for Separation of Amines Based on Their Degree of Substitution》, and you may find the article in Molecules.Application of 1195-59-1 The information in the text is summarized as follows:

A great number of biol. active compounds contain at least one amine function. Appropriate selectivity can only be accomplished in a few cases upon the substitution of these groups, thus functionalization of amines generally results in a mixture of them. The separation of these derivatives with very similar characteristics can only be performed on a preparative scale or by applying pre-optimized HPLC methods. A tris(pyridino)-crown ether was designed and synthesized for overcoming these limitations at a mol. level. It is demonstrated, that this selector mol. is able to distinguish protonated primary, secondary and tertiary amines by the formation of reversible complexes with different stabilities. This degree of substitution-specific mol. recognition of amines opens the door to develop separation processes primarily focusing on the purification of biol. active compounds in a nanomolar scale. The experimental process involved the reaction of 2,6-Pyridinedimethanol(cas: 1195-59-1Application of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Yu, Han; Ren, Jingjing; Xie, Ya; Su, Xiaofang; Wang, Aiping; Yan, Likai; Jiang, Feng; Wei, Yongge published an article in Green Chemistry. The title of the article was 《Selective iron-catalyzed aerobic oxidation of alcohols in water to carboxylic acids mediated by additives》.Recommanded Product: 100-55-0 The author mentioned the following in the article:

The direct catalytic oxidation of alcs. to carboxylic acids is very appealing, however, economic and environmentally friendly catalytic systems should be further explored from the aspect of less waste production and a convenient procedure. Herein, we display a structurally defined inorganic ligand-supported iron compound, (TBA)3[FeMo6O18(OH)6] (simplified as FeMo6), which could be used as a heterogeneous mol. catalyst in water for this conversion, with oxygen as the terminal oxidant and KCl as an additive. The oxidation of various alcs. (aromatic and aliphatic) could be achieved in almost all cases under mild conditions and provided the corresponding carboxylic acids in high yields, including some active mol. entities and natural mols. with carboxyl structures. Detailed studies showed that chloride ions could combine with the mol. catalyst FeMo6 to form a supramol. aggregate FeMo6·Cl, which could effectively catalyze the reaction, relying on the synergistic effect of chloride ions and FeMo6. Control experiments, 1H NMR studies and d. functional theory (DFT) calculations showed that the oxidation reaction might involve a free radical pathway. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Chen, Mo; Montgomery, John published an article in ACS Catalysis. The title of the article was 《Nickel-Catalyzed Intermolecular Enantioselective Heteroaromatic C-H Alkylation》.SDS of cas: 7748-36-9 The author mentioned the following in the article:

Herein, an approach involving nickel-catalyzed intermol. enantioselective C-H alkylation of heteroarenes, such as benzoxazoles, benzofurans, benzimidazoles, etc., with norbornene is presented. The process can be carried out under mild conditions using nickel(0) catalysts with N-heterocyclic carbene (NHC) ligands in the absence of Lewis acid co-catalysts. A series of NHC nickel complexes stabilized with 1,5-hexadiene was synthesized via an operationally simple approach, resulting in improved functional group tolerance and heteroarene scope. Mechanistic investigations are consistent with a ligand-to-ligand hydrogen transfer (LLHT) pathway where the C-H bond activation precedes a rate-determining reductive elimination step.Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C3H9NOIn 2019 ,《Experimental evaluation of highly efficient primary and secondary amines with lower energy by a novel method for post-combustion CO2 capture》 appeared in Applied Energy. The author of the article were Liu, Sen; Gao, Hongxia; He, Chuan; Liang, Zhiwu. The article conveys some information:

In this work, a novel method in terms of reaction energy was proposed to evaluate the potential amine absorbents for post-combustion CO2 capture, including two key parameters, i.e. the molar Gibbs energy change (ΔrGm) of proton combination with amine and the molar reaction enthalpy (ΔrHm) of protonated amine dissociation into amine and proton, which are calculated by the Van’t Hoff equation. Firstly, the equilibrium acid dissociation constant (Ka) of seven primary and secondary amines were exptl. determined at 293-323 K. The calculated ΔrGm and ΔrHm values obtained by the novel method indicated that the 2-(ethylamino)ethanol (EAE) and 2-(methylamino)ethanol (MAE) were the alternative promising absorbents among the seven tested amines, with a relatively low ΔrGm of about -57.0 kJ/mol and ΔrHm of 49.7 kJ/mol. In addition, seven amine solutions with molar concentration of 2.5 M and 5.0 M were investigated by the rate-based fast screening method to validate the reliability and applicability of the novel method. The comprehensive comparison of the absorption rate, desorption rate, CO2 equilibrium solubility and cyclic capacity, also demonstrated the same conclusion that EAE and MAE solutions presented good CO2 capture performances. The 2.5 M and 5.0 M EAE solutions obtain the highest energy efficiency for CO2 capture with the highest cyclic capacity, which is about 52.9% and 32.3% higher than those of Monoethanolamine (MEA) solution, resp. Addnl., the structure-activity anal. of seven amines suggested that the addition of hydroxyl group can obviously decrease the absorption rate and energy consumption of amine solution for CO2 removal, the alkyl group addition on or close to amino group with steric hindrance is favorable for the CO2 capture performance, while the addition of Me group on amine mol. without steric hindrance can reduce the CO2 cyclic capacity. What’s more, four tertiary amines were also investigated by using these two approaches, and the compared results further validated the accuracy and applicability of the proposed novel method. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C6H15NOIn 2020 ,《Size-dependent phase separation and thermomechanical properties of thermoplastic polyurethanes》 was published in Polymer. The article was written by Wu, Chien-Hsin; Huang, Ying-Chi; Chen, Wei-Lun; Lin, Yen-Yu; Dai, Shenghong A.; Tung, Shih-Huang; Jeng, Ru-Jong. The article contains the following contents:

Over the years, the manipulation of polymer microphase separation associated with mol. architectures has been holding great promise for rendering structure-property relationship. A series of poly (urea/malonamide) dendrons bearing rigid adamantanes in the periphery were developed to serve as branching hard segments (HS) for thermoplastic polyurethanes (TPUs) either in end-capping or pendant manner. Thermal properties, crystalline structures, and mech. properties of the TPUs were investigated by DSC, X-ray scattering, and DMA, resp. The introduction of the branching units with bulky adamantanes would expectedly hinder the crystallization of HS. Intriguingly, the dendrons not only accelerate the crystallization of the soft segment (SS, based on polycaprolactone polyol (PCL)), but promote the phase separation between HS and SS to form distinct microdomains as well. These enhanced effects revealed a size-dependent relationship with growing size (or generation) of the branching HS. With the high SS crystallinity that can freeze the chain mobility and the robust HS domains that work as the phys. crosslinking points, the resulting TPUs incorporated with adamantane-bearing units show superior shape memory behaviors. This work demonstrates that the mol. engineering on the architectures can significantly tailor the microstructures and properties of thermal plastic polymers. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Synthetic Route of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C3H6O2In 2020 ,《Sulfenylation of Arenes with Ethyl Arylsulfinates in Water》 was published in ACS Omega. The article was written by Wei, Yueting; He, Jing; Liu, Yali; Xu, Liang; Vaccaro, Luigi; Liu, Ping; Gu, Yanlong. The article contains the following contents:

A tetrabutylammonium iodide-mediated direct sulfenylation of arenes with Et arylsulfinates in water was developed. Various electron-rich arenes and Et arylsulfinates were investigated in the reaction, and a series of aryl sulfides were obtained in excellent yields. The advantages of this green protocol were simple reaction conditions (metal-free, water as the solvent, and under air), odorless and easily available sulfur reagent, broad substrate scope, and gram-scale synthesis. Moreover, the potential application of aryl sulfides was exemplified by further transformations. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts