Month: November 2022

《Construction of covalent organic framework with unique double-ring pore for size-matching adsorption of uranium》 was written by Zhang, Jie; Zhou, Lihong; Jia, Zhimin; Li, Xiaofeng; Qi, Yue; Yang, Chuting; Guo, Xinghua; Chen, Shanyong; Long, Honghan; Ma, Lijian. Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeThis research focused ontriformylphloroglucinol benzene diamine derivative covalent organic framework adsorbent uranium. The article conveys some information:

The separation and recovery of key nuclides such as uranium and plutonium from effluents related to nuclear industry is of great significance for alleviating the shortage of nuclear energy resources and protecting the environment and human health. However, the high temperature, strong acidity and radioactivity of the nuclear effluents pose a severe challenge to the separation materials used in such conditions. The diversity of structure, flexibility of design, and excellent physicochem. stability of covalent organic framework materials (COFs) provide the possibility for the directional design and preparation of adsorbents for use under harsh conditions. Herein, three COFs with similar structure, different pore sizes and connecting modules were synthesized. The ingenious structure predesign enables Dp-COF to have three carboxyl groups oriented toward the pore center and laid out in appropriate spatial positions, which builds hydrogen-bonding bridges between carboxycarbonyl and hydroxyl groups, and thus constructs for the first time a unique COF material with a double-ring pore. The inner pore size of the “”double-ring”” is slightly larger than the diameter of uranyl hydrate, which leads to a size-matching adsorption of uranium by Dp-COF, thus greatly reducing the effect of protonation. Even in the simulated spent fuel reprocessing liquid with pH = 1.0, the adsorption capacity of Dp-COF for uranium can reach 66.3 mg g-1, and the adsorption capacity reaches 317.3 mg g-1 at pH = 4.5, which is very rare among the reported COFs. More excitingly, the removal rate for uranium reaches up to an unprecedented 99.8% due to the size-matching effect, more than any analogous adsorbents. This study not only proposes new ideas for the design and regulation of the microscopic configuration of COF materials, but also provides an alternative approach for the preparation of efficient uranium adsorbents. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

Referemce:
Alcohol – Wikipedia,
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《Development and pre-clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Neisseria meningitidis serogroup C》 was written by Dalal, Juned; Rana, Rakesh; Harale, Kishore; Hanif, Sarmad; Kumar, Nitin; Singh, Deepti; Chhikara, Manoj Kumar. Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate And the article was included in Vaccine on August 23 ,2019. The article conveys some information:

Significant improvement has been made in the development of vaccines against Neisseria meningitidis infections since the introduction of polysaccharide-protein conjugate vaccines. Conventional bacterial capsular polysaccharide (PS) based conjugate vaccines require unique and expensive manufacturing facilities, complex production processes and extensive quality testing. Synthetic oligosaccharide (OS) based approach is one of the novel technologies that is being developed to simplify production of conjugate vaccines. OSs can be chem. synthesized to a desired length long enough to represent the antigenic epitopes which often present as a homogenous mixture We prepared OSs corresponding to tetramer and octamer of N. meningitidis serogroup C (MenC) PS by organic synthesis. The MenC tetramer and octamer were further conjugated with tetanus toxoid to produce resp. monovalent conjugates having the desired physico-chem. characteristics. The conjugates were evaluated in a mouse model for immunogenicity and compared with a licensed PS conjugate vaccine. Synthetic conjugates could induce anti-MenC PS IgG as well as serum bactericidal titers at levels comparable to those elicited by the licensed vaccine. The increase in length of synthetic oligomers from tetramer to octamer did not appear to increase immunogenicity. The results establish the pre-clin. proof of concept for a synthetic MenC oligosaccharide conjugate vaccine candidate. In the experimental materials used by the author, we found 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Safety of 4-Butylbenzene-1,2-diolOn November 8, 2016 ,《Sulfo-and carboxybetaine-containing polyampholytes based on poly(2-vinyl pyridine)s: Synthesis and solution behavior》 appeared in Polymer. The author of the article were Billing, Mark; Elter, Johanna K.; Schacher, Felix H.. The article conveys some information:

We present the synthesis and characterization of zwitterionic homopolymers and copolymers based on poly(2-vinyl pyridine) (P2VP). Different molar masses as well as copolymer compositions of poly(styrene-co-2-vinyl pyridine) (P(2VP-co-S)) were synthesized using RAFT (reversible addition fragmentation chain transfer) polymerization, followed by quaternization of the nitrogen atom by either 1,3-propanesultone (P2VPS, P(2VPS-co-S)) or ethyl-2-bromoacetate, followed by ester hydrolysis (P2VPC, P(2VPC-co-S)). The resulting materials were characterized using SEC, 1H and 13C NMR spectroscopy, elemental anal., and zeta potential measurements. Degrees of functionalization ranging from 33 to 76% could be determined and both P2VPC and P2VPS exhibited good solubility over the entire pH-range. Upon incorporation of increasing amounts of styrene, aqueous solubility decreased and also UCST behavior could be observed in case of P(2VP56,S-co-S44). In the experiment, the researchers used many compounds, for example, 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Safety of 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
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Shen, Haigen; Xiao, Hawen; Zhu, Lin; Li, Chaozhong published an article on January 31 ,2020. The article was titled 《Copper-Catalyzed Radical Bis(trifluoromethylation) of Alkynes and 1,3-Enynes》, and you may find the article in Synlett.Product Details of 20880-92-6 The information in the text is summarized as follows:

The copper-catalyzed radical bis(trifluoromethylation) of alkynes ArCCH [Ar = 4-tert-butylphenyl, phenanthren-9-yl, 2-methyl-1,3-benzothiazol-6-yl, [4-([[(1R,2S,5R)-5-methyl-2-(propan-2- yl)cyclohexyl]oxy]carbonyl)phenyl], etc.] and 1,3-enynes R1CCC(=CH2)R2 (R1 = 4-bromophenyl, 9-oxo-9H-fluoren-2-yl, 3-[(benzenesulfonyl)oxy]propyl, etc.; R2 = H, Me) is described. With Cu(CH3CN)4BF4as the catalyst, the reaction of arylalkynes with Togni reagent II and (bpy)Zn(CF3)2 at room temperature affords the corresponding 1,2-bis(trifluoromethylated) alkenes ArC(CF3)=CHCF3 in good yields with excellent E-stereoselectivity. Under similar conditions, the reaction of 1,3-enynes provides the corresponding 1,4-bis(trifluoromethylated) allenes R1C(CF3)=C=C(CH2CF3)R2 exclusively in satisfactory yields. The protocol exhibits broad substrate scope and excellent functional group compatibility. In the experiment, the researchers used many compounds, for example, ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Synthesis included an article by Blank, Lena; Fagnoni, Maurizio; Protti, Stefano; Rueping, Magnus. SDS of cas: 24388-23-6. The article was titled 《Visible Light-Promoted Formation of C-B and C-S Bonds under Metal- and Photocatalyst-Free Conditions》. The information in the text is summarized as follows:

A green, efficient, photoinduced synthesis of arylboronic esters and aryl sulfides has been developed. Bench stable arylazo sulfones were used as radical precursors for a photocatalyst- and additive-free carbon-heteroatom bond formation under visible light. The protocols are applicable to a wide range of substrates, providing products in good yields. In addition to this study using 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane, there are many other studies that have used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6SDS of cas: 24388-23-6) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).SDS of cas: 24388-23-6

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Alcohol – Wikipedia,
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The author of 《A facilely synthesized glutathione-functionalized silver nanoparticle-grafted covalent organic framework for rapid and highly efficient enrichment of N-linked glycopeptides》 were Ma, Yu-Fang; Wang, Li-Juan; Zhou, Ying-Lin; Zhang, Xin-Xiang. And the article was published in Nanoscale in 2019. SDS of cas: 34374-88-4 The author mentioned the following in the article:

The development of facilely synthetic materials for highly efficient enrichment of N-linked glycopeptides is essential in glycoproteome anal. In this work, by utilizing the self-assembling of glutathione (GSH) on silver nanoparticles (Ag NPs), and the formation and dispersion of Ag NPs on a robust TpPa-1 substrate, a newly functionalized covalent organic framework (COF) called TpPa-1@Ag@GSH was synthesized via a simple two step post-synthetic modification. TpPa-1@Ag@GSH and intermediate products were confirmed and evaluated by NMR spectroscopy, Fourier transform IR spectroscopy, X-ray diffraction, transmission electron microscopy, SEM-energy dispersive spectroscopy, Brunauer-Emmett-Teller and thermogravimetric analyses. Benefiting from the judicious selection of the substrate, the abundance of binding sites, relatively high affinity between GSH and N-linked glycopeptides, and the multivalent interactions between N-linked glycopeptides and unoccupied surfaces of Ag NPs, this porous material showed great performance in N-linked glycopeptide enrichment. By enriching N-linked glycopeptides in tryptic digests of human serum IgG (human IgG) followed by mass spectrometry anal., our method was proved to have good sensitivity (1 fmol), high selectivity (1 : 1500, human IgG to bovine serum albumin), high binding capacity (160 mg g-1, IgG/TpPa-1@Ag@GSH), ultra-fast capture ability (only 1 min incubation time), and good reusability (at least 5 times). It was also successfully applied to the enrichment of N-linked glycopeptides from complex biol. samples. Our work improved the enrichment selectivity of COFs, reached the most rapid capture ability among off-column enrichment materials, and provided a very facile and easily popularized post-synthetic modification route for COFs in glycoproteome anal. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4SDS of cas: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.SDS of cas: 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
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《Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation》 was published in ACS Catalysis in 2020. These research results belong to Wang, Hai; Xu, Dongyang; Guan, Erjia; Wang, Liang; Zhang, Jian; Wang, Chengtao; Wang, Sai; Xu, Hua; Meng, Xiangju; Yang, Bo; Gates, Bruce C.; Xiao, Feng-Shou. Computed Properties of C6H7NO The article mentions the following:

There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcs. to give the corresponding nitriles with mol. oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with at. dispersion boosts the catalytic performance of manganese oxides. Exptl. and theor. results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alc. dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Computed Properties of C6H7NO)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C6H7NO

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Alcohol – Wikipedia,
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《Synthesis of N-Aryl- and N-alkyl-Substituted Imidazolium Silver Complexes: Cytotoxic Screening by Using Human Cell Lines Modelling Acute Myeloid Leukaemia》 was written by Alme, Eirin; Toernroos, Karl Wilhelm; Gjertsen, Bjoern Tore; Bjoersvik, Hans-Rene. Recommanded Product: 3-Bromopropan-1-ol And the article was included in ChemMedChem in 2020. The article conveys some information:

A series of N-aryl- and N-alkyl substituted imidazoles has been synthesized and complexed with Ag+ to obtain silver-NHC complexes of the form [Ag(NHC)2]X. These silver-NHC complexes were tested in vitro against the human cell lines HL-60 and MOLM-13, which both model acute myeloid leukemia (AML). A substantial difference in cytotoxicity was revealed varying in the range 13-4 μM and 22-9 μM for HL-60 and MOLM-13, resp. Furthermore, this study revealed that when an alkyl group is installed on the imidazole scaffold, its position substantially influences the cytotoxicity of the corresponding silver NHC complex. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 3-Bromopropan-1-ol)

3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Recommanded Product: 3-Bromopropan-1-ol

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Alcohol – Wikipedia,
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《Catalyst-Controlled Chemodivergent Synthesis of Spirochromans from Diarylideneacetones and Organoboronic Acids》 was written by Liu, Na; Zhu, Wanjiang; Yao, Jian; Yin, Long; Lu, Tao; Dou, Xiaowei. Quality Control of 2-Hydroxyphenylboronic acid And the article was included in ACS Catalysis in 2020. The article conveys some information:

A chemodivergent synthesis of two series of spirochromans depending on the catalytic system was developed. Starting from diarylideneacetones and organoboronic acids, asym. rhodium catalysis led to the enantioselective synthesis of 4,4′-disubstituted 2,2′-spirobichromans I [R = H, 8(and 8′)-Br, 6(and 6′)-Cl, etc.; Ar = Ph, 3-thienyl, 4-F3CC6H4, etc.], while acid catalysis led to the formation of 4-substituted spirochroman-2,2′-chromenes such as II [R = 6(and 6′)-MeO; R1 = (E)-styryl, 2-furyl, 3-F-4-MeOC6H3, etc.]. A plausible mechanism of the chemodivergent synthesis was proposed. In addition to this study using 2-Hydroxyphenylboronic acid, there are many other studies that have used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Quality Control of 2-Hydroxyphenylboronic acid) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Quality Control of 2-Hydroxyphenylboronic acid

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《Efficient access to 3,5-disubstituted 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines involving SNAr and Suzuki cross-coupling reactions》 was written by Jismy, Badr; Tikad, Abdellatif; Akssira, Mohamed; Guillaumet, Gerald; Abarbri, Mohamed. SDS of cas: 27489-62-9 And the article was included in Molecules in 2020. The article conveys some information:

An efficient and original synthesis of various 3,5-disubstituted 7-(trifluoromethyl)pyrazolo [1,5-a]pyrimidines was reported. A library of compounds diversely substituted in C-3 and C-5 positions was easily prepared from a common starting material, 3-bromo-7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidin-5-one. In C-5 position, a SNAr type reaction was achieved by first activating the C-O bond of the lactam function with PyBroP (Bromotripyrrolidinophosphonium hexafluorophosphate), followed by the addition of amine or thiol giving monosubstituted derivatives, whereas in C-3 position, arylation was performed via Suzuki-Miyaura cross-coupling using the com. available aromatic and heteroaromatic boronic acids. Moreover, trifluoromethylated analogs of potent Pim1 kinase inhibitors were designed following this concise synthetic methodol. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 27489-62-9

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