Month: October 2022

Mohseni, Roohollah; ArabSadeghabadi, Zahra; Ziamajidi, Nasrin; Abbasalipourkabir, Roghayeh; RezaeiFarimani, Azam published the artcile< Oral Administration of Resveratrol-Loaded Solid Lipid Nanoparticle Improves Insulin Resistance Through Targeting Expression of SNARE Proteins in Adipose and Muscle Tissue in Rats with Type 2 Diabetes>, Related Products of 501-36-0, the main research area is resveratrol solid lipid nanoparticle insulin SNARE expression diabetes rat; Insulin resistance; Nanoparticles; Resveratrol; SNARE proteins.

In the current study, we developed resveratrol (RES)-loaded solid lipid nanoparticle (SLN-RES) in order to improve insulin resistance through the upregulation of SNARE protein complex in rats with type 2 diabetes. The SLN-RES characteristics include the following: the average size of 248 nm, the zeta potential of – 16.5 mV, and 79.9% RES entrapment efficiency. The release profile of SLN-RES showed an initial burst followed by a sustained release in natural condition. IR spectroscopy results revealed good incorporation of RES into core SLN. Spherical nanoparticle with less aggregation was observed under electronic microscopic examination Oral administration of SLN-RES prevented weight loss and showed better hypoglycemic effect than RES. Serum oxidative stress status was restored to the normal level by SLN-RES. Furthermore, expression of synaptosomal-associated protein 23 (Snap23), syntaxin-4 (Stx4), and vesicle-associated membrane protein 2 (Vamp2) as the major elements of SNARE protein complex were reduced by SLN-RES more significantly than RES treatment in muscle tissue. However, SLN-RES has a similar effect to RES treatment in adipose tissue. Taken together, our results revealed SLN-RES could be a modern and interestingly therapeutic approach for the improvement of insulin resistance through targeting the expression of Snap23, Stx4, and Vamp2 in adipose and muscle tissues.

Nanoscale Research Letters published new progress about Adipose tissue. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tanaka, Eiji; Koitabashi, Motoo; Kitamoto, Hiroko published the artcile< A teleomorph of the ustilaginalean yeast Moesziomyces antarcticus on barnyardgrass in Japan provides bioresources that degrade biodegradable plastics>, Safety of D-Glucosaccharic acid, the main research area is Moesziomyces teleomorph biodegradable plastic; Basidiomycetous yeast; Holomorph; Pseudozyma antarctica; Smut fungi; Teleomorph–anamorph connection; Ustilaginaceae.

The basidiomycetous yeast Moesziomyces antarcticus (often cited as Pseudozyma antarctica), originally isolated from a sediment sample obtained from Lake Vanda in Antarctica, was asexually typified but closely related to the smut fungus Moesziomyces bullatus (Ustilaginales). We found a smut fungus on an ovary of barnyardgrass (Echinochloa crus-galli) in Japan, which had been identified as M. bullatus. The teliospores germinated and formed yeast-like colonies. Physiol. and phylogenetic studies revealed that the characteristics of the yeast-like isolates coincided with those of “”P. antarctica.”” We thus recognized the smut fungus as the teleomorph of M. antarcticus, and then emended the description of M. antarcticus based on the holomorph. The identified fungus could degrade certain biodegradable plastics and produce mannosylerythritol lipids (MELs) in similar qualities as the “”P. antarctica”” type strain. This discovery provides a significant bioresource, as genetically diverse M. antarcticus isolates could be obtained from the smut fungus.

Antonie van Leeuwenhoek published new progress about Biodegradable plastics Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Safety of D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jabir, Majid; Sahib, Usama I.; Taqi, Zainab; Taha, Ali; Sulaiman, Ghassan; Albukhaty, Salim; Al-Shammari, Ahmed; Alwahibi, Mona; Soliman, Dina; Dewir, Yaser Hassan; Rizwana, Humaira published the artcile< Linalool-loaded glutathione-modified gold nanoparticles conjugated with CALNN peptide as apoptosis inducer and NF-κB translocation inhibitor in SKOV-3 cell line>, Electric Literature of 78-70-6, the main research area is linalool glutathione gold nanoparticles peptide apoptosis NFkappaB translocation inhibitor; CALNN; NF-κB translocation; SKOV-3; caspase-8; gold nanoparticles; linalool; p53.

Linalool is a monoterpene compound with various potential therapeutic applications in several medical fields. Previous studies have indicated the activity of linalool against cell lines; however, its high level of toxicity restricts its use. The aim of this study was to design and manufacture compounds with a novel structure that can be used for loading linalool, to reduce its toxicity and improve its reachable ability. We synthesized and characterized a new mol. for loading linalool onto gold nanoparticles (GNPs) capped with glutathione and conjugated with a CALNN peptide. Linalool was loaded onto the GNPs via the reaction of the surface groups of both linalool and the GNPs. Moreover, the target peptide could be loaded onto the surface of the GNPs via a chem. reaction. The cytotoxic effects of linalool-GNP (LG) and linalool-GNP-CALNN peptide (LGC) conjugates against ovarian cancer cells were investigated, as were the possible mechanisms underlying the induction of apoptosis. Our findings illustrated the significant antiproliferative effect of LG and LGC on SKOV-3 cells. The cytotoxicity assay demonstrated that LG and LGC were selectively toxic in cancer cells and induced apoptosis by activating caspase-8, the p53 protein, and various proteins involved in apoptosis. The present data demonstrated that LG and LGC have a high therapeutic potential and should be given particular consideration as anticancer drug-delivery systems, as LG and LGC were remarkably more cytotoxic against a cancer cell line than were linalool and GNPs alone. We concluded that LG and LGC are promising compounds that can be used for treating ovarian cancer (SKOV-3) cells via the induction of apoptosis through extrinsic and intrinsic pathways.

International Journal of Nanomedicine published new progress about Antitumor agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Shang-Zheng; Romano, Ciro; Martin, Ruben published the artcile< Site-Selective Catalytic Deaminative Alkylation of Unactivated Olefins>, Category: alcohols-buliding-blocks, the main research area is catalyst deaminative alkylation unactivated olefin.

A catalytic deaminative alkylation of unactivated olefins is described. The protocol was characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both α-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gan, Zhending; Wei, Wenyao; Li, Yi; Wu, Jiamin; Zhao, Yongwei; Zhang, Lili; Wang, Tian; Zhong, Xiang published the artcile< Curcumin and resveratrol regulate intestinal bacteria and alleviate intestinal inflammation in weaned piglets>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is intestinal bacteria inflammation curcumin resveratrol; curcumin; intestinal bacteria; intestinal inflammatory; resveratrol; toll-like-receptor 4; weaned piglets.

Human infants or piglets are vulnerable to intestinal microbe-caused disorders and inflammation due to their rapidly changing gut microbiota and immaturity of their immune systems at weaning. Resveratrol and curcumin have significant anti-inflammatory, bacteria-regulating and immune-promoting effects. The purpose of this study was to investigate whether dietary supplementation with resveratrol and curcumin can change the intestinal microbiota and alleviate intestinal inflammation induced by weaning in piglets. One hundred eighty piglets weaned at 21 ± 2 d were fed a control diet (CON group) or supplemented diet (300 mg/kg of antibiotics, ANT group; 300 mg/kg of resveratrol and curcumin, resp., HRC group; 100 mg/kg of resveratrol and curcumin, resp., LRC group; 300 mg/kg of resveratrol, RES group; 300 mg/kg of curcumin, CUR group) for 28 days. The results showed that compared with the CON group, curcumin alone and antibiotics decreased the copy numbers of Escherichia coli. Both curcumin and resveratrol down-regulated the level of Toll-like-receptor 4 mRNA and protein expression in the intestine to inhibit the release of critical inflammation mols. (interleukin-1β, tumor necrosis factor-α), and increase the secretion of Ig. Our results suggested that curcumin and resveratrol can regulate weaned piglet gut microbiota, down-regulate the TLR4 signaling pathway, alleviate intestinal inflammation, and ultimately increase intestinal immune function.

Molecules published new progress about Chroococcidiopsis thermalis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tabrizi, Reza; Tamtaji, Omid Reza; Lankarani, Kamran B.; Akbari, Maryam; Dadgostar, Ehsan; Dabbaghmanesh, Mohammad Hossein; Kolahdooz, Fariba; Shamshirian, Amir; Momen-Heravi, Mansooreh; Asemi, Zatollah published the artcile< The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials>, SDS of cas: 501-36-0, the main research area is meta analysis resveratrol antiobesity agent obesity; Resveratrol; meta-analysis; overweight; weight loss.

This systematic review and meta-anal. of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 reports, 36 RCTs were eligible for including to our meta-anal. The pooled results, using random-effects model showed that resveratrol supplementation significantly decreased body weight (SMD = -0.17; 95% CI, -0.33, -0.01; P=0.03; I2: 62.6), body mass index (BMI) (SMD = -0.20; 95% CI, -0.35, -0.05; P=0.01; I2: 60.6), fat mass (SMD = -0.32; 95% CI, -0.62, -0.03; P=0.03; I2: 77.9) and waist circumference (WC) (SMD = -0.42; 95% CI, -0.68, -0.16; P=0.001; I2: 75.2), and significantly increased lean mass (SMD=1.21; 95% CI, 0.75, 1.67; P<0.001; I2: 87.6). We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P=0.40; I2: 85.3) and adiponectin levels (SMD=0.08; 95% CI, -0.39, 0.55; P=0.74; I2: 91.0). Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-anal. demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels. Critical Reviews in Food Science and Nutrition published new progress about Adiponectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Chunyan; Liu, Yun; Teng, Mengying; Jiao, Kailin; Zhen, Jing; Wu, Maoxuan; Li, Zhong published the artcile< Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling.>, Formula: C14H12O3, the main research area is EZH2; Estrogen receptor; Phospho-ERK1/2; Proliferation; Resveratrol.

Enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in breast cancer and plays an important role in maintaining the cell proliferative capacity. However, the mechanisms underlying the transcriptional regulation of EZH2 in estrogen receptor (ER)-positive breast cancer cells remain unclear. The antitumor effects of resveratrol have been reported. However, whether EZH2 was involved in these effects needs further exploration. Here, we showed that EZH2 is required for estrogen-induced cell proliferation in ER-positive breast cancer. Exposure to 17β-estradiol (E2) upregulated EZH2 via ERα signaling, and this effect was blocked by U0126, a MEK inhibiter. Resveratrol inhibited the proliferation and colony formation in ER-positive breast cancer cells and downregulated EZH2 through inhibition of phospho-ERK1/2. These findings indicated that ERK1/2 and ER signaling-mediated EZH2 upregulation is crucial for the proliferation of ER-positive breast cancer cells. The suppression of EZH2 expression by ERK1/2 dephosphorylation is important for the antiproliferative activities of resveratrol against ER-positive breast cancer cells.

Cell biology and toxicology published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Banda, Jagadeesh; Lakshmanan, Ramalingam; Katepalli, Ramesh Babu; Reddy Venati, Uday Kumar; Koppula, Ramesh; Shiva Prasad, V. V. S. published the artcile< Determination of mesalazine, a low bioavailability olsalazine metabolite in human plasma by UHPLC-MS/MS: Application to a pharmacokinetic study>, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is mesalazine determination blood olsalazine pharmacokinetics UHPLC mass spectrometry; Derivatization; Human plasma; LC–MS/MS; Mesalazine; Method validation; Pharmacokinetics.

Olsalazine sodium, salicylate derivative (prodrug) is effectively bioconverted to mesalazine (5-aminosalicylic acid; 5-ASA), which has an anti-inflammatory activity in ulcerative colitis. In this article, a novel highly sensitive and selective method was developed and validated to determine mesalazine in human plasma using a derivatization technique to enhance the signal intensity by using ultra-HPLC coupled to tandem mass spectrometry (UHPLC-MS/MS) with an electrospray ionization interface. The sample preparation consisted of a derivatization with propionyl anhydride followed by liquid liquid extraction (LLE) to remove the interference and minimize the matrix effect of human plasma. The multiple reaction monitoring (MRM) mode of the neg. ion was performed and the transitions of m/z 208.1→107.0 and m/z 211.1→110.1 were used to measure the derivative of mesalazine and mesalazine-d3. The chromatog. separation was achieved using kinetex XB-C18 (100 × 4.6 mm 2.6 μ) anal. column with 0.1% formic acid in water and acetonitrile as mobile phase with a gradient elution. Nominal retention times of mesalazine and IS were 3.08 and 3.07 min, resp. Absolute recovery was found to be between 82-95% for analyte and about 78% for IS. The standard curves was linear (R2 > 0.995) in the concentration range 0.10 to 12.0 ng/mL with lower limit of quantification (LLOQ) in human plasma was 0.10 ng/mL. The average intra-day/inter-day precision values (%CV) were in the range from 0.6-2.9 % and 1.3-3.8 %, resp., while the average accuracy value was 103.8-107.2%. This method has been successfully applied to the human pharmacokinetics of olsalazine sodium 250 mg capsules following single oral administration.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Name: Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Springer, Margherita; Moco, Sofia published the artcile< Resveratrol and its human metabolites-effects on metabolic health and obesity>, HPLC of Formula: 501-36-0, the main research area is review obesity metabolism resveratrol metabolite; diabetes; metabolic pathways; metabolism; obesity; polyphenols; resveratrol.

A review. Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clin. studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported mol. mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.

Nutrients published new progress about Adipogenesis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Xiangchao; Ai, Yao; Wang, Rongzhou; Liu, Liping; Yang, Jiazhi; Li, Feng published the artcile< Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is quinoline preparation green chem; aminobenzyl alc ketone acceptorless dehydrogenative coupling ruthenium catalyst.

A ruthenium complex bearing a functional 2,2′-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH2)Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines I [R = H, Cl, Br; R1 = H, F, Cl, Me, OMe; R2 = t-Bu, cyclopropyl, Ph, pyrazin-2-yl, etc.; R3 = H, Me, Et] and 5,6-dihydrobenzo[c]acridine via acceptorless dehydrogenative coupling of o-aminobenzyl alcs. 2-NH2-4-R-5-R1-C6H2CH2OH with ketones R2C(O)CH2R3 and 1-tetralone in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biol. active mol. was also undertaken. Notably, this research exhibits new potential of metal-ligand bifunctional catalysts for acceptorless dehydrogenative reactions.

Journal of Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts