Month: October 2022

Quach, Linda; Dutta, Subhabrata; Pflueger, Philipp M.; Sandfort, Frederik; Bellotti, Peter; Glorius, Frank published the artcile< Visible-Light-Initiated Hydrooxygenation of Unactivated Alkenes-A Strategy for Anti-Markovnikov Hydrofunctionalization>, Name: But-3-en-1-ol, the main research area is unactivated alkene hydrooxygenation visible light anti Markovnikov hydrofunctionalization.

Hydrofunctionalization of unactivated alkenes is an indispensable mean in synthetic chem. Given that addition of electrophilic species into alkenes intrinsically follows the Markovnikov rule, a regioselectivity switch presents a major challenge. Herein, authors present a visible-light-promoted strategy for the selective anti-Markovnikov hydrooxygenation of unactivated alkenes. Therefore, an innovative reagent was carefully designed to release a highly reactive and strongly underdeveloped alkoxycarbonyloxyl radical upon reduction, which selectively adds into alkenes. Hydrogen atom abstraction from 2-phenylmalononitrile is the key to form the product. Authors believe that this methodol. enlarges the toolbox for regioselective hydrofunctionalization and could serve as a complementary strategy to the established hydroboration/oxidation protocol.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Shu; Zhou, Qingya; Wang, Mengya; Dale, Jackson; Qiang, Zhe; Fan, Yuchi; Zhu, Meifang; Ye, Changhuai published the artcile< Modulating electromagnetic interference shielding performance of ultra-lightweight composite foams through shape memory function>, Quality Control of 87-73-0, the main research area is paraffin chitosan glucaric acid polymer CNT coating; polyurethane foam EMI shileding.

High-performance electromagnetic interference shielding (EMI) materials are desirable in aerospace, military and mobile electronics applications. However, fabrication of smart and ultra-lightweight EMI shielding materials with adjustable EMI shielding performance through an energy-efficient and environmental-friendly process is still challenging. Herein, we demonstrate using a conductive biomass-derived D-glucaric acid-chitosan/single-walled carbon nanotube (SWNT/GA-chitosan) polymer composite layer and a crystallized paraffin layer to fabricate ultra-lightweight polyurethane foams with shape memory and adjustable EMI shielding functions, of which the shape change via external stimulus enables the foams to adjust EMI shielding efficiency autonomously. The foam coated with synthesized conductive composite layers shows an exceptional EMI shielding effectiveness of 56 dB at an ultra-low d. of 0.03 g/cm3 with only 0.171 vol% SWNT. The foam also exhibits ultra-high durability over 2000 compression-recovery cycles. Furthermore, introduction of paraffin layer as a reversible network results in shape memory foams with high fixity ratio >95% and recovery ratio >90%. These foams exhibit a wide range of adjustable EMI shielding efficiency from 18 dB to 30 dB by controlling their macroscopic shape from compression. Such smart foams with shape memory and adjustable EMI shielding functions fabricated by an environmental-friendly strategy represent a promising material candidate for the wide applications of EMI shielding.

Composites, Part B: Engineering published new progress about Alkanes Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moeini, Nazanin; Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Anchoring Ni (II) on Fe3O4@tryptophan: A recyclable, green and extremely efficient magnetic nanocatalyst for one-pot synthesis of 5-substituted 1H-tetrazoles and chemoselective oxidation of sulfides and thiols>, Synthetic Route of 699-12-7, the main research area is sulfoxide preparation; disulfide preparation; tetrazole preparation; sulfide oxidation nickel ironoxide tryptophan nanoparticle catalyst; thiol oxidation nickel ironoxide tryptophan nanoparticle catalyst; cyanide azide cycloaddition nickel ironoxide tryptophan nanoparticle catalyst.

A green, novel and extremely efficient nanocatalyst was successfully synthesized by the immobilization of Ni as a transition metal on Fe3O4 nanoparticles coated with tryptophan. This nanostructured material was characterized using Fourier transform IR spectroscopy, transmission electron microscopy, SEM, energy-dispersive X-ray spectroscopy, thermogravimetric anal., inductively coupled plasma optical emission spectroscopy, vibrating sample magnetometry and X-ray diffraction. The prepared nanocatalyst was applied for the oxidation of sulfides, oxidative coupling of thiols and synthesis of 5-substituted 1H-tetrazoles. The use of non-toxic, green and inexpensive materials, easy separation of magnetic nanoparticles from a reaction mixture using a magnetic field, efficient and one-pot synthesis, and high yields of products are the most important advantages of this nanocatalyst.

Applied Organometallic Chemistry published new progress about Cyanides (inorganic) Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Synthetic Route of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Qi; Gu, Peng; Zhang, Hao; Luo, Xin; Zhang, Jibiao; Zheng, Zheng published the artcile< Response of submerged macrophytes and leaf biofilms to the decline phase of Microcystis aeruginosa: Antioxidant response, ultrastructure, microbial properties, and potential mechanism>, Product Details of C6H12O6, the main research area is Microcystis leaf biofilm submerged macrophyte; Cyanobacterial exudates and extracts; Decline phase; Microbial properties; N-acylated-L-homoserine lactones; Submerged macrophyte.

Decaying cyanobacterial blooms carry a potential risk for submerged macrophyte and periphyton biofilms in aquatic environments. This study comprehensively studied the responses in growth, oxidative response, detoxification pathway, and ultrastructure characteristics of aquatic plants to Microcystis aeruginosa (M. aeruginosa) exudates and extracts released during the decline phase. Particular emphasis was placed on the variation of extracellular polymeric substances (EPS) and quorum-sensing signaling mols. The results showed that superoxide dismutase, peroxidase, and glutathione S-transferase were significantly induced as antioxidant response, and the malondialdehyde content increased. Increased content of MC-LR (1.129 μg L-1) and NH+4-N (1.35 mg L-1) were found in the decline phase of M. aeruginosa, which played a vital role in the damage to submerged plants. In addition, a change in the amount of osmophilic granules and a variation of organelles and membranes was observed A broad distribution of α-D-glucopyranose polysaccharides was dominant and aggregated into clusters in biofilm EPS in response to exposure to decaying M. aeruginosa. Furthermore, exposure to exudates and extracts changed the abundance and structure of the microbial biofilm community. Increased contents of N-acylated-L-homoserine lactone signal mol. might result in a variation of biofilm EPS production in response to decaying M. aeruginosa. These results expand the understanding of how submerged macrophyte and periphyton biofilms respond to environmental stress caused by exudates and extracts of decaying M. aeruginosa.

Science of the Total Environment published new progress about Allelochemicals Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Michalak, Michal; Bisek, Bartosz; Nowacki, Michal; Gorecki, Marcin published the artcile< Base-Catalyzed, Solvent-Free Synthesis of Rigid V-Shaped Epoxydibenzo[b,f][1,5]diazocines>, Product Details of C4H8O, the main research area is fluorinated aminophenone tetramethylguanidine catalyst autocondensation cross condensation; epoxydibenzo diazocine preparation.

A novel method for the synthesis of epoxydibenzo[b,f][1,5]diazocines exhibiting a V-shaped mol. architecture is reported. The unique approach is based on unprecedented base-catalyzed, solvent-free autocondensation and cross-condensation of fluorinated o-aminophenones. The structure of the newly synthesized diazocines was confirmed independently by X-ray anal. and chiroptical methods. The rigidity of the diazocine scaffold allowed for the separation of the racemate into single enantiomers that proved to be thermally stable up to 140°C. Furthermore, the inertness of the diazocine scaffold was demonstrated by performing a series of typical transformations, including transition metal-catalyzed reactions, proceeding without affecting the bis-hemiaminal subunit.

Journal of Organic Chemistry published new progress about Condensation reaction. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ziemianowicz, Daniel S.; Sarpe, Vladimir; Schriemer, David C. published the artcile< Quantitative Analysis of Protein Covalent Labeling Mass Spectrometry Data in the Mass Spec Studio>, COA of Formula: C4H8N2O, the main research area is protein covalent labeling mass spectrometry.

Covalent labeling with mass spectrometry (CL-MS) provides a direct measure of the chem. and structural features of proteins with the potential for resolution at the amino-acid level. Unfortunately, most applications of CL-MS are limited to narrowly defined differential analyses, where small numbers of residues are compared between two or more protein states. Extending the utility of high-resolution CL-MS for structure-based applications requires more robust computational routines and the development of methodol. capable of reporting of labeling yield accurately. Here, we provide a substantial improvement in the anal. of CL-MS data with the development of an extended plug-in built within the Mass Spec Studio development framework (MSS-CLEAN). All elements of data anal.-from database search to site-resolved and normalized labeling output-are accommodated, as illustrated through the nonselective labeling of the human kinesin Eg5 with photoconverted 3,3′-azibutan-1-ol. In developing the new features within the CL-MS plug-in, we identified addnl. complexities associated with the application of CL reagents, arising primarily from digestion-induced bias in yield measurements and ambiguities in site localization. A strategy is presented involving the use of redundant site labeling data from overlapping peptides, the imputation of missing data, and a normalization routine to determine relative protection factors. These elements together provide for a robust structural interpretation of CL-MS/MS data while minimizing the over-reporting of labeling site resolution Finally, to minimize bias, we recommend that digestion strategies for the generation of useful overlapping peptides involve the application of complementary enzymes that drive digestion to completion.

Analytical Chemistry (Washington, DC, United States) published new progress about Homo sapiens. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, COA of Formula: C4H8N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Ligand-controlled phosphine-free Co(II)-catalysed cross-coupling of secondary and primary alcohols>, Application of C7H9NO, the main research area is ketone preparation; primary alc secondary cross coupling cobalt catalyst; aryl quinoline preparation; amino alc secondary cross coupling cobalt catalyst.

Cobalt(II) complexes (5 mol% Co) bearing phosphine-free N N N pincer ligands efficiently catalyze C-C coupling of secondary and primary alcs. to selectively form α-alkylated ketones with a good functional group compatibility using NaOH (20 mol%) as a base at 120 °C. The NH group on the N N N-Co(II) precatalyst controlled the activity and selectivity. This simple catalytic system was also involved in the synthesis of 2-aryl quinolines, e.g., I, via the dehydrogenative annulation of 2-aminobenzyl alcs. with secondary alcs.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Pan; Li, Yuqiang; Tao, XU published the artcile< Molybdenum-Catalyzed Cross-Coupling of Benzyl Alcohols: Direct C-OH Bond Transformation via [2 + 2]-Type Addition and Elimination>, Electric Literature of 76-84-6, the main research area is benzyl alc deoxygenative cross coupling molybdenum catalyst.

Traditional cross-couplings catalyzed by transition metal catalysts generally rely on the classic oxidative addition-transmetalation-reductive elimination process, which requires low-valent precious metals and an inert atm. and which initiates from carbon-alide or pesudo carbon-halide bonds. Herein, an unprecedented molybdenum-oxo-complex-catalyzed intermol. cross-coupling of benzyl alcs. has been reported. Various alcs. including primary, secondary, and tertiary substrates can proceed efficiently under these conditions. Several functional groups sensitive to the low-valent transition metals, such as aryl halides, can be well tolerated. The mechanistic studies and DFT calculations suggest that an intramol. concerted cyclization was involved in the reverse [2 + 2]-type elimination process.

Organic Letters published new progress about Addition reaction ([2 + 2]). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Sifan; Wang, Yu; Wu, Zibo; Shi, Weiliang; Lei, Yibo; Davies, Paul W.; Shu, Wei published the artcile< A Radical-Initiated Fragmentary Rearrangement Cascade of Ene-Ynamides to [1,2]-Annulated Indoles via Site-Selective Cyclization>, Name: But-3-en-1-ol, the main research area is annulated indole regioselective preparation; ene ynamide fragmentary rearrangement cascade radical initiated.

Herein, a radical triggered fragmentary cyclization cascade reaction of ene-ynamides was presented, providing a rapid access into [1,2]-annulated indoles I [R = H, Me, SMe, etc.; R1 = Ph, 4-MeC6H4, 3-pyridyl, etc.; R2 = H, Me, n-Bu; n = 1,2,3] by an intermol. radical addition, intramol. cyclization, desulfonylative aryl migration, and site-selective C(sp2)-N cyclization sequence. DFT calculations support oxidation of N-centered radical species to cations prior to the C-N bond formation, followed by an unusual aza-Nazarov cyclization.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Dejian; Li, Peipei; Dong, Zhe; Wang, Teng; Sun, Kunlai; Zhao, Yuqin; Wang, Bin; Chen, Yin published the artcile< Structure and immunoregulatory activity of β-D-galactofuranose-containing polysaccharides from the medicinal fungus Shiraia bambusicola>, SDS of cas: 3458-28-4, the main research area is galactofuranose polysaccharide immunoregulation macrophage Shiraia; Galactofuranose; Macrophages; Medical fungi; Polysaccharide; Structure.

To explore bioactive polysaccharides from medicinal fungi, a homogeneous heteropolysaccharide SB1-1 was extracted from the stroma of Shiraia bambusicola by enzyme assisted extraction, ethanol precipitation, anion-exchange and size-exclusion chromatogs. Chem. and spectroscopic analyses showed that SB1-1 was a neutral polysaccharide composed of mannose, glucose and galactose at a molar ratio of 1.1:1.9:1.0, and had a mol. weight of 18.3 kDa. SB1-1 was composed of a mannan core and glucose and galactose side chains. The mannan core was composed of (1 → 2)-α-Manp substituted by the side chains (1 → 6)-α-D-Manp, (1 → 4)- α-D-Glcp and (1 → 6)-α-D-Glcp with different ds.p. at the C-6. The galactose side chains had the backbone of (1 → 6)-β-D-Galf. There were two branch sites on every five sugars on average at the O-2 of →6)-β–Galf(1→, and the branches consisted of (→2)-β-D-Galf(1→ and terminal β-D-Galf) 1→. The potential immunomodulatory activities of SB1-1 on RAW264.7 macrophages were investigated. The results showed that SB1-1 could activate macrophage and significantly improve its phagocytic ability by neutral red uptake assay. Addnl., SB1-1 enhanced the productions of IL-1, IL-6, IL-12 and TNF-α in the RAW264.7 macrophages by stimulation of SB1-1, while significantly increased the production of inducible nitric oxide synthase (iNOS) production This study demonstrated that the galactofuranose-containing polysaccharide SB1-1 from S. bambusicola which is a novel mannogalactoglucan, could enhance the activation of macrophages.

International Journal of Biological Macromolecules published new progress about Acid hydrolysis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts