Month: October 2022

《Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives》 was published in Journal of Inorganic Biochemistry in 2020. These research results belong to Wei, Xiaonan; Yang, Yaxing; Ge, Jiangfeng; Lin, Xue; Liu, Dandan; Wang, Shuxiang; Zhang, Jinchao; Zhou, Guoqiang; Li, Shenghui. Related Products of 26153-38-8 The article mentions the following:

Thirteen novel palladium(II) complexes of the general formula [Pd(bipy)(O,O’-dkt)](PF6), (where bipy is 2,2′-bipyridine and O,O’-dkt is β-diketonate ligand hispolon or its derivative) have been prepared through a metal-ligand coordination method that involves spontaneous formation of the corresponding diketonate scaffold. The obtained palladium(II) complexes have been characterized by NMR spectroscopy, ESI-mass spectrometry as well as elemental anal. The cytotoxicity anal. indicates that most of the obtained palladium(II) complexes show promising growth inhibition in three human cancer cell lines. Flow cytometry anal. shows complex 3e could promote intracellular reactive oxygen species (ROS) accumulation and lead cancer cell death. And the suppression of ROS accumulation and the rescue of cell viability in HeLa cells by N-acetyl-L-cysteine (NAC) suggest the possible link between the increase in ROS generation and cytotoxicity of complex 3e. Flow cytometry anal. also reveal that complex 3e cause cell cycle arrest in the G2/M phase and collapse of the mitochondrial membrane potential, promote the generation of ROS and lead to tumor cell apoptosis. The interactions of complex 3e with calf thymus DNA (CT-DNA) have been evaluated by UV-Vis spectroscopy, fluorescence quenching experiments and viscosity measurements, which reveal that the complex interact with CT-DNA through minor groove binding and/or electrostatic interactions. Further, the results of fluorescence titration and site marker competitive experiment on bovine serum albumin (BSA) suggest that complex 3e can quench the fluorescence of BSA via a static quenching process and bind to BSA in Sudlow’s site II. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《In silico evaluation of the antibacterial and modulatory activity of lapachol and nor-lapachol derivates》 was written by Figueredo, Fernando Gomes; Ramos, Ingrid T. L.; Paz, Josinete A.; Silva, Tania M. S.; Camara, Celso A.; Oliveira-Tintino, Cicera Datiane de Morais; Relison Tintino, Saulo; Maia de Farias, Pablo Antonio; Coutinho, Henrique Douglas Melo; Fonteles, Marta Maria de F.. Category: alcohols-buliding-blocks And the article was included in Microbial Pathogenesis in 2020. The article conveys some information:

To investigate pharmacol. properties of 2-(2-hydroxyethylamine)-3-(3-methyl-2-butenyl)-1,4-dihydro-1,4-naphthalenedione, 2-(2-hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone and 2-(3-hydroxy-propylamine)-3-(3-methyl-2-butenyl)-[1,4]naphthoquinone using computational prediction models, in addition to evaluating the in vitro antibacterial and modulatory activity of these compounds against bacterial ATCC strains and clin. isolates. The substances were synthesized from 2-hydroxy-quinones, lapachol and nor-lapachol obtaining the corresponding 2-methoxylated derivatives via di-Me sulfate alkylation in a basic medium, these then reacted chemoselectively with 2-ethanolamine and 3-propanolamine to form the corresponding amino alcs. The antibacterial activity and modulatory activity of the substances were assayed by broth microdilution method to determine MIC. The mol. structures were analyzed using the ChEMBL database to predict possible pharmacol. targets, which pointed to the mol. 2- (2-hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone as a probable antibacterial agent for the proteins Replicative DNA helicase and RecA. The compounds had low mol. weight and a small number of rotatable bonds. The MICs of the substances were not clin. significant, however, the association with gentamicin and amikacin reduced MICs of these antibiotics. Combination of these substances with aminoglycosides may be therapeutic alternative to bacterial resistance and reduction of side effects. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines》 was written by Varun, Begur Vasanthkumar; Vaithegi, Kannan; Yi, Sihyeong; Park, Seung Bum. Related Products of 7748-36-9 And the article was included in Nature Communications in 2020. The article conveys some information:

The development of a strategy for the synthesis of meta-aminoaryl nicotinates from 3-formyl(aza)indoles was reported. The strategy was mechanistically different from the reported routes and involved the transformation of (aza)indole scaffolds into substituted meta-aminobiaryl scaffolds via Aldol-type addition and intramol. cyclization followed by C-N bond cleavage and re-aromatization. Unlike previous synthetic routes, this biomimetic method utilizes propiolates as enamine precursors and thus allows access to ortho-unsubstituted nicotinates. In addition, the synthetic feasibility toward the halo-/boronic ester-substituted aminobiaryls clearly differentiates the present strategy from other cross-coupling strategies. Most importantly, our method enables the late-stage conjugation of bioactive (hetero)arylamines with nicotinates and nicotinamides and allowed access to the previously unexplored chem. space for biomedical research. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Etherification of phenols by amines via transient diazonium intermediates》 was written by Reynard, Guillaume; Mayrand, Hugo; Lebel, Helene. Reference of 3-Aminopropan-1-ol And the article was included in Canadian Journal of Chemistry in 2020. The article conveys some information:

The synthesis of alkyl aryl ethers from electron poor phenols and amines using 1,3-propanedinitrite was described. Due to the mild conditions, functionalized primary, secondary and tertiary alkyl groups were successfully introduced, denoting a highly tolerant process that allowed for unprotected alcs. and acetals. The reaction was thought to proceeded through the formation of a diazonium intermediate that undergoes subsequent SN2> or SN1 reactions. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Kwihwan; Jiang, Jing; Yamada, Tsuyoshi; Sajiki, Hironao published their research in Chemical & Pharmaceutical Bulletin in 2021. The article was titled 《Ruthenium-on-carbon-catalyzed facile solvent-free oxidation of alcohols: efficient progress under solid-solid (liquid)-gas conditions》.Recommanded Product: 3-Pyridinemethanol The article contains the following contents:

A protocol for the ruthenium-on-carbon (Ru/C)-catalyzed solvent-free oxidation of alcs., which proceeds efficiently under solid-solid (liquid)-gas conditions, was developed. Various primary and secondary alcs. were transformed to corresponding aldehydes and ketones in moderate to excellent isolated yields by simply stirring in the presence of 10% Ru/C under air or oxygen conditions. The solvent-free oxidation reactions proceeded efficiently regardless of the solid or liquid state of the substrates and reagents and could be applied to gram-scale synthesis without loss of the reaction efficiency. Furthermore, the catalytic activity of Ru/C was maintained after five reuse cycles. In addition to this study using 3-Pyridinemethanol, there are many other studies that have used 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zalesak, Frantisek; Kovac, Ondrej; Lachetova, Eliska; Stastna, Nikola; Pospisil, Jiri published their research in Journal of Organic Chemistry in 2021. The article was titled 《Unified Approach to Benzo[d]thiazol-2-yl-Sulfonamides》.Application of 4048-33-3 The article contains the following contents:

In this paper, a unified approach to N-substituted and N,N-disubstituted benzothiazole (BT) sulfonamides I [R = n-Bu, cyclohexyl, Bn, furan-2-ylmethyl, etc.; R1 = H, Me; RR1 = -(CH2)5-, -(CH2)2CH(OH)(CH2)2], II, III (R2 = propan-2-yl, Bn, oxiran-2-ylmethyl, etc.; RR2 = -(CH2)6-) and IV (Ar = Ph, 3-fluorophenyl, 4-chlorophenyl, etc.) was reported. The approach to BT-sulfonamides I and II starts from simple com. available building blocks (benzo[d]thiazole-2-thiol and primary and secondary amines such as allylamine, benzylamine, piperidine, etc.) that are connected via (a) a S oxidation/S-N coupling approach, (b) a S-N coupling/S-oxidation sequence, or via (c) a S-oxidation/S-F bond formation/SuFEx approach. The labile N-H bond in N-monoalkylated BT-sulfonamides III (pKa (BTSO2N(H)Bn) = 3.34 ± 0.05) further allowed to develop a simple weak base-promoted N-alkylation method and a stereoselective microwave-promoted Fukuyama-Mitsunobu reaction. N-Alkyl-N-aryl BT-sulfonamides IV were accessed with the help of the Chan-Lam coupling reaction. Developed methods were further used in stereo and chemoselective transformations of podophyllotoxin and several amino alcs. such as 3-aminopropan-1-ol and 6-aminohexan-1-ol. In the experiment, the researchers used many compounds, for example, 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Application of 4048-33-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yaseen, Anaheed A.; Al-Tikrity, Emaad T. B.; Yousif, Emad; Ahmed, Dina S.; Kariuki, Benson M.; El-Hiti, Gamal A. published their research in Polymers (Basel, Switzerland) in 2021. The article was titled 《Effect of Ultraviolet Irradiation on Polystyrene Containing Cephalexin Schiff Bases》.Reference of 3-Hydroxybenzaldehyde The article contains the following contents:

Synthesis and application of new UV photostabilizers for polystyrene and this research was focused on four cephalexin Schiff bases I [Ar = 3-OHC6H4, 4-BrC6H4, 4-OMeC6H4, 4-NMe2C6H4]. The reaction of cephalexin and 3-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, 4-methoxybenzaldehyde, and 4-bromobanzaldehyde under acidic condition afforded the corresponding Schiff bases I in high yields. The Schiff bases were characterized and their surfaces were examined The Schiff bases were mixed with polystyrene to form homogenous blends and their effectiveness as photostabilizers was explored using different methods. The methods included monitoring the changes in the IR spectra, weight loss, depression in mol. weight, and surface morphol. on irradiation In the presence of the Schiff bases, the formation of carbonyl group fragments, weight loss, and decrease in mol. weight of polystyrene were lower when compared with pure polystyrene. In addition, undesirable changes in the surface such as the appearance of dark spots, cracks, and roughness were minimal for irradiated polystyrene containing cephalexin Schiff bases. Mechanisms by which cephalexin Schiff bases stabilize polystyrene against photodegradation was also suggested. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Reference of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Reference of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Li; Wu, Hong; Cao, Yu; Fan, Chunyang; Zhao, Rui; He, Xueyi; Yang, Pengfei; Shi, Benbing; You, Xinda; Jiang, Zhongyi published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Weakly Humidity-Dependent Proton-Conducting COF Membranes》.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The article contains the following contents:

State-of-the-art proton exchange membranes (PEMs) often suffer from significantly reduced conductivity under low relative humidity, hampering their efficient application in fuel cells. Covalent organic frameworks (COFs) with pre-designable and well-defined structures hold promise to cope with the above challenge. However, fabricating defect-free, robust COF membranes proves an extremely difficult task due to the poor processability of COF materials. Herein, a bottom-up approach is developed to synthesize intrinsic proton-conducting COF (IPC-COF) nanosheets (NUS-9) in aqueous solutions via diffusion and solvent co-mediated modulation, enabling a controlled nucleation and in-plane-dominated IPC-COF growth. These nanosheets allow the facile fabrication of IPC-COF membranes. IPC-COF membranes with crystalline, rigid ion nanochannels exhibit a weakly humidity-dependent conductivity over a wide range of humidity (30-98%), 1-2 orders of magnitude higher than that of benchmark PEMs, and a prominent fuel cell performance of 0.93 W cm-2 at 35% RH and 80 °C arising from superior water retention and Grotthuss mechanism-dominated proton conduction. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeFor acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gauthier, Maxime; Coutrot, Frederic published their research in Chemistry – A European Journal in 2021. The article was titled 《Weinreb Amide, Ketone and Amine as Potential and Competitive Secondary Molecular Stations for Dibenzo-[24]Crown-8 in [2]Rotaxane Molecular Shuttles》.Electric Literature of C6H15NO The article contains the following contents:

This paper reported the synthesis and study of new pH-sensitive DB24C8-based [2]rotaxane mol. shuttles that contain within their axle four potential sites of interaction for the DB24C8: ammonium, amine, Weinreb amide and ketone. In the protonated state, the DB24C8 lay around the best ammonium site. After either deprotonation or deprotonation-then-carbamoylation of the ammonium, different localizations of the DB24C8 were seen, depending on both the number and nature of the secondary stations and steric restriction. Unexpectedly, the results indicated that the Weinreb amide was not a proper secondary mol. station for the DB24C8. Nevertheless, through its methoxy side chain, it slowed down the shuttling of the macrocycle along the threaded axle, thereby partitioning the [2]rotaxane into two translational isomers on the NMR timescale. The ketone was successfully used as a secondary mol. station, and its weak affinity for the DB24C8 was similar to that of a secondary amine. After reading the article, we found that the author used 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Electric Literature of C6H15NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Canning, Peter; Bataille, Carole; Bery, Nicolas; Milhas, Sabine; Hayes, Angela; Raynaud, Florence; Miller, Ami; Rabbitts, Terry published an article in 2021. The article was titled 《Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds》, and you may find the article in Journal of Immunological Methods.SDS of cas: 7748-36-9 The information in the text is summarized as follows:

The use of intracellular antibodies as templates to derive surrogate compounds is an important objective because intracellular antibodies can be employed initially for target validation in pre-clin. assays and subsequently employed in compound library screens. LMO2 is a T cell oncogenic protein activated in the majority of T cell acute leukemias. We have used an inhibitory intracellular antibody fragment as a competitor in a small mol. library screen using competitive surface plasmon resonance (cSPR) to identify compounds that bind to LMO2. We selected four compounds that bind to LMO2 but not when the anti-LMO2 intracellular antibody fragment is bound to it. These findings further illustrate the value of intracellular antibodies in the initial stages of drug discovery campaigns and more generally antibodies, or antibody fragments, can be the starting point for chem. compound development as surrogates of the antibody combining site. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts