Month: October 2022

In 2022,Guo, Hongshuang; Priimagi, Arri; Zeng, Hao published an article in Advanced Functional Materials. The title of the article was 《Optically Controlled Latching and Launching in Soft Actuators》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Snapping is an abrupt reaction, in which mech. instability allows the structure to rapidly switch from one stabilized form to another. Snapping is attained through a sudden release of prestored elastic energy. It is perfected by natural species to enhance their preying, locomotion, and reproduction abilities. Recent developments in responsive materials research has allowed the realization of bioinspired snappers and rapidly moving soft robots triggered by external stimuli. However, it remains a grand challenge to reversibly and accurately control the snapping dynamics in terms of, e.g., onset timing and speed of motion. Here, a facile method to obtain light-fueled snapping-like launching with precise control over the elastic energy released and the onset timing is reported. The elastic energy is prestored in a light-responsive liquid crystal elastomer actuator, and the launching event is dictated by releasing the energy through a photothermally induced crystal-to-liquid transition of a liquid-crystalline adhesive latch. The method provides manual control over the amount of prestored energy, motion speed upon multiple launching events, and enables demonstrations such as jumping and catapult motions in soft robots and concerted motions of multiple launchers. The results provide a practical solution for controlled fast motions in soft small-scale robotics. The experimental process involved the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Category: alcohols-buliding-blocks)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 2,6-PyridinedimethanolIn 2019 ,《Unprecedented isolation of a dinuclear tin (II) complex stabilized by pyridine-2,6-dimethanol: structure, DFT and in vitro screening of cytotoxic properties》 appeared in Applied Organometallic Chemistry. The author of the article were I., Mantasha; Raza, Kausar Md.; Shahid, M.; Ansari, Azaj; Ahmad, Musheer; Khan, Ishaat M.. The article conveys some information:

The authors report a novel dinuclear Sn(II) complex, [Sn2(Hpdm)2(H2O)6]·2H2O 2Cl (1) (H2pdm (3) = pyridine-2,6-dimethanol), which was crystallized out and characterized by elemental anal., FTIR, 1H and 13C NMR, single crystal x-ray studies and D. Functional Theory (DFT) anal. X-ray structure of 1 confirmed it to be a dinuclear alkoxo-bridged Sn(II) species where each metal adopts a seven coordinate distorted pentagonal bipyramidal (pbp) geometry. This is the first heptacoordinated Sn(II) complex ever isolated apart from already reported stannylenes. Spin d. plots from DFT support the +2 oxidation state of each tin metal. Hirshfeld surface anal. reveals various H-bonding interactions in the mol. and mol. docking results along with DFT confirm higher binding affinity of the present complex towards DNA. Moreover, the complex exhibits promising anticancer activities against HeLa and A549 cancer cell lines. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Name: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Name: 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 27489-62-9In 2022 ,《Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells》 appeared in Journal of Medicinal Chemistry. The author of the article were Zhang, Shiyan; Yan, Ziqin; Li, Yafang; Gong, Yang; Lyu, Xilin; Lou, Jianfeng; Zhang, Daizhou; Meng, Xiangjing; Zhao, Yujun. The article conveys some information:

Despite recent clin. progress in peptide-based dual inhibitors of MDM2/4, small-mol. ones with robust antitumor activities remain challenging. To tackle this issue, 31 (YL93) was structure-based designed and synthesized, which had MDM2/4 binding Ki values of 1.1 and 642 nM, resp. In three MDM4-overexpressing cancer cell lines harboring wild-type p53, 31 shows improved cell growth inhibition activities compared to RG7388, an MDM2-selective inhibitor in late-stage clin. trials. Mechanistic studies show that 31 increased cellular protein levels of p53 and p21 and upregulated the expression of p53-targeted genes in RKO cells with MDM4 amplification. In addition, 31 induced cell-cycle arrest and apoptosis in western blot and flow cytometry assays. Taken together, dual inhibition of MDM2/4 by 31 elicited stronger antitumor activities in vitro compared to selective MDM2 inhibitors in wild-type p53 and MDM4-overexpressing cancer cells. The results came from multiple reactions, including the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9HPLC of Formula: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C6H13NOIn 2021 ,《Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005》 appeared in Journal of Medicinal Chemistry. The author of the article were Papa, Patrick; Whitefield, Brandon; Mortensen, Deborah S.; Cashion, Dan; Huang, Dehua; Torres, Eduardo; Parnes, Jason; Sapienza, John; Hansen, Joshua; Correa, Matthew; Delgado, Mercedes; Harris, Roy; Hegde, Sayee; Norris, Stephen; Bahmanyar, Sogole; Plantevin-Krenitsky, Veronique; Liu, Zheng; Leftheris, Katerina; Kulkarni, Ashutosh; Bennett, Brydon; Hur, Eun Mi; Ringheim, Garth; Khambatta, Godrej; Chan, Henry; Muir, Jeffrey; Blease, Kate; Burnett, Kelven; LeBrun, Laurie; Morrison, Lisa; Celeridad, Maria; Khattri, Roli; Cathers, Brian E.. The article conveys some information:

The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines such as interleukin-2 (IL-2). Herein, we report the synthesis and structure-activity relationship (SAR) of a novel series of PKC-θ inhibitors. Through a combination of structure-guided design and exploratory SAR, suitable replacements for the basic C4 amine of the original lead (3) were identified. Property-guided design enabled the identification of appropriately substituted C2 groups to afford potent analogs with metabolic stability and permeability to support in vivo testing. With exquisite general kinase selectivity, cellular inhibition of T cell activation as assessed by IL-2 expression, a favorable safety profile, and demonstrated in vivo efficacy in models of acute and chronic T cell activation with oral dosing, CC-90005 (57) was selected for clin. development. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Computed Properties of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 6381-59-5In 2016 ,《Optimization of cold-active CMCase production by psychrotrophic Sphingomonas sp. FLX-7 from the cold region of China》 appeared in Cellulose (Dordrecht, Netherlands). The author of the article were Li, Dapeng; Feng, Lu; Liu, Keran; Cheng, Yi; Hou, Ning; Li, Chunyan. The article conveys some information:

Organic solid waste consists of 70 % biodegradables, such as cellulose, which is unable to be degraded quickly and efficiently in the cold region of China. Psychrotrophic cellulose-degrading bacteria play an important role in cellulose degradation at low temperatures In this study, a psychrotrophic cellulose-degrading FLX-7 strain with high carboxymethyl cellulase (CMCase) activity was isolated from the soil of a solid waste landfill under the environmental temperature of -10 °C. The FLX-7 strain was identified as Sphingobacterium sp. based on morphol. and physiol. and biochem. properties as well as 16S rRNA gene sequence anal. To improve the cold-active CMCase production of FLX-7, fermentation conditions were optimized using response surface methodol. based on a Box-Behnken design. The maximum CMCase activity (16.95 U/mL) was obtained at optimal fermentation conditions (inoculum size 2.1 %, temperature 10.4 °C, incubation time 73.5 h, and pH 7.2). The optimum pH and temperature for enzymic reaction of cold-active CMCase were 5.0 and 25 °C, resp. The cold-active CMCase was stable at a wide pH range of 5.0-9.0 and temperature range of 10-30 °C. The FLX-7 strain could be distributed via a psychrotrophic cellulose-degrading strain library and applied more broadly to organic solid waste composting in cold regions. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C7H6O2In 2020 ,《An Organocatalytic Newer Synthetic Strategy Toward the Access of Polyfunctionalized 4H-Pyrans via Multicomponent Reactions》 appeared in Polycyclic Aromatic Compounds. The author of the article were Ramesh, Rathinam; Jayamathi, Jayaraj; Karthika, Chinnagoundar; Malecki, Jan Grzegorz; Lalitha, Appaswami. The article conveys some information:

An energy efficient, facile, and environmentally benign synthetic method to obtain pharmaceutically fortunate, diverse 4H-pyrans from frequently accessible aryl aldehydes, malononitrile, and dissimilar 1,3-diketoesters is described. The reactions took place smoothly at ambient temperature using 2-aminopyridine as a low-cost organocatalyst. The present domino strategy furnishes, the desired products in high yields with shorter reaction times. The structures of the o-nitro substituted skeletons were unambiguously confirmed by mono-crystal XRD. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 3-PyridinemethanolIn 2022 ,《Reductive Alkylation of Azides and Nitroarenes with Alcohols: A Selective Route to Mono- and Dialkylated Amines》 appeared in Journal of Organic Chemistry. The author of the article were Borthakur, Ishani; Maji, Milan; Joshi, Abhisek; Kundu, Sabuj. The article conveys some information:

Herein, we demonstrated an efficient protocol for reductive alkylation of azides/nitro compounds via a borrowing hydrogen (BH) method. By following this protocol, selective mono- and dialkylated amines were obtained under mild and solvent-free conditions. A series of control experiments and deuterium-labeling experiments were performed to understand this catalytic process. Mechanistic studies suggested that the Ir(III)-H was the active intermediate in this reaction. KIE study revealed that the breaking of the C-H bond of alc. might be the rate-limiting step. Notably, this solvent-free strategy disclosed a high TON of around 5600. Based on kinetic studies and control experiments, a metal-ligand cooperative mechanism was proposed. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Name: 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Name: 3,5-DihydroxybenzaldehydeIn 2019 ,《A novel resveratrol derivative induces oxidative stress, G1 cell cycle arrest and premature senescence in A549 cells》 appeared in Latin American Journal of Pharmacy. The author of the article were Yang, Jie; Li, Jing; Qu, Xiao-Yu; Liu, Guo-Yun; Liu, Ren-Min. The article conveys some information:

Resveratrol has been reported to be a potential chemopreventive and anticancer agent. However, its poor bioavailability is being considered as a major obstacle in translating its effects in humans. Here, we report the synthesis and the anti-proliferative activities of fluorinated groups (CF3 and OCF3) substituted resveratrol derivatives A novel OCF3 substituted active derivative (A-3) owning the excellent stability and cell uptake ability in A549 cells, could improve the anti-proliferative activity (about 5 fold). In addition, A-3 could cause a clear block of cells in G1 phase (81.5%) and induce obvious premature senescence, via an apoptosis-independent mechanism; while resveratrol could cause an accumulation of cells in S phase (57.8%). Besides, A-3 treatment could cause an oxidized cellular environment in A549 cells. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 1195-59-1In 2021 ,《Pincer Ligand Enhanced Rhodium-Catalyzed Carbonylation of Formaldehyde: Direct Ethylene Glycol Production》 was published in Asian Journal of Organic Chemistry. The article was written by Meyer, Tim; Konrath, Robert; Kamer, Paul C. J.; Wu, Xiao-Feng. The article contains the following contents:

Formaldehyde is one of the most important bulk chems. and is produced on a million tone scale (52 million tons in 2017).[1] Since the middle of the last century, the challenge has remained to produce the valuable ethylene glycol (EG) directly from the C1 building block formaldehyde in a single step. In the systems reported so far, the reaction conditions were very harsh, often with pressures above 400 bar. However, under milder conditions, the selectivity was on the side of glycol aldehyde (GA) and the hydrogenation product methanol. Only traces of EG could be generated in the presence of a Rh catalyst. Herein, the authors describe a new Rh catalyst system with pincer ligand, which allows the direct one pot synthesis of EG from easy to handle paraformaldehyde (PFA) at remarkable mild conditions (70 bar, 100°C) and overcomes the aforementioned limitations with yield up to 40%. In the part of experimental materials, we found many familiar compounds, such as 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 2-Hydroxyphenylboronic acidIn 2019 ,《Ruthenium(III)-bis(phenolato)bipyridine/TiO2 hybrids: unprecedented photocatalytic hydrogen evolution》 was published in Dalton Transactions. The article was written by Mongal, Binitendra Naath; Tiwari, Amritanjali; Malapaka, Chandrasekharam; Pal, Ujjwal. The article contains the following contents:

In this work, two new bis-(hydroxyphenyl)bipyridine based ruthenium complexes with 4-picoline (coded as MCS-B4M) and isonicotinic acid (coded as MCS-B5M), which act as ancillary ligands, have been synthesized and employed for the first time as photosensitizers in photocatalytic hydrogen evolution studies. The photocatalyst MCS-B5M/TiO2-Pt showed an impressive hydrogen generation rate of up to 4.2 mmol h-1 and turnover number (TON) of 84 959 after 5 h. The better performance of B5TP over B4TP was due to the higher excited state lifetime of MCS-B5M (∼2.6 ns) than that of MCS-B4M (∼1.4 ns). This leads to a higher probability of electron transfer to the TiO2/Pt composite in the case of the former and a stronger coupling of MCS-B5M excited states with the conduction band of the TiO2/Pt composite by the -COOH linkers of the isonicotinic acid moiety, resulting in better photosensitization as observed in the UV-Vis (DRS mode) absorbance study. The comparative study of the two dyes clearly shows the manifestations of their resp. ancillary ligands having contrasting electronic properties. This work gives a new class of ruthenium photosensitizers as efficient light harvesting photocatalysts.2-Hydroxyphenylboronic acid(cas: 89466-08-0Safety of 2-Hydroxyphenylboronic acid) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Safety of 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts