Month: October 2022

Murata, Miki; Ueda, Yosuke; Hyogo, Mayu; Kohari, Yoshihito; Namikoshi, Takeshi; Watanabe, Shinji published an article in Journal of Chemical Research. The title of the article was 《Ruthenium-catalysed dehydrogenative C-H borylation of arenes with pinacolborane》.Formula: C14H21BO2 The author mentioned the following in the article:

A ruthenium complex prepared in situ from [RuCl2(p-cymene)]2 and TpMe2K [TpMe2 = hydrotris(3,5-dimethylpyrazolyl)borate] is efficient for aromatic C-H borylation with pinacolborane (4,4,5,5-tetramethyl-1,3,2-dioxaborolane). Arenes were borylated at more electron-rich positions. DFT calculations and kinetic isotope effect experiments suggest that the catalytic cycle should involve an electrophilic aromatic substitution with a borenium cation. In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Formula: C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Formula: C14H21BO2 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Okunlola, Adenike; Odeniyi, Michael Ayodele; Arhewoh, Matthew Ikhuoria published an article in Progress in Biomaterials. The title of the article was 《Microsphere formulations of ambroxol hydrochloride: influence of Okra (Abelmoschus esculentus) mucilage as a sustained release polymer》.Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride The author mentioned the following in the article:

Ambroxol hydrochloride (AH), a secretion-releasing expectorant, is a good candidate for sustained delivery. Mucilages are biodegradable, inexpensive carriers in microsphere formulations. The study aimed to prepare microspheres of AH using Okra mucilage obtained from pods of Abelmoschus esculentus combined with sodium alginate at various polymer/drug ratios. Okra mucilage was characterized for morphol., swelling, viscosity and flow properties. AH microspheres were prepared by ionic emulsification method and characterized using size, entrapment efficiency, swelling index and dissolution time (t50). A full 2 by 3 factorial exptl. design using three factors (Okra mucilage/alginate ratio X1; drug/polymer ratio X2; and polymer concentration X3), each at two levels, was used to determine the effects of formulation variables on the responses. Optimized formulations of AH microspheres had sizes ranging from 250.91 ± 16.22 to 462.10 ± 23.85μm; swelling index 1.35 ± 0.05 and 3.20 ± 0.03 and entrapment 55.70 ± 3.55-94.11 ± 4.50%. The microspheres exhibited sustained release of AH over a prolonged period as revealed by the dissolution time (t50) 2.85 ± 1.03-7.50 ± 0.96 h. Drug release kinetics generally followed zero order, implying that the process is constant and independent of the initial concentration of drug. Polymer concentration had the highest influence on microsphere size, entrapment efficiency and dissolution time while Okra/alginate ratio had the highest influence on swelling. Okra mucilage was a suitable polymer that could serve as an alternative to synthetic polymers in sustaining the release of ambroxol hydrochloride. After reading the article, we found that the author used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Name: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sashidhara, Koneni V.; Kumar, Abdhesh; Dodda, Ranga Prasad; Kumar, Bikash published an article in Tetrahedron Letters. The title of the article was 《A new iodine catalyzed regioselective synthesis of xanthene synthons》.COA of Formula: C12H14O3 The author mentioned the following in the article:

This Letter describes the iodine catalyzed one-pot regioselective synthesis of p-condensed xanthenes as our key point of transformation, which provides an efficient access to five skeletally diverse scaffolds in excellent yields. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).COA of Formula: C12H14O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Zhong; Duan, XiXin; Gnanasekarc, Pitchaimari; Yan, Ning; Shi, Junyou published an article in Biomass Conversion and Biorefinery. The title of the article was 《Review: cascade reactions for conversion of carbohydrates using heteropolyacids as the solid catalysts》.Application In Synthesis of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The author mentioned the following in the article:

A review. Abstract: Conversion of biomass into renewable chems. and fuels has received significant attention as an approach to enhance global sustainability. Biomass conversion, especially carbohydrate conversion, commonly involves cascade reactions. During these cascade reactions, various activity sites on carbohydrates may have different reactivities that enable us to control the final products through adjusting these activity sites. Heteropolyacids (HPAs), one of the major solid acid catalysts, are extensively used in biomass conversion owing to their numerous excellent physicochem. properties, such as strong Bronsted acidity, oxidizability, structural versatility, and easy design. Accordingly, this review aims to outline recent breakthroughs in obtaining platform chems. from carbohydrates by cascade reactions involving heteropolyacid catalysts. Moreover, the relationship between the final products and the structure of heteropolyacid catalysts is discussed and insights will help us to design more efficient solid acid catalysts for conversion of biomass to more sustainable chem. products. The experimental part of the paper was very detailed, including the reaction process of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Application In Synthesis of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Application In Synthesis of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Synthesis of 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes》 were Sashidhara, Koneni V.; Kumar, Abdhesh; Rao, K. Bhaskara. And the article was published in Tetrahedron Letters in 2011. HPLC of Formula: 153759-59-2 The author mentioned the following in the article:

Convenient and facile one step synthesis of medicinally relevant 3,6-epoxy[1,5]dioxocines e. g., I from 2-hydroxyarom. benzaldehydes is described. The scope of the method was validated by examining the use of both electron rich and electron-deficient 2-hydroxyarom. benzaldehydes. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2HPLC of Formula: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).HPLC of Formula: 153759-59-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Yu, Jianfei; Duan, Meng; Wu, Weilong; Qi, Xiaotian; Xue, Peng; Lan, Yu; Dong, Xiu-Qin; Zhang, Xumu published 《Readily Accessible and Highly Efficient Ferrocene-Based Amino-Phosphine-Alcohol (f-Amphol) Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of Simple Ketones》.Chemistry – A European Journal published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

We have successfully developed a series of novel and modular ferrocene-based amino-phosphine-alc. (f-Amphol) ligands and applied them to iridium-catalyzed asym. hydrogenation of various simple ketones to afford the corresponding chiral alcs. with excellent enantioselectivities and conversions (98-99.9 % ee, >99 % conversion, turnover number up to 200,000). Control experiments and d. functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asym. hydrogenation. In the part of experimental materials, we found many familiar compounds, such as (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Chang, Li; Zhang, Xiqi; Ding, Yi; Liu, Hongliang; Liu, Mingzhu; Jiang, Lei published 《Ionogel/Copper Grid Composites for High-Performance, Ultra-Stable Flexible Transparent Electrodes》.ACS Applied Materials & Interfaces published the findings.Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

Production of high-performance and stable low-cost copper (Cu)-based flexible transparent electrodes (FTEs) is urgently needed for the development of new-generation flexible optoelectronic devices, but it still remains challenging. Herein, a facile approach is developed to fabricate high-performance, ultra-stable Cu grid (CuG)-based FTEs by UV lithog.-assisted electroless deposition of patterned Cu on flexible polyethylene terephthalate (PET), which is then encapsulated by a thin poly(1-vinyl-3-ethylimidazolium bis(trifluoromethanesulfonyl)imide) (P[VEIM][NTf2]) ionogel layer to improve the mech. flexibility and stability. The as-prepared composite FTE (ionogel/CuG@ PET) exhibits a sheet resistance of 10.9 Ω sq-1 and optical transmittance of 90% at 550 nm. Introduction of the thin uniform P[VEIM][NTf2] ionogel nanofilm by virtue of the superwettability of the Cu layer endows the electrode with excellent mech. flexibility and stability. This new high-performance Cu-based FTE should be an attractive alternative to indium tin oxide for practical optoelec. applications. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Nature (London, United Kingdom) included an article by Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia. Electric Literature of C4H11NO. The article was titled 《Modular click chemistry libraries for functional screens using a diazotizing reagent》. The information in the text is summarized as follows:

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Electric Literature of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Current Organocatalysis included an article by Mosallanezhad, Asiyeh; Kiyani, Hamzeh. SDS of cas: 100-83-4. The article was titled 《Green Synthesis of 3-Substituted-4-arylmethylideneisoxazol-5(4H)-one Derivatives Catalyzed by Salicylic Acid》. The information in the text is summarized as follows:

The efficient and environmental friendliness procedure for the synthesis of isoxazol-5(4H)-ones was introduced. Salicylic acid was used as an inexpensive, easy to handle and safe catalyst for the synthesis of title compounds 3-Substituted-4-arylmethylideneisoxazol-5(4H)-ones were obtained from readily available aryl/heteroaryl aldehydes and β-keto esters via the cyclocondensation reaction without using thermal, microwave or ultrasound conditions. It must be highlighted that the procedure is operationally mild and simple, and the desired small heterocycles were obtained in good to high yields.3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Chemistry – A European Journal included an article by Kuehn, Laura; Jammal, Dominik G.; Lubitz, Katharina; Marder, Todd B.; Radius, Udo. Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane. The article was titled 《Stoichiometric and Catalytic Aryl-Cl Activation and Borylation using NHC-stabilized Nickel(0) Complexes》. The information in the text is summarized as follows:

NHC-nickel (NHC = N-heterocyclic carbene) complexes are efficient catalysts for the C-Cl bond borylation of aryl chlorides using NaOAc as a base and B2pin2 (pin = pinacolato) as the boron source. The catalysts [Ni2(ICy)4(μ-(η2:η2)-COD)] (1, ICy = 1,3-dicyclohexylimidazolin-2-ylidene; COD = 1,5-cyclooctadiene), [Ni(ICy)2(η2-C2H4)] (2), and [Ni(ICy)2(η2-COE)] (3, COE = cyclooctene) compare well with other nickel catalysts reported previously for aryl-chloride borylation with the advantage that no further ligands had to be added to the reaction. Borylation also proceeded with B2neop2 (neop = neopentylglycolato) as the boron source. Stoichiometric oxidative addition of different aryl chlorides to complex 1 was highly selective affording trans-[Ni(ICy)2(Cl)(Ar)] (Ar = 4-(F3C)C6H4, 11; 4-(MeO)C6H4, 12; C6H5, 13; 3,5-F2C6H3, 14). In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts