Month: October 2022

Akhrem, Irena S.; Avetisyan, Dzhul’etta V.; Afanas’eva, Lyudmila V.; Artyushin, Oleg I. published the artcile< Simple and Efficient ""One-Pot"" Synthesis of Diphenylaryl (Heteroaryl) Methanols from Benzene>, Quality Control of 76-84-6, the main research area is diphenyl aryl methanol preparation.

A simple and efficient one-pot method for the synthesis of diphenyl(aryl)methanols I [Ar = Ph, 4-FC6H4, 2-thienyl, etc.] from benzene was developed using the known reaction of benzene with CCl4·AlCl3. This approach appeared fruitful when the reaction was performed uring CCl4 as a solvent. This method allowed the selective synthesis of Ph2CCl2 in good yield.

ChemistrySelect published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Quality Control of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kleban, Ihor; Krokhmaliuk, Yevhen; Reut, Sofiia; Shuvakin, Serhii; Pendyukh, Vyacheslav V.; Khyzhan, Oleksandr I.; Yarmoliuk, Dmytro S.; Tymtsunik, Andriy V.; Rassukana, Yuliya V.; Grygorenko, Oleksandr O. published the artcile< Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates>, Application of C4H8O, the main research area is enyne hetero preparation hydroboration; bromoallyl derivative preparation lithiation borylation; heterabicycloalkanyl trifluoroborate preparation.

An approach to the synthesis of oxa- and azabicyclo[n.1.0]alkan-1-yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: the 1st based on the lithiation-borylation of the corresponding 2-bromoallyl derivatives, and the other relying on regioselective hydroboration of the appropriate hetera-substituted enynes. The 2nd method appeared to be more efficient in terms of scalability and substrate scope. Further steps included ring closing-metathesis, mild Pd-catalyzed cyclopropanation with diazomethane, and reaction with KHF2 and furnished the title compounds in up to 50 g scale in a single run (10-41% overall yield, 4-5 steps).

European Journal of Organic Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mudududdla, Ramesh; Jain, Shreyans K.; Bharate, Jaideep B.; Gupta, Ajai P.; Singh, Baldev; Vishwakarma, Ram A.; Bharate, Sandip B. published the artcile< ortho-Amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate>, Quality Control of 4396-13-8, the main research area is hydroxybenzyl lactam regioselective preparation; phenol lactam tandem Knoevenagel condensation Diels Alder cycloaddition; perchloric acid amidoalkylation catalyst.

An efficient method for ortho-amidoalkylation of phenols via Mannich-type condensation with formaldehyde and lactams using recyclable solid acid catalyst is described. This is the first report for ortho-amidoalkylation of phenols by lactams via Mannich-type condensation. LC-ESI-MS/MS based mechanistic study revealed that reaction proceeds through o-quinone methide (o-QM) and an oxazine intermediate via tandem Knoevenagel condensation, formal [4 + 2]-Diels-Alder cycloaddition and acid catalyzed oxazine ring-opening.

Journal of Organic Chemistry published new progress about Amidoalkylation. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Quality Control of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brocklehurst, Cara E.; Laumen, Kurt; La Vecchia, Luigi; Shaw, Duncan; Vogtle, Markus published the artcile< Diastereoisomeric Salt Formation and Enzyme-Catalyzed Kinetic Resolution as Complementary Methods for the Chiral Separation of cis-/trans-Enantiomers of 3-Aminocyclohexanol>, SDS of cas: 6850-39-1, the main research area is aminocyclohexanol chiral separation diastereomeric salt formation enzymic kinetic resolution.

This contribution demonstrates the preparative-scale synthesis of (1S,3S)-3-aminocyclohexanol by either enzymic kinetic resolution of Cbz-protected 3-aminocyclohexanols or direct diastereoisomeric salt formation with (R)-mandelic acid. The salt formation demonstrates how a single enantiomer, (1S,3S)-3-aminocyclohexanol (R)-mandelate, can be effectively isolated from the cis/trans racemic mixture and subsequently converted to the free amine, (1S,3S)-3-aminocyclohexanol, by ion-exchange chromatog. We have also demonstrated how the other three enantiomers of 3-aminocyclohexanol can be prepared by either diastereoisomeric salt formation or enzymic kinetic resolution

Organic Process Research & Development published new progress about Chiral resolution (by diastereomeric salt formation). 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rahman, Habibur Md.; Akter, Rokeya; Bhattacharya, Tanima; Abdel-Daim, Mohamed M.; Alkahtani, Saad; Arafah, Mohammed W.; Al-Johani, Norah S.; Alhoshani, Norah M.; Alkeraishan, Nora; Alhenaky, Alhanof; Abd-Elkader, Omar H.; El-Seedi, Hesham R.; Kaushik, Deepak; Mittal, Vineet published the artcile< Resveratrol and neuroprotection: impact and its therapeutic potential in Alzheimer's disease>, Reference of 501-36-0 , the main research area is review resveratrol neuroprotection Alzheimer disease; Alzheimer’s disease; bioavailability; neuroprotective; oxidative stress; resveratrol; therapeutic agent.

A review. Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic inflammation. Exactly, resveratrol, a polyphenol present in red wine, and many plants are indicated to show the neuroprotective effect on mechanisms mostly above. Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most exptl. research on AD and resveratrol has been performed in many species, both in vitro and in vivo, during the last few years. Nevertheless, resveratrol’s effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective mol. mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.

Frontiers in Pharmacology published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Reference of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Laengle, D.; Wesseler, F.; Floetgen, D.; Leek, H.; Plowright, A. T.; Schade, D. published the artcile< Unique photoaffinity probes to study TGFβ signaling and receptor fates>, COA of Formula: C4H8N2O, the main research area is dihydropyridine annulated preparation transforming growth factor beta pharmacophore SAR.

A novel synthetic approach is used to prepare a diverse set of “”first-in-class”” dihydropyridine-based TGFβ receptor degraders bearing photoaffinity labels. These probes serve as valuable tools to study TGFβ receptor fates and dynamics – an important challenge in chem. biol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Dihydropyridines Role: DGN (Diagnostic Use), PAC (Pharmacological Activity), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, COA of Formula: C4H8N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Panda, Chakadola; Doyle, Lorna M.; Gericke, Robert; McDonald, Aidan R. published the artcile< Rapid Iron(III)-Fluoride-Mediated Hydrogen Atom Transfer>, Product Details of C19H16O, the main research area is pyridylmethylamine iron fluoride preparation oxidant hydrogen atom transfer; crystal mol structure pyridylmethylamine iron fluoride; hydrocarbon oxidative carbon hydrogen activation kinetics pyridylmethylamine iron fluoride; biomimetic chemistry; fluoride oxidant; high-valent oxidants; nonheme iron; proton-coupled electron transfer.

Authors anticipate high-valent metal-fluoride species will be highly effective hydrogen atom transfer (HAT) oxidants because of the magnitude of the H-F bond (in the product) that drives HAT oxidation They prepared a dimeric FeIII(F)-F-FeIII(F) complex (1) by reacting [FeII(NCCH3)2(TPA)](ClO4)2 (TPA = tris(2-pyridylmethyl)amine) with difluoro(phenyl)-λ3-iodane (difluoroiodobenzene). 1 Was a sluggish oxidant, however, it was readily activated by reaction with Lewis or Broensted acids to yield a monomeric [FeIII(TPA)(F)(X)]+ complex (2) where X = F/OTf. 1 And 2 were characterized using NMR, EPR, UV/Vis, and FT-IR spectroscopies and mass spectrometry. 2 Was a remarkably reactive FeIII reagent for oxidative C-H activation, demonstrating reaction rates for hydrocarbon HAT comparable to the most reactive FeIII and FeIV oxidants.

Angewandte Chemie, International Edition published new progress about Activation energy. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balamurugan, Gunasekaran; Balaji, Sundarraman; Ramesh, Rengan; Bhuvanesh, Nattamai S. P. published the artcile< Synthesis and Structures of Arene Ruthenium (II)-NHC Complexes: Efficient Catalytic α-alkylation of ketones via Hydrogen Auto Transfer Reaction>, Formula: C7H9NO, the main research area is arene ruthenium heterocyclic compound complex preparation; aryl alkyl ketone alkanol ruthenium catalyst chemoselective alkylation; alkyl aryl ketone preparation; hydroxymethyl aniline ketone ruthenium catalyst heterocyclization; quinoline preparation.

A panel of six new arene Ru (II)-NHC complexes (NHC = 1,3-diethyl-(5,6-dimethyl)benzimidazolin-2-ylidene, 1,3-dicyclohexylmethyl-(5,6-dimethyl)benzimidazolin-2-ylidene and 1,3-dibenzyl-(5,6-dimethyl)benzimidazolin-2-ylidene) were synthesized from the transmetallation reaction of Ag-NHC with [(η6-arene)RuCl2]2 and characterized. The ruthenium (II)-NHC complexes were developed as effective catalysts for α-alkylation of ketones and synthesis of bioactive quinoline using primary/amino alcs. as coupling partners resp. The reactions were performed with 0.5 mol% catalyst load in 8 h under aerobic condition and the maximum yield was up to 96%. Besides, the different alkyl wingtips on NHC and arene moieties were studied to differentiate the catalytic robustness of the complexes in the transformations.

Applied Organometallic Chemistry published new progress about Alkylation catalysts, regioselective. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ueno, Masaharu; Kusaka, Ryo; Ohmura, Satoshi D.; Miyoshi, Norikazu published the artcile< Environmentally Benign Ritter Reaction Using Bismuth Salts as a Catalyst>, Computed Properties of 76-84-6, the main research area is Ritter bismuth salt catalyst green.

The authors developed an environmentally benign Ritter reaction of alcs. with nitriles using a com. available bismuth salt as a less harmful catalyst. The detailed reaction profiles revealed that consumption of the ether byproduct as the reaction proceeded was the key for optimizing this reaction, and the yield of the target amide was improved by adding a small amount of water. This finding clearly reveals the significance of using a bismuth salt as the catalyst, as it is not deactivated in the presence of water. This catalyst system has a broad substrate scope, and even with 1 mol-% of the catalyst, the reaction progresses smoothly. It is also possible to react stoichiometric amounts of nitriles and alcs., thus reducing the amount of organic solvent required for the reaction. Furthermore, as the inexpensive bismuth catalyst can be easily removed using aqueous hydrochloric acid, a purification process that only required washing and drying without any organic solvents was successfully established.

European Journal of Organic Chemistry published new progress about Green chemistry. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts