Month: October 2022

《Synthesis and biological activity of some new- 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione derivatives》 was written by Tabassum, Zeaba; Nizami, Syed Azhar; Gurumurthy, M.. SDS of cas: 100-83-4 And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2020. The article conveys some information:

Imidazole on reaction with 1-(4-chlorophenyl) ethanone in the presence of absolute ethanol gave 1-(4-(-imidazol-1-yl) phenyl) ethanone, condensation of this with various benzaldehydes offered 1-(4-(Imidazol-1-yl)phenyl) -3-phenylprop-2-en-1-ones I [R = Ph, 3-hdroxyphenyl, 4-methoxyphenyl, 2-hydroxy-3-methoxy Ph, 3-nitrophenyl], which on cyclization with thiourea yielded 4-(4-(1H-imidazol-1-yl)phenyl)-6-phenylpyrimidine-2(1H)-thione II. The structures of newly synthesized compounds II were confirmed by FTIR, 1HNMR and mass spectral data. Compounds II were screened for in-vitro anti-inflammatory activity by inhibition of albumin denaturation technique and antiproteinase action. All the synthesized substituted thiopyrimidine compounds II showed moderate to good anti-inflammatory activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

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Sawano, Takahiro; Matsui, Takeshi; Koga, Marina; Ishikawa, Eri; Takeuchi, Ryo published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Iridium-catalyzed C3-selective asymmetric allylation of 7-azaindoles with secondary allylic alcohols》.Name: Oxetan-3-ol The article contains the following contents:

Iridium-catalyzed C3-selective asym. allylation of 7-azaindoles with racemic secondary allylic alcs. to give only branched allylation products in good to high yields with high enantioselectivity (up to >99.5% ee) was reported. Allylic alcs. and 7-azaindoles with a variety of functional groups including halogen and heteroaromatic groups were compatible with the reaction conditions. Furthermore, transformations of the obtained allylation products were demonstrated without a significant loss of enantiomeric excess. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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In 2022,Wilhelmsen, Christopher A.; Zhang, Xuntong; Myhill, Jesse A.; Morken, James P. published an article in Angewandte Chemie, International Edition. The title of the article was 《Enantioselective Synthesis of Tertiary β-Boryl Amides by Conjunctive Cross-Coupling of Alkenyl Boronates and Carbamoyl Chlorides》.COA of Formula: C13H26B2O4 The author mentioned the following in the article:

Synthesis of versatile β tert-boryl amides is accomplished by conjunctive cross-coupling of α-substituted alkenyl boron “”ate”” complexes and carbamoyl chloride electrophiles. This reaction can be accomplished in an enantioselective fashion using a palladium catalyst in combination with MandyPhos. The addition of water results in enhanced chemoselectivity for the conjunctive coupling product relative to the Suzuki-Miyaura cross-coupling product. Transformations of the reaction products were examined as well as application to the synthesis of (+)-adalinine. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9COA of Formula: C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.COA of Formula: C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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《Investigation on Physical Properties of Sn-Modified Cubic Cu2O Nanostructures》 was written by Budhiraja, Narender; Sapna; Kumar, Vinod; Tomar, Monika; Gupta, Vinay; Singh, S. K.. COA of Formula: C4H12KNaO10This research focused ontin copper oxide nanostructure phys property. The article conveys some information:

Cubic Cu2-x SnxO (0 ≤x ≤0.4) nanostructures have been developed with the solvothermal method. X-ray diffraction data anal. confirms the formation of a pristine Cu2O phase below x = 0.3 Sn2+ substitution, and SnO-related phases appear in 0.3 substitute sample indicating phase segregation starts at x≥0.3. The magnetization vs. applied field (M – H) curves have been determined using a vibrating sample magnetometer at 300 K which reveals that ferromagnetic behavior of synthesized nanomaterials is reliant on the substituent concentration and enhanced gradually with its addition in the material. Photoluminescence spectra show that ferromagnetism originates from the induced magnetic moment in defects created as cation vacancies in the host material. Beside these, the dielec. measurements were performed at various frequencies (20 Hz-1 MHz) and in the temperature range of 100 to 350 K. In addition to this study using Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate, there are many other studies that have used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5COA of Formula: C4H12KNaO10) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. COA of Formula: C4H12KNaO10 It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

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Dhiman, Priya; Bhatia, Meenakshi published their research in Journal of Inclusion Phenomena and Macrocyclic Chemistry on December 31 ,2020. The article was titled 《Pharmaceutical applications of cyclodextrins and their derivatives》.Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol The article contains the following contents:

A review. Cyclodextrins (CDs) are abundantly explored in the field of medicines for the design of various types of drug delivery systems. They are cyclic oligosaccharides carrying α (1,4) glucopyranose units and able to build aqueous soluble inclusion complexes with various small and large drug mols. These mols. have a unique structural feature and categorized into hydrophobic, hydrophilic and ionic derivatives Villiers and Schardinger in 1891, first described the chem. nature and types of cyclodextrin. Cramer and co-workers in 1955 illustrated their latent to make water soluble inclusion complexes with various active components. These CDs mols. are used in pharmaceutical field practically and economically to improve the stability, solubility as well as bioavailability of drug mols. In this review article phys. characteristic, chem. nature and applications of different cyclodextrin and their derivatives in different drug delivery systems and toxicol. effects are engrossed. In addition to this study using rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, there are many other studies that have used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol) was used in this study.

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Recommanded Product: rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

Referemce:
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Yu, Li; Bhattacharya, Dhruva; Wang, Zhenhan; Wang, Mingwu published an article in Graefe’s Archive for Clinical and Experimental Ophthalmology. The title of the article was 《Topical administration of ambroxol eye drops augments tear secretion in rabbits》.Synthetic Route of C13H19Br2ClN2O The author mentioned the following in the article:

To investigate if topical administration of ambroxol promotes tear secretion and to compare with Diquas ophthalmic eye drop. Two consecutive studies were conducted using sixteen (32 eyes) New Zealand White rabbits. The first study compared the efficacy of ambroxol hydrochloride (0.05%, 0.2%, and 1.0%) on tear and mucin secretion when administered twice daily. Tear secretion was assessed by Schirmer test I and mucin production by conjunctival impression cytol. and PAS stain. The second study compared 0.2% ambroxol hydrochloride with Diquas. A human goblet cell line and human conjunctival tissue were used to test the effect of ambroxol hydrochloride on the expression of aquaporin 5 (AQP5) and MUC5AC, using reverse transcriptase-quant. polymerase chain reaction and immunoblotting. All three concentrations of ambroxol hydrochloride demonstrated significant efficacy on tear stimulation within 2 wk of treatment and total mucin component appeared increased. When administered topically twice daily, 0.2% ambroxol hydrochloride was more effective in augmenting tear secretion than Diquas. With 24 h of treatment, 5μM of ambroxol hydrochloride upregulated AQP5 and MU5AC mRNA and MUC5AC protein in a goblet cell line. When tested on preserved human conjunctiva tissue, a trend of increased production of MUC5AC protein was seen (P = 0.26). Ambroxol is effective in augmenting tear secretion at the ocular surface in rabbits. With actions desirable of a candidate dry eye drug, further investigation of ambroxol and related compounds is warranted to explore their value toward clin. application. The experimental part of the paper was very detailed, including the reaction process of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Synthetic Route of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Synthetic Route of C13H19Br2ClN2O It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

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In 2018,Mahmud, Asif; Mahmud, Shadman Sharar; Moniruzzaman, Md. published 《Electroless deposition of p-type cuprous oxide thin film for solar application》.IOP Conference Series: Materials Science and Engineering published the findings.Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

Solar cells hold a promising prospect in the foreseeable future. Presently cuprous oxides (Cu2O), due to their excellent photovoltaic properties, are being considered as p-type semiconductor materials for solar cell. This work aims at electroless deposition of p-type Cu2O thin film on copper substrate and studying its various properties through characterizations. A bath containing varying amounts of CuCl2.2H20, CoCl2.6H20, NaH2PO2.6H20 and KNaTar.4H2O (Potassium sodium tartrate tetrahydrate) was used for the process. NaOH pellets were used in order to get the desired pH level ranging from 11 to 14. The bath temperature was varied between 30°C to 70°C. The deposited films were characterized by Scanning Electron Microscope (SEM) equipped with Energy Dispersive Spectroscopy (EDS), X-ray diffractometer (XRD) and UV spectroscopy. It was observed that thin films were deposited at different conditions and uniform deposition of Cu2O thin film was visible at pH 14. The coating thickness was found to be in the range of 0.48 to 4.6μm. The bandgap for the deposited Cu2O was found to be in the range of 1.3-1.4 eV. Some variation in results at different pH were observed and the reasons were identified. In the experiment, the researchers used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Miller, Miles A.; Kim, Eunha; Cuccarese, Michael F.; Plotkin, Alec L.; Prytyskach, Mark; Kohler, Rainer H.; Pittet, Mikael J.; Weissleder, Ralph. SDS of cas: 27489-62-9. The article was titled 《Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease》. The information in the text is summarized as follows:

The receptor tyrosine kinase Mer (MERTK) is a promising drug target in cancer, where it can influence the metastasis-promoting signaling of both tumor cells and immune cells alike; however, no small mol. probes currently exist to selectively image Mer. In this work, we design and synthesize a selective near-IR fluorescent mol. probe of Mer (MERi-SiR). Confocal microscopy of metastases in mice reveals predominant probe accumulation in Mer-expressing tumor-associated macrophages. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.SDS of cas: 27489-62-9

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In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Harinath, Adimulam; Bhattacharjee, Jayeeta; Panda, Tarun K.. Formula: C7H7BrO. The article was titled 《Facile reduction of carboxylic acids to primary alcohols under catalyst-free and solvent-free conditions》. The information in the text is summarized as follows:

A facile protocol for the deoxygenative hydroboration of aliphatic and aryl carboxylic acids afforded corresponding primary alcs. under solvent-free and catalyst-free conditions was reported. The reaction proceeded under ambient temperature exhibited good tolerance towards various functional groups and generates quant. yields. The plausible mechanism involved the formation of Lewis acid-base adducts as well as the liberation of hydrogen gas. The results came from multiple reactions, including the reaction of (4-Bromophenyl)methanol(cas: 873-75-6Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Formula: C7H7BrO It undergoes efficient trimethylsilylation reaction with 1,1,1,3,3,3-hexamethyldisilazane in the presence of catalytic amount of aspartic acid in acetonitrile.

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The author of 《Perylenebisimide-fullerene dyads as heavy atom free triplet photosensitizers with unique singlet oxygen generation efficiencies》 were Ozturk, Ezel; Eserci, Hande; Okutan, Elif. And the article was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2019. Electric Literature of C6H15NO The author mentioned the following in the article:

We report the synthesis, characterization, photophys. and photochem. properties of two novel perylenebisimide-fullerene dyads (7 and 8) bearing one or two perylenebisimide (PBI) units as light harvester and a fullerene as spin converter. The mol. structures of all synthesized compounds were elucidated by elemental analyses, mass spectrometry, FT-IR, 1H and 13C NMR techniques. Their optical properties were investigated by UV-vis absorption and 2D/3D fluorescence emission spectroscopies. The photochem. studies via direct and indirect method endorsed PBI-fullerene dyads (7 and 8) as efficient heavy atom free tripletphotosensitizers whereas perylene derivatives did not exhibit any singlet oxygen production The PBI-fullerene dyads exhibit excellent singlet oxygen quantum yields of 0.93 and 0.95. The PBI-fullerene dyads (7 and 8) are also able to use in the photooxidation of 1,5-dihydroxynaphtalene (DHN) to produce juglone and are recognized as stronger than MB as conventional triplet photosensitizers. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Electric Literature of C6H15NO

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