Month: October 2022

Oloo, Williamson N.; Szavuly, Miklos; Kaizer, Jozsef; Que, Lawrence Jr. published the artcile< Nonheme diiron oxygenase mimic that generates a diferric-peroxo intermediate capable of catalytic olefin epoxidation and alkane hydroxylation including cyclohexane>, Computed Properties of 76-84-6, the main research area is nonheme diiron oxygenase mimic intermediate olefin epoxidation alkane hydroxylation.

Herein are described substrate oxidations with H2O2 catalyzed by [FeII(IndH)(CH3CN)3](ClO4)2 [IndH = 1,3-bis(2′-pyridylimino)isoindoline], involving a spectroscopically characterized (μ-oxo)(μ-1,2-peroxo)diiron(III) intermediate (2) that is capable of olefin epoxidation and alkane hydroxylation including cyclohexane. Species 2 also converts ketones to lactones with a decay rate dependent on [ketone], suggesting direct nucleophilic attack of the substrate carbonyl group by the peroxo species. In contrast, peroxo decay is unaffected by the addition of olefins or alkanes, but the label from H218O is incorporated into the epoxide and alc. products, implicating a high-valent iron-oxo oxidant that derives from O-O bond cleavage of the peroxo intermediate. These results demonstrate an ambiphilic diferric-peroxo intermediate that mimics the range of oxidative reactivities associated with O2-activating nonheme diiron enzymes.

Inorganic Chemistry published new progress about Alkenes Role: BUU (Biological Use, Unclassified), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lasser, Elliott C.; Walters, Alton; Reuter, Stewart R.; Lang, Joseph published the artcile< Histamine release by contrast media>, HPLC of Formula: 35564-86-4, the main research area is histamine release contrast media; methylglucamines contrast media allergy.

Close arterial injections of x-ray contrast media into dogs increased plasma histamine (I) [51-45-6] levels in blood draining the liver or lungs. I levels were increased by injections of methylglucamine acetrizoate [22154-43-4], methylglucamine diatrizoate [131-49-7], or methylglucamine iodipamide [3521-84-4]. The Na salts of the contrast media showed much less histamine-releasing activity than the methylglucamine salts. Methylglucamine chloride [6284-40-8] also elevated plasma I. It is suggested that some allergic reactions to contrast media are mediated by I release.

Radiology (Oak Brook, IL, United States) published new progress about Allergy. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, HPLC of Formula: 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zheng; Lin, Qing; Ma, Ning; Liu, Song; Han, Mingyang; Yan, Xiuli; Liu, Qingbin; Solan, Gregory A.; Sun, Wen-Hua published the artcile< Direct synthesis of ring-fused quinolines and pyridines catalyzed by NNHY-ligated manganese complexes (Y = NR2 or SR)>, Computed Properties of 5344-90-1, the main research area is cationic manganese complex preparation; fused quinoline pyridine preparation green chem; gamma amino secondary alc ketone coupling cyclization.

Four cationic manganese(I) complexes, [(fac-NNHN)Mn(CO)3]Br (Mn-1-Mn-3) and [(fac-NNHS)Mn(CO)3]Br (Mn-4) (where NNH is a 5,6,7,8-tetrahydro-8-quinolinamine moiety), have been synthesized and evaluated as catalysts for the direct synthesis of quinolines and pyridines by the reaction of a γ-amino alc. with a ketone or secondary alc.; NNHS-ligated Mn-4 proved the most effective of the four catalysts. The reactions proceeded well in the presence of catalyst loadings in the range 0.5-5.0 mol% and tolerated diverse functional groups such as alkyl, cycloalkyl, alkoxy, chloride and hetero-aryl. A mechanism involving acceptorless dehydrogenation coupling (ADC) has been proposed on the basis of DFT calculations and exptl. evidence. Significantly, this manganese-based catalytic protocol provides a promising green and environmentally friendly route to a wide range of synthetically important substituted monocyclic, bicyclic as well as tricyclic N-heterocycles (including 50 quinoline and 26 pyridine examples) with isolated yields of up to 93%.

Catalysis Science & Technology published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

McKay, G.; Blair, H. S.; Gardner, J. published the artcile< Rate studies for the adsorption of dyestuffs onto chitin>, Application In Synthesis of 6054-98-4, the main research area is dye adsorption chitin model; film mass transfer dye model.

The rate of adsorption of dyestuffs on chitin in the initial stages of the adsorption process depends on the film mass transfer coefficient A model has been developed to determine the film mass transfer coefficients The anal. is based on a nonlinear equilibrium isotherm and utilizes a computer program to predict theor. concentration vs. time curves. The overall average external mass transfer coefficients are 2.8 × 10-3, 2.9 × 10-3, 3.8 × 10-3, and 0.9 × 10-3 cm/s for Acid Blue 25  [6408-78-2], Acid Blue 158  [6370-08-7], Mordant Yellow 5  [6054-98-4], and Direct Red 84  [6409-83-2], resp. Equilibrium data for the adsorption of the 4 dyestuffs on chitin are presented and analyzed using the Langmuir, Freundlich, and general isotherm expressions. The adsorption capacity of chitin at monolayer coverage is 190 and 200 mg dye/g for Acid Blue 25 and Acid Blue 158, resp. Mordant Yellow 5 and Direct Red 84 adsorption capacities are 50 and 40 mg dye/g chitin, resp.

Journal of Colloid and Interface Science published new progress about Adsorptive wastewater treatment. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application In Synthesis of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruschhaupt, Peter; Varzi, Alberto; Passerini, Stefano published the artcile< Natural Polymers as Green Binders for High-Loading Supercapacitor Electrodes>, Product Details of C6H12O6, the main research area is natural polymer green binder high loading supercapacitor electrode; binders; carbohydrates; flexible electrodes; high mass loading; supercapacitors.

The state-of-the-art aqueous binder for supercapacitors is CM-cellulose (CMC). However, it limits the mass loading of the coatings owing to shrinkage upon drying. In this work, natural polymers, i.e., guar gum (GG), wheat starch (WS), and potato starch (PS), were studied as alternatives. The flexibility and adhesion of the resulting coatings and electrochem. performance was tested. The combination of 75:25 (weight/weight) ratio PS/GG showed a promising performance. Electrodes were characterized by SEM, thermal, adhesion, and bending tests. Their electrochem. properties were determined by cyclic voltammetry, electrochem. impedance spectroscopy, and cycling experiments The PS/GG mixture conformed well to criteria for industrial production, enabling mass loadings higher than CMC (7.0 mg cm-2) while granting the same specific capacitance (26 F g-1) and power performance (20 F g-1 at 10 A g-1). Including the mass of the current collector, this represents a +45% increase in specific energy at the electrode level.

ChemSusChem published new progress about Binders. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Minghui; Wei, Jinli; Huang, Ting; Lei, Luping; Shen, Chenguang; Lai, Jinzhi; Yang, Min; Liu, Lei; Yang, Yang; Liu, Guoshi; Liu, Yingxia published the artcile< Resveratrol inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured Vero cells>, Synthetic Route of 501-36-0 , the main research area is resveratrol inhibition cultured Vero cell SARS CoV replication.

Resveratrol (3,4,5-trihydroxy-trans-stilbene, RES) is a phenolic compound produced by various members of spermatophytes such as grapes, mulberry, and peanuts. RES exhibits capacity to inhibit SARS-CoV-2 infection in the in-vitro cell culture. The results suggest a potential utility of RES as a novel therapy for COVID-19 infection.

Phytotherapy Research published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Erban, Alexander; Fehrle, Ines; Martinez-Seidel, Federico; Brigante, Federico; Mas, Agustin Lucini; Baroni, Veronica; Wunderlin, Daniel; Kopka, Joachim published the artcile< Discovery of food identity markers by metabolomics and machine learning technology>, Electric Literature of 87-73-0, the main research area is Salvia Linum Sesamum food processing marker metabolomics.

Verification of food authenticity establishes consumer trust in food ingredients and components of processed food. Next to genetic or protein markers, chems. are unique identifiers of food components. Non-targeted metabolomics is ideally suited to screen food markers when coupled to efficient data anal. This study explored feasibility of random forest (RF) machine learning, specifically its inherent feature extraction for non-targeted metabolic marker discovery. The distinction of chia, linseed, and sesame that have gained attention as “”superfoods”” served as test case. Chem. fractions of non-processed seeds and of wheat cookies with seed ingredients were profiled. RF technol. classified original seeds unambiguously but appeared overdesigned for material with unique secondary metabolites, like sesamol or rosmarinic acid in the Lamiaceae, chia. Most unique metabolites were diluted or lost during cookie production but RF technol. classified the presence of the seed ingredients in cookies with 6.7% overall error and revealed food processing markers, like 4-hydroxybenzaldehyde for chia and succinic acid monomethylester for linseed additions RF based feature extraction was adequate for difficult classifications but marker selection should not be without human supervision. Combination with alternative data anal. technologies is advised and further testing of a wide range of seeds and food processing methods.

Scientific Reports published new progress about Flax. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian; Sankar, Raman Vijaya; Anjalikrishna, Puthannur K.; Suresh, Cherumuttathu H.; Gunanathan, Chidambaram published the artcile< Catalytic Formal Conjugate Addition: Direct Synthesis of δ-Hydroxynitriles from Nitriles and Allylic Alcohols>, Quality Control of 627-27-0, the main research area is delta hydroxynitrile preparation green chem; nitrile allylic alc selective formal conjugate addition ruthenium catalyst.

Alcs. and nitrile functionalities have widespread applications in biochem. and chem. synthesis. Catalytic transformations involving C-C bond formation relying on unsaturated coupling partners create important pathways for processes in synthetic, material, and medicinal chem. The discovery of a simple and selective coupling of nitriles with allylic alcs. catalyzed by a ruthenium pincer complex is described, which tolerates reactive functional groups such as carbamate, sulfonate, olefin, cyano, and trifluoromethyl-substituted benzyl nitriles. Homo allylic alcs. also provided 1,4-addition products following the isomerization of double bonds. Mechanistic studies supported that the allylic alcs. initially undergo selective oxidation by the catalyst to α,β-unsaturated carbonyl compounds followed by 1,4-conjugate addition of benzyl nitriles catalyzed by a base and subsequent catalytic reduction of carbonyl functionality, leading to the formation of δ-hydroxynitrile products. The catalytic cycle of this tandem process is established by d. functional theory studies. Remarkably, anipamil drug is successfully synthesized using this catalytic protocol. The utility of the δ-hydroxynitrile products in the synthesis of biol. active mols. and their further functionalization are also demonstrated.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jian; Hansen, Thomas; Zhang, Qing-Ju; Liu, De-Yong; Sun, Yao; Yan, Hao; Codee, Jeroen D. C.; Schmidt, Richard R.; Sun, Jian-Song published the artcile< 1-Picolinyl-5-azido Thiosialosides: Versatile Donors for the Stereoselective Construction of Sialyl Linkages>, HPLC of Formula: 4064-06-6, the main research area is glycan sialooligosaccharide preparation sialylation picolinyl azido protected thiosialoside; directing groups; glycan antennae; glycosylation; sialoside; stereoselective sialylation.

With the picolinyl (Pic) group as a C-1 located directing group and N3 as versatile precursor for C5-NH2, a novel 1-Pic-5-N3 thiosialyl donor was designed and synthesized, based on which a new sialylation protocol was established. In comparison to conventional sialylation methods, the new protocol exhibited obvious advantages, including excellent α-stereoselectivity in the absence of a solvent effect, broad substrate scope encompassing the challenging sialyl 8- and 9-hydroxy groups of sialic acid acceptors, flexibility in sialoside derivative synthesis, high temperature tolerance and easy scalability. In particular, the applicability to the synthesis of complex and bioactive N-glycan antennae when combined with the MPEP glycosylation protocol via the “”latent-active”” strategy has been shown. Mechanistically, the excellent α-stereoselectivity of the novel sialylation protocol could be attributed to the dramatic electron-withdrawing effect of the protonated Pic groups, which was supported by control reactions and DFT calculations

Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, HPLC of Formula: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Yanan; Gao, Xudong; Xue, Zihan; Wang, Yajie; Lu, Yangpeng; Zhang, Min; Panichayupakaranant, Pharkphoom; Chen, Haixia published the artcile< Characterization, antioxidant activities, and inhibition on α-glucosidase activity of corn silk polysaccharides obtained by different extraction methods>, HPLC of Formula: 3458-28-4, the main research area is review alpha glucosidase antioxidant polysaccharides extraction; Corn silk; Extraction method; Polysaccharide.

A review. The polysaccharides (CSPw, CSPc, CSPa, and CSPu) were prepared by hot water extraction, acid-assisted extraction, alk.-assisted extraction, and ultrasound-assisted extraction from corn silk, resp. High performance gel permeation chromatog. (HPGPC), fourier-transform IR (FT-IR) spectroscopy, and SEM (SEM) results indicated that the extraction methods had an obvious impact on the mol. weight, structure, and morphol. of the CSPs. Among the four polysaccharides, CSPu showed the highest inhibitory α-glucosidase activity, which might be related to its smaller mol. weight Furthermore, kinetics analyses revealed that CSPu had significant inhibition of α-glucosidase in a non-reversible and competitive manner. Fluorescence quenching anal. illustrated that the interaction mechanism of CSPu and α-glucosidase was claimed as a static quenching mechanism. Isothermal titration calorimetry (ITC) anal. showed that the main driving forces for the interaction of CSPu with α-glucosidase was hydrogen bonding and the binding interactions of them occurred spontaneously.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts