Month: October 2022

Pourhanifeh, Mohammad H.; Shafabakhsh, Rana; Reiter, Russel J.; Asemi, Zatollah published the artcile< The Effect of Resveratrol on Neurodegenerative Disorders: Possible Protective Actions Against Autophagy, Apoptosis, Inflammation and Oxidative Stress>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol neurodegenerative disorder autophagy apoptosis inflammation oxidative stress; Parkinson’s disease; Resveratrol; apoptosis; autophagy; inflammation; oxidative stress..

A review. The prevalence of neurodegenerative disorders characterized by the loss of neuronal function is rapidly increasing. The pathogenesis of the majority of these diseases is not entirely clear, but current evidence has shown the possibility that autophagy, apoptosis, inflammation and oxidative stress are involved. The present review summarizes the therapeutic effects of resveratrol on neurodegenerative disorders, based on the especially mol. biol. of these diseases. The PubMed, Cochrane, Web of Science and Scopus databases were searched for studies published in English until March 30th, 2019 that contained data for the role of inflammation, oxidative stress, angiogenesis and apoptosis in the neurodegenerative disorders. There are also studies documenting the role of mol. processes in the progression of central nervous system diseases. Based on current evidence, resveratrol has potential properties that may reduce cell damage due to inflammation. This polyphenol affects cellular processes, including autophagy and the apoptosis cascade under stressful conditions. Current evidence supports the beneficial effects of resveratrol on the therapy of neurodegenerative disorders.

Current Pharmaceutical Design published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vervandier-Fasseur, Dominique; Latruffe, Norbert published the artcile< The potential use of resveratrol for cancer prevention>, SDS of cas: 501-36-0 , the main research area is review resveratrol anticancer agent cancer; approach strategies; cancer; innovative formulations; mechanisms; prevention; resveratrol.

A review. In addition to the traditional treatments of cancer and cancer prevention, the use of natural compounds, especially those found in food, should be considered. To clarify if resveratrol has the potential for cancer prevention and the possibility of use in therapy, the following must be taken into account: data from epidemiol., clin. protocol (case and control), preclin. studies (lab animals), use of established cell lines as models of cancer cells, test tube assays (enzymes activities), and requirements of nanotechnologies in order to discover new drugs to fight cancer. From this perspective and future expected advances, more information is needed such as improved efficacy, methods of application, and the synergistic sensitization of resveratrol as an adjuvant. In addition, resveratrol nanoformulation is considered to overcome its weak bioavailability.

Molecules published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Daoqian; Lu, Long; Shen, Qilong published the artcile< [Ag(bpy)(PPhtBu2)(OCF3)]: a stable nucleophilic reagent for chemoselective and stereospecific trifluoromethoxylation of secondary alkyl nosylates>, SDS of cas: 6290-03-5, the main research area is alkyl nosylate bipyridyl phosphinyl trifluoromethoxy silver preparation trifluoromethoxylation; trifluoromethoxy alkane enantioselective chemoselective preparation.

The development of a thermally stable and light-insensitive nucleophilic trifluoromethoxylative reagent [Ag(bpy)(PPhtBu2)(OCF3)], which was synthesized in high yields via a three-step one-pot process from easily available trifluoromethyl triflate (TFMT) and AgF at room temperature, was described. The high reactivity of reagent [Ag(bpy)(PPhtBu2)(OCF3)] was demonstrated by its high yielding chemoselective and stereospecific SN2-type trifluoromethoxylation with secondary alkyl nosylates.

Organic Chemistry Frontiers published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, SDS of cas: 6290-03-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghinato, Simone; Dilauro, Giuseppe; Perna, Filippo Maria; Capriati, Vito; Blangetti, Marco; Prandi, Cristina published the artcile< Directed ortho-metalation-nucleophilic acyl substitution strategies in deep eutectic solvents: the organolithium base dictates the chemoselectivity>, Recommanded Product: Triphenylmethanol, the main research area is benzamide preparation chemoselective green chem; diisopropyl arylamide boron compound Suzuki Miyaura cross coupling; electrophile diisopropyl arylamide ortho metalation nucleophilic acyl substitution; alkyl aryl ketone preparation chemoselective; organolithium diisopropyl arylamide nucleophilic acyl substitution.

Directed ortho metalation (DoM) or nucleophilic acyl substitution (SNAc) can be efficiently programmed on the same aromatic carboxylic acid amide RC(O)N(i-Pr)2 (R = Ph, 4-H3COC6H4, 4-ClC6H4, 3-H3CC6H4, 1-methyl-1H-indol-2-yl), in a choline chloride-based eutectic mixture, by simply switching the nature of the organolithium reagent R1Li (R1 = Bu, Me, Ph, hexyl). Telescoped, one-pot ortho-lithiation/Suzuki-Miyaura cross-couplings have also been demonstrated for the first time in deep eutectic solvents.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kasper, Stefan; Foch, Caroline; Messinger, Diethelm; Esser, Regina; Lamy, Francois-Xavier; Rothe, Vivien; Chen, Wenfeng; Cheng, Ann-Lii; Rouyer, Magali; Brodowicz, Thomas; Zielinski, Christoph published the artcile< Noninferiority of cetuximab every-2-weeks versus standard once-weekly administration schedule for the first-line treatment of RAS wild-type metastatic colorectal cancer>, Recommanded Product: Calcium folinate, the main research area is cetuximab anticancer agent RAS metastatic colorectal cancer; Administration schedule; Cetuximab; Metastatic colorectal cancer; Noninferiority; Overall survival; Pooled analysis.

This study assessed whether cetuximab 500 mg/m2 administered every 2 wk (Q2W), when combined with chemotherapy as a first-line (1L) treatment, was noninferior to the approved dose (400 mg/m2 followed by 250 mg/m2 once weekly [Q1W]) for overall survival (OS) in adults with RAS wild-type metastatic colorectal cancer (mCRC).This pooled anal. included patients receiving 1L treatment with cetuximab Q1W or Q2W in combination with chemotherapy from post-authorisation studies with patient-level data available to the sponsor. Baseline characteristics were adjusted with a propensity score using inverse probability of treatment weighting (IPTW). Noninferiority in terms of OS was tested with a noninferiority margin for the hazard ratio (HR) of 1.25 using a Cox proportional hazards regression model. Secondary outcomes were progression-free survival (PFS), overall response rate (ORR) and rates of lung/liver metastases resection and serious adverse events.OS time was noninferior in the Q2W cohort (n = 554) compared to the Q1W cohort (n = 763), with a HR after IPTW (95% confidence interval) of 0.827 (0.715-0.956) and median OS times of 24.7 (Q1W) and 27.9 (Q2W) months. There were no major differences in PFS (HR: 0.915 [0.804-1.042]). The odds ratios (ORs) after IPTW for ORR (1.292 [1.031-1.617]) and the rates of lung/liver metastases resection (1.419 [1.043-1.932]) favored the Q2W regimen. No differences were noted in the occurrence rate of any SAE between groups; the OR after IPTW was 1.089 (0.858-1.382). The cetuximab Q2W regimen was noninferior to the Q1W regimen for OS in the 1L treatment of mCRC.

European Journal of Cancer published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (BRAF). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Qizhen; Pang, Zhengyuan; Liu, Jingwei; Zhou, Yi; Sun, Yang; Yin, Zheng; Lou, Zhiyong published the artcile< Photoaffinity palladium reagents for capture of protein-protein interactions>, HPLC of Formula: 25055-82-7, the main research area is photoaffinity palladium reagent cysteine containing protein interaction.

Protein-protein interactions (PPIs) are indispensable in almost all cellular processes. Probing of complex PPIs provides new insights into the biol. system of interest and paves the way for the development of therapeutics. Herein, the authors report a strategy for the capture of protein-protein interactions using photoaffinity palladium reagents. First, the palladium-mediated reagent site specifically transferred a photoaffinity modified aryl group to the designated cysteine residue. Next, the photoaffinity group was activated by UV radiation to trap the proximal protein residue for the formation of a crosslink. This strategy was used to capture the PYL-ABA-PP2C interaction, which is at the core of the abscisic acid (ABA) signaling pathway. The authors’ results indicated that this palladium-mediated strategy can serve as an alternative for incorporating an increasing number of diverse substrates for protein crosslinking through cysteine modifications and can be explored for use in mapping protein-peptide or protein-protein interaction surfaces and in trapping potential interacting partners.

Organic & Biomolecular Chemistry published new progress about Photocrosslinking. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, HPLC of Formula: 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bowser, Brandon H.; Wang, Shu; Kouznetsova, Tatiana B.; Beech, Haley K.; Olsen, Bradley D.; Rubinstein, Michael; Craig, Stephen L. published the artcile< Single-Event Spectroscopy and Unravelling Kinetics of Covalent Domains Based on Cyclobutane Mechanophores>, COA of Formula: C4H8O, the main research area is spectroscopy unravelling kinetics covalent cyclobutane mechanophore.

Mechanochem. reactions that lead to an increase in polymer contour length have the potential to serve as covalent synthetic mimics of the mech. unfolding of noncovalent “”stored length”” domains in structural proteins. Here we report the force-dependent kinetics of stored length release in a family of covalent domain polymers based on cis-1,2-substituted cyclobutane mechanophores. The stored length is determined by the size (n) of a fused ring in an [n.2.0] bicyclic architecture, and it can be made sufficiently large (>3 nm per event) that individual unravelling events are resolved in both constant-velocity and constant-force single-mol. force spectroscopy (SMFS) experiments Replacing a methylene in the pulling attachment with a Ph group drops the force necessary to achieve rate constants of 1 s-1 from ca. 1970 pN (dialkyl handles) to 630 pN (diaryl handles), and the substituent effect is attributed to a combination of electronic stabilization and mech. leverage effects. In contrast, the kinetics are negligibly perturbed by changes in the amount of stored length. The independent control of unravelling force and extension holds promise as a probe of mol. behavior in polymer networks and for optimizing the behaviors of materials made from covalent domain polymers.

Journal of the American Chemical Society published new progress about Conformers. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miyoshi, Norikazu; Kimura, Shodai; Kubo, Shigeki; Ohmura, Satoshi D.; Ueno, Masaharu published the artcile< Chemoselective Ketone Synthesis by the Strontium-mediated Alkylation or Arylation of N,N-Dimethylamides or Urea>, COA of Formula: C19H16O, the main research area is ketone preparation chemoselective strontium mediated; dimethylamide urea alkyl aryl iodide alkylation arylation.

Ketone synthesis via the addition of organometallic reagents to amides has long been investigated. In many cases, it is necessary to control the solvent, reaction temperature, and adhere to strict nucleophile stoichiometry for each combination of amide and organometallic reagent. Strontium, with an electronegativity comparable to lithium but a larger ionic radius, may display high reactivity with the characteristics of monoalkylation. Here, authors showed that the monoalkylation of various N,N-dimethylamide derivatives with alkyl iodides to afford the ketones proceeds smoothly under generally mild temperature conditions. By this method, not only aromatic amides but also α-proton-bearing aliphatic amides were suitable substrates for ketone synthesis. In addition, It was found that tetramethylurea, typically a poor electrophile, also reacted to afford benzophenone in good yield with excellent selectivity.

Asian Journal of Organic Chemistry published new progress about Alkali metal organometallic compounds Role: FMU (Formation, Unclassified), RGT (Reagent), FORM (Formation, Nonpreparative), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Meng-Juan; Li, Hong-Xi; Young, David J.; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Reaction condition controlled nickel(II)-catalyzed C-C cross-coupling of alcohols>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is nickel cluster catalyst preparation crystal structure; primary secondary alc acceptorless dehydrogenation coupling; aryl alkyl ketone preparation; unsaturated ketone preparation; quinoline preparation.

A controlled approach to a diverse range of β-alkylated secondary alcs., α-alkylated ketones and α,β-unsaturated ketones using the acceptorless dehydrogenation coupling methodol. employing a Ni(II) 4,6-dimethylpyrimidine-2-thiolate cluster catalyst under different reaction conditions was reported. This catalyst could tolerate a wide range of substrates and exhibited a high activity for the annulation reaction of secondary alcs. with 2-aminobenzyl alcs. to yield quinolines. This work is an example of precise chemoselectivity control by careful choice of reaction conditions.

Organic & Biomolecular Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Potrzasaj, Aleksandra; Ociepa, Michal; Chaladaj, Wojciech; Gryko, Dorota published the artcile< Bioinspired Co-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes>, Computed Properties of 627-27-0, the main research area is oxetane radical ring opening regioselective cobalt catalyst.

Oxetanes are valuable building blocks due to their well-explored propensity to underwent ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, authors present a bioinspired cobalt catalysis-based strategy to access unprecedented modes of radical reactivity via oxetane ring opening. This powerful approach give access to nucleophilic radicals that engage in reactions with SOMOphiles and low-valent transition metals. Importantly, the regioselectivity of these processes complements known methodologies.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts