Month: October 2022

Pang, Xueli; Yu, Weisong; Cao, Changdai; Yuan, Xiaoxiang; Qiu, Jun; Kong, Fanyu; Wu, Jihong published the artcile< Comparison of Potent Odorants in Raw and Ripened Pu-Erh Tea Infusions Based on Odor Activity Value Calculation and Multivariate Analysis: Understanding the Role of Pile Fermentation>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is odorant raw ripened Pu erh tea pile fermentation; aroma extract dilution analysis (AEDA); odor active marker; odor activity value (OAV); odor threshold (OT); pu-erh tea infusion.

Infusions prepared from raw pu-erh tea (RAPT) and ripened pu-erh tea (RIPT) showed remarkable aroma differences. Predominant odorants in RAPT and RIPT infusions were identified and compared by the combined use of gas chromatog.-olfactometry, aroma extract dilution anal., odor activity values (OAVs), and multivariate anal. A total of 35 and 19 odorants (OAV > 1) were detected in RIPT and RAPT, resp. Odorants in RAPT and RIPT are significantly different in both odor properties and aroma compound intensities. Overall, RAPT contained a complex variety of chem. classes with diverse odors and moderate odor intensities, while RIPT is dominated by structurally and organoleptically similar compounds with high potency. Specifically, stale and musty smelling methoxybenzenes contributed the most to RIPT, while floral-, sweet-, and woody-smelling terpene alcs., terpene ketones, and phenolic compounds were the predominant odorants in RAPT. Orthogonal partial least squares discriminant anal. revealed that linalool, α-ionone, 1,2,4-trimethoxybenzene, 1,2,3-trimethoxy-5-methylbenzene, 1,2,3,4-tetramethoxybenzene, and 1,2,3-trimethoxybenzene underwent remarkable changes during pile fermentation and could be used as potential odor-active markers for RIPT and RAPT discrimination. The comprehensive aroma characterization of pu-erh tea and determination of the effect of pile fermentation on odorant alteration herein will provide guidance for pu-erh tea flavor quality control and evaluation.

Journal of Agricultural and Food Chemistry published new progress about Fermentation (pile). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Zhuying; Xie, Qigui; Chen, Zhanlei; Ni, Haibin; Xia, Liang; Zhao, Qiufeng; Chen, Zhiyun; Chen, Peifeng published the artcile< Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1-mediated epithelial-to-mesenchymal transition>, Application of C14H12O3, the main research area is MALAT EM resveratrol invasion migration human gastric cancer cell; epithelial-to-mesenchymal transition; gastric cancer; invasion; metastasis-associated lung adenocarcinoma transcript 1; migration; resveratrol.

Resveratrol, a natural polyphenolic phytoalexin, was reported to exert multiple anticancer effects as a traditional Chinese medicine. However, research regarding the anticancer mechanism of resveratrol for the treatment and prevention of gastric cancer has reported conflicting results. In the present study, it was determined that resveratrol inhibited cell viability in a dose-dependent manner in the human gastric cancer cell line BGC823. Cell migration and invasion were suppressed significantly following treatment with 200μM resveratrol. Addnl., resveratrol inhibited metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression, which was overexpressed in gastric cancer cells. Further experiments revealed that MALAT1 knockdown suppressed cell viability, migration, invasion and epithelial-to-mesenchymal transition in BGC823 cells. The present study indicated that resveratrol inhibited migration and invasion in human gastric cancer cells via suppressing MALAT1-mediated epithelial-to-mesenchymal transition, providing novel evidence for understanding the anticancer mechanism of resveratrol.

Experimental and Therapeutic Medicine published new progress about Cell invasion. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, M.-Z.; Meng, M.; Duan, S.-Q.; Feng, C.-C.; Wang, C.-L. published the artcile< Structure characterization, physicochemical property and immunomodulatory activity on RAW264.7 cells of a novel triple-helix polysaccharide from Craterellus cornucopioides>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Craterellus macrophage immunomodulation polysaccharide; Chemical structure; Craterellus cornucopioides; Polysaccharide; Stability immunomodulatory activity.

In the study, a new triple-helix polysaccharide with favorable stability was purified from C. cornucopioides. Its structural characterization, stability and solution behavior were investigated by the GC-MS, periodate oxidation-smith degradation, FT-IR, 1D and 2D NMR spectroscopy, methylation anal., Scanning electron microscope, Congo-red, CD, TGA and DSC anal. The results showed that Craterellus cornucopioide polysaccharide (CCP) possessed the mol. weight of 1.97 × 103 kDa, is mainly composed of mannose (48.73%), galactose (17.37%), glucose (15.97%) and xylose (17.93%), resp. It was a heteroglycan with (1 → 3)-linked-β-D-Manp-(1 → 6)-linked a-D-Galp backbone distributed by (1 → 4)-linked-a-D-Xylp-t-a-D-Manp and t-β-D-Glup units at O-6. The result of TGA and DSC assay indicated that CCP has a favorable thermal stability. MTT and Scanning electro microscopy (SEM) assay showed that CCP could significantly improve the proliferation activity and induce cells activation of RAW264.7 in a certain range of concentrations and period.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Guoqi; Wu, Jing; Zheng, Shengping; Neary, Michelle C.; Mao, Jincheng; Flores, Marco; Trovitch, Ryan J.; Dub, Pavel A. published the artcile< Redox-Noninnocent Ligand-Supported Vanadium Catalysts for the Chemoselective Reduction of C=X (X = O, N) Functionalities>, Reference of 403-41-8, the main research area is vanadium ligand catalyst reduction ketone aldehyde imine ester carboxamide.

Catalysis is the second largest application for V after its use as an additive to improve steel production Mol. complexes of vanadium(V) are particularly useful and efficient catalysts for oxidation processes; however, their ability to catalyze reductive transformations has yet to be fully explored. Here the authors report the first examples of polar organic functionality reduction mediated by V. Open-shell VIII complexes that feature a π-radical monoanionic 2,2′:6′,2”-terpyridine ligand (Rtpy•)- functionalized at the 4′-position (R = (CH3)3SiCH2, Ph) catalyze mild and chemoselective hydroboration and hydrosilylation of functionalized ketones, aldehydes, imines, esters, and carboxamides with turnover numbers (TONs) of up to ∼1000 and turnover frequencies (TOFs) of up to ∼500 h-1. Computational evaluation of the precatalyst synthesis and activation revealed underappreciated complexity associated with the redox-active tpy chelate.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Waldie, Sarah; Moulin, Martine; Porcar, Lionel; Pichler, Harald; Strohmeier, Gernot A.; Skoda, Maximilian; Forsyth, V. Trevor; Haertlein, Michael; Maric, Selma; Cardenas, Marite published the artcile< The Production of Matchout-Deuterated Cholesterol and the Study of Bilayer-Cholesterol Interactions>, SDS of cas: 434-16-2, the main research area is cholesterol lipid bilayer small angle neutron scattering MS NMR.

The deuteration of biomols. provides advanced opportunities for neutron scattering studies. For low resolution studies using techniques such as small-angle neutron scattering and neutron reflection, the level of deuteration of a sample can be varied to match the scattering length d. of a specific D2O/H2O solvent mixture This can be of major value in structural studies where specific regions of a complex system can be highlighted, and others rendered invisible. This is especially useful in analyses of the structure and dynamics of membrane components. In mammalian membranes, the presence of cholesterol is crucial in modulating the properties of lipids and in their interaction with proteins. Here, a protocol is described for the production of partially deuterated cholesterol which has a neutron scattering length d. that matches that of 100% D2O solvent (hereby named matchout cholesterol). The level of deuteration was determined by mass spectrometry and NMR. The cholesterol match-point was verified exptl. using small angle neutron scattering. The matchout cholesterol was used to investigate the incorporation of cholesterol in various phosphatidylcholine supported lipid bilayers by neutron reflectometry. The study included both saturated and unsaturated lipids, as well as lipids with varying chain lengths. It was found that cholesterol is distributed asym. within the bilayer, positioned closer to the headgroups of the lipids than to the middle of the tail core, regardless of the phosphatidylcholine species.

Scientific Reports published new progress about Bilayer membranes. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Chun-Wei; Lin, Mei-Huei; Chan, Chieh-Kai; Su, Kuan-Yu; Wu, Chia-Hui; Lo, Wei-Chih; Lam, Sarah; Cheng, Yu-Ting; Liao, Pin-Hsuan; Wong, Chi-Huey; Wang, Cheng-Chung published the artcile< Automated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions>, Name: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is predictive stereoselective glycosylation automated quantification hydroxyl group reactivity; carbohydrates; diastereoselectivity; glycosylation; hydroxyl; predictive algorithms.

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable. We have developed a database of acceptor nucleophilic constants (Aka) to quantify the nucleophilicity of hydroxyl groups in glycosylation influenced by the steric, electronic and structural effects, providing a connection between experiments and computer algorithms. The subtle reactivity differences among the hydroxyl groups on various carbohydrate mols. can be defined by Aka, which is easily accessible by a simple and convenient automation system to assure high reproducibility and accuracy. A diverse range of glycosylation donors and acceptors with well-defined reactivity and promoters were organized and processed by the designed software program “”GlycoComputer”” for prediction of glycosylation reactions without involving sophisticated computational processing. The importance of Aka was further verified by random forest algorithm, and the applicability was tested by the synthesis of a Lewis A skeleton to show that the stereoselectivity and yield can be accurately estimated

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Name: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Zihui; Yang, Hui; Yin, Shuai; Zhang, Jian; Yang, Zhenhua; Yuan, Kedong; Ding, Yi published the artcile< Electrochemical reduction of functionalized carbonyl compounds: enhanced reactivity over tailored nanoporous gold>, Recommanded Product: (4-Ethynylphenyl)methanol, the main research area is reusable nanoporous gold catalyst preparation pore size carbonyl reduction; carbonyl compound diphenylsilane gold nanocatalyst electrochem reduction chemoselective; alc preparation.

The effect of the pore size of nanoporous gold (NPG) on electrochem. reduction of functionalized carbonyl compounds was investigated. NPG with a pore size of ∼30 nm significantly enhanced the reactivity with high chemoselectivity at a low-potential. Typically, p-nitrobenzaldehyde reduction demonstrated a high turnover frequency (TOF) up to 232000 h-1.

Nanoscale published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Recommanded Product: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Jiabin; Cui, Chuanguo; Xiao, Zhiyin; Zhong, Wei; Lu, Chunxin; Jiang, Xiujuan; Li, Xueming; Liu, Xiaoming published the artcile< Iron(0) tricarbonyl η4-1-azadiene complexes and their catalytic performance in the hydroboration of ketones, aldehydes and aldimines via a non-iron hydride pathway>, Product Details of C8H9FO, the main research area is iron tricarbonyl azadiene hydroboration catalyst ketone aldehyde aldimine mechanism; crystal structure mol iron tricarbonyl azadiene complex preparation protonation.

Six iron(0) tricarbonyl complexes (1a-f) with a η4-1-azadiene moiety were prepared and their performance in the hydroboration of unsaturated organic compounds was investigated. All the complexes exhibit catalytic activity towards hydroboration of ketones, aldehydes and aldimines with pinacolborane (HBpin) as a hydride source to lead to secondary alcs., primary alcs., and secondary amines, resp., after hydrolysis of the hydroboration products. Of the iron(0) tricarbonyl complexes, complex 1e is the most robust one and was employed throughout the catalytic investigation. Its preference towards the three types of substrates is as follows: aldimines > aldehydes ≫ ketones. In total, 24 substrates were examined for the catalytic hydroboration reactivity and generally, isolation yields ranging from 40% to 95% were achieved. Mechanistic investigation suggests that the catalytic hydroboration of the substrates proceeds via intramol. hydride transfer without going through an Fe-H intermediate. As indicated by 1H NMR spectroscopic monitoring, the substrates and the borane agent bind to the iron center and the imine N atom, resp., which facilitates the hydride transfer by activating the B-H bond and polarizing the double bond of the substrates.

Dalton Transactions published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Product Details of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Shuang-Jiang; Yu, Jie; Yan, Da-Wei; Wang, Da-Cheng; Gao, Jin-Ming; Zhang, Qiang published the artcile< Meroterpene-like compounds derived from β-caryophyllene as potent α-glucosidase inhibitors>, Formula: C8H6O5, the main research area is meroterpene derivative preparation beta caryophyllene glucosidase inhibitor antidiabetic agent.

Meroterpenoids isolated from guava (Psidium guajava) and Rhodomyrtus tomentosa possess special skeletons which incorporate terpenoids with phloroglucinol derivatives Most of these meroterpenoids showed high cytotoxicity against cancer cell lines. However, their chem. diversity is very limited. Here, we employed a biomimetic hetero-cycloaddition starting from ortho-quinone methides and an abundant natural product, β-caryophyllene, to generate meroterpene-like compounds Considering that the source plant has hyperglycemic functions, α-glucosidase was selected as a target for bioassay. Nine compounds were screened out for promising activities (IC50 < 15 μM), which were better than the pos. controls, genistein and acarbose. The best inhibitor 12 (IC50 = 2.73 μM) possessed 2 caryophyllene moieties. They represented a new type of skeleton possessing activities against α-glucosidase. The kinetic study exhibited that these inhibitors belong to a non-competitive type. All of these inhibitors may provide an opportunity to develop a new class of antidiabetic agents. Organic & Biomolecular Chemistry published new progress about Antidiabetic agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mondal, Akash; Sahoo, Manoj Kumar; Subaramanian, Murugan; Balaraman, Ekambaram published the artcile< Manganese(I)-Catalyzed Sustainable Synthesis of Quinoxaline and Quinazoline Derivatives with the Liberation of Dihydrogen>, Application of C7H9NO, the main research area is manganese catalyzed sustainable synthesis quinoxaline quinazoline derivative dehydrogenative coupling.

Direct synthesis of N-heterocycles via the acceptorless dehydrogenative coupling is very challenging and scarcely reported under 3d transition-metal catalysis. Here, we have developed an efficient Mn(I)-catalyzed sustainable synthesis of various quinoxalines from 1,2-diaminobenzenes and 1,2-diols via the acceptorless dehydrogenative coupling reaction. Further, this strategy was successfully applied for the unprecedented synthesis of quinazolines by the reaction of 2-aminobenzyl alc. with primary amides. The present protocol provides an atom-economical and sustainable route for the synthesis of various quinoxaline and quinazoline derivatives by employing an earth-abundant manganese salt and simple phosphine-free NNN-tridentate ligand.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts