Month: October 2022

Zhou, Qingqing; Xu, Beibei; Tang, Xuan; Dai, Sheng; Ding, Bingjie; Li, Difan; Zheng, Anna; Zhang, Tong; Yao, Yefeng; Gong, Xueqing; Hou, Zhenshan published the artcile< Role of Organic Fluoride Salts in Stabilizing Niobium Oxo-Clusters Catalyzing Epoxidation>, Reference of 627-27-0, the main research area is organic fluoride salt stabilizing niobium Oxo Clusters catalyst epoxidation.

Easily available organic salts can stabilize/modify niobium (Nb) oxo-clusters. The as-synthesized Nb oxo-clusters have been characterized by various methods. These Nb oxo-clusters were catalytically active for the epoxidation of allylic alcs. and olefins with H2O2 as an oxidant. Notably, [email protected] appeared as highly dispersed nanosized particles and showed the highest catalytic activity, which can be attributed to the following reasons on the basis of characterization. First, the strong coordination of fluorine ions with Nb sites and the steric protection with bulky organic cations led to high stabilization and dispersion of the oxo-clusters in the course of the reaction. Second, a hydrogen-bond interaction between the coordinated fluorine atom and the -OH group of allylic alc. favored the epoxidation reaction. Third, the electron d. of Nb sites decreased due to the strong electron-withdrawing ability of F- adjacent to Nb sites, thus promoting the electrophilic oxygen transfer to the C=C bond.

Langmuir published new progress about Epoxidation catalysts. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Youngjin; Jo, HyunA; Cho, Jae Hyun; Dhanasekaran, Danny N.; Song, Yong Sang published the artcile< Resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer>, Electric Literature of 501-36-0, the main research area is review resveratrol anticancer tumor microenvironment hypoxia oxidative stress cancer; cancer; chemoresistance; metastasis; resveratrol; tumor microenvironment.

A review. Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.

International Journal of Molecular Sciences published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Pengkang; Ren, Bo; Wang, Xiaochang C.; Jin, Xin; Shi, Xuan published the artcile< Mechanism of microbial metabolic responses and ecological system conversion under different nitrogen conditions in sewers>, Synthetic Route of 76-84-6, the main research area is microbial metabolic responses ecol system nitrogen condition sewer; Ecological system; Functional bioconversion; Metabolization response; Nitrogen source; Urban sewer system.

However, the mechanisms underlying the involvement of nitrogen-associated pollutants in sewer ecosystems remain unknown. In this study, the effects of two typical nitrogen ratios (organic/inorganic nitrogen: 7/3 (Group A) and 3/7 (Group B)) on carbon, nitrogen, and sulfur bioconversions were investigated in a pilot sewer. The distribution of amino acids, such as proline, glycine and methionine, was significantly different between Groups A and B, and carbon-associated communities (based on 16S rRNA gene copies) were more prevalent in Group A, while sulfur and nitrogen-associated communities were more prevalent in Group B. To explore the effect of nitrogen on microbial response mechanisms, metagenomics-based methods were used to investigate the roles of amino acids involved in carbon, nitrogen, and sulfur bioconversion in sewers. Proline, glycine, and tyrosine in Group A promoted the expression of genes associated with cell membrane transport and increased the rate of protein synthesis, which stimulated the enrichment of carbon-associated communities. The transmembrane transport of higher concentrations of alanine and methionine in Group B was essential for cell metabolism and nutrient transport, thereby enriching nitrogen and sulfur-associated communities. In this investigation, insights into carbon, nitrogen and sulfur bioconversions in sewer ecosystems were revealed, significantly improving the understanding of the sewer ecosystem within a community context.

Water Research published new progress about Acidithiobacillus. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bueno Duarte, Gustavo Henrique; de Piloto Fernandes, Anna Maria Alves; Silva, Alex Aparecido Rosini; Zamora-Obando, Hans R.; Amaral, Alan Goncalves; de Sousa Mesquita, Alessandra; Schmidt-Filho, Jayr; Cordeiro de Lima, Vladmir C.; D’Almeida Costa, Felipe; Andrade, Victor Piana; Porcari, Andreia M.; Eberlin, Marcos Nogueira; Simionato, Ana Valeria Colnaghi published the artcile< Gas chromatography-mass spectrometry untargeted profiling of non-Hodgkin's lymphoma urinary metabolite markers>, Formula: C6H10O8, the main research area is gas chromatog mass spectrometry non Hodgkin lymphoma metabolomic biomarker; Biomarkers; Gas chromatography-mass spectrometry; Metabolomics; Non-Hodgkin’s lymphoma.

Abstract: Non-Hodgkin’s lymphoma (NHL) is a cancer of the lymphatic system where the lymphoid and hematopoietic tissues are infiltrated by malignant neoplasms of B, T, and natural killer lymphocytes. Effective and less invasive methods for NHL screening are urgently needed. Herein, we report an untargeted gas chromatog.-mass spectrometry (GC-MS) method to investigate metabolic changes in non-volatile derivatized compounds from urine samples of NHL patients (N = 15) and compare them to healthy controls (N = 34). Uni- and multivariate data anal. showed 18 endogenous metabolites, including amino acids and their metabolites, sugars, small organic acids, and vitamins, as statistically significant for group differentiation. A receiver operating characteristic curve (ROC) generated from a support vector machine (SVM) algorithm-based model achieved 0.998 of predictive accuracy, displaying the potential and relevance of GC-MS-detected urinary non-volatile compounds for predictive purposes. Furthermore, a specific panel of key metabolites was also evaluated, showing similar results. All in all, our results indicate that this robust GC-MS method is an effective screening tool for NHL diagnosis and it is able to highlight different pathways of the disease.

Analytical and Bioanalytical Chemistry published new progress about Cancer diagnosis. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiel, Andreas; Sauer, Daniel F.; Markel, Ulrich; Mertens, M. A. Stephanie; Polen, Tino; Schwaneberg, Ulrich; Okuda, Jun published the artcile< An artificial ruthenium-containing β-barrel protein for alkene-alkyne coupling reaction>, SDS of cas: 627-27-0, the main research area is ruthenium barrel protein preparation alkene alkyne coupling catalyst regioselective.

A modified Cp*Ru complex, equipped with a maleimide group, was covalently attached to a cysteine of an engineered variant of Ferric hydroxamate uptake protein component: A (FhuA). This synthetic metalloprotein catalyzed the intermol. alkene-alkyne coupling of 3-butenol with 5-hexynenitrile. When compared with the protein-free Cp*Ru catalyst, the biohybrid catalyst produced the linear product with higher regioselectivity.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ceballos, Francisco C.; Virseda-Berdices, Ana; Resino, Salvador; Ryan, Pablo; Martinez-Gonzalez, Oscar; Perez-Garcia, Felipe; Martin-Vicente, Maria; Brochado-Kith, Oscar; Blancas, Rafael; Bartolome-Sanchez, Sofia; Vidal-Alcantara, Erick Joan; Alboniga-Diez, Oihane Elena; Cuadros-Gonzalez, Juan; Blanca-Lopez, Natalia; Martinez, Isidoro; Martinez-Acitores, Ignacio Ramirez; Barbas, Coral; Fernandez-Rodriguez, Amanda; Jimenez-Sousa, Maria Angeles published the artcile< Metabolic profiling at COVID-19 onset shows disease severity and sex-specific dysregulation>, Formula: C6H10O8, the main research area is metabolic profiling COVID 19 disease severity sex specific dysregulation; COVID-19; Spanish hospitals; disease onset; metabolomics; severity; sex-specific.

Metabolic changes through SARS-CoV-2 infection has been reported but not fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 and its early detection can be used as a prognosis marker of severity. Therefore, we aimed to characterize metabolic and cytokine profile at COVID-19 onset and its relationship with disease severity to identify metabolic profiles predicting disease progression. We performed a retrospective cross-sectional study in 123 COVID-19 patients which were stratified as asymptomatic/mild, moderate and severe according to the highest COVID-19 severity status, and a group of healthy controls. We performed an untargeted plasma metabolic profiling (gas chromatog. and capillary electrophoresis-mass spectrometry (GC and CE-MS)) and cytokine evaluation. After data filtering and identification we observed 105 metabolites dysregulated (66 GC-MS and 40 CE-MS) which shown different expression patterns for each COVID-19 severity status. These metabolites belonged to different metabolic pathways including amino acid, energy, and nitrogen metabolism among others. Severity-specific metabolic dysregulation was observed, as an increased transformation of L-tryptophan into L-kynurenine. Thus, metabolic profiling at hospital admission differentiate between severe and moderate patients in the later phase of worse evolution. Several plasma pro-inflammatory biomarkers showed significant correlation with deregulated metabolites, specially with L-kynurenine and L-tryptophan. Finally, we describe a strong sex-related dysregulation of metabolites, cytokines and chemokines between severe and moderate patients. In conclusion, metabolic profiling of COVID-19 patients at disease onset is a powerful tool to unravel the SARS-CoV-2 mol. pathogenesis. This technique makes it possible to identify metabolic phenoconversion that predicts disease progression and explains the pronounced pathogenesis differences between sexes.

Frontiers in Immunology published new progress about COVID-19. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kulyk, Dmytro S.; Wan, Qiongqiong; Sahraeian, Taghi; Badu-Tawiah, Abraham K. published the artcile< Dehydration of gas-phase benzyl amine alcohols studied at atmospheric pressure>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is benzyl alc dehydration mechanism mass spectrum.

Gas-phase ion chem. is a useful approach for the investigation of phys. organic chem. and the study of reactivity, structure, and thermochem. properties of ionic and neutral organic substrates. Herein, one-step dehydration of gas-phase benzyl amine alcs. to give benzazetidines was discovered without the use of catalysts. Mechanistic investigations of the gas-phase dehydration reactions were explored to study the possible influence of charged microdroplet acceleration during electrospray ionization (ESI) and collisions occurring during ion transfer through the atm. pressure interface (API) of the mass spectrometer. The product ion distribution was observed to be less sensitive to droplet effects (spray distance and voltage), and temperature of transfer capillary in the API. However, the product ion distribution exhibit high sensitivity to different S-lens radio frequency (RF) voltage of the API, providing evidence that the dehydration reaction is driven by collisions during ion transfer in the API. With this insight, we developed atm. pressure thermal dissociation platform that allowed thermal-induced collisions outside of the mass spectrometer when the benzyl amine alcs. are carried through a heated coiled tube. Up to 98% dissociation efficiency was achieved with the coiled tube heated to a temperature of 200°C, yielding only the desired benzazetidine product. By performing the atm. pressure thermal dissociation experiment outside of the mass spectrometer, we believe it will be straightforward to collect the dehydration product.

International Journal of Mass Spectrometry published new progress about Atmospheric chemistry. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Juyeol; Kang, Soyeong; Kim, Jungjoon; Moon, Dohyun; Rhee, Young Ho published the artcile< A Convergent Synthetic Strategy towards Oligosaccharides containing 2,3,6-Trideoxypyranoglycosides>, Formula: C12H20O6, the main research area is palladium catalyst ring closure metathesis oligosaccharide preparation crystal structure; oligosaccharide deoxypyranoglycoside preparation stereoselective hydroalkoxylation alkoxyallene; asymmetric synthesis; carbohydrates; diastereoselectivity; oligosaccharides; palladium.

A de novo synthetic strategy for the production of oligosaccharides containing 2,3,6-trideoxypyranoglycoside is reported. The key event is the Pd-catalyzed asym. diastereoselective hydroalkoxylation of ene-alkoxyallene-linked glycosidic fragments. The utility of this approach was demonstrated by the activation-free, stereo-divergent, and convergent synthesis of various 2-deoxyoligosaccharides, as well as their aglycon conjugates.

Angewandte Chemie, International Edition published new progress about Cross-metathesis. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yin, Shenyi; Xi, Ruibin; Wu, Aiwen; Wang, Shu; Li, Yingjie; Wang, Chaobin; Tang, Lei; Xia, Yuchao; Yang, Di; Li, Juan; Ye, Buqing; Yu, Ying; Wang, Junyi; Zhang, Hanshuo; Ren, Fei; Zhang, Yuanyuan; Shen, Danhua; Wang, Lin; Ying, Xiangji; Li, Zhongwu; Bu, Zhaode; Ji, Xin; Gao, Xiangyu; Jia, Yongning; Jia, Ziyu; Li, Nan; Li, Ziyu; Ji, Jia-Fu; Xi, Jianzhong Jeff published the artcile< Patient-derived tumor-like cell clusters for drug testing in cancer therapy>, Recommanded Product: Calcium folinate, the main research area is gastric colorectal breast cancer recurrence metastases.

Several patient-derived tumor models emerged recently as robust preclin. drug-testing platforms. However, their potential to guide clin. therapy remained unclear. Here, we report a model called patient-derived tumor-like cell clusters (PTCs). PTCs result from the self-assembly and proliferation of primary epithelial, fibroblast, and immune cells, which structurally and functionally recapitulate original tumors. PTCs enabled us to accomplish personalized drug testing within 2 wk after obtaining the tumor samples. The defined culture conditions and drug concentrations in the PTC model facilitate its clin. application in precision oncol. PTC tests of 59 patients with gastric, colorectal, or breast cancers revealed an overall accuracy of 93% in predicting their clin. outcomes. We implemented PTC to guide chemotherapy selection for a patient with mucinous rectal adenocarcinoma who experienced recurrence with metastases after conventional therapy. After three cycles of a nonconventional therapy identified by the PTC, the patient showed a pos. response. These findings need to be validated in larger clin. trials, but they suggest that the PTC model could be prospectively implemented in clin. decision-making for therapy selection.

Science Translational Medicine published new progress about Allele frequency. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Recommanded Product: Calcium folinate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaurasia, Shivkumar R.; Tiwari, Abhishek R.; Bhanage, Bhalchandra M. published the artcile< Synthesis of quinolines via acceptorless dehydrogenative tandem cyclization of 2-amionbenzyl alcohol with alcohols using magnetic CuNiFeO nanocatalyst>, Related Products of 5344-90-1, the main research area is copper nickel iron oxide catalyst preparation surface structure; aminobenzyl alc hydroxy compound CuNiFeO catalyst dehydrogenative tandem heterocyclization; quinoline preparation green chem.

The preparation of nano CuNiFeO and its application in the synthesis of quinolines was reported. The prepared nanocatalyst was characterized using various characterization techniques such as XRD, FEG-SEM, EDX, HR-TEM and XPS. Nano CuNiFeO as a heterogeneous catalyst showed a very high efficiency towards double dehydrogenation tandem cyclization reaction of 2-amionbenzyl alc. with alcs. resulting into a simple, sustainable and environment friendly synthesis of quinolines. Due to the magnetic property associated with nanocatalyst, it was easily separated from the reaction mixture using external magnet and could be reused up to five cycles. To the best of our knowledge, this is for the first time a heterogenous magnetic CuNiFeO nanocatalyst was being reported for this reaction.

Molecular Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Related Products of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts