Month: October 2022

Zhao, Hang; Song, An; Zhang, Yunjia; Shu, Linyi; Song, Guangyao; Ma, Huijuan published the artcile< Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis>, Application In Synthesis of 501-36-0 , the main research area is meta analysis resveratrol lipid type 2 diabetes.

Objective : Few studies have considered the effect of resveratrol on blood lipid levels, and the results of these studies are inconsistent. In this study, the first meta-anal. on the effect of resveratrol on blood lipid levels in patients with type 2 diabetes was conducted. Methods : This study used keywords such as type 2 diabetes, total cholesterol, triglyceride (TG), high-d. lipoprotein, low-d. lipoprotein, and resveratrol and their abbreviations, free words, and related words to search PubMed, Cochrane Library, and Embase. The Cochrane risk of bias tool was used to evaluate the risk of bias, and Review Manager 5.3 and Stata 13.0 were used for data merging and statistical anal. Results : Ten randomized controlled trials involving a total of 363 patients with type 2 diabetes were included in the anal. The results show that longer resveratrol intervention time (≥6 mo) can reduce TG levels. But resveratrol increased total cholesterol in patients within obesity range. In type 2 diabetes patients with obesity and in those who took lipid-lowering drugs, resveratrol increased low-d. lipoprotein levels. Conclusions : Resveratrol can improve TG in patients with type 2 diabetes.

Obesity published new progress about High-density lipoproteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ullah, Shafi; Khan, Shafi Ullah; Khan, Abbas; Junaid, Muhammad; Rafiq, Humaira; Htar, Thet Thet; Zhao, Yaxue; Shah, Syed Adnan Ali; Wadood, Abdul published the artcile< Prospect of Anterior Gradient 2 homodimer inhibition via repurposing FDA-approved drugs using structure-based virtual screening>, Related Products of 6054-98-4, the main research area is anterior Gradient homodimer inhibition FDA approved drug structure screening; AGR2 homodimer; Cancer; Dimer inhibitor; Drug repositioning; Virtual screening.

Anterior Gradient 2 (AGR2) has recently been reported as a tumor biomarker in various cancers, i.e., breast, prostate and lung cancer. Predominantly, AGR2 exists as a homodimer via a dimerization domain (E60-K64); after it is self-dimerized, it helps FGF2 and VEGF to homo-dimerize and promotes the angiogenesis and the invasion of vascular endothelial cells and fibroblasts. Up till now, no small mol. has been discovered to inhibit the AGR2-AGR2 homodimer. Therefore, the present study was performed to prepare a validated 3D structure of AGR2 by homol. modeling and discover a small mol. by screening the FDA-approved drugs library on AGR2 homodimer as a target protein. Thirteen different homol. models of AGR2 were generated based on different templates which were narrowed down to 5 quality models sorted by their overall Z-scores. The top homol. model based on PDB ID = 3PH9 was selected having the best Z-score and was further assessed by Verify-3D, ERRAT and RAMPAGE anal. Structure-based virtual screening narrowed down the large library of FDA-approved drugs to ten potential AGR2-AGR2 homodimer inhibitors having FRED score lower than – 7.8 kcal/mol in which the top 5 drugs’ binding stability was counter-validated by mol. dynamic simulation. To sum up, the present study prepared a validated 3D structure of AGR2 and, for the first time reported the discovery of 5 FDA-approved drugs to inhibit AGR2-AGR2 homodimer by using structure-based virtual screening. Moreover, the binding of the top 5 hits with AGR2 was also validated by mol. dynamic simulation. A validated 3D structure of Anterior Gradient 2 (AGR2) was prepared by homol. modeling, which was used in virtual screening of FDA-approved drugs library for the discovery of prospective inhibitors of AGR2-AGR2 homodimer.

Molecular Diversity published new progress about Anterior gradient protein 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Related Products of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ananiadou, Antonela; Papamokos, George; Steinhart, Martin; Floudas, George published the artcile< Effect of confinement on the dynamics of 1-propanol and other monohydroxy alcohols>, HPLC of Formula: 104-76-7, the main research area is monohydroxy alc dynamic confinement.

We report the effect of confinement on the dynamics of three monohydroxy alcs. (1-propanol, 2-ethyl-1-hexanol, and 4-methyl-3-heptanol) differing in their chem. structure and, consequently, in the dielec. strength of the “”Debye”” process. D. functional theory calculations in bulk 1-propanol identified both linear and ring-like associations composed of up to five repeat units. The simulation results revealed that the ring structures, with a low dipole moment (∼2 D), are energetically preferred over the linear assemblies with a dipole moment of 2.18 D per repeat unit. Under confinement in nanoporous alumina (in templates with pore diameters ranging from 400 to 20 nm), all dynamic processes were found to speed up irresp. of the mol. architecture. The characteristic freezing temperatures of the α and the Debye-like processes followed the pore size dependence: Ta,D = Tbulka,D – A/d1/2, where d is the pore diameter The characteristic “”freezing”” temperatures for the Debye-like (the slow process for confined 1-propanol is non-Debye) and the α-processes decrease, resp., by 6.5 and 13 K in confined 1-propanol, by 9.5 and 19 K in confined 2-ethyl-1-hexanol, and by 9 and 23 K in confined 4-methyl-3-heptanol within the same 25 nm pores. In 2-ethyl-1-hexanol, confinement reduced the number of linearly associated repeats from approx. heptamers in the bulk to dimers within 25 pores. In addition, the slower process in bulk 2-ethyl-1-hexanol and 4-methyl-3-heptanol, where the signal is dominated by ring-like supramol. assemblies, is clearly non-Debye. The results suggest that the effect of confinement is dominant in the latter assemblies. (c) 2021 American Institute of Physics.

Journal of Chemical Physics published new progress about Alcohols Role: PRP (Properties). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pasquariello, Rolando; Verdile, Nicole; Brevini, Tiziana A. L.; Gandolfi, Fulvio; Boiti, Cristiano; Zerani, Massimo; Maranesi, Margherita published the artcile< The role of resveratrol in mammalian reproduction>, Formula: C14H12O3, the main research area is review resveratrol polyphenol female male reproduction; cryopreservation; oocyte quality; ovary function; phytoestrogens; polyphenols; reproduction; sirtuin; sperm quality; spermatozoa; testis function.

A review. Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function.

Molecules published new progress about Anti-apoptotic agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Silva, Lorena Mara A.; Filho, Elenilson G. Alves; Rodrigues, Tigressa Helena S.; Louredo, Francisca Jamila C.; Zocolo, Guilherme J.; Canuto, Kirley M.; Mikich, Sandra B.; Liebsch, Dieter; De Almeida, Adriana; De Brito, Edy S. published the artcile< Metabolomic Profiling of Phloem Sap from Different Pine Species and Implications on Black Capuchin>, Computed Properties of 492-62-6, the main research area is metabolomic phloem sap monosaccharide pine specie animal plant interaction; Capuchin monkey; Data fusion; NMR; Phloem sap; SPME–GC–MS.

In most com. pine farms in southern Brazil, black capuchin causes damage to wood and financial losses when it removes bark from some pine species to feed upon underlying vascular tissues. Therefore, this study aimed to evaluate the variability of the primary metabolites of phloem saps from 10 different species of pine by NMR spectroscopy, as well as the aroma compounds using SPME-GC-MS. Each technique provided a different set of metabolites that we can correlate to monkey predilection. The PCA showed monosaccharide (detected by NMR) and α-pinene (pine-like and resinous flavor descriptors) as attractive compounds for monkeys. On the other hand, the low content of monosaccharide and the high content of β-phellandrene (citrus odor descriptor) was observed in less attacked pine species (P. patula). The data fusion on primary metabolites and aroma compounds corroborated the individual analyses, complementing the comprehension of the monkey predilection. Thus, P. elliottii was an avoided tree even with high content of sugars possibly due to its high content of β-phellandrene (citrus odor). The results are useful for further behavioral studies to determine the role that each highlighted metabolite plays in chem. mediated animal-plant interactions.

Journal of Chemical Ecology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Upadhyaya, Kapil; Bagul, Rahul S.; Crich, David published the artcile< Influence of Configuration at the 4- and 6-Positions on the Conformation and Anomeric Reactivity and Selectivity of 7-Deoxyheptopyranosyl Donors: Discovery of a Highly Equatorially Selective L-glycero-D-gluco-Heptopyranosyl Donor>, Formula: C12H20O6, the main research area is structure property stereoselective glycosylation glycoside disaccharide preparation; nucleophilic substitution hydrogen bonding glycosyl triflate neuraminic ulosonic acid; stereoselective glycosylation glycoside preparation configuration conformation deoxyheptopyranosyl disaccharide NMR.

The preparation of four per-O-benzyl-D- or L-glycero-D-galacto and D- or L-glycero-D-gluco heptopyranosyl sulfoxides and the influence of their side-chain conformations on reactivity and stereoselectivity in glycosylation reactions are described. The side-chain conformation in these donors is determined by the relative configuration of its point of attachment to the pyranoside ring and the two flanking centers in agreement with a recent model. In the D- and L-glycero-D-galacto glycosyl donors, the D-glycero-D-galacto isomer with the more electron-withdrawing trans,gauche conformation of its side chain was the more equatorially selective isomer. In the D- and L-glycero-D-gluco glycosyl donors, the L-glycero-D-gluco isomer with the least disarming gauche-gauche side-chain conformation was the most equatorially selective donor. Variable temperature NMR studies, while supporting the formation of intermediate glycosyl triflates at -80°C in all cases, were inconclusive owing to a change in the decomposition mechanism with the change in configuration. It is suggested that the equatorial selectivity of the L-glycero-D-gluco isomer arises from H-bonding between the glycosyl acceptor and O6 of the donor, which is poised to deliver the acceptor anti-periplanar to the glycosyl triflate, resulting in a high degree of SN2 character in the displacement reaction.

Journal of Organic Chemistry published new progress about Conformation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arslan, Burcu; Gulcemal, Suleyman published the artcile< α-Alkylation of arylacetonitriles with primary alcohols catalyzed by backbone modified N-heterocyclic carbene iridium(I) complexes>, Computed Properties of 5344-90-1, the main research area is nitrogen heterocyclic carbene iridium complex preparation; aryl arylpropanenitrile preparation; arylquinolin amines preparation; arylacetonitrile alc alpha alkylation catalyst nitrogen heterocyclic carbene iridium.

A series of backbone-modified N-heterocyclic carbene (NHC) complexes of iridium(I) I [Ar = 4-MeOC6H4; Y = X = Ph, 4-MeOC6H4; YX = HC=CHCH=CH] had been synthesized and characterized. The electronic properties of the NHC ligands had been assessed by comparison of the IR carbonyl stretching frequencies of the in situ prepared [IrCl(CO)2(NHC)] complexes in CH2Cl2. These new complexes I [Ar = Ph, 4-CF3C6H4, 4-MeOC6H4; Y = X = H], together with previously prepared I [Ar = 4-MeOC6H4; Y = X = Ph, 4-MeOC6H4; YX = HC=CHCH=CH], were applied as catalysts for the α-alkylation of arylacetonitriles with an equimolar amount of primary alcs. or 2-aminobenzyl alc. The catalytic activities of these complexes I [Ar = Ph, 4-CF3C6H4, 4-MeOC6H4; Y = X = H, Ph, 4-MeOC6H4; YX = HC=CHCH=CH] could be controlled by modifying the N-substituents and backbone of the NHC ligands. The NHC-IrI complex I [Ar = Y = X = 4-MeOC6H4] bearing 4-methoxybenzyl substituents on the N-atoms and 4-methoxyphenyl groups at the 4,5-positions of imidazole exhibited the highest catalytic activity in the α-alkylation of arylacetonitriles with primary alcs. Various α-alkylated nitriles Ar1CH(CN)CH2Ar2 [Ar1 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.; Ar2 = Ph, 2-pyridyl, 4-MeC6H4, etc.] and aminoquinolines II [R = H, Cl, Br, Me, OMe] were obtained in high yields through a borrowing hydrogen pathway by using 0.1 mol% I [Ar = Y = X = 4-MeOC6H4] and a catalytic amount of KOH (5 mol%) under an air atm. within significantly short reaction times.

Dalton Transactions published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Ning; Luo, Zhiwen; Jin, Ming; Sheng, Weiwei; Wang, Han-Tsing; Long, Xinyi; Wu, Yue; Hu, Piaopiao; Xu, Hong; Zhang, Xu published the artcile< Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina>, Related Products of 501-36-0 , the main research area is aging zebrafish; mTOR; mitochondrial dysfunction; mitophagy; resveratrol; retina.

It is currently believed that aging is closely linked with mitochondrial dysfunction, and that resveratrol exhibits anti-aging and neuroprotective effects by improving mitochondrial function, even though the mechanisms are not well defined. This study explored mitochondrial quality (mitochondrial DNA integrity and copy number), mitochondrial function (fusion/fission, mitophagy/autophagy), antioxidant system and activity of the Akt/mTOR and Ampk/Sirt1/Pgc1a pathways, and inflammation in aging zebrafish retinas to identify the probable mechanisms of resveratrol’s anti-aging and neuroprotective effects. mtDNA integrity, mtDNA copy number, mitochondrial fusion regulators, mitophagy, and antioxidant-related genes were all decreased whereas Akt/mTOR activity and inflammation was increased upon aging in zebrafish retinas. Resveratrol was shown to not only increase mitochondrial quality and function, but also to suppress Akt/mTOR activity in zebrafish retinas. These results support the notion that mitochondrial dysfunction and increased Akt/mTOR activity are major players in age-related retinal neuropathy in zebrafish, and demonstrate a trend towards mitochondrial fragmentation in the aging retina. Importantly, resveratrol promoted mitochondrial function, up-regulating Ampk/Sirt1/Pgc1a, and down-regulated Akt/mTOR pathway activity in zebrafish retinas, suggesting that it may be able to prevent age-related oculopathy.

Aging published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Akiyama, Ryo; Sugaya, Mariko; Shinozaki, Hiraku; Yamamoto, Tetsuya published the artcile< NHC-coordinated palladacycle catalyzed 1,2-addition of arylboronates to unactivated ketones>, Name: Triphenylmethanol, the main research area is carbene palladacycle catalyzed addition arylation arylboronate unactivated ketone; tertiary alc preparation; substituted gamma lactone preparation.

Pd catalyzed intermol. 1,2-addition of arylboronate to unactivated ketone was studied. NHC-coordinated palladacycle exhibited catalytic activity for the reactions and provided the corresponding tertiary alcs. and γ,γ-disubstituted γ-lactones in good to excellent yields.

Synthetic Communications published new progress about 1,2-Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ai, Han-Jun; Wang, Hai; Li, Chong-Liang; Wu, Xiao-Feng published the artcile< Rhodium-Catalyzed Carbonylative Coupling of Alkyl Halides with Phenols under Low CO Pressure>, Reference of 699-12-7, the main research area is rhodium catalyst carbonylative coupling alkyl halide phenol carbon monoxide.

A rhodium-catalyzed carbonylative transformation of alkyl halides under low pressure of CO has been developed. This robust catalyst system allows using phenols as the carbonylative coupling partner and, meanwhile, exhibits high functional group tolerance and good chemoselectivity. Substrates even with a large steric hindrance group or multiple reaction sites can be selectively converted into the desired products in good to excellent yields. A gram-scale experiment was performed and delivered an almost quant. amount of the product. Control experiments were performed as well, and a possible reaction mechanism is proposed.

ACS Catalysis published new progress about Coupling reaction (carbonylative). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Reference of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts