Month: October 2022

Podrojkova, Natalia; Patera, Jan; Popescu, Radian; Skoviera, Jan; Orinakova, Renata; Orinak, Andrej published the artcile< Pyrolysis Degradation of Cellulose over Highly Effective ZnO and ZnO-CuO Nanocatalysts>, Recommanded Product: But-3-en-1-ol, the main research area is zinc copper oxide nanocatalyst cellulose pyrolysis degradation.

Pyrolysis of lignocellulosic biomass with the use of appropriative catalysts can lead to the production of high yields of fuels – bio-oils. Here, zinc oxide – copper oxide (ZnO-CuO) nanocatalysts were synthesized by solvothermal synthesis. High-angle annular dark-field imaging scanning transmission electron microscopy (HAADF-STEM), high-resolution transmission electron microscopy (HRTEM), and energy-dispersive X-ray spectroscopy (EDXS) results suggested that ZnO-CuO nanoparticles (D=23±5 nm) exhibit porous nanostructure. The pyrolytic degradation of cellulose using pyrolysis-gas chromatog.-mass spectrometry (Py-GC/MS) unit has been studied over ZnO and ZnO-CuO nanocatalysts at the temperature range 400-800 °C. The activation energy of ZnO-CuO (67.21 and 70.04 kJ/mol) was lower by 30 kJ/mol from the activation energy of clean ZnO and the calculated rate constants showed that the cellulose pyrolytic reaction is faster using ZnO-CuO catalyst. Nanoporous ZnO-CuO shifted the products maximum towards lower temperatures (< 500 °C), reduced the content of aldehydes at 400-500 °C and enhanced the overall product composition and bio-oil yield. Porous structure of ZnO nanocatalysts had a significant effect on the product selectivity and reaction mechanism of cellulose pyrolysis. ChemistrySelect published new progress about Acids Role: TEM (Technical or Engineered Material Use), USES (Uses). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bialon, Marietta; Krzysko-lupicka, Teresa; Nowakowska-Bogdan, Ewa; Wieczorek, Piotr P. published the artcile< Chemical composition of two different lavender essential oils and their effect on facial skin microbiota>, Computed Properties of 78-70-6, the main research area is facial skin microbiota; gas chromatography with mass spectrometry; lavender essential oil.

Lavender oil is one of the most valuable aromatherapy oils, its anti-bacterial and anti-fungal activities can be explained by main components such as linalool, linalyl acetate, lavandulol, geraniol, or eucalyptol. The aim of the study was to assess the anti-microbial effects of two different lavender oils on a mixed microbiota from facial skin. The com. lavender oil and essential lavender oil from the Crimean Peninsula, whose chem. composition and activity are yet to be published, were used. Both oils were analyzed by gas chromatog. coupled to mass spectrometry. The composition and properties of studied oils were significantly different. The com. ETJA lavender oil contained 10% more linalool and linalyl acetate than the Crimean lavender oil. Both oils also had different effects on the mixed facial skin microbiota. The Gram-pos. bacilli were more sensitive to ETJA lavender oil, and Gram-neg. bacilli were more sensitive to Crimean lavender oil. However, neither of the tested oils inhibited the growth of Gram-pos. cocci. The tested lavender oils decreased the cell number of the mixed microbiota from facial skin, but ETJA oil showed higher efficiency, probably because it contains higher concentrations of monoterpenoids and monoterpenes than Crimean lavender oil does.

Molecules published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bohigues, Benjamin; Rojas-Buzo, Sergio; Moliner, Manuel; Corma, Avelino published the artcile< Coordinatively Unsaturated Hf-MOF-808 Prepared via Hydrothermal Synthesis as a Bifunctional Catalyst for the Tandem N-Alkylation of Amines with Benzyl Alcohol>, Product Details of C9H8O, the main research area is coordinatively unsaturated hafnium MOF808 hydrothermal bifunctional catalyst.

The modulated hydrothermal synthesis (MHT) of an active and selective Hf-MOF-808 material for the N-alkylation reaction of aniline with benzyl alc. under base-free mild reaction conditions is reported. Through kinetic experiments and isotopically labeled NMR spectroscopy studies we have demonstrated that the reaction mechanism occurs via borrowing hydrogen (BH) pathway, in which the alc. dehydrogenation is the limiting step. The high concentration of defective – OH groups generated on the metallic nodes through MHT synthesis enhances the alc. activation, while the unsaturated Hf4+,which acts as Lewis acid site, is able to borrow the hydrogen from the methylene position of benzyl alc. This fact makes this material at least 14 times more active for the N-alkylation reaction than the material obtained via solvothermal synthesis. The methodol. described in this work could be applied to a wide range of aniline and benzyl alc. derivates, showing in all cases high selectivity toward the corresponding N-benzylaniline product. Finally, Hf-MOF-808, which acts as a true heterogeneous catalyst, can be reused at least four consecutive runs without any activity loss.

ACS Sustainable Chemistry & Engineering published new progress about Alkylation. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Product Details of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Passera, Alessandro; Mezzetti, Antonio published the artcile< The Manganese(I)-Catalyzed Asymmetric Transfer Hydrogenation of Ketones: Disclosing the Macrocylic Privilege>, Related Products of 403-41-8, the main research area is chiral aryl alkyl alc synthesis asym transfer hydrogenation acetophenone; ligand designed manganese catalyzed asym transfer hydrogenation acetophenone; alcohols; asymmetric catalysis; hydrogenation; ligand design; manganese.

The bis(carbonyl) manganese(I) complex [Mn(CO)2(ligand)]Br with a chiral (NH)2P2 macrocyclic ligand catalyzes the asym. transfer hydrogenation of polar double bonds with 2-propanol as the hydrogen source. Ketones (43 substrates) are reduced to alcs. in high yields (up to >99%) and with excellent enantioselectivities (90-99% ee). A stereochem. model based on attractive CH-π interactions is proposed.

Angewandte Chemie, International Edition published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kuljiraseth, J.; Wangriya, A.; Malones, J. M. C.; Klysubun, W.; Jitkarnka, S. published the artcile< Synthesis and characterization of AMO LDH-derived mixed oxides with various Mg/Al ratios as acid-basic catalysts for esterification of benzoic acid with 2-ethylhexanol>, SDS of cas: 104-76-7, the main research area is aqueous miscible organic solvent layered double hydroxide esterification; acid base property.

Proven to possess distinguishable phys. and acid-base properties superior to conventional LDHs, aqueous miscible organic solvent-layered double hydroxides (AMO-LDHs) were thus synthesized and used as precursors to prepare the Mg/Al mixed oxide catalysts in this work. The AMO-LDH based oxide catalysts with various ratios of Mg/Al were studied for the chem. and phys. properties and the activity on esterification of benzoic acid with 2-ethylhexanol. The catalysts were characterized using BET, XRD, TGA, and XPS. Moreover, the acid-base properties were studied. As a result, the Mg/Al mixed oxides after calcination at 500 °C still had the clay structure, and were found to possess both acid and base sites. As the Mg/Al ratio increased, the total d. of acid and basic sites decreased. Moreover, the acid-basic strength depended on their phase compositions and coordination number The activity of calcined LDHs catalysts was tested for the esterification of benzoic acid with 2-ethylhexanol, aimed at producing 2-ethylhexyl benzoate as the desired chem. The products were analyzed using GC-MS/TOF. In summary, the conversion of benzoic acid was enhanced significantly using the Mg-Al mixed oxides as the catalysts, owing to the acid-base sites (both Mg2+-O2- and Al3+-O2- pairs) of the catalysts. The catalyst with the Mg/Al ratio of 4:1 can convert 66% benzoic acid to 2-ethylhexyl benzoate. Moreover, the other products were composed of 2-ethylhexanal, 3-heptanone, and 3-heptanol because of acid-base pairs.

Applied Catalysis, B: Environmental published new progress about Acidity. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Xiaolong; Hou, Chunyan; Yan, Yizhe; Shi, Miaomiao; Liu, Yanqi published the artcile< Comparison of structural characterization and antioxidant activity of polysaccharides from jujube (Ziziphus jujuba Mill.) fruit>, Category: alcohols-buliding-blocks, the main research area is Ziziphus fruit polysaccharide antioxidant activity; Antioxidant activities; Jujube; Polysaccharide; Structural characterization.

The aim of this paper was to prepare purified fractions of polysaccharides from jujube (Ziziphus jujuba Mill.) fruit and further compare their structural characteristics and antioxidant activities. Firstly, three purified jujube polysaccharides, named PZMP1, PZMP2 and PZMP3, were successfully prepared by DEAE-Sepharose Fast Flow and Sephacryl S-300 columns. Then, their characteristics were studied and then compared by using chem. testing, high-performance gel permeation chromatog. (HPGPC), gas chromatog. (GC), Fourier transform IR spectroscopy (FT-IR), methylation anal., NMR spectroscopy, X-ray diffraction (XRD), SEM (SEM) and at. force microscopy (AFM). Thereafter, their antioxidant activities were also contrasted. The data achieved demonstrated that the three jujube polysaccharides derived from different adsorption capacity of DEAE-Sepharose Fast Flow and Sephacryl S-300 columns possessed different structural characteristics and antioxidant activity, and with higher galacturonic acid content could exhibit better antioxidant bioactivities, which could provide certain directions for the functional and medicinal purposes development of jujube polysaccharides.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huo, Shuaicong; Kong, Siqi; Zeng, Guang; Feng, Qi; Hao, Zhiqiang; Han, Zhangang; Lin, Jin; Lu, Guo-Liang published the artcile< Efficient access to quinolines and quinazolines by ruthenium complexes catalyzed acceptorless dehydrogenative coupling of 2-aminoarylmethanols with ketones and nitriles>, Safety of (2-Aminophenyl)methanol, the main research area is quinoline preparation; quinazoline preparation; ketone aminoarylmethanol dehydrogenative coupling reaction ruthenium catalyst; nitrile aminoarylmethanol dehydrogenative coupling reaction ruthenium catalyst.

Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alc. ligands, I (R = H, Me; R1 = H, Me, Ph; R2 = Me, Ph) with RuCl3·xH2O in refluxing EtOH afforded the corresponding Ru(III) complexes II, as chlorides, which were well characterized by IR, HR-MS and X-ray single crystal structural determination These Ru complexes II showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols [2-NH2-3-R3-5-R4C6H2CH2OH (R3 = H, Me, Br; R4 = H, F, Cl, Br) and 3-amino-3-phenyl-1-propanol] with ketones [R5C(O)CH3 (R5 = Ph, pyridin-3-yl, thiophen-2-yl, etc.), cycloheptanone and 1,2,3,4-tetrahydronaphthalen-1-one] and nitriles R6CN (R6 = Ph, 3-bromophenyl, thien-2-yl, etc.), giving the quinolines III, IV, V and 2,6-diphenylpyridine and quinazolines VI in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinolines III, IV, V and 2,6-diphenylpyridine and quinazolines VI derivatives by using phosphine-free ligand based Ru catalysts II.

Molecular Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Safety of (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Javid, Ahmad Zare; Hormoznejad, Razie; Yousefimanesh, Hojat Allah; Haghighi-Zadeh, Mohammad Hosein; Zakerkish, Mehrnoosh published the artcile< Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis.>, Synthetic Route of 501-36-0 , the main research area is Antioxidant; Inflammation; Periodontal disease; Resveratrol; Type 2 diabetes mellitus.

BACKGROUND: Diabetes mellitus and periodontal disease are two common and chronic diseases with bidirectional relationship influence public health and quality of life. The aims of this study was to study the impact of resveratrol supplementation in adjunct with non-surgical periodontal therapy on inflammatory, antioxidant, and periodontal markers in patients with type 2 diabetes with periodontal disease. MATERIALS AND METHODS: In this randomized clinical trial, 43 patients with diabetes and chronic periodontitis were randomly allocated into two intervention and control groups receiving either resveratrol supplements or placebo for 4 weeks. Serum levels of interleukin 6 (IL6), tumor necrosis factor α (TNFα), total antioxidant capacity (TAC) and clinical attachment loss (CAL) as the main index of periodontal marker were measured pre-intervention and post-intervention. RESULTS: In the intervention group, the mean serum level of IL6 was reduced significantly (P = 0.039) post-intervention (2.19 ± 1.09 and 1.58 ± 1.06). No significant differences were seen in the mean levels of IL6, TNFα, TAC and CAL between two groups post-intervention. CONCLUSIONS: It is suggested that daily consumption of resveratrol supplement may not change TNFα, TAC and CAL, but it would be beneficial in reducing serum levels of IL6. Therefore, further studies are suggested to investigate the effects of resveratrol supplementation along with NST on periodontal status.

Diabetes & metabolic syndrome published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Beer, Roseri J. A. C.; Boegels, Berry; Schaftenaar, Gijs; Zarzycka, Barbara; Quaedflieg, Peter J. L. M.; van Delft, Floris L.; Nabuurs, Sander B.; Rutjes, Floris P. J. T. published the artcile< Enzyme-Specific Activation versus Leaving Group Ability>, COA of Formula: C5H11NO, the main research area is trypsin catalysis dipeptide synthesis substrate preparation leaving group.

Enzyme-specific activation and the substrate mimetics strategy are effective ways to circumvent the limited substrate recognition often encountered in protease-catalyzed peptide synthesis. A key structural element in both approaches is the guanidinophenyl (OGp) ester, which enables important interactions for affinity and recognition by the enzyme; at least, this is usually the explanation given for its successful application. In this study we show that leaving group ability is of equal or even greater importance. To this end we used both exptl. and computational methods to examine: (1) synthesis of close analogs of OGp, and their evaluation in a dipeptide synthesis assay with trypsin, (2) mol. docking studies to provide insights into the binding mode, and (3) ab initio calculations to evaluate their electronic properties.

ChemBioChem published new progress about Dipeptides Role: BPN (Biosynthetic Preparation), BIOL (Biological Study), PREP (Preparation) (synthesis). 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, COA of Formula: C5H11NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ozturk, Yasin; Gunaydin, Caner; Yalcin, Fatma; Naziroglu, Mustafa; Braidy, Nady published the artcile< Resveratrol enhances apoptotic and oxidant effects of paclitaxel through TRPM2 channel activation in DBTRG glioblastoma cells>, Synthetic Route of 501-36-0, the main research area is .

Numerous studies have reported a strong association between increased production of reactive oxygen species (ROS) and the pathobiol. of several diseases, and cancer in particular. Therefore, manipulation of cellular oxidative stress levels represents an important therapeutic target. Recently, resveratrol (RESV), a naturally occurring phytochem., has been shown to sensitize several cell lines to the anticancer effects of other chemotherapeutic agents, including paclitaxel (PAX). However, the mol. mechanisms of action of RESV through oxidative sensitive TRPM2 channel activation remain unclear. The aim of this study was to evaluate the effect of combination therapy of RESV and PAX on activation of TRPM2 in DBTRG glioblastoma cells. DBTRG cells were divided into four treatment groups: control, RESV (50 μM), PAX (50 μM), and PAX + RESV for 24 h. Our data shows that markers for apoptosis, mitochondrial membrane depolarization and mitochondrial function, intracellular steady-state ROS levels, caspase 3 activity, TRPM2 c.d., and Ca2+ florescence intensity were significantly increased in DBTRG cells following treatment with PAX and RESV, resp., although cell viability was also decreased by these treatments. These biochem. markers were further increased to favor the anticancer effects of PAX in DBTRG cells in combination with RESV. The PAX and RESV-mediated increase in c.d. and Ca2+ florescence intensity was decreased with a TRPM2 blocker. This suggests that for this combination therapy to have a substantial effect on apoptosis and cell viability, the TRPM2 channel must be stimulated.

Oxidative Medicine and Cellular Longevity published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts