Month: October 2022

Tabrizi, Reza; Tamtaji, Omid Reza; Lankarani, Kamran B.; Akbari, Maryam; Dadgostar, Ehsan; Dabbaghmanesh, Mohammad Hossein; Kolahdooz, Fariba; Shamshirian, Amir; Momen-Heravi, Mansooreh; Asemi, Zatollah published the artcile< The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials>, Formula: C14H12O3, the main research area is meta analysis resveratrol antiobesity agent obesity; Resveratrol; meta-analysis; overweight; weight loss.

This systematic review and meta-anal. of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 reports, 36 RCTs were eligible for including to our meta-anal. The pooled results, using random-effects model showed that resveratrol supplementation significantly decreased body weight (SMD = -0.17; 95% CI, -0.33, -0.01; P=0.03; I2: 62.6), body mass index (BMI) (SMD = -0.20; 95% CI, -0.35, -0.05; P=0.01; I2: 60.6), fat mass (SMD = -0.32; 95% CI, -0.62, -0.03; P=0.03; I2: 77.9) and waist circumference (WC) (SMD = -0.42; 95% CI, -0.68, -0.16; P=0.001; I2: 75.2), and significantly increased lean mass (SMD=1.21; 95% CI, 0.75, 1.67; P<0.001; I2: 87.6). We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P=0.40; I2: 85.3) and adiponectin levels (SMD=0.08; 95% CI, -0.39, 0.55; P=0.74; I2: 91.0). Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-anal. demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels. Critical Reviews in Food Science and Nutrition published new progress about Adiponectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dewidar, Assem A.; Sorial, George A. published the artcile< Effect of surfactin on removal of semi-volatile organic compound: Emphasis on enhanced biofiltration performance>, Recommanded Product: 2-Ethylhexan-1-ol, the main research area is surfactin semi volatile organic compound biofiltration; Biosurfactant; Biotrickling filter; Fungi; Semi-volatile organic compound (SVOC); Surfactin.

The performance of a lab-scale biotrickling filter inoculated with a mixed fungal consortium was investigated for the simultaneous abatement of 2-ethylhexanol; a hydrophobic semi-volatile organic compound, and propylene glycol monomethyl ether. The biotrickling filter performance was investigated in the presence of lipopeptide-type biosurfactant, surfactin. The effect of surfactin on the removal efficiency and elimination capacity was examined at stretched inlet loading rates: 1.04 to 15.7 and 3.2-48 g m-3 h-1 of propylene glycol monomethyl ether and 2-ethylhexanol, resp. Seeding the biotrickling filter with 50 mg L-1 of surfactin maintained high and consistent removal efficiencies of propylene glycol monomethyl ether and 2-ethylhexanol up to loading rates of 15.7 and 32 g m-3 h-1, with removal efficiencies of 98.5 and 99%, resp. Once the loading rate of 2-ethylhexanol increased to 48 g m-3 h-1, a substrate inhibition was observed, accompanied by a sudden decrease in removal efficiency from 99.2 to 62.3%. At the same loading rates, the biotrickling filter performance was improved by reseeding 100 mg L-1 of surfactin, hence, reinstated the removal efficiency of 2-ethylhexanol to 92.7% and achieving a maximum elimination capacity of 44.5 g m-3 h-1. This enhanced semi-volatile organic compounduptake rate was further confirmed by a considerable increase in reaction rate constant from 0.005 to 0.017 s-1. A batch study was also conducted at the end of the exptl. run to better understand the correlation between surfactin concentrations and the time-dependent partition coefficient of 2-ethylhexanol. Biofilm microbial community structure revealed relative abundancy of 72 and 28% of Trichoderma asperellum and Fusarium solani, resp. The findings of this study show for the first time that the removal of a semi-volatile organic compd such as 2-ethylhexanol is feasible in the presence of surfactin and hence improving the bioavailability of hydrophobic semi-volatile organic compound

Environmental Research published new progress about Bioavailability. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Recommanded Product: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ozyilmaz, Ali Tuncay; Ozgen, Begum; Celik, Cumali published the artcile< Poly(o-aminobenzyl alcohol) films with and without organic compound on AISI 316 surface; synthesis and the corrosion performances>, Synthetic Route of 5344-90-1, the main research area is aminobenzyl alc organic compound corrosion performance.

In this work, we obtained the anticorrosive properties of polymer films (SS/PABA and SS/PABAORG) synthesized on stainless steel surface by adding an organic substance to aniline derived oaminobenzyl alc. monomer synthesis medium. Firstly, we prepared the polymer coating bath by dissolving 0.15 M o -aminobenzyl alc. monomer in the electrolyte solvent containing acetonitrile and 0.15 M LiClO4. From this bath, poly (o-aminobenzyl alc.) (PABA) film was synthesized in 30 segments by cyclic voltammetry (CV) technique at a scanning rate of 50 mV/s at a potential range of -0.20/1.80 V on the AISI 316 (SS) working electrode in contrast to the platinum electrode. For the synthesis of organic structure doped polymer film (PABA-ORG), we repeated the same synthesis process by dissolving C21H27NO2(k) (ORG) at low concentration in the same bath. We investigated the corrosion performances of bare SS, SS/PABA, and SS/PABA-ORG substrates, using open circuit potential – time, anodic polarization, and AC impedance techniques in the solution of corrosion study. As a result, we observed that the organic additive added to the synthesis medium caused changes in the synthesis behavior of PABA. Corrosion performance tests showed that PABA and PABA-ORG films increased the corrosion protection performance of the SS electrode, and we observed a reduction of the corrosion rate of the SS electrode.

Journal of the Turkish Chemical Society, Section A: Chemistry published new progress about Anodic polarization. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Huaibo; McMillan, Alastair J.; Constantin, Timothee; Mykura, Rory C.; Julia, Fabio; Leonori, Daniele published the artcile< Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route toward contra-Thermodynamic Olefins>, HPLC of Formula: 627-27-0, the main research area is Merging Halogen Atom Transfer Cobalt Catalysis Elimination Alkyl Halides.

We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with desaturative cobalt catalysis. The methodol. is high-yielding, tolerates many functionalities, and was used to access industrially relevant materials. In contrast to thermal E2 eliminations where unsym. substrates give regioisomeric mixtures, this approach enables, by fine-tuning of the electronic and steric properties of the cobalt catalyst, to obtain high olefin positional selectivity. This unprecedented mechanistic feature has allowed access to contra-thermodn. olefins, elusive by E2 eliminations.

Journal of the American Chemical Society published new progress about Crystal structure. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghanbari Kermanshahi, Mohammad; Bahrami, Kiumars published the artcile< Fe3O4@BNPs@SiO2-SO3H as a highly chemoselective heterogeneous magnetic nanocatalyst for the oxidation of sulfides to sulfoxides or sulfones>, COA of Formula: C8H10OS, the main research area is sulfoxide preparation green chem chemoselective; sulfone preparation green chem chemoselective; sulfide oxidation iron oxide nanocatalyst.

The preparation and characterization of magnetic acidic boehmite nanoparticles as a heterogeneous catalyst, which is called Fe3O4@BNPs@SiO2-SO3H were described. This catalyst works efficiently in the selective oxidation of sulfides RSR1 [R = Ph, 4-bromobenzyl, prop-2-en-1-yl, benzothiazol-2-yl, etc.; R1 = Me, benzyl, carboxymethyl, etc.; RR1 = -(CH2-)4] and 9H-thioxanthen-9-one to sulfoxides RS(O)R1 or sulfones RS(O)2R1 in the presence of H2O2 as a green oxidant. It can easily be separated from the reaction medium by using an external magnet and it was recycled 6 times without loss of magnetic catalytic properties.

RSC Advances published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Miao; Yue, Xin; Xu, Ruirui; Tang, Weijun; Xue, Dong; Li, Chaoqun; Lei, Ming; Xiao, Jianliang; Wang, Chao published the artcile< Transition-Metal-Free Hydrogen Autotransfer: Diastereoselective N-Alkylation of Amines with Racemic Alcohols>, Reference of 403-41-8, the main research area is diastereoselective alkylation amines alc chiral amine synthesis; alcohols; alkylation; amines; deuterium; reaction mechanisms.

A practical method for the synthesis of α-chiral amines by alkylation of amines with alcs. in the absence of any transition-metal catalysts has been developed. Under the co-catalysis of a ketone and NaOH, racemic secondary alcs. reacted with Ellman’s chiral tert-butanesulfinamide by a hydrogen autotransfer process to afford chiral amines with high diastereoselectivities (up to >99:1) [e.g., 1-phenylethanol + (R)-(+)-tert-butanesulfinamide → I (70%, > 95:5 d.r.) in presence of acetophenone and NaOH in toluene]. Broad substrate scope and up to a 10 g scale production of chiral amines were demonstrated. The method was applied to the synthesis of chiral deuterium-labeled amines with high deuterium incorporation and optical purity, including examples of chiral deuterated drugs. The configuration of amine products is found to be determined solely by the configuration of the chiral tert-butanesulfinamide regardless of that of alcs., and this is corroborated by DFT calculations Further mechanistic studies showed that the reaction is initiated by the ketone catalyst and involves a transition state similar to that proposed for the Meerwein-Ponndorf-Verley (MPV) reduction, and importantly, it is the interaction of the sodium cation of the base with both the nitrogen and oxygen atoms of the sulfinamide moiety that makes feasible, and determines the diastereoselectivity of, the reaction.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts, stereoselective. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sau, Abhijit; Palo-Nieto, Carlos; Galan, M. Carmen published the artcile< Substrate-Controlled Direct α-Stereoselective Synthesis of Deoxyglycosides from Glycals Using B(C6F5)3 as Catalyst>, Related Products of 4064-06-6, the main research area is stereoselective glycosylation catalyst boron glycal disaccharide.

B(C6F5)3 enables the metal-free unprecedented substrate-controlled directαstereoselective synthesis of deoxyglycosides from glycals. 2,3-UnsaturatedαO-glycoside products are obtained with deactivated glycals at 75 degrees C in the presence of the catalyst, while 2-deoxyglycosides are formed using activated glycals that bear no leaving group at C-3 at lower temperatures The reaction proceeds in good to excellent yields via concomitant borane activation of glycal donor and nucleophile acceptor. The method is exemplified with the synthesis of a series of rare and biol. relevant oligosaccharide analogs.

Journal of Organic Chemistry published new progress about 4064-06-6. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duchow, Elizabeth G.; Duchow, Mark W.; Plum, Lori A.; DeLuca, Hector F. published the artcile< Vitamin D binding protein greatly improves bioactivity but is not essential for orally administered vitamin D>, Quality Control of 434-16-2, the main research area is vitaminD calcium homeostasis 7dehydrocholesterol; ultraviolet light; vitamin D; vitamin D binding protein.

Vitamin D3 is a prohormone that is essential for calcium homeostasis. It is naturally produced in the skin by UV-B (UVB) irradiation of 7-dehydrocholesterol. In the absence of skin production, vitamin D3 can also be obtained from oral sources. However, the actual biol. equivalence of naturally produced (i.e., UVB-irradiation of skin) and oral vitamin D3 has not been determined We previously identified a unique and specific transport mechanism for skin-generated vitamin D3 which requires vitamin D binding protein (DBP); a mechanism that differs from absorption and transport of oral vitamin D3. In the following report, we examined the impact of this difference on the biol. activity of vitamin D3. We report that UVB-generated vitamin D3 is more potent at raising serum calcium compared to oral vitamin D3, with the total biol. activity being twofold higher. By examining the excretion of radiolabeled vitamin D3 injected unbound or pre-bound by DBP, we attributed the increased activity of skin-generated vitamin D3 to a significant reduction in biliary excretion of DBP-bound vitamin D relative to unbound vitamin D. Thus, removal of vitamin D3 from the skin by the natural DBP system markedly improves biol. activity compared to that given orally.

Physiological Reports published new progress about Homeostasis, calcium. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Quality Control of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yu-Heng; Yang, Qiaomu; Walsh, Patrick J.; Schelter, Eric J. published the artcile< Light-mediated aerobic oxidation of C(sp3)-H bonds by a Ce(IV) hexachloride complex>, Safety of Triphenylmethanol, the main research area is alc aldehyde ketone carboxylic acid preparation; alkane arene photochem oxygenation cerium hexachloride catalyst.

A photochem. C(sp3)-H oxygenation of alkane and arene substrates catalyzed by [NEt4]2[CeIVCl6] under mild conditions (1 atm, 25°C) is described. Time-course studies reveal that the hydrocarbons are oxidized in a stepwise fashion to afford alcs., aldehydes, ketones, and carboxylic acids. The catalyst resting state, [CeIVCl6]2-, is observed by UV-visible spectroscopy. On/off light-switching experiments, quantum yield measurements, and the absence of a kinetic isotope effect on parallel C-H/C-D functionalization suggest that ligand-to-metal charge transfer of [NEt4]2[CeIVCl6] to generate Cl is the turnover-limiting step. The involvement of a highly reducing excited-state [NEt4]3[CeIIICl6]* species as well as photo-excited aldehyde, under black light irradiation appears to facilitate the conversion of primary alcs. and aldehydes to carboxylic acids. Remarkably, this approach is found to be capable of direct activation of light alkanes, including methane and ethane.

Organic Chemistry Frontiers published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Yu; Jin, Guo-Jie; Wang, Xing-Jie; Kong, Cai-Lin; Liu, Ji Bin; Tao, Yong-Sheng published the artcile< Chemical profiles and aroma contribution of terpene compounds in Meili (Vitis vinifera L.) grape and wine>, Quality Control of 78-70-6, the main research area is aroma terpene glycoside grape wine; Cedrol (PubChem CID: 65575); Citronellol (PubChem CID: 8842); Farnesol (PubChem CID: 445070); GC–MS; Geraniol (PubChem CID: 637566); Geranyl acetone (PubChem CID: 1549778); Linalool (PubChem CID: 6549); Mathematical regression; Meili; Menthol (PubChem CID: 1254); Nerol (PubChem CID: 643820); Terpene compound; Terpinene (PubChem CID: 7462); Terpineol (PubChem CID: 17100); Wine aroma.

The chem. profiles and aroma contribution of terpene compounds in Meili grapes and wine were analyzed. Bound terpene compounds were extracted using methanol, purified using Amberlite XAD-2 resin, concentrated in methanol/ethyl acetate, and enzymically hydrolyzed to release aglycons. Free terpene compounds were identified using solid-phase microextraction (SPME) coupled with gas chromatog.-mass spectrometry (GC-MS). Wine aroma characteristics were quantified by a trained sensory panel. Seventeen terpene glycosides were quantified in grapes and wines as pentosyl-glucopyranoside, the content of which ranged from 804 to 836 μg/kg, and from 155 to 192 μg/L, resp. Eight free terpenes were present in wines with their content ranging from 40.1 to 59.7 μg/L. Linalool was abundant both in bound and free terpenes, and math. regression revealed that terpenes, especially linalool (contribution efficient > 0.4), contributed heavily to Meili wine aroma. Finally, a mol. rearrangement scheme based on linalool was proposed in Meili grape and wine.

Food Chemistry published new progress about Flavor. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Quality Control of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts