Month: October 2022

Cao, Fei; Mao, Anruo; Yang, Bobin; Ge, Chenyang; Wang, Dawei published the artcile< The preparation of a Co@C3N4 catalyst and applications in the synthesis of quinolines from 2-aminobenzyl alcohols with ketones>, Electric Literature of 5344-90-1, the main research area is cobalt doped carbon nitride catalyst quinoline synthesis aminobenzenemethanol ketone.

An unsym. diphenylphosphino-pyridinyl-triazole ligand was synthesized and characterized through IR, NMR and MS and the corresponding earth-abundant metal complex (cobalt) was prepared Considering energy consumption and environmental friendliness, it is necessary to turn this diphenylphosphino-pyridinyl-triazole cobalt complex into a recyclable catalyst, which could easily be reused. Therefore, a heterogeneous catalyst was synthesized through Co-doping of C3N4, and the Co-nanoparticles on C3N4 revealed high catalytic activity for the synthesis of quinolines with good recovery performance.

New Journal of Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Michel, Olga; Blasiak, Piotr; Saczko, Jolanta; Kulbacka, Julita; Drag-Zalesinska, Malgorzata; Rzechonek, Adam published the artcile< Electropermeabilization of metastatic chondrosarcoma cells from primary cell culture>, Electric Literature of 1492-18-8, the main research area is chondrosarcoma metastasis primary cell culture electropermeabilization; chondrosarcoma; electroporation; lung metastasis; primary cell cultures.

Primary cell cultures are challenging, but reliable model reflecting tumor response in vitro. The study was designed to examine if the increased electropermeabilization can overcame initial drug insensitivity in chondrosarcoma cells from lung metastasis. We established a primary cell culture and evaluated the cytotoxic impact of four drugs-cisplatin (CDDP), camptothecin, 2-methoxyestradiol, and leucovorin calcium (LeuCa). After determination of parameters allowing for electropermeabilization, we performed electrochemotherapy in vitro with the least toxic drugs-CDDP and LeuCa. Although combining CDDP and leucovorin together increased their toxicity and supported apoptosis, application of pulsed elec. fields (PEFs) brought no advantage for their efficacy. The study emphasizes the need for introduction of primary cell cultures into studies on pulse elec. fields as model frequently less sensitive to PEF-based treatments than continuous cell lines.

Biotechnology and Applied Biochemistry published new progress about Animal tissue culture, primary. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Yu; Reddy, D. Prabhakar; Yu, Biao published the artcile< A dehydrative glycosylation protocol mediated by nonafluorobutanesulfonyl fluoride (NfF)>, HPLC of Formula: 4064-06-6, the main research area is stereoselective glycosylation catalyst nonafluorobutanesulfonyl fluoride dehydrative disaccharide glycoside preparation.

A new dehydrative glycosylation protocol that proceeds through selective activation of glycosyl hemiacetals with nonafluorobutanesulfonyl fluoride (NfF) has been disclosed. Contrary to the major classical glycosylation reactions that proceed under acidic or neutral conditions, the present glycosylation reaction proceeds under mild basic conditions. In the absence of an external acceptor, self-condensation of the glycosyl hemiacetal occurs, providing the corresponding sym. 1,1′-disaccharides in high yields.

Tetrahedron published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, HPLC of Formula: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Tong-Xin; Zhu, Xue; Xia, Shilu; Wang, Xin; Zhang, Pengling; Zhang, Guisheng published the artcile< NHC-Catalyzed Three-Component Hydroalkylation Reactions of [60]Fullerene: An Umpolung Approach to Diverse Monoalkylated Hydrofullerenes>, COA of Formula: C4H8O, the main research area is alkyl fullerene preparation green chem; fullerene reductive alkylation chloroalkyl benzaldehyde unsaturated aldehyde alc thiol.

A novel N-heterocyclic carbene-catalyzed three-component umpolung hydroalkylation of [60]fullerene with 4-(chloromethyl)benzaldehydes/α,β-unsaturated aldehydes and alcs./thiols has been developed for the flexible and efficient preparation of diverse monoalkylated hydrofullerenes. Organic catalysis, broad substrate scope, excellent functional group tolerance, and products with high diversity and complexity levels are attractive features of this protocol.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Wenkang; Zhang, Yilin; Zhu, Haiyan; Ye, Dongdong; Wang, Dawei published the artcile< Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is copper triazolylnaphthyridinylpyridine complex preparation catalyst.

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment

Green Chemistry published new progress about Catalysts. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Surrati, Amal; Evseev, Sergey; Jourdan, Fabien; Kim, Dong-Hyun; Sottile, Virginie published the artcile< Osteogenic response of human mesenchymal stem cells analysed using combined intracellular and extracellular metabolomic monitoring>, Electric Literature of 87-73-0, the main research area is metabolite osteogenesis mesenchymal stem cell; Mesenchymal stem cells; Osteogenesis; Differentiation; Metabolomics; LC-MS; Metabolomics profiling.

The skeleton is a metabolically active organ undergoing continuous remodelling initiated by mesenchymal progenitors present in bone and bone marrow. Under certain pathol. conditions this remodelling balance shifts towards increased resorption resulting in weaker bone microarchitecture, and there is consequently a therapeutic need to identify pathways that could inversely enhance bone formation from stem cells. Metabolomics approaches recently applied to stem cell characterization could help identify new biochem. markers involved in osteogenic differentiation. Combined intra- and extracellular metabolite profiling was performed by liquid chromatog.-mass spectrometry (LC-MS) on human mesenchymal stem cells (MSCs) undergoing osteogenic differentiation in vitro. Using a combination of univariate and multivariate analyses, changes in metabolite and nutrient concentration were monitored in cultures under osteogenic treatment over 10 days. A subset of differentially detected compounds was identified in differentiating cells, suggesting a direct link to metabolic processes involved in osteogenic response. These results highlight new metabolite candidates as potential biomarkers to monitor stem cell differentiation towards the bone lineage.

Cellular Physiology & Biochemistry published new progress about Biomarkers. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fan, Yiqing; Zhang, Yongjie; Liu, Yan; Jiang, Hongyu; Zhou, Ying; Tang, Chunlei; Fan, Weizheng published the artcile< Pyrazolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: design, synthesis and biological evaluation>, Synthetic Route of 167938-56-9, the main research area is pyrazolopyrimidine macrocyclic preparation tropomyosin receptor kinase inhibition docking; Antitumor; Design and synthesis; High selectivity; The next-generation Trk inhibitor; Tropomyosin receptor kinase.

A series of pyrazolo[1,5-a]pyrimidine derivatives I [R = H, F, Cl; X1 = (CH2)2, CH2CMe2, (R)-CHMeCH2, (S)-CHMeCH2; X2 = (CH2)2, (CH2)3, (R)-CHMeCH2, (S)-CHMeCH2, (S)-CH2CHMe, (R)-CH2CHMe] was synthesized and evaluated the their biol. activity as the second-generation Trk inhibitors. The best compounds I [R = F; X1 = CH2CMe2; X2 = (R)-CHMeCH2] (IC50 = 1.40 and 1.80 nM, against TrkA, TrkAG595R, resp.) and I [R = F; X1 = (S)-CHMeCH2; X2 = (R)-CHMeCH2] (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, resp.) showed a kinase activity comparable to TPX-0005, and I [R = F; X1 = (S)-CHMeCH2; X2 = (R)-CHMeCH2] (IC50 = 350 nM against ALK) had a higher selectivity of Trk inhibition than TPX-0005, which was of great significance for reducing toxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Synthetic Route of 167938-56-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xuegui; Bian, Jun; Li, Danqi; Liu, Changfeng; Xu, Shuangshuang; Zhang, Gongling; Zhang, Lixin; Gao, Pinyi published the artcile< Structural features, antioxidant and acetylcholinesterase inhibitory activities of polysaccharides from stem of Physalis alkekengi L.>, Formula: C6H12O6, the main research area is Physalis stem polysaccharide antioxidant acetylcholinesterase structural property.

Physalis alkekengi L.(P. alkekengi) is an important medicinal plant in China. In this study, two polysaccharides (SPAP-1 and SPAP-2) were isolated from the stem of P. alkekengi using hot water extraction method. The extract was further purified by DEAE-cellulose and Sephadex G-200 chromatog. The chem. characteristics, surface features and thermal stability of SPAP-1 and SPAP-2 were evaluated. For the first time, high-performance liquid chromatog. with refractive index detection and amino column (without sample derivatization) was performed to analyze the monosaccharide composition of polysaccharides obtained from the stem of P. alkekengi. As a result, SPAP-1 (Mw = 9.1 kDa) consisted of rhamnose, arabinose, galacturonic acid, mannose, and glucose in the ratio of 1.0:1.5:1.9:29.1:1.03, while SPAP-2 (Mw = 13.5 kDa) comprised of rhamnose, xylose, arabinose, mannose and glucose in the ratio of 31.8:14.8:1.0:6.5:22.6. Addnl., the antioxidant effects of SPAP-1 and SPAP-2 were evaluated by ferric reducing power, 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulfonate acid) (ABTS) and 2.2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. The results showed that the purified polysaccharides exerted significant scavenging activities. Subsequently, acetylcholinesterase inhibitory effects in vitro of the polysaccharides were investigated, which showed that, SPAP-1 and SPAP-2 showed moderate acetylcholinesterase inhibitory activities. Thus, the polysaccharide content in P. alkekengi stem as promising source of natural products possess good antioxidant activities and may exert beneficial effects on cognitive function.

Industrial Crops and Products published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Emayavaramban, Balakumar; Chakraborty, Priyanka; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker published the artcile< Cp*Co(III)-catalyzed N-alkylation of amines with secondary alcohols>, Reference of 403-41-8, the main research area is amine alkylation sec alc cobalt catalyst; tetrahydroquinoline preparation; aminoalc intramol amination cobalt catalyst.

Herein Cp*Co(III)-catalyzed direct N-alkylation of amines starting from secondary alcs. was reported for the first time. The reaction tolerates a wide variety of functional groups, including various aryl amines and amides. Various 1,5-aminoalcs. efficiently underwent intramol. amination with excellent isolated yields of the expected 2-aryltetrahydroquinolines. The preliminary mechanistic investigations and DFT calculations suggest that [Cp*CoI2] is an active species, that PCy3 stabilizes the high-valent hydride intermediate, and that the reaction indeed proceeds through hydrogen auto-transfer processes.

Organic Chemistry Frontiers published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Paradiz Dominguez, Maximilian; Demirkurt, Beguem; Grzelka, Marion; Bonn, Daniel; Galmiche, Laurent; Audebert, Pierre; Brouwer, Albert M. published the artcile< Fluorescent Liquid Tetrazines>, Application In Synthesis of 104-76-7, the main research area is branched alkoxy tetrazine photophys property rheol viscosity; excited states; fluorescence; inter system crossing; rheology; viscosity.

Tetrazines with branched alkoxy substituents are liquids at ambient temperature that despite the high chromophore d. retain the bright orange fluorescence that is characteristic of this exceptional fluorophore. Here, we study the photophys. properties of a series of alkoxy-tetrazines in solution and as neat liquids We also correlate the size of the alkoxy substituents with the viscosity of the liquids We show using time-resolved spectroscopy that intersystem crossing is an important decay pathway competing with fluorescence, and that its rate is higher for 3,6-dialkoxy derivatives than for 3-chloro-6-alkoxytetrazines, explaining the higher fluorescence quantum yields for the latter. Quantum chem. calculations suggest that the difference in rate is due to the activation energy required to distort the tetrazine core such that the nπ*S1 and the higher-lying ππ*T2 states cross, at which point the spin-orbit coupling exceeding 10 cm-1 allows for efficient intersystem crossing to occur. Femtosecond time-resolved anisotropy studies in solution allow us to measure a pos. relationship between the alkoxy chain lengths and their rotational correlation times, and studies in the neat liquids show a fast decay of the anisotropy consistent with fast exciton migration in the neat liquid films.

Molecules published new progress about Anisotropy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts