Month: October 2022

Zhang, Zhipeng; He, Zhiqin; Xie, Yuxing; He, Tiantong; Fu, Yaofeng; Yu, Yang; Huang, Fei published the artcile< Bronsted acid-catalyzed homogeneous O-H and S-H insertion reactions under metal- and ligand-free conditions>, Application of C4H8O, the main research area is alkoxy acetate preparation; alc diazo compound OH bond insertion Bronsted acid catalyzed; phenylethylidene amino oxy acetate preparation; oximes with diazo compound OH insertion Bronsted acid catalyzed; thio aryl acetate preparation; thiol diazo compound SH insertion Bronsted acid catalyzed.

Under metal- and ligand-free conditions, the economical and accessible CF3SO3H successfully catalyzed homogeneous O-H bond insertion reactions between hydroxyl compounds and diazo compounds to afford alkoxy acetates. Including phenols, alcs., water and oximes, these O-H bond insertion reactions were very general and functional-group tolerant. Here, the O-H bond insertion of oximes (ketoximes and aldoximes) to gave phenylethylidene(amino(oxy)acetates) was reported and their structures were characterized by X-ray crystallog. Moreover, a simple and effective method for S-H insertion reactions of thiols to gave thio(aryl)acetates was also developed, delivering the desired C-S bond products with good to excellent yields. It was worth noting that the efficacy of the developed methodol. could be further shown by the expeditious synthesis of the PPAR agonist MBX-102 acid.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Dianfeng; Wang, Jinguo; Xu, Fengxia; Zhang, Nianchen; Men, Yong published the artcile< Mesoporous (001)-TiO2 nanocrystals with tailored Ti3+ and surface oxygen vacancies for boosting photocatalytic selective conversion of aromatic alcohols>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is mesoporous anatase catalyst morphol aromatic alc oxidation.

Selective conversion of aromatic alcs. to value-added chems. is becoming an emerging research hotspot in heterogeneous photocatalysis, but its critical challenge is how to construct highly efficient photocatalysts. Herein, mesoporous (001)-TiO2 nanocrystals with tailored Ti3+ and surface oxygen vacancies have been fabricated by a facile hydrothermal route, showing remarkably boosted photoactivity for selective conversion of aromatic alcs. to carbonyl compounds in water medium under visible-light irradiation Results attest that the remarkably boosted photoactivity was mainly correlated with the strong synergetic effect of exposed (001) facets, Ti3+ self-doping, and surface oxygen vacancies, leading to the enhanced reactant (aromatic alcs. and O2) activation via the high surface energy of (001) facets, the improved visible-light absorbance via the intrinsic band gap narrowing, and the escalated photoelectron-hole separation efficiency via Ti3+ and surface oxygen vacancies acting as electron sinks. Meanwhile, a plausible photocatalytic mechanism for selective conversion of aromatic alcs. to carbonyl compounds has been elucidated in detail based on active species identified by capture experiments It is hoped that this work can deliver some new insights into the rational design of highly efficient photocatalysts applied in future green organic selective transformation reactions.

Catalysis Science & Technology published new progress about Crystallinity. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhong, Lin-Fang; Shang, Zhi-Chun; Sun, Fu-Juan; Zhu, Pan-Hu; Yin, Yong; Kong, Ling-Yi; Yang, Ming-Hua published the artcile< Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation>, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde, the main research area is formyl phloroglucinol meroterpenoid preparation anticandidal antibiofilm; Antibiofilm activity; Anticandidal activity; Essential oil; Formyl phloroglucinol meroterpenoids.

Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata. Cedartriol B (I) showed the best anticandidal ability that was powerfully comparable to fluconazole when testing against several strains in vitro. The antibiofilm activity was also found for the I treating group which was evidenced to block the hyphal elongation and filamentation of C. albicans. Therefore, compound I is a promising candidate for further antifungal-based structure modification.

Bioorganic Chemistry published new progress about [4+2] Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Recommanded Product: 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anandan, Sampath-Kumar; Webb, Heather K.; Do, Zung N.; Gless, Richard D. published the artcile< Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble epoxide hydrolase>, Recommanded Product: 3-Aminocyclohexanol, the main research area is unsym aryl urea derivative preparation soluble epoxide hydrolase inhibitor; aryl amide derivative preparation soluble epoxide hydrolase inhibitor.

Incorporation of an adamantyl group in prototypical soluble epoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. Replacement of the adamantyl group in unsym. ureas and amides with substituted aryl rings to identify equipotent and metabolically stable sEH inhibitors, e.g., I and II, is explored. Aryl rings, especially those substituted in the para position with a strongly electron withdrawing substituent, afforded enzyme IC50 values comparable to the adamantyl compounds in an ether substituted, unsym. N,N’-diaryl urea or amide scaffold.

Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yuqing; Liu, Dan; Wang, Dingyi; Lai, Shanshan; Zhong, Ruting; Liu, Yuanyuan; Yang, Chengfeng; Liu, Bin; Sarker, Moklesur Rahman; Zhao, Chao published the artcile< Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice>, Related Products of 3458-28-4, the main research area is Grifola polysaccharide type 2 diabetes gut microbiota regulation hypoglycemia; Grifola frondosa polysaccharide; Hypoglycemic; Intestinal microflora; Purification; Single-molecule real-time sequencing.

GFP-N, a novel heteropolysaccharide with a mol. weight of 1.26 × 107 Da, was isolated from maitake mushroom and purified by anion-exchange chromatog. on a DEAE cellulose-52 column and gel-filtration chromatog. on a Sephadex G-100 column. Its structure was characterized by Fourier transform IR spectroscopy and one-dimensional (1H- and 13C-) NMR spectra, 1H-1H correlation spectroscopy, and 1H-13C heteronuclear single-quantum coherence spectroscopy. The structure of GFP-N consisted of L-arabinose, D-mannose and D-glucose and mainly contained three kinds of linkage type units as( →2,6)-a-D-Manp-(1 → 4, a-L-Araf-C1→, and →3,6)-β-D-Glcp-(1 →). GFP-N could activate insulin receptor substrate 1, phosphatidylinositol-3-kinase, and glucose transporter 4 and inhibit c-Jun N-terminal kinase 1/2 for hypoglycemic effects in diabetic mouse livers. This is also the first report of the regulatory efficacy of Grifola frondosa polysaccharide on intestinal microflora in vivo using single-mol. real-time sequencing. These results indicated that polysaccharide from maitake mushroom could be as an enhancer to improve type 2 diabetes and a healthy food option to help regulate gut microbiota in diabetic individuals.

Food and Chemical Toxicology published new progress about Actinobacteria. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jaradat, Nidal; Khasati, Ahmad; Hawi, Maram; Hawash, Mohammed; Shekfeh, Suhaib; Qneibi, Mohammad; Eid, Ahmad M.; Arar, Mohammad; Qaoud, Mohammed T. published the artcile< Antidiabetic, antioxidant, and anti-obesity effects of phenylthio-ethyl benzoate derivatives, and molecular docking study regarding α-amylase enzyme>, Safety of 2-(Phenylthio)ethanol, the main research area is phenylthio ethylbenzoate antidiabetic antioxidant antiobesity mol docking alpha amylase.

In addition to their wide therapeutic application, benzoates and benzoic acid derivatives are the most commonly utilized food preservatives. The purpose of this study was to estimate the antioxidant, anti-diabetic, and anti-obesity activities of four 2-(phenylthio)-Et benzoate derivatives utilizing standard biomedical assays. The results revealed that the 2a compound has potent antidiabetic activity through the inhibition of α-amylase and α-glycosidase with IC50 doses of 3.57 ± 1.08 and 10.09 ± 0.70 μg/mL, resp., compared with the pos. control acarbose (IC50 = 6.47 and 44.79 μg/mL), resp. In addition, by utilizing the β-carotene linoleic acid and DPPH methods, the 2a compound showed the highest antioxidant activity compared with pos. controls. Moreover, the 2a compound showed potential anti-lipase activity with an IC50 dose of 107.95 ± 1.88 μg/mL compared to orlistat (IC50 = 25.01 ± 0.78 μg/mL). A mol. docking study was used to understand the interactions between four derivatives of (2-(phenylthio)-Et benzoate with α-amylase binding pocket. The present study concludes that the 2a compound could be exploited for further antidiabetic, antioxidant, and anti-obesity preclin. and clin. tests and design suitable pharmaceutical forms to treat these global health problems.

Scientific Reports published new progress about Antidiabetic agents. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghadermazi, Mohammad; Molaei, Somayeh; Ghadermazi, Nahid published the artcile< Introduction of Fe into mesoporous MCM-41 for the synthesis of 5-substituted 1H-Tetrazoles from aryl nitriles in water>, Recommanded Product: 2-(Phenylthio)ethanol, the main research area is mesoporous supported iron silica catalyst preparation; tetrazole sulfoxide preparation green chem; aryl nitrile sulfide oxidation water.

In this exploration, new recyclable mesoporous-supported iron particles with the ligand and without ligand (MCM-41@ 3,4,5-tri hydroxyphenyl acetic acid @Fe and MCM-41@Fe) have been developed through post-functionalization modification of silica MCM-41. These catalysts were demonstrated to be novel, effective, and green for the synthesis of 5-substituted 1H-tetrazoles from aryl nitriles in water. In these systems, 5-substituted 1H-tetrazoles are produced as the only product. Fe3+ species were identified as active sites. The ordered mesoporous iron-silica catalyst with the ligand displayed better catalytic activity compared to iron-silica catalyst without the ligand, which was ascribed to the improvement of the inter-action of iron with the support. The catalysts can be easily separated using simple recovery and reused several times with consistent activity.

Microporous and Mesoporous Materials published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jiazhe; Lou, Qixin; Rong, Jingjing; Yang, You published the artcile< Gold(I)-promoted α-selective sialylation of glycosyl ortho-hexynylbenzoates for the latent-active synthesis of oligosialic acids>, Synthetic Route of 4064-06-6, the main research area is sialoside capsular polysaccharide meningitidis; oligosialic acid coupling gold catalyst stereoselective sialylation hexynylbenzoate synthesis.

A gold(I)-promoted α-selective sialylation approach with 5-N,4-O-oxazolidinone-protected sialyl ortho-hexynylbenzoates as donors is described for the stereoselective synthesis of α-sialosides. Iterative couplings of the ‘active’ sialyl ortho-hexynylbenzoates and the ‘latent’ sialyl ortho-iodobenzoates provide a new approach for the ‘latent-active’ synthesis of α-(2→9)-linked oligosialic acids that are relevant to N. meningitidis sero-group C capsular polysaccharide.

Organic & Biomolecular Chemistry published new progress about Coupling reaction. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts