Month: October 2022

Zhao, Jie; Ji, Shufang; Guo, Chenxi; Li, Haijing; Dong, Juncai; Guo, Ping; Wang, Dingsheng; Li, Yadong; Toste, F. Dean published the artcile< A heterogeneous iridium single-atom-site catalyst for highly regioselective carbenoid O-H bond insertion>, Recommanded Product: (R)-Butane-1,3-diol, the main research area is hydroxy ester preparation regioselective; alc diazo ester insertion iridium catalyst.

A strategy for selective carbenoid O-H insertion that exploits an engineered heterogeneous iridium single-atom catalyst, thus providing opportunities for organic transformations by merging material science and catalysis was reported. This catalytic protocol delivers excellent selectivities (up to 99:1) for the functionalization of aliphatic over phenolic O-H bonds R1C6H4CH(R2)C(O)OMe (R1 = H, 4-Br, 3-F, 4-Me; R2 = cyclohexyl, Bn, 2,2,2-trifluoroethyl, 1-methyl-1H-indol-3-yl, etc.), whereas the analogus homogeneous catalyst, Ir(ttp)COCl (ttp = 5,10,15,20-tetra-p-tolylporphyrinato), provided modest preferences. D.-functional-theory calculations suggest that the site-selectivity derives from the lower oxidation state of the iridium metal center in the heterogeneous catalyst and its impact on the absorption energies of the reactants. These results showcase an example of a heterogeneous single-atom catalyst providing superior site-selectivity and provide a complementary strategy to address challenges in catalysis for organic synthesis.

Nature Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Recommanded Product: (R)-Butane-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Putta, V. P. Rama Kishore; Gujjarappa, Raghuram; Tyagi, Ujjawal; Pujar, Prasad P.; Malakar, Chandi C. published the artcile< A metal- and base-free domino protocol for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines and related scaffolds>, Category: alcohols-buliding-blocks, the main research area is arylthiazinone preparation; benzoselenazine preparation; diaryldiazocine dione preparation; benzothiazine preparation.

Efficient protocols have been described for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines, 2-arylthiazin-4-ones and diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones. These transformations were successfully driven towards product formation under mild acid catalyzed reaction conditions at room temperature using 2-aminoaryl/hetero-aryl alkyl alcs. and amides as substrates. The merits of the present methods also rely on the easy access of rarely explored bioactive scaffolds like 1,3-benzoselenazine derivatives, for which well-documented methods are rarely known in the literature. A broad range of substrates with both electron-rich and electron-deficient groups were well-tolerated under the developed conditions to furnish the desired products in yields up to 98%. The scope of the devised method was not only restricted to the synthesis of 1,3-benzoselenazines, but it was further extended towards the synthesis of 1,3-benzothiazines, 1,3-benzothiazinones and the corresponding eight-membered N-heterocycles such as diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones.

Organic & Biomolecular Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hongyan; Xie, Wancui; Sun, Haihong; Cao, Kewei; Yang, Xihong published the artcile< Effect of the structural characterization of the fungal polysaccharides on their immunomodulatory activity>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is immunomodulatory agent extracellular polysaccharide Aspergillus Sanguisorba Rumia Zizania; Extracellular polysaccharide; Fungus; Immunomodulatory activity; Structural characterization.

The immunomodulatory effects of the four extracellular polysaccharides, namely WPA, WPB, AP2A, and TP1A, which were isolated from the fermented broth of Aspergillus aculeatus, A. terreus and Trichoderma sp. KK19L1, were investigated in vitro. WPA, WPB, AP2A, and TP1A were not toxic to RAW264.7 cells. These polysaccharides enhanced cell viability. WPA, WPB, AP2A, and TP1A showed increased immunomodulatory effect by strengthening the phagocytic activity and enhancing the release of NO, TNF-α and IL-6 from RAW264.7 cells. WPA, WPB, AP2A, and TP1A exhibited different immunomodulatory activity in vitro due to their different structural characterizations, and their immunoregulatory effects decreased successively in the following order: WPA, WPB, AP2A, and TP1A. The extracellular polysaccharides WPA, WPB, AP2A, and TP1A had potent immunomodulatory effects and could be used as potential immunomodulatory agents in the fields of functional food and medicine.

International Journal of Biological Macromolecules published new progress about Animal gene, TNFA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Jicheng; Li, Xiaolei; Qi, Xiaotian; Duan, Xiyan; Cracraft, Weston L.; Guzei, Ilia A.; Liu, Peng; Tang, Weiping published the artcile< Site-Selective and Stereoselective O-Alkylation of Glycosides by Rh(II)-Catalyzed Carbenoid Insertion>, Application In Synthesis of 4064-06-6, the main research area is transition state crystal structure glycoside preparation disaccharide; crystal structure glycoside preparation stereoselective glycosylation catalyst disaccharide; rhodium catalyzed regioselective stereoselective glycosylation alkylation glycoside preparation DFT; regioselective stereoselective glycosylation protecting group alkylation glycoside carbenoid catalyzed.

Carbohydrates are synthetically challenging mols. with vital biol. roles in all living systems. Selective synthesis and functionalization of carbohydrates provide tremendous opportunities to improve our understanding on the biol. functions of this fundamentally important class of mols. However, selective functionalization of seemingly identical hydroxyl groups in carbohydrates remains a long-standing challenge in chem. synthesis. We herein describe a practical and predictable method for the site- and stereoselective alkylation of carbohydrate hydroxyl groups via Rh(II)-catalyzed insertion of metal carbenoid intermediates. This represents one of the mildest alkylation methods for the systematic modification of carbohydrates. D. functional theory (DFT) calculations suggest that the site-selectivity is determined in the Rh(II)-carbenoid insertion step, which prefers insertion into hydroxyl groups with an adjacent axial substituent. The subsequent intramol. enolate protonation determines the unexpected high stereoselectivity. The most prevalent trans-1,2-diols in various pyranoses can be systematically and predictably differentiated based on the model derived from DFT calculations We also demonstrated that the selective O-alkylation method could significantly improve the efficiency and stereoselectivity of glycosylation reactions. The alkyl groups introduced to carbohydrates by OH insertion reaction can serve as functional groups, protecting groups, and directing groups.

Journal of the American Chemical Society published new progress about Alkylation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application In Synthesis of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Diana J.; Targos, Karina; Wickens, Zachary K. published the artcile< Electrochemical Synthesis of Allylic Amines from Terminal Alkenes and Secondary Amines>, Safety of But-3-en-1-ol, the main research area is allylic amine preparation electrochem diastereoselective; secondary amine unactivated alkene coupling.

Allylic amines are valuable synthetic targets en route to diverse biol. active amine products. Current allylic C-H amination strategies remain limited with respect to the viable N-substituents. Herein, authors disclose a new electrochem. process to prepare aliphatic allylic amines by coupling two abundant starting materials: secondary amines and unactivated alkenes. This oxidative transformation proceeds via electrochem. generation of an electrophilic adduct between thianthrene and the alkene substrates. Treatment of these adducts with aliphatic amine nucleophiles and base provides allylic amine products in high yield. This synthetic strategy is also amenable to functionalization of feedstock gaseous alkenes at 1 atm. In the case of 1-butene, high Z-selective crotylation is observed This strategy, however, is not limited to the synthesis of simple building blocks; complex biol. active mols. are suitable as both alkene and amine coupling partners. Preliminary mechanistic studies implicate vinylthianthrenium salts as key reactive intermediates.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhunia, Subhajit; Molla, Rostam Ali; Kumari, Vandana; Islam, Sk. Manirul; Bhaumik, Asim published the artcile< Zn(II) assisted synthesis of porous salen as an efficient heterogeneous scaffold for capture and conversion of CO2>, Safety of 2,4,6-Trihydroxyisophthalaldehyde, the main research area is zinc salphen functionalized porous polymer preparation heterogeneous catalyst; carbon dioxide cyclization epoxide zinc salphen polymer heterogeneous catalyst; dioxolanone derivative preparation.

The authors have designed a unique strategy to obtain a Zn-salphen functionalized porous polymer (Zn@SBMMP) with high Zn content (15.3%) by an easy one-step, cost effective and scalable process, from the solvothermal reaction of 3,3′-diaminobenzidine, phloroglucinoldialdehyde, and zinc acetate in DMF under N2, which shows unprecedented catalytic efficiency in the CO2 fixation reaction via cycloaddition of CO2 with epoxides. The authors hypothesize that a high d. of Zn-Schiff base/salphen units present in the porous polymer network is responsible for the exceptionally high catalytic performance of Zn@SBMMP.

Chemical Communications (Cambridge, United Kingdom) published new progress about Carbon sequestration. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Safety of 2,4,6-Trihydroxyisophthalaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Burns, Michael; Bi, Wenying; Kim, Hui; Lall, Manjinder S.; Li, Chao; O’Neill, Brian T. published the artcile< Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction>, Recommanded Product: But-3-en-1-ol, the main research area is biocatalytic cascade reaction ketoreductase transaminase.

A biocatalytic cascade to produce tert-Bu ((2R,4R)-2-methyltetrahydro-2H-pyran-4-yl)carbamate has been demonstrated at the multikilogram scale. In this reaction, a racemic ketone is resolved by reducing the undesired ketone using a ketone reductase (KRED). The reduction is stereospecific for the 2-position of substrate (2S)-ketone leaving the (2R)-ketone unreacted. After the (2S)-ketone has been depleted, a transaminase is added to catalyze the enantioselective transamination of the ketone, resulting in formation of the (2R, 4R)-amine 6. The product is recovered from the aqueous reaction after Boc protection.

Organic Process Research & Development published new progress about Biochemical reaction kinetics. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maji, Milan; Chakrabarti, Kaushik; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Sustainable synthesis of N-heterocycles in water using alcohols following the double dehydrogenation strategy>, HPLC of Formula: 403-41-8, the main research area is quinoline preparation green chem; acridine preparation green chem; naphthyridine preparation green chem; secondary alc amino aralkylalc dehydrogenation oxidative cyclization iridium complex; nitro aralkylalc secondary alc dehydrogenation oxidative cyclization iridium complex.

The present study describes the first example of synthesis of pharmaceutically relevant N-heterocycles like substituted quinolines I (R1 = Ph, 2-pyridinyl, benzo[d][1,3]dioxol-5-yl, 3-phenylpropyl, etc.; R2 = H, Me; R1R2 = -(CH2)3-; R3 = H, Cl, Br, Me; R4 = H; R3R4 = -CH=CH-CH=CH-), acridines e.g., II and 1,8-naphthyridines III in water under air using 2-aminoaryl alcs. or 2-nitroaryl alcs. 2-R5-4-R4-5-R3C6H2CH2OH (R5 = NH2, NO2) and 2-amino-3-pyridinemethanol with secondary alcs. R1CH(OH)CH2R2 and R6(OH) (R6 = cyclopentyl, 1,2,3,4-tetrahydronaphthalen-2-yl, cyclohexyl, cycloheptyl) in presence of a new water soluble Ir-complex e.g., IV·Cl. The viability and efficiency of this approach were demonstrated by the efficient synthesis of biol. active natural product (±)-galipinine and gram scale synthesis of various N-heteroaromatics Several kinetic experiments and DFT calculations were carried out to support the plausible reaction mechanism which disclosed that this system followed a concerted outer sphere mechanism for the dehydrogenation of alcs.

Journal of Catalysis published new progress about Acridines Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uslu, B.; Yilmaz, S.; Ozkan, S. A. published the artcile< Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry>, Application of C14H8N2Na2O6, the main research area is olsalazine sodium determination pharmaceutical voltammetry.

The electrochem. oxidation of olsalazine Na was studied by cyclic, linear sweep, differential pulse and square wave voltammetry using glassy C disk electrode in different buffer systems. Best results were obtained for the determination of olsalazine using the differential pulse voltammetric technique in phosphate buffer at pH 7.0. The electroactive species exhibits a diffusion-controlled voltammetric wave and its differential pulse peak current shows a linear dependence on olsalazine concentration in the range between 2 × 10-6 M and 2 × 10-4 M. This relation was applied to the determination of olsalazine in com. capsule dosage forms. The recovery study shows good accuracy and precision for the assay developed. A UV spectrophotometric assay is also reported for comparison.

Pharmazie published new progress about Differential pulse voltammetry. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Application of C14H8N2Na2O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts