Month: October 2022

Stokstad, Erik published the artcile< Engineered tomatoes get a healthy dose of vitamin D.>, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is .

Knocking out a gene boosts precursors of essential nutrient.

Science (New York, N.Y.) published new progress about 434-16-2. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Name: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xinya; Wang, Xiaohua; Zhen, Nuo; Gu, Jin; Zhang, Hao; Dong, Bo; Wang, Feng; Liu, Heng published the artcile< Sodium complexes bearing cavity-like conformations: a highly active and well-controlled catalytic system for macrolactone homo- and copolymerization>, COA of Formula: C19H16O, the main research area is sodium complex catalyst ROP macrolactone homo copolymerization.

This report describes the synthesis of a series of sodium complexes bearing cavity-like conformations formed with the aid of sterically hindered phenoxide and 15-crown-5 ether ligands. All the complexes are well-characterized via NMR spectroscopy anal., and through single crystal X-ray studies and DFT calculations it is found that the size of the cavity is very similar to that of macrolactone monomers. During subsequent studies of the ring-opening polymerization (ROP) of macrolactones, the present sodium complexes demonstrate high catalytic efficiencies in the ROP of pentadecalactone and ethylene brassylate, affording the corresponding polyester products in high yields. Moreover, due to chain propagation being confined within the cavity, transesterification can be suppressed because of mutual steric repulsion between the ligands and polymer chains, which further allows polymerization to proceed in a well-controlled manner. Owing to such uniqueness, block copolymerization between macrolactones and other cyclic esters can be also successfully achieved.

Polymer Chemistry published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bernardelli, Patrick; Bladon, Michael; Lorthiois, Edwige; Manage, Ajith C.; Vergne, Fabrice; Wrigglesworth, Roger published the artcile< Resolution of trans-3-aminocyclohexanol>, SDS of cas: 6850-39-1, the main research area is Resolution separation enzymic amino cyclohexanol preparation; crystal structure hydroxycyclohexylimino thiadiazolyl benzamide preparation; mol structure hydroxycyclohexylimino thiadiazolyl benzamide preparation.

(R,R)- and (S,S)-trans-3-Aminocyclohexanol were prepared via an enzymic resolution of (±)-trans-1-acetoxy-3-benzylamido-cyclohexane with >95% enantiomeric excess. The reaction of 5-(4-cyanophenyl)-3-methyl-2-(methylthio)-1,3,4-thiadiazolium perchlorate with (-)-(1R,3R)-3-aminocyclohexanol thus prepared gave 4-[4,5-dihydro-5-[[(1R,3R)-3-hydroxy-1-cyclohexyl]imino]-4-methyl-1,3,4-thiadiazol-2-yl]benzonitrile (I). The crystal and mol. structures of 4-[4,5-dihydro-5-[[(1R,3R)-3-hydroxy-1-cyclohexyl]imino]-4-methyl-1,3,4-thiadiazol-2-yl]benzamide were reported.

Tetrahedron: Asymmetry published new progress about Crystal structure. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, SDS of cas: 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthireddy, S. N. R.; Mathoor Illam, Praseetha; Rit, Arnab published the artcile< Ruthenium(II) Complexes of Heteroditopic N-Heterocyclic Carbene Ligands: Efficient Catalysts for C-N Bond Formation via a Hydrogen-Borrowing Strategy under Solvent-Free Conditions>, Electric Literature of 5344-90-1, the main research area is ruthenium imidazolylidene triazolylidene complex preparation crystal structure benzylation catalyst; crystal structure ruthenium imidazolylidene triazolylidene complex; mol structure ruthenium imidazolylidene triazolylidene complex; benzyl alc coupling reaction benzylation aniline derivative carbeneruthenium catalyst; quinoline derivative preparation.

Both imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) have evolved to be elite groups of N-heterocyclic carbene (NHC) ligands for homogeneous catalysis. To develop efficient Ru(II)-based catalysts incorporating these ligands for C-N bond-forming reactions via H-borrowing methodol., the authors used chelating ligands integrated with ImNHC and mesoionic tzNHC donors connected via a CH2 spacer with a diverse triazole backbone. The synthesized Ru(II) complexes 3 are highly efficient for C-N bond formation across a wide range of primary amine and alc. substrates under solvent-free conditions, and among all of the complexes studied here, catalyst 3a with a mesityl substituent displayed maximum activity. Catalyst 3a is also effective for the selective mono-N-methylation of various anilines using MeOH as a coupling partner, known to be relatively more difficult than other alcs. Also, complex 3a also delivers various substituted quinolines successfully via the reaction of 2-aminobenzyl alc. with several secondary alcs. Importantly, catalyst 3a exhibited the highest activity among the reported Ru(II) complexes for both the N-benzylation of aniline [achieving a turnover number (TON) of 50000] and the realization of quinoline 8a by reacting 2-aminobenzyl alc. with 2-phenylethanol (attaining a TON of 30000). The significance of electronic tuning in the Ru(II) complexes of chelating ligands featuring a combination of ImNHC and tzNHC donors with various triazole backbones is demonstrated by applying them in diverse C-N bond-forming reactions via a H-borrowing strategy. Notably, the Ru(II) complex 3a having an N-mesityl substituent displayed the highest activity among known Ru(II) complexes for both the N-benzylation of aniline [a turnover number (TON) of 50000] and the synthesis of quinoline via the reaction of 2-aminobenzyl alc. with 2-phenylethanol (a TON of 30000).

Inorganic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brain, K. R.; Green, D. M.; Jones, A. C.; Walters, K. A.; Api, A. M.; Selechnik, D.; Joshi, K. published the artcile< In vitro human skin absorption of linalool: Effects of vehicle composition, evaporation and occlusion on permeation and distribution>, Synthetic Route of 78-70-6, the main research area is Linalool; Occlusion; Vehicle effects.

In vitro human skin permeation and distribution of the fragrance material linalool (3,7-dimethyl-1,6-octadien-3-ol, CAS Number 78-70-6) following application in a range of single and mixed vehicles was determined, under unoccluded and occluded conditions, using human epidermal membranes. Vehicles were (70/30 volume/volume) ethanol[EtOH]/water, dipropyleneglycol [DPG], di-Et phthalate [DEP], (25/75 volume/volume) EtOH/DEP, (25/75 volume/volume) EtOH/DPG and petrolatum. Worst case absorbed dose values (% applied dose) for linalool under unoccluded conditions varied from 1.84% (DPG) to 4.08% (EtOH/water) and under occluded conditions from 5.9% (DEP) to 14.7% (EtOH/water). Occlusion always increased absorption but the magnitude of the effect varied with the vehicle from 2 to 6-fold. This study demonstrated that in vitro human skin permeation of linalool varied quite widely between test vehicles and that the magnitude of the effect of occlusion was also vehicle dependent. This was particularly significant in view of the reported variations in biol. responses using different vehicles (Lalko et al., 2004; Politano et al., 2006).

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Elavarasan, Samaraj; Bhaumik, Asim; Sasidharan, Manickam published the artcile< An Efficient Mesoporous Cu-Organic Nanorod for Friedlaender Synthesis of Quinoline and Click Reactions>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is hierarchical mesoporous organic polymer copper complex preparation surface area; aminobenzyl alc arylketone heterogeneous catalyst Friedlaender synthesis green chem; phenylquinoline preparation; benzylamine heterogeneous catalyst aerobic oxidative dehydrogenation green chem; arylalkyne azide benzylhalide heterogeneous catalyst regioselective click green chem.

A triazine functional hierarchical mesoporous organic polymer (HMOP) with nanorod morphol. together with large BET surface area ∼1218 m2g-1, huge pore volume&γτ”” ;6 mLg-1 and dual micro/mesopore architectures. Subsequent Cu-coordination with nitrogen atoms of the HMOP provided a robust catalyst (Cu-HMOP) to accomplish multi-step cascade reactions for preparation of N-heterocycles by different routes. For instance, the Cu-HMOP efficiently catalyzed one-pot sequential multi-step oxidative dehydrogenative coupling of 2-aminobenzyl alc. with diverse aromatic ketones to afford corresponding quinolines in excellent isolated yields (up to 97%). Secondly, the present catalyst exhibited good aerobic oxidative dehydrogenation activity of amines to imines. Thirdly, for “”click”” reaction involving azides-alkynes, the Cu-HMOP produced quant. yield for 1,4-disubstituted 1,2,3-triazole derivatives at room temperature using water as solvent. Verification of active metal leaching by a hot filtration test as well as reusability of the retrieved Cu-HMOP catalysts showed a consistent activity in the multi-component quinoline synthesis as model reaction.

ChemCatChem published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jie; Scarano, Aurelia; Gonzalez, Nestor Mora; D’Orso, Fabio; Yue, Yajuan; Nemeth, Krisztian; Saalbach, Gerhard; Hill, Lionel; de Oliveira Martins, Carlo; Moran, Rolando; Santino, Angelo; Martin, Cathie published the artcile< Biofortified tomatoes provide a new route to vitamin D sufficiency>, Synthetic Route of 434-16-2, the main research area is biofortified tomatoe provide vitamin D sufficiency.

Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of provitamin D3 in tomato by genome editing, modifying a duplicated section of phytosterol biosynthesis in Solanaceous plants, to provide a biofortified food with the added possibility of supplement production from waste material.

Nature Plants (London, United Kingdom) published new progress about Alkaloidal steroidal glycosides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Synthetic Route of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Xu-Hui; Zheng, Xu; Chen, Zeng-Hui; Zhang, Yu-Ying; Du, Ming; Dong, Xiu-Ping; Qin, Lei; Zhu, Bei-Wei published the artcile< Fresh and grilled eel volatile fingerprinting by e-Nose, GC-O, GC-MS and GC × GC-QTOF combined with purge and trap and solvent-assisted flavor evaporation>, Safety of 2-Ethylhexan-1-ol, the main research area is odor grilled eel volatile fingerprinting; E-Nose; Eel; Extraction methods; Fingerprinting; GC × GC-QTOF; Volatiles.

Fresh and grilled eel were investigated with respect to their volatile compounds and different fingerprinting techniques. An electronic nose (e-Nose) was applied to distinguish the odor between fresh and grilled eels. Purge and trap (P&T) and solvent-assisted flavor evaporation (SAFE) method were used to extract volatile compounds and further analyzed by a gas chromatog. combined with quadrupole mass spectrometry (GC-MS) and a two-dimensional gas chromatog. combined with hybrid quadrupole time-of-flight mass spectrometry (GC × GC-QTOF). SAFE extracted more ketone, alc. and high boiling volatiles in eels than P&T. Considering some distinct compounds extracted by P&T, a P&T and SAFE combined method was chosen. There were 155 volatiles detected in fresh and grilled eels, 93 volatiles were identified. Due to the higher peak capacity, GC × GC-QTOF detected 39 compounds more than GC-MS. The key characteristic volatiles of grilled eel were Me Pr disulfide, di-Me trisulfide, heptane, octane, and camphene. Volatile fingerprinting can be a reference benchmark for identification and quality appraisal of fresh and grilled eel products.

Food Research International published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sattarinezhad, A.; Roozbeh, J.; Shirazi Yeganeh, B.; Omrani, G. R.; Shams, M. published the artcile< Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial>, SDS of cas: 501-36-0 , the main research area is resveratrol antioxidant albuminuria diabetic nephropathy; Albuminuria; Diabetes complications; Diabetes mellitus; Diabetic nephropathy; Resveratrol.

Albuminuria is the most important indicator of diabetic nephropathy (DN). Resveratrol, a natural compound found in grape skins and red wine, has antioxidant effects. This study aimed to evaluate the effects of resveratrol on DN.In this randomized, double-blind, placebo-controlled clin. trial, 60 patients with type 2 diabetes and albuminuria were randomly assigned to receive either resveratrol (500 mg/day) or placebo for 90 days. Losartan (12.5 mg/day) was also administered to all participants. Primary outcomes were urinary albumin/creatinine ratio, estimated glomerular filtration rate (eGFR) and serum creatinine levels. Secondary outcomes were oxidative stress markers, and anthropometric and biochem. measures. Mean urine albumin/creatinine ratio was significantly reduced in the resveratrol group vs placebo (-46.4 mg/g, 95% CI: -64.5 to -28.3 vs 29.9 mg/g, 95% CI: 4.9 to 54.9; P < 0.001), whereas eGFR (1.7 mL/min/1.73 m2, 95% CI: -3.4 to 6.8 vs -4.0, 95% CI: -8.2 to 0.2; P = 0.08) and serum creatinine (-0.3 mg/dL, 95% CI: -0.1 to 0.1 vs 0.1 mg/dL, 95% CI: -0.0 to 0.1; P = 0.13) were unchanged. Serum antioxidant enzymes were significantly increased with resveratrol. After adjusting for confounding variables, the effect of resveratrol in reducing urinary albumin excretion was still significant (P < 0.001). Regression anal. revealed that every 1-cm decrease in waist circumference and 1-μmol/L increase in nitric oxide (NO) was associated with 9.4 mg/g and 4.0 mg/g reductions, resp., of urine albumin/creatinine ratio. This clin. trial has shown that resveratrol may be an effective adjunct to angiotensin receptor blockers (ARBs) for reducing urinary albumin excretion in patients with DN (ClinicalTrials.gov: NCT02704494). Diabetes & Metabolism published new progress about Albuminuria. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al-Masri, Harbi Tomah; Almejled, Akram Ali published the artcile< Hg(II) and Ru(II) complexes of mono- and dichalcogenides of bis(diphenylphosphino)amine chelating ligands: Synthesis, characterization and catalytic activity in transfer hydrogenation of acetophenone derivatives>, Application In Synthesis of 403-41-8, the main research area is ruthenium aminobisphosphino iodo carbonyl complex catalyst preparation crystal structure; transfer hydrogenatio catalyst ruthenium aminobisphosphino iodo carbonyl complex.

Reactions of C10H7-1-N(PPh2)2 (1) and C10H7-1-N(P(Se)Ph2)2 (2) ligands with mercury(II)iodide in equimolar ratio gave cis-[HgI2{-κ2P,P}] (3) and cis-[HgI2{-κ2Se,Se}] (4). Also, refluxing of monooxidized thioyl and selenoyl bis(phosphino)amine ligands C10H7-1-N(P(E)Ph2)(PPh2) (E = S (5), Se (6)) with [Ru(CO)3Cl2]2 dimer afforded cis-[Ru(CO)2Cl2{-κ2P,S}] (7) and cis-[Ru(CO)2Cl2{-κ2P,Se}] (8). Complexes , , and were identified and characterized by multinuclear NMR (1H, 13C, 31P and 77Se NMR) and IR spectroscopy. The mol. structure of was determined by single x-ray crystallog. is the first structurally characterized example of this kind of κ2P,S -bidentate ligand. The novel ruthenium(II) complexes and show high catalytic activity in the transfer hydrogenation of acetophenone derivatives to 1-phenylethanol derivatives in the presence of 2-propanol as the hydrogen source.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Chalcogenides Role: RCT (Reactant), RACT (Reactant or Reagent) (di-). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts