Month: October 2022

Zhang, Si-Xuan; Ding, Yan; Wang, Jun-Jie; Shen, Chuanji; Zhou, Xiaocong; Chu, Xue-Qiang; Ma, Mengtao; Shen, Zhi-Liang published the artcile< Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives>, Safety of Triphenylmethanol, the main research area is diaryl ester preparation; ethoxycyclopropoxy trimethylsilane diaryl methanol ring opening dehydroxylative cross coupling.

A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols R(R1)C(OH)R2 (R = Ph, 2-methylphenyl, 4-iodophenyl, naphthalen-1-yl, etc.; R1 = H, Ph, 4-methylphenyl, 4-chlorophenyl; R2 = Ph, 4-methoxyphenyl, 4-fluorophenyl, etc.) with a (1-ethoxycyclopropoxy)trimethylsilane was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters R(R1)C((CH2)2C(O)OCH2CH3)R2 in moderate to good yields, which could be applied to the functionalization of complex mols. I and II derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft III.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Ye; Liang, Jun; Gao, Jia-Ning; Shen, Yu; Kuang, Hai-Xue; Xia, Yong-Gang published the artcile< Novel LC-MS/MS method for complete composition analysis of polysaccharides by aldononitrile acetate and multiple reaction monitoring>, Name: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride, the main research area is plant polysaccharide composition liquid chromatog tandem mass spectrometry; Aldononitrile acetate derivatization; LC-MS/MS; Monosaccharide compositions; Polysaccharides.

Carbohydrate anal. has always been a challenging task due to the occurrence of high polarity and multiple isomers. Aldoses are commonly analyzed by gas liquid chromatog. (GLC) following aldononitrile acetate derivatization (AND). However, the GLC technique cannot be applied for the simultaneous determination of aldoses, ketoses, and uronic acids. In this study, a new method based on the combination of liquid chromatog.-tandem mass spectrometry (LC-MS/MS) and AND is developed for the complete characterization of monosaccharide composition (i.e., aldoses, ketoses, alditols, amino sugars, and uronic acids) in plant-derived polysaccharides. In addition to discussing the possible byproducts, the study optimizes the multiple reaction monitoring (MRM) parameters and LC conditions. The final separation of 17 carbohydrates is performed on a BEH Shield RP18 column (150 mm x 2.1 mm, 1.7μm) within 25 min, without using any buffer salt. Notably, the complex polysaccharides extracted from Ligusticum chuanxiong, Platycodon grandiflorum, Cyathula officinalis Kuan, Juglans mandshurica Maxim, and Aralia elata (Miq.). Seem bud can be successfully characterized using the developed method. Overall, the results demonstrated that the newly established LC-MS/MS MRM method is more effective and powerful than the GLC-based methods reported previously, and it is more suitable for the anal. of highly complex natural polysaccharides, including complex pectins, fructosans, and glycoproteins.

Carbohydrate Polymers published new progress about Alditols Role: ANT (Analyte), ANST (Analytical Study). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Name: (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Furusawa, Yuka; Nakamura, Hitoshi; Ashitani, Tatsuya published the artcile< Differences in the ""egumi"" taste of moso-bamboo shoots: research using chemical analysis and two types of taste sensors>, COA of Formula: C6H12O6, the main research area is Phyllostachys shoot oxalic acid fructose egumi taste.

We conducted our research with the aim of determining whether the “”egumi”” taste of moso-bamboo shoots differs depending on the production area and how the “”egumi”” taste of bamboo shoots from Yamagata Prefecture, which is near the northern limit of cultivation, differs. The investigation was conducted using conventional chem. anal. methods to quant. evaluate the presence and content of homogentisic acid and oxalic acid in bamboo shoots from different regions. In addition, qual. evaluation, for which chem. anal. alone is insufficient, was conducted using taste sensors, which have rarely been used. As a result, chem. anal. showed that homogentisic acid was not identified among the two substances considered to be major components of egumi taste, while oxalic acid was identified in all samples. Therefore, it is highly likely that oxalic acid is responsible for the “”egumi”” taste in this study. In addition, qual. anal. using taste sensors revealed that there is a difference in “”egumi”” taste depending on the origin of the bamboo shoot. It was suggested that bamboo shoots from Yamagata Prefecture, near the northern limit of cultivation, had a stronger “”egumi”” taste than those from Kyoto and Fukuoka Prefectures.

Journal of Wood Science published new progress about Astringency. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Speranza, Eric Demian; Colombo, Manuel; Heguilor, Santiago; Tatone, Leandro Martin; Colombo, Juan Carlos published the artcile< Alterations in the sterol signature of detritivorous fish along pollution gradients in the Rio de la Plata basin (Argentina): From plant to sewage-based diet>, Synthetic Route of 434-16-2, the main research area is sterol detritivorous fish pollution sewage diet; Coprostanol; Detritivory; Fish; Sewage; Sterols.

In order to assess the impact of sewage pollution on the diet of the strict detritivorous and migratory South American fish, Prochilodus lineatus, 16 sterol biomarkers were analyzed by gas chromatog.-mass spectrometry from fish muscle (n: 144) collected along 1200 km in the Rio de la Plata basin. Sterol concentrations were fairly homogeneous (2.4 ± 1.3 mg g-1 dry weight), but their proportion in lipids was highly variable and inversely related to both body mass and lipid contents, reflecting the more conservative character of sterols compared to the rapid accumulation of fat as fish grows. As expected, the muscle sterol signature was widely dominated by cholesterol (92 ± 4.5% of total sterols), but it exhibited a remarkable diversity with variable proportions of fecal coprostanol (4.0 ± 4.4%) and plant sterols (3.1 ± 1.9%, e.g. sitosterol and campesterol). Muscle sterols exhibited contrasting geog. differences associated with dietary shifts from plant-derived detritus in the northern reaches of the basin (N: Parana and Uruguay Rivers), to sewage dominated inputs at Buenos Aires (BA). Fish from BA are fattier (lipids: 35 ± 18 vs. 15 ± 9.0% at N), with higher total sterol contents (2.6 ± 1.3 vs. 1.9 ± 1.0 mg g-1), abundant coprostanol (5.3 ± 4.4 vs. 0.46 ± 1.1%) and lower plant sterols (2.6 ± 1.6 vs 4.6 ± 2.0%), reflecting a diet shifted to anthropogenic organic matter as opposed to vegetal detritus in the north. Accordingly, BA fish presented lower phyto/fecal sterol ratios (0.37 ± 0.21 vs. 0.91 ± 0.12 at N) and higher copro/epicoprostanol ratios (0.95 ± 0.082 vs 0.51 ± 0.25 at N), indicating fresh fecal inputs which provide a valuable supply of easily absorbed organic matter at this site. In addition, the sterol signature allowed to distinguish migratory fish from BA collected 900 km north (previously identified by their pollutant fingerprint and biochem. composition). In fact, coprostanol concentrations show a direct relationship with human populations along the basin, highlighting the usefulness of fecal sterol biomarkers as tracers of polluted fish stocks.

Environmental Research published new progress about Biomarkers. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Synthetic Route of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Akbari, Maryam; Tamtaji, Omid Reza; Lankarani, Kamran B.; Tabrizi, Reza; Dadgostar, Ehsan; Kolahdooz, Fariba; Jamilian, Mehri; Mirzaei, Hamed; Asemi, Zatollah published the artcile< The Effects of Resveratrol Supplementation on Endothelial Function and Blood Pressures Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials>, Computed Properties of 501-36-0 , the main research area is resveratrol RCT endothelial function blood pressure MetS human; Blood pressures; Endothelial function; Meta-analysis; Metabolic syndrome; Resveratrol.

There are current trials investigating the effect of resveratrol supplementation on endothelial function and blood pressures among patients with metabolic syndrome (MetS); however, the findings are controversial. This systematic review and meta-anal. of randomized controlled trials (RCTs) were carried out to summarize the effects of resveratrol supplementation on endothelial activation and blood pressures among patients with MetS and related disorders. This study searched systematically online databases including: PubMed-Medline, Embase, ISI Web of Science and Cochrane Central Register of Controlled Trials until Oct., 2018. Two independent authors extracted data and assessed the quality of included articles. Data were pooled using the fixed- or random-effects model and considered as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 electronic citations, 28 RCTs (with 33 findings reported) were included in the meta-analyses. The findings showed that resveratrol intervention significantly increased flow-mediated dilatation (FMD) levels (SMD 1.77; 95% CI 0.25, 3.29; P = 0.02; I2: 96.5). However, resveratrol supplements did not affect systolic blood pressure (SBP) (SMD – 0.27; 95% CI – 0.57, 0.03; P = 0.07; I2: 88.9) and diastolic blood pressure (DBP) (SMD – 0.21; 95% CI – 0.52, 0.11; P = 0.19; I2: 89.8). Resveratrol supplementation significantly increased FMD among patients with MetS and related disorders, but did not affect SBP and DBP. Addnl. prospective studies are needed to investigate the effect of resveratrol supplementation on endothelial function and blood pressures, using higher-dose of resveratrol with longer durations.

High Blood Pressure & Cardiovascular Prevention published new progress about Diastolic blood pressure. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Computed Properties of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Linhan; Zhou, Ting; Zhong, Linyu; Zhou, Qian; Gu, Gang; Hu, Mengjun; Chen, Fengping; Lin, Sheng published the artcile< Bioremediation of quinclorac injury on tobacco by a rhizosphere bacterium>, Application In Synthesis of 87-73-0, the main research area is rhizosphere bacterium tobacco quinclorac injury bioremediation; Bioremediation; Herbicide; Klebsiella variicola; Plant growth-promoting bacterium; Tobacco.

The presence of herbicides residues in soil represents a serious problem for agriculture. Quinclorac is a common herbicide applied in rice field, but its residue can cause abnormal growth in successive crop of tobacco in Southern China. Remediation by microorganisms is considered to be an environmentally friendly method to remove such pollutants injury. The aims of this study were to obtain quinclorac remediation isolates and to investigate the possible mechanism(s) of remediation. Six bacterial isolates were obtained from rhizosphere of rice-tobacco rotation fields, and were found to be capable of degrading quinclorac on a mineral salt medium (MSM), with degradation efficiency ranging from 2.1 to 23.7%. Among these isolates, J5 had the highest degradation efficiency, and was identified as Klebsiella variicola based on phylogenetic anal. and a metabolic profile generating by Biolog GEN III system. Bioremediation of quinclorac injury was confirmed using pot assays with tobacco, in which J5 reversed the detrimental effect of quinclorac on leaf area, leaf number, and plant height. The J5 isolate also seemed to promote plant growth, in terms of tobacco seedling growth and seed germination, which were 2.2 times and 1.6 times higher compared to untreated control, resp. The mechanisms of plant growth promoting (PGP) traits were found to involve nitrogen-fixing, indole-3-acetic acid (IAA) production, and phosphate solubilization ability. In addition, proteomic anal. and relative quant. PCR revealed an elevated level of 4-hydroxyphenylacetate 3-monooxygenase (HPMO) in quinclorac-treated J5, suggesting that this enzyme may play an important role in quinclorac remediation. This study showed that the J5 isolate could be exploited to not only assist in soil remediation due to quinclorac residue issues but also promote tobacco growth.

World Journal of Microbiology & Biotechnology published new progress about Germination. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Jingxiu; Chen, Qingmao; Luo, Zhigao; Tang, Xiaodong; Zhao, Jinwu published the artcile< N-Heterocyclic carbene copper catalyzed quinoline synthesis from 2-aminobenzyl alcohols and ketones using DMSO as an oxidant at room temperature>, Product Details of C7H9NO, the main research area is quinoline preparation; aminobenzyl alc Friedlander reaction ketone heterocyclic carbene catalyst.

A facile and practical process for the synthesis of quinolines through an N-heterocyclic carbene copper catalyzed indirect Friedlander reaction from 2-aminobenzyl alc. and aryl ketones using DMSO as an oxidant at room temperature is reported. The quinolines, e.g., I (R1 = 4-MeC6H4, 2-ClC6H4, 3-thienyl, etc., R2 = H; R1 = Ph, R2 = Me), were synthesized in acceptable yields.

RSC Advances published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Product Details of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pal, Kumar Bhaskar; Guo, Aoxin; Das, Mrinmoy; Bati, Gabor; Liu, Xue-Wei published the artcile< Superbase-Catalyzed Stereo- and Regioselective Glycosylation with 2-Nitroglycals: Facile Access to 2-Amino-2-deoxy-O-glycosides>, SDS of cas: 4064-06-6, the main research area is aminoglycoside regioselective stereoselective glycosylation catalyst DFT glycoconjugate nitroglucal aminodeoxyglycoside.

An efficient super-base-catalyzed stereo- and regioselective glycosylation of 2-nitroglycals with high functional group compatibility is reported. The ion pair generated from alc. and a catalytic amount of P4-t-Bu was vital for the successful implementation of this stereoselective glycosylation under mild conditions, producing moderate to good yields. Under reported reaction conditions, 2-nitrogalactals produce α-stereoisomers exclusively, while 2-nitroglucal yielded more β-products. The notable difference between the outcomes was investigated by the d. functional theory (DFT) study. In addition, we have synthesized the key intermediate of a mucin-type core-6 glycoconjugate, thus illustrating the synthetic potency of this method.

ACS Catalysis published new progress about Aminoglycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jakobs, Ruth; Schweiger, Rabea; Mueller, Caroline published the artcile< Aphid infestation leads to plant part-specific changes in phloem sap chemistry, which may indicate niche construction>, Electric Literature of 87-73-0, the main research area is Tanacetum Macrosiphoniella Uroleucon phloem sap chem metabolomics niche construction; aphid; metabolomics; niche conformance; niche construction; phloem sap chemistry.

Phloem sap quality can differ between and within plants, and affect the performance of aphids. In turn, aphid infestation may change the chem. composition and nutritional value of phloem sap. However, the effects of different aphid species on the overall phloem sap composition of distinct parts within plant individuals in relation to aphid performance remain unclear. To test the specificity of plant responses to aphids, we used two chemotypes of Tanacetum vulgare plants and placed the monophagous aphids Macrosiphoniella tanacetaria and Uroleucon tanaceti on different plant parts (stems close to the inflorescence, young and old leaves). Aphid population growth was determined and sugars, organic acids, amino acids and metabolic fingerprints of phloem exudates were analyzed. Macrosiphoniella tanacetaria performed best on stems, whereas U. tanaceti performed best on old leaves, indicating differences in niche conformance. Aphid infestation led to distinct changes in the phloem exudate composition of distinct metabolite classes, differing particularly between plant parts but less between chemotypes. In summary, plant responses to aphids are highly specific for the chemotype, plant part, metabolite class and aphid species. These changes may indicate that aphids construct their own niche, optimizing the food quality on the plant parts they prefer.

New Phytologist published new progress about Flower. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jinli; Chen, Ling; Dong, Yibo; Yang, Jinchen; Wu, Yangjie published the artcile< A Cu2O/TBAB-promoted approach to synthesize heteroaromatic 2-amines via one-pot cyclization of aryl isothiocyanates with ortho-substituted amines in water>, Application of C7H9NO, the main research area is aryl isothiocyanate amine copper catalyst desulfurization dehydrogenative cyclization; heteroaromatic amine preparation green chem.

An efficient approach to synthesize heteroaromatic 2-amines from one-pot desulfurization/dehydrogenative cyclization of aryl isothiocyanates with ortho-substituted amines in water was developed. This approach tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to synthesize heteroaromatic 2-amines in moderate to excellent yields. A plausible mechanism was proposed and the role of TBAB and Cu2O in the present strategy was suggested with the help of ESI mass spectrometry.

Organic & Biomolecular Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Application of C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts