Month: October 2022

Li, Ting; Cheng, Xinpeng; Qian, Pengcheng; Zhang, Liming published the artcile< Gold-catalysed asymmetric net addition of unactivated propargylic C-H bonds to tethered aldehydes>, HPLC of Formula: 627-27-0, the main research area is chiral fused homopropargylic alc preparation enantioselective density functional theory; propargylic aldehyde intramol addition gold bifunctional phosphine ligand catalyst.

The asym. one-step net addition of unactivated propargylic C-H bonds to aldehydes such as 7-(dimethyl(phenyl)silyl)hept-6-ynal, 4-(benzyloxy)-7-(tert-butyldimethylsilyl)hept-6-ynal, 7-(tert-Butyldimethylsilyl)-2-phenylhept-6-ynal, etc. leads to an atom-economic construction of versatile chiral homopropargylic alcs. e.g., I, but has not yet been realized. Here, implementation in an intramol. manner under mild reaction conditions have been showed. This chem.-via cooperative gold catalysis enabled by chiral bifunctional phosphine ligands (1R/1S)-II (R = Me, Cy; R1 = H, Me)-achieves asym. catalytic deprotonation of propargylic C-H (pKa > 30) by a tertiary amine group (pKa ≈ 10) of the ligand in the presence of much more acidic aldehydic α-hydrogens (pKa ≈ 17). The reaction exhibits a broad scope and readily accommodates various functional groups. The cyclopentane/cyclohexane-fused homopropargylic alc. products e.g., III are formed with excellent enantiomeric excesses and high trans-selectivities with or without a preexisting substrate chiral center. D. functional theory studies of the reaction support the conceived reaction mechanism and the calculated energetics corroborate the observed stereoselectivity and confirm addnl. metal-ligand cooperation.

Nature Catalysis published new progress about Alcohols, chiral Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (homopropargylic-). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scaglione, Francesco; Musazzi, Umberto M.; Minghetti, Paola published the artcile< Considerations on D-mannose mechanism of action and consequent classification of marketed healthcare products>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is review Dmannose mechanism healthcare product; D-mannose; FimH adhesin; medical device; product administrative classification; urinary tract infection.

A review. Urinary tract infections (UTls) are very common disorders that affect adult women. Indeed, 50% of all women suffer from UTIs at least one time in their lifetime; 20-40% of them experience recurrent episodes. The majority of UTIs seems to be due to uropathogenic Escherichia coli that invades urothelial cells and forms quiescent bacterial reservoirs. Recurrences of UTls are often treated with non-prescribed antibiotics by the patients, with increased issues connected to antibiotics resistance. D-mannose, a monosaccharide that is absorbed but not metabolized by the human body, has been proposed as an alternative approach for managing UTIs since it can inhibit the bacterial adhesion to the urothelium. This manuscript discusses the mechanisms through which D-mannose acts to highlight the regulatory aspects relevant for determining the administrative category of healthcare products placed on the market. The existing literature permits to conclude that the anti- adhesive effect of D-mannose cannot be considered as a pharmacol. effect and, therefore, D-mannose-based products should be classified as medical devices composed of substances.

Frontiers in Pharmacology published new progress about Antibiotics (resistance). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Ming-Liang; Chen, Jun-Jie; Xu, Hui; Huang, Zhi-Cong; Huang, Wei; Liu, Yu-Wen; Wang, Xing; Liu, Min; Guo, Zi-Qiong; Dai, Hui-Xiong published the artcile< Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters>, Category: alcohols-buliding-blocks, the main research area is aryl thioester nucleophile haloalkane palladium norbornene catalyst decarbonylaive Catellani; alkyl nucleophilic arene preparation.

Herein, a novel decarbonylative Catellani reaction via palladium-catalyzed, norbornene (NBE)-mediated polyfunctionalization of aromatic thioesters, which served as readily available carboxylic acid derivs was reported. A variety of alkenyl, alkyl, aryl and sulfur moieties was conveniently introduced into the ipso-positions of the aromatic thioesters. By combining carboxyl-directed C-H functionalization and the classical Catellani reaction, this protocol allows for the construction of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted arenes from simple aromatic acids. Furthermore, the late-stage functionalization of a series of drug mols. highlights the potential utility of the reaction.

JACS Au published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Changchen; Wang, Hongquan; Bo, Zhao; Xia, Leilei; Jiang, Haiyue; Bo, Pan published the artcile< The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects>, Electric Literature of 492-62-6, the main research area is decellularized cartilage tissue regeneration cytotoxicity macrophage response; Costal cartilage defect; Decellularized cartilage; Macrophage response; Thoracic deformity.

After harvesting multiple costal cartilages, the local defect disrupts the integrity of the chest wall and may lead to obvious thoracic complications, such as local depression and asymmetry of the bilateral thoracic height. Decellularized materials have been used for tissue reconstruction in clin. surgeries. To apply xenogenic decellularized cartilage in costal cartilage defects, porcine-derived auricular and costal cartilage was tested for characterization, cytotoxicity, macrophage response, and tissue regeneration. Most of the DNA and α-Gal were effectively removed, and the collagen was well preserved after the decellularization process. The glycosaminoglycan (GAG) content decreased significantly compared to that in untreated cartilage. The decellularized auricular cartilage had a larger pore size, more pores, and a higher degradation rate than the decellularized costal cartilage. No apparent nuclei or structural damage was observed in the extracellular matrix. The decellularized auricular cartilage had a higher cell proliferation rate and more prominent immunomodulatory effect than the other groups. Two types of decellularized cartilage, particularly decellularized auricular cartilage, promoted the tissue regeneration in the cartilage defect area, combined with noticeable cartilage morphol. and increased chondrogenic gene expression. In our research, the functional components and structure of the extracellular matrix were well preserved after the decellularization process. The decellularized cartilage had better biocompatibility and suitable microenvironment for tissue regeneration in the defect area, suggesting its potential application in cartilage repair during the surgery. Autologous costal cartilage has been widely used in various surgeries, while the cartilage defects after the harvesting of multiple costal cartilages may cause localized chest wall deformities. Decellularized cartilage is an ideal material that could be produced in the factory and applied in surgeries. In this study, both decellularized costal cartilage and auricular cartilage preserved original structure, functional biocompatibility, immunosuppressive effects, and promoted tissue regeneration in the cartilage defect area.

Acta Biomaterialia published new progress about Aggrecans Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lindberg, B.; Asplund, L.; Fellner-Feldegg, H.; Kelfve, P.; Siegbahn, H.; Siegbahn, K. published the artcile< ESCA applied to liquids. ESCA spectra from molecular ions in solution>, Quality Control of 35564-86-4, the main research area is ESCA spectra pyridylsulfamoylphenylazosalicylate; salicylate pyridylsulfamoylphenylazo ESCA.

The application of ESCA to the N-methylglucamine salt of 5-[p-(2-pyridylsulfamoyl)phenylazo]salicylic acid is described. By exchange of one of the ions in the solution the ESCA spectra of the individual ionic components are deduced. Broadening of N lines in the spectrum indicates different chem. forms in solution

Chemical Physics Letters published new progress about Photoelectron spectra. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Quality Control of 35564-86-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaur, Mandeep; U Din Reshi, Noor; Patra, Kamaless; Bhattacherya, Arindom; Kunnikuruvan, Sooraj; Bera, Jitendra K. published the artcile< A Proton-Responsive Pyridyl(benzamide)-Functionalized NHC Ligand on Ir Complex for Alkylation of Ketones and Secondary Alcohols>, Electric Literature of 5344-90-1, the main research area is pyridylbenzamidecarbene iridium complex preparation catalyst alkylation ketone alc; crystal structure pyridylbenzamidecarbene iridium complex; mol structure pyridylbenzamidecarbene iridium complex; Borrowing-Hydrogen; Homogeneous Catalysis; Hydrogen transfer; Metal-Ligand Cooperation; Proton-Responsive Ligand; Reaction Mechanism.

A Cp*Ir(III) complex (1) of a newly designed ligand L1 featuring a proton-responsive pyridyl(benzamide) appended on N-heterocyclic carbene (NHC) was synthesized. The mol. structure of 1 reveals a dearomatized form of the ligand. The protonation of 1 with HBF4 in THF gives the corresponding aromatized complex [Cp*Ir(L1H)Cl]BF4 (2). Both compounds were characterized spectroscopically and by x-ray crystallog. The protonation of 1 with acid was examined by 1H NMR and UV-visible spectra. The proton-responsive character of 1 is exploited for catalyzing α-alkylation of ketones and β-alkylation of secondary alcs. using primary alcs. as alkylating agents through H-borrowing methodol. Compound 1 is an effective catalyst for these reactions and exhibits a superior activity in comparison to a structurally similar Ir complex [Cp*Ir(L2)Cl]PF6 (3) lacking a proton-responsive pendant amide moiety. The catalytic alkylation was characterized by a wide substrate scope, low catalyst and base loadings, and a short reaction time. The catalytic efficacy of 1 is also demonstrated for the syntheses of quinoline and lactone derivatives via acceptorless dehydrogenation, and selective alkylation of two steroids, pregnenolone and testosterone. Detailed mechanistic studies and DFT calculations substantiate the role of the proton-responsive ligand in the H-borrowing process.

Chemistry – A European Journal published new progress about Alkylating agents (pyridyl(benzamide) Ir complexes). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shaito, Abdullah; Posadino, Anna Maria; Younes, Nadin; Hasan, Hiba; Halabi, Sarah; Alhababi, Dalal; Al-Mohannadi, Anjud; Abdel-Rahman, Wael M.; Eid, Ali H.; Nasrallah, Gheyath K.; Pintus, Gianfranco published the artcile< Potential adverse effects of resveratrol a literature review>, Formula: C14H12O3, the main research area is review resveratrol toxicity bioavailability stilbenoid; anticancer; antioxidant effects; biphasic; oxidative DNA damage; pro-oxidant effects; reactive oxygen species (ROS); resveratrol.

A review. Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol’s health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound Ever since, several pharmacol. activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clin. trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

International Journal of Molecular Sciences published new progress about Bioavailability. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alfonzo, Edwin; Hande, Sudhir M. published the artcile< α-Heteroarylation of Thioethers via Photoredox and Weak Bronsted Base Catalysis>, Safety of 2-(Phenylthio)ethanol, the main research area is Heteroarylation thioether photoredox weak Bronsted base catalysis; Classical Minisci Reaction with Thioethers.

We report the C-H activation of thioethers to α-thio alkyl radicals and their addition to N-methoxyheteroarenium salts for the redox-neutral synthesis of α-heteroaromatic thioethers. Studies are consistent with a two-step activation mechanism, where oxidation of thioethers to sulfide radical cations by a photoredox catalyst is followed by α-C-H deprotonation by a weak Bronsted base catalyst to afford α-thio alkyl radicals. Further, N-methoxyheteroarenium salts play addnl. roles as a source of methoxyl radical that contributes to α-thio alkyl radical generation and a sacrificial oxidant that regenerates the photoredox catalytic cycle.

Organic Letters published new progress about Bronsted bases Role: CAT (Catalyst Use), USES (Uses). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Major, Mate M.; Balogh, Szabolcs; Simon, Jozsef; Bakos, Jozsef; Farkas, Gergely published the artcile< New chiral thioether-phosphite ligands and their rhodium-coordination chemistry: steric and electronic properties, dynamic processes and application in catalysis>, Safety of 2-(Phenylthio)ethanol, the main research area is rhodium thioether phosphite chiral BINOL ester complex preparation; asym hydrogenation catalyst rhodium thioether BINOL phosphite cyclooctadiene complex.

Thioether-phosphite ligands (S)-BINOL-PO(CH2)nSPh (SP’s, n = 2, 3; BINOL-H2 = 1,1′-binaphthyl-2,2′-diol, H8-1,1′-binaphthyl-2,2′-diol) with axially chiral binaphthyl or 5,5′,6,6′,7,7′,8,8′-octahydrobinaphthyl moiety and their [Rh(COD)(SP)]BF4 complexes have been synthesized to study their coordination chem. and catalytic features and to compare them to those of the structurally analogous phosphine-phosphites (S)-BINOL-PO(CH2)nPPh2 (PP’s). NMR exchange studies on [Rh(COD)(SP)]BF4 complexes showed selective 1,5-cyclooctadiene dynamics. Firm evidence has been found that this fluxional process involves dissociation of the Rh-sulfur bond. Based on in situ NMR studies, SP ligands can form two types of bis-ligated species at ligand-to-metal ratio higher than 1. Unlike bis-ligated phosphine-phosphite complexes, bis-ligated thioether-phosphite Rh-complexes can efficiently catalyze asym. hydrogenation reactions due to their distinct coordination chem.

Journal of Coordination Chemistry published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Ruohan; Liu, Han; Tang, Arthur H.; Payne, Richard J.; Li, Xuechen published the artcile< A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation>, Synthetic Route of 4064-06-6, the main research area is stereoselective glycosylation pseudaminic acid bimodal glycoside donor.

A robust methodol. for the stereocontrolled chem. glycosylation of pseudaminic acid has been developed to afford both α- (axial) and β- (equatorial) glycosides reliably with complete stereoselectivity, using a common glycosyl donor (7N-Cbz/5N-azido Pse thioglycoside) simply by changing the reaction conditions. In the CH2Cl2/MeCN cosolvent, highly β-selective pseudaminylation was observed, while addition of 5.0 equiv DMF in CH2Cl2 gave the α-pseudaminosides.

Organic Letters published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Synthetic Route of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts