Month: October 2022

Nguyen, Thao T.; Nguyen, Khang X.; Pham, Phuc H.; Ly, Duc; Nguyen, Duyen K.; Nguyen, Khoa D.; Nguyen, Tung T.; Phan, Nam T. S. published the artcile< Copper-catalyzed synthesis of pyrido-fused quinazolinones from 2-aminoarylmethanols and isoquinolines or tetrahydroisoquinolines>, Computed Properties of 5344-90-1, the main research area is aminoarylmethanol isoquinoline copper catalyst amination annulation cascade reacation; isoquinolino quinazolinone preparation; tetrahydroisoquinoline aminoarylmethanol copper catalyst amination annulation cascade reacation; dihydroisoquinolino quinazolinone preparation.

Pyrido-fused quinazolinones were synthesized via copper-catalyzed cascade C(sp2)-H amination and annulation of 2-aminoarylmethanols with isoquinolines or pyridines. The transformation proceeded readily in the presence of a com. available CuCl2 catalyst with mol. oxygen as a green oxidant. Moreover, the dehydrogenative cross-coupling of 2-aminoarylmethanols with tetrahydroisoquinolines were explored, in which CuBr exhibited higher catalytic activity than CuCl2. Broad substrate scope with good tolerance of functionalities were observed under the optimized reaction conditions. The bioactive naturally occurring alkaloid rutaecarpine was obtained by this strategy. The remarkable feature of this protocol was that complicated heterocyclic structures were readily achieved in a single synthetic step from easily accessible reactants and catalysts. The pathway to pyrido-fused quinazolinones would be complementary to existing protocols.

Organic & Biomolecular Chemistry published new progress about Amination. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Meng-Juan; Li, Hong-Xi; Young, David J.; Li, Hai-Yan; Lang, Jian-Ping published the artcile< Reaction condition controlled nickel(II)-catalyzed C-C cross-coupling of alcohols>, Category: alcohols-buliding-blocks, the main research area is nickel cluster catalyst preparation crystal structure; primary secondary alc acceptorless dehydrogenation coupling; aryl alkyl ketone preparation; unsaturated ketone preparation; quinoline preparation.

A controlled approach to a diverse range of β-alkylated secondary alcs., α-alkylated ketones and α,β-unsaturated ketones using the acceptorless dehydrogenation coupling methodol. employing a Ni(II) 4,6-dimethylpyrimidine-2-thiolate cluster catalyst under different reaction conditions was reported. This catalyst could tolerate a wide range of substrates and exhibited a high activity for the annulation reaction of secondary alcs. with 2-aminobenzyl alcs. to yield quinolines. This work is an example of precise chemoselectivity control by careful choice of reaction conditions.

Organic & Biomolecular Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Dong; von Krbek, Larissa K. S.; Yu, Le; Ronson, Tanya K.; Thoburn, John D.; Carpenter, John P.; Greenfield, Jake L.; Howe, Duncan J.; Wu, Biao; Nitschke, Jonathan R. published the artcile< Glucose Binding Drives Reconfiguration of a Dynamic Library of Urea-Containing Metal-Organic Assemblies>, Application In Synthesis of 4064-06-6, the main research area is iron urea functionalized ditopic formylpyridine helicate preparation crystal structure; host guest binding activity inclusion iron helicate saccharide mutarotation; dynamic combinatorial library; glucose binding; host-guest systems; metal-organic assemblies; supramolecular chemistry.

A bis-urea-functionalized ditopic subcomponent assembled with 2-formylpyridine and FeII, resulting in a dynamic library of metal-organic assemblies: an irregular FeII4L6 structure and three FeII2L3 stereoisomers: left- and right-handed helicates and a meso-structure. This library reconfigured in response to the addition of monosaccharide derivatives, which served as guests for specific library members, and the rate of saccharide mutarotation was also enhanced by the library. The (P) enantiomer of the FeII2L3 helical structure bound β-D-glucose selectively over α-D-glucose. As a consequence, the library collapsed into the (P)-FeII2L3 helicate following glucose addition The α-D-glucose was likewise transformed into the β-D-anomer during equilibration and binding. Thus, β-D-glucose and (P)-3 amplified each other in the product mixture, as metal-organic and saccharide libraries geared together into a single equilibrating system.

Angewandte Chemie, International Edition published new progress about Crystal structure. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Application In Synthesis of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Tianlin; Jiang, Tian; Liu, Ning; Wu, Caiyun; Xu, Huaide; Lei, Hongjie published the artcile< Biotransformation of phenolic profiles and improvement of antioxidant capacities in jujube juice by select lactic acid bacteria>, COA of Formula: C8H18O, the main research area is biotransformation phenolic antioxidant jujube juice lactic acid bacteria; Antioxidant capacity; Fermentation; Flavor volatiles; Jujube juice; Probiotics.

The objective of this study was to investigate the effects of four com. lactic acid bacteria (LAB), namely L. acidophilus, L. casei, L. helveticus and L. plantarum, on the phenolic profiles, antioxidant capacities and flavor profiles of jujube juices prepared from two crop varieties (Ziziphus Jujuba cv. Muzao and Hetian). Results showed that both jujube juices were excellent matrixes for LAB growth with more than 11 log CFU/mL of viable counts at the end of fermentation LAB fermentation dramatically increased total phenolic content, while decreased total flavonoid content of jujube juices. However, antioxidant capacities based on DPPH and FRAP methods were significantly improved by LAB fermentation and pos. correlated with caffeic acid and rutin contents. Furthermore, a total of 74 volatile compounds were identified and increased in total content by LAB fermentation, which resulted in 22 and 19 new flavor volatiles formation in Muzao juice and Hetian juice, resp.

Food Chemistry published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Komorowska, Justyna; Wątroba, Mateusz; Szukiewicz, Dariusz published the artcile< Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer's disease.>, COA of Formula: C14H12O3, the main research area is Alzheimer’s disease; Antioxidation; Central nervous system; Polyphenols; Resveratrol.

PURPOSE: The prevalence of Alzheimer’s Disease is rising, in part due to increase in the medium age of residents in developed countries. The aim of the study has been to determine whether resveratrol (RSV) can be effective in the prevention or treatment of Alzheimer’s Disease, providing its antioxidant, anti-inflammatory, and SIRT1-activating properties. METHODS: A systematic review of some experimental and clinical studies has been made. The eligibility criteria have comprised: maximum 10 years passed from the study publication, geographical diversity of the studies performed, and – as much as possible – pertaining of the reviewed study results both to animal models of AD, and to humans. RESULTS: After the final assessment of the eligibility criteria, 96 research studies have been included in the review. Overall results suggest that RSV can be effectively used in the prevention of AD, especially in reference to its familial forms with an early onset. At the same time, efficacy of RSV in the treatment of AD needs further studies, aimed at: improving its transport through the blood-brain barrier (BBB), performing prospective clinical in vivo trials on large groups of patients, and determining the optimal RSV dosage. DISCUSSION: Providing RSV mechanisms of action, inhibitory in reference to many pathomechanisms of AD, it seems very likely that RSV could be effective in AD prevention. The main limitations referring to such presumption include: limited permeability of BBB to RSV, and scarcity of clinical studies on RSV pertaining to large groups of humans.

Advances in medical sciences published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sai, Masahiro published the artcile< Direct Synthesis of Indanes via Iron-Catalyzed Dehydrative Coupling/Friedel-Crafts Cyclization of Two Different Alcohols>, Safety of Triphenylmethanol, the main research area is iron catalyzed cascade dehydrative coupling Friedel Crafts alc; indane synthesis atom economic green.

We report herein a novel iron-catalyzed cascade dehydrative coupling/Friedel-Crafts cyclization of two different alcs., providing a variety of indanes, which are ubiquitous substructures found in natural products, pharmaceuticals, and functional materials. Importantly, the developed approach is highly atom-economic and environmentally benign, as it employs readily available alcs. as substrates and generates water as the only byproduct. Thus, e.g., benzhydrol + t-BuOH → 1,1-dimethyl-3-phenylindan (82%) employing Fe(OTf)3 and PhCF3 as solvent at 105°.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schuh, Lukas; Mueller, Philipp; Torvisco, Ana; Stueger, Harald; Wrodnigg, Tanja M.; Haas, Michael published the artcile< Synthesis of D-Galactose-Substituted Acylsilanes and Acylgermanes. Model Compounds for Visible Light Photoinitiators with Intriguing High Solubility>, SDS of cas: 4064-06-6, the main research area is photocatalyst acylgermane acylsilane synthesis galactose glycoside preparation; acylgermane acylsilane synthesis galactose crystal structure photoinitiator crystal structure.

A convenient synthetic method to obtain D-galactose-substituted acylsilanes and acylgermanes is described. These acyl group 14 compounds are easily accessible in good yields. Their structural properties were analyzed by a combination of NMR, single crystal X-ray crystallog., and UV/vis spectroscopy. A D-galactose-substituted tetra-acylgermane represents a new interesting visible light photoinitiator based on its absorption properties as well as its high solubility

Organometallics published new progress about Crystal structure. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Xiao-Ying; Dong, Quan-Xiu; Zhu, Jie; Sun, Xun; Zhang, Li-Fan; Qiu, Mandy; Yu, Xiao-Lin; Liu, Rui-Tian published the artcile< Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy>, COA of Formula: C14H12O3, the main research area is resveratrol tau cognitive deficit neuropathol tauopathy; Alzheimer’s disease; Resveratrol; neuroinflammation; oligomer; synapse loss; tau..

Background: Alzheimer’s Disease (AD) is characterized by the presence of extracellular amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles assembled by the microtubuleassocd. protein tau. Increasing evidence demonstrated that tau pathol. played an important role in AD progression. Resveratrol (RSV) has previously proved to exert neuroprotective effect against AD by inhibiting Aβ generation and Aβ-induced neurocytotoxicity, while its effect on tau pathol. is still unknown. Methods: The effect of RSV on tau aggregation was measured by Thioflavin T fluorescence and Transmission electron microscope imaging. The effect of RSV on tau oligomer-induced cytotoxicity was assessed by MTT assay and the uptake of extracellular tau by N2a cells was determined by immunocytochem. 6-mo-old male PS19 mice were treated with RSV or vehicle by oral administration (gavage) once a day for 5 wk. The cognitive performance was determined using Morris water maze test, object recognition test and Y-maze test. The levels of phosphorylated-tau, gliosis, proinflammatory cytokines such as TNF-α and IL-1β, and synaptic proteins including synaptophysin and PSD95 in the brains of the mice were evaluated by immunoblotting, immunostaining and ELISA, resp. Results: RSV significantly inhibited tau aggregation and tau oligomer-induced cytotoxicity, and blocked the uptake of extracellular tau oligomers by N2a cells. When applied to PS19 mice, RSV treatment effectively rescued cognitive deficits, reducing the levels of phosphorylated tau, neuroinflammation and synapse loss in the brains of mice. Conclusion: These findings suggest that RSV has promising therapeutic potential for AD and other tauopathies.

Current Alzheimer Research published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, COA of Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Blackmun, Dominique E.; Chamness, Stephen A.; Schindler, Corinna S. published the artcile< Intramolecular, Visible Light-Mediated Aza Paterno-Buchi Reactions of Unactivated Alkenes>, Recommanded Product: But-3-en-1-ol, the main research area is azetidine preparation Aza Paterno Buchi reaction; unactivated alkene intramol visible light Aza Paterno Buchi reaction.

Azetidines are of particular interest in medicinal chem. for their favorable properties, including increased resistance to oxidative metabolism and lower lipophilicity. The recent development of [2 + 2] reactions has significantly expanded the limited repertoire of methods for azetidine synthesis, but access to more complex architectures still requires further development. Herein, authors report a visible-light enabled intramol. [2 + 2] cycloaddition of unactivated alkenes that proved previously unreactive to access tricyclic azetidines with 3D complex structures and high levels of saturation

Organic Letters published new progress about [2+2] Cycloaddition reaction. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhenguo; Liu, Xiaoxiao; Ji, Liang; Zhang, Ting; Jia, Zhenhua; Loh, Teck-Peng published the artcile< Metal-Free Access to (Spirocyclic)Tetrahydro-β-carbolines in Water Using an Ion-Pair as a Superacidic Precatalyst>, Reference of 76-84-6, the main research area is tetrahydro carboline preparation; aryl aldehyde tryptamine Pictet Spengler triarylcarbonium ion pair catalyst; spirocyclic tetrahydro carboline preparation; cyclic ketone tryptamine Pictet Spengler triarylcarbonium ion pair catalyst.

The unprecedented triarylcarbonium ion-pair-catalyzed Pictet-Spengler reaction of tryptamines with aromatic aldehydes and cyclic ketones in water was disclosed. Under metal-free conditions, diverse tetrahydro-β-carbolines/spirocyclic tetrahydro-β-carbolines I [R1 = H, Me, Cl, etc.; R2 = H; R3 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2R3 = (CH2)5, CH2CH2CH(Me)CH2CH2, CH2CH2N(Boc)CH2CH2, etc.] were obtained in good yields with excellent functional group tolerance, including late-stage modification of natural products and small mol. drugs. The practicability of this protocol was also characterized in the gram-scale synthesis of komavine and several other functional compounds Preliminary mechanistic studies indicated that in aqueous media the in situ-generated superacidic species from the carbonium ion pair with water was crucial to promote the Pictet-Spengler reaction.

ACS Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts