Month: October 2022

Arcadi, Antonio; Calcaterra, Andrea; Fabrizi, Giancarlo; Fochetti, Andrea; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea published the artcile< One-pot synthesis of dihydroquinolones by sequential reactions of o-aminobenzyl alcohol derivatives with Meldrum's acids>, Synthetic Route of 5344-90-1, the main research area is quinolinone dihydro preparation; aminobenzyl alc heterocyclization Meldrum acid.

The functionalized 3,4-dihydroquinolin-2-ones I (R1 = Me, 4-MeOC6H4CH2, 4-BrC6H4CH2, 4-MeSC6H4CH2, 2-furylmethyl; R2 = H, Cl; R3 = H, Me, MeO; R4 = H, CF3) have been assembled in good to high yields through the sequential reaction of readily available N-Ts-o-aminobenzyl alcs. II with 5-R1-substituted Meldrum’s acids under mild basic conditions. Highly diastereoselective synthesis of trans-3-R1-4-phenyl-1-tosyl-3,4-dihydroquinolin-2(1H)-ones was accomplished from 2-(tosylamino)-α-phenylbenzenemethanol under the same reaction conditions. Regarding the reaction mechanism, the formation of dihydroquinolones proceeds through the in situ generation of aza-o-QMs followed by conjugate addition of enolate/cyclization/elimination of acetone and CO2.

Organic & Biomolecular Chemistry published new progress about Amino alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Synthetic Route of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lim, Bumhee; Lee, Jinah; Kim, Byungjin; Lee, Rang; Park, Jaehyun; Oh, Dong-Chan; Gam, Jongsik; Lee, Jeeyeon published the artcile< Target Identification of a 1,3,4-Oxadiazin-5(6H)-One Anticancer Agent via Photoaffinity Labelling>, Application In Synthesis of 25055-82-7, the main research area is oxadiazinone protein anticancer agent photoaffinity labeling probe.

Rational design and synthetic feasibility are critical factors for the photoaffinity labeling (PAL) approach, which can identify protein targets of bioactive small mols. under native cellular conditions. In this study, we developed photoaffinity labeling probes derived from 1,3,4-oxadiazin-5(6H)-ones (OPALs) for LL-2003, a previously reported potential anticancer agent against IGF-1R and Src. Our photoaffinity labeling strategy enabled successful photo-crosslinking of the probes (OPAL-6 and OPAL-8) with the target proteins in both mammalian cell lysates and live MCF7, A549, HepG2 and HeLa cells in situ. In vitro and in situ labeling demonstrated different patterns and expression levels of the proteome, and the strongest band for Src appeared in the A549 cell line. An in-gel fluorescence scan combined with MS/MS anal. of the IGF-1R overexpressed insect proteome labeled by OPAL-6 and OPAL-8 identified the binding location of the synthesized probes.

Asian Journal of Organic Chemistry published new progress about Antitumor agents. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Application In Synthesis of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yue-Lin; Zhang, Zhong; Li, Hai-Lou; Li, Xu-Yan; Yang, Guo-Yu published the artcile< An Oxalate-Functionalized Tetra-ZrIV-Substituted Sandwich-Type Silicotungstate: Hydrothermal Synthesis, Structural Characterization, and Catalytic Oxidation of Thioethers>, Product Details of C8H10OS, the main research area is thioether oxidation zirconium silicotungstate POM catalyst; sulfoxide preparation zirconium silicotungstate POM catalyst; crystal structure zirconium silicotungstate POM preparation.

A previously unknown inorganic-organic hybrid polyoxidometalate constructed from oxalate-functionalized tetra-ZrIV-substituted dimeric silicotungstate, (NH4)3Na5K6[Zr4(μ3-O)2(μ-OH)2(ox)2(SiW10O37)2]·23H2O (1, ox = oxalate) has been synthesized under mild hydrothermal conditions and characterized by FTIR spectroscopy, elemental anal., TGA, single-crystal and powder x-ray diffraction. Compound 1 contains a centrosym. polyoxidoanion structure with two [SiW10O37]10- units sandwiching a [Zr4(μ3-O)2(μ-OH)2(ox)2]6+ cluster. The catalytic performances of 1 involving oxygenation reactions of thioethers by H2O2 were evaluated, showing that 1 is an excellent catalyst for the catalytic oxidation of thioethers to sulfoxides/sulfones.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carr, Georgina; Haslam, Iain S.; Simmons, Nicholas L. published the artcile< Voltage Dependence of Transepithelial Guanidine Permeation Across Caco-2 Epithelia Allows Determination of the Paracellular Flux Component>, COA of Formula: C7H18ClNO5, the main research area is guanidine organic cation paracellular permeation intestine Caco2 cell.

The aim of this study was to investigate transepithelial ionic permeation via the paracellular pathway of human Caco-2 epithelial monolayers and its contribution to absorption of the base guanidine. Confluent monolayers of Caco-2 epithelial cells were mounted in Ussing chambers and the transepithelial conductance and elec. p.d. determined after NaCl dilution or medium Na substitution (bi-ionic conditions). Guanidine absorption (Ja-b) was measured ± transepithelial potential gradients using bi-ionic p.d.’s. Basal NaCl replacement with mannitol gives a transepithelial dilution p.d. of 28.0 ± 3.1 mV basal solution electropos. (PCl/PNa = 0.34). Bi-ionic p.d.’s (basal replacements) indicate a cation selectivity of NH4+ > K+∼Cs+ > Na+ > Li+ > tetraethylammonium+ > N-methyl-d-glucamine+∼choline+. Transepithelial conductances show good correspondence with bi-ionic potential data. Guanidine Ja-b was markedly sensitive to imposed transepithelial p.d. The ratio of guanidine to mannitol permeability (measured simultaneously) increased from 3.6 in the absence of an imposed p.d. to 13.8 (basolateral neg. p.d.). Hydrated monovalent ions preferentially permeate the paracellular pathway (Eisenman sequence 2 or 3). Guanidine may access the paracellular pathway because absorptive flux is sensitive to the transepithelial p.d. An alternative method to assess paracellular-mediated flux of charged organic mols. is suggested.

Pharmaceutical Research published new progress about Biological permeation (transepithelial ionic). 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, COA of Formula: C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gholinejad, Mohammad; Rasouli, Zahra; Najera, Carmen; Sansano, Jose M. published the artcile< Palladium Nanoparticles on a Creatine-Modified Bentonite Support: An Efficient and Sustainable Catalyst for Nitroarene Reduction>, COA of Formula: C7H9NO, the main research area is creatine modified bentonite support palladium nanoparticle preparation thermal stability; nitroarene palladium catalyst chemoselective reduction green chem; aryl amine preparation; Amino acids; clays; heterogeneous catalysis; nitro reduction; palladium.

Creatine as the nitrogen-rich, green and cheap compound is used for modification of natural bentonite and the resulting material is employed for the stabilization of palladium nanoparticles having an average diameter of 3 nm. This new material bento-crt@Pd was characterized using different techniques such as X-ray diffraction (XRD), Fourier-transform IR spectroscopy (FTIR), solid state UV-vis, SEM (SEM), transmission electron microscopy (TEM), XPS, thermogravimetric anal. (TGA) and energy-dispersive X-ray spectroscopy (EDX). This green catalyst promoted efficient reduction of aromatic nitro compounds in aqueous media. By using this catalyst nitroarenes having electron donating as well as electron withdrawing groups were reduced efficiently to their corresponding amines at room temperature The catalyst can be recycled seven times and the reused catalyst was characterized by TEM and XPS.

ChemPlusChem published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yunqin; He, Haiqing; Chen, Zixi; Huang, Yingying; Xiang, Guisheng; Li, Penghua; Yang, Xingkuan; Lu, Gang; Xiao, Guozhi published the artcile< Merging Reagent Modulation and Remote Anchimeric Assistance for Glycosylation: Highly Stereoselective Synthesis of α-Glycans up to a 30-mer>, SDS of cas: 4064-06-6, the main research area is branched oligosaccharide preparation glycosylation reagent modulation anchimeric assistance; 1,2-cis glycosylation; reagent modulation; remote anchimeric assistance; structure elucidation; synthetic methods.

The efficient synthesis of long, branched, and complex carbohydrates containing multiple 1,2-cis glycosidic linkages is a long-standing challenge. Here, we report a merging reagent modulation and 6-O-levulinoyl remote anchimeric assistance glycosylation strategy, which is successfully applied to the first highly stereoselective synthesis of the branched Dendrobium Huoshanense glycans and the linear Longan glycans containing up to 30 contiguous 1,2-cis glucosidic bonds. DFT calculations shed light on the origin of the much higher stereoselectivities of 1,2-cis glucosylation with 6-O-levulinoyl group than 6-O-acetyl or 6-O-benzoyl groups. Orthogonal one-pot glycosylation strategy based on glycosyl ortho-alkynylbenzoates and ortho-(1-phenylvinyl)benzoates has been demonstrated in the efficient synthesis of complex glycans, precluding such issues as aglycon transfer inherent to orthogonal one-pot synthesis based on thioglycosides.

Angewandte Chemie, International Edition published new progress about Dendrobium catenatum. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Pei; Wang, Xing-Yu; Wang, Zhijuan; Zhao, Jinjin; Cao, Xu-Dong; Xiong, Xiao-Chun; Yuan, Yu-Chao; Zhu, Songlei; Guo, Dong; Zhu, Xu published the artcile< Defluorinative Alkylation of Trifluoromethyl Benzimidazoles Enabled by Spin-Center Shift: a Synergistic Photocatalysis/Thiol Catalysis Process with CO2·->, Electric Literature of 627-27-0, the main research area is difluoromethyl benzimidazole preparation; trifluoromethyl benzimidazole unactivated alkene reductive defluoroalkylation iridium.

Authors describe a catalytic strategy for direct single C(sp3)-F bond alkylation of trifluoromethylbenzimidazoles under a photoinduced thiol-catalysis process. The CO2 radical anion (CO2·-) was proven the efficient single electron reductant to realize such transformation. The spin-center shift of the generated radical anion intermediate is the key step to realize the C-F bond activation in mild conditions with high efficiency.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhai, Pingan; Li, Wenhui; Lin, Jianying; Li, Xing; Wei, Wen-Long; Chen, Wenwen published the artcile< Hydrazones as Substrates in the Synthesis of Isoxazolidines via a KOH-Promoted One-Pot Three-Component Cycloaddition with Nitroso Compounds and Olefins>, Safety of But-3-en-1-ol, the main research area is isoxazolidine preparation diastereoselective; hydrazone nitroso compound olefin one pot three component cycloaddition.

Hydrazones have been employed as the starting materials in a KOH-mediated one-pot three-component cycloaddition with readily accessible nitroso compounds and olefins to construct various isoxazolidines. Compared with diazo compounds as starting materials, this methodol. could afford a wider range of products in good to excellent yields and diastereoselectivities for most substrates, and hydrazones are cheaper, more accessible, and safer substrates. The exptl. study shows that the choice of suitable hydrazones is crucial.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Kalicharan; Mondal, Avijit; Pal, Debjyoti; Srimani, Dipankar published the artcile< Sustainable Synthesis of Quinazoline and 2-Aminoquinoline via Dehydrogenative Coupling of 2-Aminobenzyl Alcohol and Nitrile Catalyzed by Phosphine-Free Manganese Pincer Complex>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is sustainable synthesis quinazoline aminoquinoline dehydrogenative annulation; phosphine free manganese pincer complex catalyzed dehydrogenative coupling; dehydrogenative coupling aminobenzyl alc nitrile one pot reaction.

A sustainable synthesis of quinazoline and 2-aminoquinoline via acceptorless dehydrogenative annulation is presented. The reaction is catalyzed by earth-abundant well-defined manganese complexes bearing NNS ligands. Furthermore, a one-pot synthetic strategy for the synthesis of 2-alkylaminoquinolines through sequential dehydrogenative annulation and N-alkylation reaction has also been demonstrated.

Organic Letters published new progress about Aminoquinolines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Y. N.; Cao, Y. N.; Sun, J.; Liang, Z.; Wu, Q.; Cui, S. H.; Zhi, D. F.; Guo, S. T.; Zhen, Y. H.; Zhang, S. B. published the artcile< Anti-breast cancer activity of resveratrol encapsulated in liposomes>, Application In Synthesis of 501-36-0 , the main research area is breast cancer anttumor liposome resveratrol.

Resveratrol (RES) is a naturally occurring and effective drug for tumor prevention and treatment. However, its low levels of aqueous solubility, stability, and poor bioavailability limit its application, especially when used as a free drug. In this study, RES was loaded into peptide and sucrose liposomes (PSL) to enhance the physico-chem. properties of RES and exploit RES delivery mediated by liposomes to effectively treat breast cancer. RES loaded PSL (the complex: PSL@RES) were stable, had a good RES encapsulation efficiency, and prolonged RES-release in vitro. PSL@RES was exceptionally efficient for inhibiting the growth of cancer cells, as the IC50 of PSL@RES in MCF-7 cells was found to be only 20.89 μmol L-1. The therapeutic efficacy of PSL@RES was evaluated in mice bearing breast cancer. The results showed that PSL@RES at a dosage of 5 mg kg-1 was more effective than 10 mg kg-1 free RES, and PSL@RES inhibited tumor growth completely at a dosage of 10 mg kg-1. PSL@RES induced apoptosis in breast tumor by upregulation of p53 expression. This then downregulated Bcl-2 and upregulated Bax, thereby inducing Caspase-3 activation. More importantly, encapsulation of RES within peptide liposomes greatly reduced the toxicity of free RES to mice. Overall, the simple formulation of liposomal nanocarriers of RES developed in this study produces satisfactory outcomes to encourage further applications of liposomal carriers for the treatment of breast cancer.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts