Month: October 2022

Tian, Bingren; Liu, Jiayue published the artcile< Resveratrol: a review of plant sources, synthesis, stability, modification and food application>, Quality Control of 501-36-0 , the main research area is botanical origin; common reaction; resveratrol; stability; synthesis.

Resveratrol, a stilbene mol. belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chem. changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. © 2019 Society of Chem. Industry

Journal of the Science of Food and Agriculture published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Isilar, Ozer; Bulut, Adnan; Sahin Yaglioglu, Ayse; Demirtas, Ibrahim; Arat, Esra; Turk, Mustafa published the artcile< Synthesis and biological evaluation of novel urea, thiourea and squaramide diastereomers possessing sugar backbone>, Formula: C12H20O6, the main research area is antiproliferative antitumor aminoglycoside disaccharide preparation; aminoglycoside disaccharide preparation urea thiourea squaramide human; Antiproliferative activity; Cytotoxicity; Squaramide; Sugar; Thiourea; Urea.

A series of novel chiral 14 urea, thiourea and squaramide stereoisomers possessing carbohydrate backbones as well as amide functional groups was synthesized and characterized by their, 1H NMR, 13C NMR, FT-IR, HRMS, optical rotation, and m.ps. Their antiproliferative activities were investigated against HeLa and PC3 cell lines. Aminoglycosides I (X = S, O) showed better activities at 25μM against PC3 cell line with respect to the standard 5-fluorouracil (5-FU). Especially, the compounds 9 and 11 showed higher activities than the standard 5-FU even at low concentration (5μM) against HeLa cell line. IC50 results also confirm these activities. The compounds I (X = S, O) have the IC50 values of 1.10μM and 1.02μM, resp. while 5-FU has 2.51μM.

Carbohydrate Research published new progress about Aminoglycosides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Qinyang; Cheng, Xiaofang; Cui, Yueyue; Xia, Qin; Yan, Xueyu; Zhang, Mingyuan; Lan, Ganqiu; Liu, Jiaqi; Shan, Tizhong; Huang, Yanna published the artcile< Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway>, Formula: C14H12O3, the main research area is resveratrol skeletal muscle fiber AdipoR1 AMPK PGC1 alpha.

This study was conducted to investigate the effect and underlying mechanism of Resveratrol (RES) in regulating skeletal muscle fiber-type switching. We found that RES had no effect on the body weight and food intake of Kunming mice (KM mice) that were orally administered with 400 mg kg-1 d-1 RES for 12 wk. Notably, the RES administration significantly increased the expression of myosin heavy chain (MyHC) 1, MyHC2a, and MyHC2x in the extensor digitorum longus (EDL) and soleus (SOL) muscles. Furthermore, the muscle immunostaining of the results showed that the RES treatment led to the myofiber type transition from glycolytic to oxidative in muscles. The mRNA and protein levels of the adiponectin receptor (AdipoR), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in EDL and SOL were drastically increased after RES treatment. Moreover, the plasma Adiponectin (AdipoQ) protein levels were higher in the RES-treated mice compared to the control mice. Moreover, the in vitro results further demonstrated that the 20μM RES treatment increased the expression of AdipoR1, AdipoR2, AMPK, PGC-1α and MyHC1, but decreased the expression of MyHC2b in C2C12 myoblasts. Furthermore, mechanistic studies revealed that silencing the AdiopR1, not the AdiopR2, abolished the effect of RES on the expression of AMPK and PGC-1α in the C2C12 cells. These results indicated that RES could regulate skeletal fiber switching through the AdiopR1-AMPK-PGC-1α pathway. This work may provide a new strategy for enhancing endurance and relieving muscle diseases caused by oxidative muscle fiber deficiency.

Food & Function published new progress about Adiponectin receptor 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Formula: C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lutz, Marius D. R.; Gasser, Valentina C. M.; Morandi, Bill published the artcile< Shuttle arylation by Rh(I) catalyzed reversible carbon-carbon bond activation of unstrained alcohols>, Electric Literature of 76-84-6, the main research area is tertiary alc green preparation crystal structure mol; triaryl alc ketone bond activation rhodium catalyst.

Herein, a rhodium(I)-catalyzed shuttle arylation cleaving the C(sp2)-C(sp3) bond in unstrained triaryl alcs. via a redox-neutral β-carbon elimination mechanism was reported. A selective transfer hydrocarbylation of substituted (hetero)aryl groups from tertiary alcs. to ketones was realized, employing benign alcs. as latent C-nucleophiles. All preliminary mechanistic experiments support a reversible β-carbon elimination/migratory insertion mechanism. In a broader context, this novel reactivity offers a new platform for the manipulation of tertiary alcs. in catalysis.

Chem published new progress about Bond activation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Loro, Camilla; Oble, Julie; Foschi, Francesca; Papis, Marta; Beccalli, Egle M.; Giofre, Sabrina; Poli, Giovanni; Broggini, Gianluigi published the artcile< Acid-mediated decarboxylative C-H coupling between arenes and O-allyl carbamates>, SDS of cas: 627-27-0, the main research area is aryl propanamine preparation; diaryl propane preparation; indane preparation; allyl tosyl carbamate arene decarboxylative coupling acid catalyst.

Treatment of O-allyl N-tosyl carbamates RNHC(O)OC(R1)(R2)(CH2)nCH=CHR3 (R = Ts, o-Ns; R1 = R2 = R3 = H, Me; n = 0, 1) with aromatic compounds ArH (Ar = 2,4,6-trimethylphenyl, 2-methylphenyl, 1,3,5-triethylphenyl, etc.) of Cu(OTf)2 or TMSOTf as promoters affords N-substituted 1-arylpropan-2-amines ArCH2CH(CH3)NHR3, 1,2- or 1,1-diarylpropanes I, or indanes II (R4 = R5 = H, Me), depending on the nature of the promoter and of aryl substrates. A full mechanistic rational allowing appreciation of the outcome of these novel C-H based cascades is proposed. An initial acid promoted decarboxylative/deamidative Friedel-Crafts allylation takes place. After protonation of the allylated arene, evolution of the resulting cation may follow different paths depending on the nature of the arene partner and of the allyl moiety in the carbamate.

Organic Chemistry Frontiers published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Bai; Mei, Huihui; Chang, Yongxin; Xu, Kuoxi; Yang, Li published the artcile< A novel near-infrared turn-on fluorescent probe for the detection of Fe3+ and Al3+ and its applications in living cells imaging>, Quality Control of 5344-90-1, the main research area is fluorescent probe detection iron aluminum cell imaging; Cells imaging; Fe(3+) and Al(3+); Fluorescent detection.

A new hemicyanidine-based colorimetric-fluorescent probe L (I) has been synthesized and characterized by x-ray single crystal diffraction, NMR, HRMS and other technologies. The probe L serves as a “”turn-on”” probe for the detection of Fe3+ and Al3+ ions in DMF-HEPES system with a high sensitivity and an excellent selectivity. The probe L manifesting the color of the solution containing L turns red on the addition of Fe3+, and turns pink on the addition of Al3+. The fluorescence turn-on detection of Fe3+ and Al3+ ions is attributed to the photo-induced electron transfer (PET) process and the exertion of the chelation-enhanced fluorescence effect (CHEF) mechanism. The results of thin layer silica gel plate coloration experiments also present the same characteristics. Addnl., further the probe L exhibit good cell permeability and could be employed to monitor Fe3+ and Al3+ ions in the living cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetry. 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Quality Control of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Santana, Andres G.; Montalvillo-Jimenez, Laura; Diaz-Casado, Laura; Mann, Enrique; Jimenez-Barbero, Jesus; Gomez, Ana M.; Asensio, Juan Luis published the artcile< Single-Step Glycosylations with 13C-Labelled Sulfoxide Donors: A Low-Temperature NMR Cartography of the Distinguishing Mechanistic Intermediates>, Related Products of 4064-06-6, the main research area is NMR glycosylation cartog glycosyl sulfoxide donor intermediate detection monitoring; NMR spectroscopy; carbohydrates; glycosylation; isotopic labelling; reaction mechanisms.

Glycosyl sulfoxides have gained recognition in the total synthesis of complex oligosaccharides and as model substrates for dissecting the mechanisms involved. Reactions of these donors are usually performed under pre-activation conditions, but an exptl. more convenient single-step protocol has also been reported, whereby activation is performed in the presence of the acceptor alc.; yet, the nature and prevalence of the reaction intermediates formed in this more complex scenario have comparatively received minimal attention. Herein, a systematic NMR-based study employing both 13C-labeled and unlabeled glycosyl sulfoxide donors for the detection and monitoring of marginally populated intermediates is reported. The results conclusively show that glycosyl triflates play a key role in these glycosylations despite the presence of the acceptor alc. Importantly, the formation of covalent donor/acceptor sulfonium adducts was identified as the main competing reaction, and thus a non-productive consumption of the acceptor that could limit the reaction yield was revealed.

Chemistry – A European Journal published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shin, Mi Hee; Lee, Yuri; Kim, Min-Kyoung; Lee, Dong Hun; Chung, Jin Ho published the artcile< UV increases skin-derived 1α,25-dihydroxyvitamin D3 production, leading to MMP-1 expression by altering the balance of vitamin D and cholesterol synthesis from 7-dehydrocholesterol>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is UV radiation dihydroxyvitamin D3 MMP1 vitamin D cholesterol dehydrocholesterol; 1α,25-dihydroxyvitamin D(3); 7-dehydrocholesterol; 7-dehydrocholesterol reductase; CYP27B1; Cholesterol; MMP-1; UV.

Here, we investigated the effect of skin-derived 1α,25(OH)2D3, synthesized purely within the keratinocytes, on MMP-1 expression. Treatment of human epidermal keratinocytes with 1α,25(OH)2D3, but not 7DHC or 25OHD3, significantly increased MMP-1 expression. UV irradiation increases 1α,25(OH)2D3 levels, and ketoconazole inhibits UV-induced production of 1α,25(OH)2D3. Upregulation of MMP-1 by UV was reversed by inhibition of 1α,25(OH)2D3 synthesis using ketoconazole or CYP27B1 siRNA. In keratinocytes, 7DHC is a substrate for both cholesterol and 1α,25(OH)2D3 synthesis. We demonstrated that UV irradiation leads to decreased expression of DHCR7 (7-dehydrocholesterol reductase), the enzyme that converts 7DHC to cholesterol. Inhibition of DHCR7 with its inhibitor BM15766 decreased cholesterol synthesis and increased UV-induced MMP-1 expression, which was attenuated by ketoconazole. These findings suggest that UV-induced reduction of DHCR7 leads to a decrease in cholesterol synthesis, thereby increasing 7DHC availability for 1α,25(OH)2D3 production, which enhances MMP-1 expression. Finally, UV irradiation in human skin in vivo significantly increased CYP27B1 mRNA and decreased DHCR7 mRNA expression.

Journal of Steroid Biochemistry and Molecular Biology published new progress about Homo sapiens. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Guanping; Zou, Wenying; Zhong, Yihui published the artcile< Sulfonamides repress cell division in the root apical meristem by inhibiting folates synthesis>, Synthetic Route of 1492-18-8, the main research area is sulfonamide folic acid synthesis cell division root apical meristem.

Sulfonamides, as broad-spectrum antibiotics, are widely used to protect against bacterial infections in livestock production A large number of sulfa antibiotics are discharged into soil and water system, which poses a great threat to the safety of organisms. The antibacterial mechanism of sulfonamides is to prevent folate biosynthesis by competitively inhibiting bacterial dihydropteroate synthetase (DHPS). The inhibitory effect of sulfanilamide on root growth has been reported, but the mechanism has not been determined Here, we used high performance liquid chromatog. with UV detector (HPLC-UV) and transgenic technol. to study the effect of sulfonamides on folate synthesis in plants. The results showed that the application of sulfonamide sharply reduced the content of folic acid in plants, resulting in strong inhibition of cell division in the root apical meristem. The inhibition of sulfonamide on cell division can be relieved by supplementing synthetic folic acid and folinic calcium salt hydrate. The transgenic plants expressing the bacterial antibiotic resistance genes (ARGs) Sul1 or Sul2 showed obvious antibiotic resistance. Taking these results together, we suggest that sulfonamides repress cell proliferation in the root apical meristem by competitively inhibiting the biosynthesis of folic acid in plants.

Journal of Hazardous Materials Advances published new progress about Antibiotic resistance. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Synthetic Route of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez-Flores, M. Shantal; Falcao, Soraia I.; Escuredo, Olga; Seijo, M. Carmen; Vilas-Boas, Miguel published the artcile< Description of the volatile fraction of Erica honey from the northwest of the Iberian Peninsula>, Related Products of 78-70-6, the main research area is hotrienol phenylacetaldehyde volatile Erica honey; Erica; GC–MS; Honey; Palynological analysis; SPME; VOCs.

Heather honey is highly appreciated by consumers for its sensorial profile, which varies depending on the flora used by the honeybees. Volatile compounds contribute to these qualities. Characterization of the volatile profile related to the botanical origin is of great interest for the standardization of unifloral honey. For this reason, 33 heather honey samples from northwest of the Iberian Peninsula were analyzed by headspace solid-phase microextraction (HS-SPME) to identify the key volatile compounds in this type of honey. The aim of this research was to provide a descriptive anal. of these compounds, and to find whether there is any relationship with the main Erica species. A total of 58 volatile organic compounds were found, with hotrienol, phenylacetaldehyde, and cis-linalool being the most abundant. A principal component anal. and Spearmans rank correlation showed the homogeneity of the volatile profile in the samples, and their close relationship with the main pollen types.

Food Chemistry published new progress about Erica. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts