Month: October 2022

Keith, D. Jamin; Townsend, Steven D. published the artcile< Total Synthesis of the Congested, Bisphosphorylated Morganella morganii Zwitterionic Trisaccharide Repeating Unit>, Reference of 4064-06-6, the main research area is zwitterionic polysaccharide immune response phosphoglycerol phosphocholine oligosaccharide; oligosaccharide Morganella Morganii trisaccharide repeating unit Zwitterionic phosphorylated glycosylation.

Zwitterionic polysaccharides (ZPS) activate T-cell-dependent immune responses by major histocompatibility complex class II presentation. Herein, we report the first synthesis of a Morganella morganii ZPS repeating unit as an enabling tool in the synthesis of novel ZPS materials. The repeating unit incorporates a 1,2-cis-α-glycosidic bond; the problematic 1,2-trans-galactosidic bond, Gal-β(1→3)-GalNAc; and phosphoglycerol and phosphocholine residues which have not been previously observed together as functional groups on the same oligosaccharide. The successful third generation approach leverages a first in class glycosylation of a phosphoglycerol functionalized acceptor. To install the phosphocholine unit, a highly effective phosphocholine donor was synthesized.

Journal of the American Chemical Society published new progress about Glycosylation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Reference of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Le-Niculescu, H.; Roseberry, K.; Levey, D. F.; Rogers, J.; Kosary, K.; Prabha, S.; Jones, T.; Judd, S.; McCormick, M. A.; Wessel, A. R.; Williams, A.; Phalen, P. L.; Mamdani, F.; Sequeira, A.; Kurian, S. M.; Niculescu, A. B. published the artcile< Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs>, Formula: C20H21CaN7O7, the main research area is gene expression betulin neuroprotectant FKBP5 biomarker diagnosis stress disorder.

The biol. fingerprint of environmental adversity may be key to understanding health and disease, as it encompasses the damage induced as well as the compensatory reactions of the organism. Metabolic and hormonal changes may be an informative but incomplete window into the underlying biol. We endeavored to identify objective blood gene expression biomarkers for psychol. stress, a subjective sensation with biol. roots. To quantify the stress perception at a particular moment in time, we used a simple visual analog scale for life stress in psychiatric patients, a high-risk group. Then, using a stepwise discovery, prioritization, validation, and testing in independent cohort design, we were successful in identifying gene expression biomarkers that were predictive of high-stress states and of future psychiatric hospitalizations related to stress, more so when personalized by gender and diagnosis. One of the top biomarkers that survived discovery, prioritization, validation, and testing was FKBP5, a well-known gene involved in stress response, which serves as a de facto reassuring pos. control. We also compared our biomarker findings with telomere length (TL), another well-established biol. marker of psychol. stress and show that newly identified predictive biomarkers such as NUB1, APOL3, MAD1L1, or NKTR are comparable or better state or trait predictors of stress than TL or FKBP5. Over half of the top predictive biomarkers for stress also had prior evidence of involvement in suicide, and the majority of them had evidence in other psychiatric disorders, providing a mol. underpinning for the effects of stress in those disorders. Some of the biomarkers are targets of existing drugs, of potential utility in patient stratification, and pharmacogenomics approaches. Based on our studies and analyses, the biomarkers with the best overall convergent functional evidence (CFE) for involvement in stress were FKBP5, DDX6, B2M, LAIR1, RTN4, and NUB1. Moreover, the biomarker gene expression signatures yielded leads for possible new drug candidates and natural compounds upon bioinformatics drug repurposing analyses, such as calcium folinate and betulin. Our work may lead to improved diagnosis and treatment for stress disorders such as PTSD, that result in decreased quality of life and adverse outcomes, including addictions, violence, and suicide.

Molecular Psychiatry published new progress about Actin-related protein 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (type A). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Lichen; Semba, Kazuhiko; Nakao, Yoshiaki published the artcile< para-Selective C-H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis>, Reference of 660867-80-1, the main research area is selective carbon hydrogen bond activation borylation benzamide pyridine; iridium complex aluminum Lewis acid catalyst benzamide borylation; C-H activation; Lewis acids; boronate esters; iridium; regioselectivity.

Para-Selective C-H borylation of benzamides and pyridines was achieved by cooperative Ir/Al catalysis. A combination of Ir catalysts commonly employed for arene C-H borylation and bulky Al-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C-H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (multi-substituted). 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Reference of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lian, Shengyang; Fan, Shuling; Yang, Ying; Yu, Bin; Dai, Chunxiao; Qu, Yuanyuan published the artcile< Selenium nanoparticles with photocatalytic properties synthesized by residual activated sludge>, Computed Properties of 492-62-6, the main research area is dye selenite selenium nanoparticle photocatalyst activated sludge wastewater treatment; Activated sludge; Biosynthesis; Photocatalysis; Rhodamine B; Selenium nanoparticles.

The treatment and disposal of residual activated sludge is a worldwide problem and the research on its reuse is still only in the earliest stages. Selenite is a toxic pollutant, while selenium nanoparticles (SeNPs) are environmentally friendly and have promising application prospects. At present, the reduction mechanism of selenite under the complex system is still poorly understood. In order to explore the mechanism of SeNPs synthesis by activated sludge resource utilization, SeNPs were synthesized by activated sludge extracts of domestic sewage (DSeNPs) and coking sewage (CSeNPs), resp. The synthesis process, zeta potential and morphol. size of SeNPs were changed by pH value, extract concentration and extract composition Under the same synthesis conditions, the morphologies of DSeNPs and CSeNPs were mainly spherical and pseudo-spherical, while CSeNPs also contained pseudo-rod shape particles. The sizes and crystal grains of CSeNPs were smaller than those of DSeNPs. Compared with DSeNPs, a specific protein (∼35 kDa) was found on the surface of CSeNPs using SDS-PAGE. By analyzing the fluorescence images of the two SeNPs, it was found that the relative contents of proteins, α-D-glucopyranose polysaccharides, and β-D-glucopyranose polysaccharides on their surfaces were obviously different (P < 0.05). The present study demonstrated that proteins, polysaccharides, humic-like and fulvic acid-like substances cooperated in the formation and stabilization of SeNPs. Furthermore, CSeNPs (bandgap: 1.68 eV) had more desirable photocatalytic performance than DSeNPs (bandgap: 1.84 eV). Under the light condition, CSeNPs could degrade Rhodamine B faster without adding hydrogen peroxide. This experiment provided a new insight into the resource utilization of activated sludge and a reference for the synthesis of nanometer selenium with excellent performance. Science of the Total Environment published new progress about Domestic wastewater. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balaji, Sundarraman; Balamurugan, Gunasekaran; Ramesh, Rengan; Semeril, David published the artcile< Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3H)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide>, HPLC of Formula: 5344-90-1, the main research area is palladium benzoylhydrazone chelating complex preparation catalyst dehydrogenative coupling aminobenzamide; crystal structure palladium benzoylhydrazone chelating palladacycle complex; mol structure palladium benzoylhydrazone chelating palladacycle complex; quinazolinone preparation; benzyl alc dehydrogenative coupling reaction aminobenzamide palladium benzoylhydrazone catalyst.

A convenient protocol for the 1-pot synthesis of quinazolin-4(3H)-ones using Pd(II) complexes via dehydrogenative coupling of readily available benzyl alcs. and 2-aminobenzamide was described. New structurally related Pd(II) N^O chelating complexes of general configuration [Pd(L)Cl(PPh3)] (L = dimethylamino benzoylhydrazone ligands) were designed and synthesized. The formation of the complexes was recognized by anal. and spectral methods (FTIR, NMR, HR-MS). The presence of a square-planar geometry around the Pd(II) ion was confirmed by single crystal x-ray diffraction study. A wide range of substituted quinazolinones were successfully achieved from a diverse range of benzyl alcs. in good to excellent yields using 1.0 mol % of catalyst loading under aerobic conditions. Also, control experiments reveal that the dehydrogenative coupling reaction involves initially the formation of an aldehyde intermediate and subsequent formation of a cyclic aminal intermediate.

Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, HPLC of Formula: 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saltiel, Jack; Krishnan, Sumesh B.; Gupta, Shipra; Hernberg, E. Aliea; Clark, Ronald J. published the artcile< Photochemistry and photophysics of cholesta-5,7,9(11)-trien-3β-ol: a fluorescent analogue of cholesterol>, Related Products of 434-16-2, the main research area is cholestatrienol fluorescent analog photochem photophysics; Cholestatrienol rearrangement; Endoperoxide phototoproducts; Fluorescence triplet yields.

Cholesta-5,7,9(11)-trien-3β-ol (9,11-dehydroprovitamin D3, CTL) is used as a fluorescent probe to track the presence and migration of cholesterol in vivo. CTL is known to be photochem. active, but little consideration has been given to the formation efficiency and possible toxicity of its photoproducts. In degassed THF (THF) solution, we isolated the photoproduct of CTL and of its 25-hydroxy derivative (HOCTL), and X-ray crystal structures were obtained for HOCTL and the photorearrangement product. The X-ray crystal structure and its 1H NMR spectrum confirm the product structure as a pentacyclic HOCTL isomer. In the presence of air in THF, endoperoxide formation via [2+4] addition of 1O2* across the B ring of CTL or HOCTL becomes the dominant photoreaction. The UV spectrum and decay kinetics of the triplet state of HOCTL, the precursor of 1O2*, are determined by transient absorption spectroscopy. We confirm the proposed structure of the endoperoxide by X-ray crystallog. Kinetics anal. of quantum yields provides rate constants for photophys. and photochem. events.

Photochemical & Photobiological Sciences published new progress about Crystal structure. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iyer, Gayatri R.; Wigginton, Janis; Duren, William; LaBarre, Jennifer L.; Brandenburg, Marci; Burant, Charles; Michailidis, George; Karnovsky, Alla published the artcile< Application of differential network enrichment analysis for deciphering metabolic alterations>, Related Products of 87-73-0, the main research area is metabolome glutathione type 1 2 diabetes pregnancy; differential networks; enrichment analysis; metabolic disorders; metabolomics and lipidomics; partial correlation networks.

Modern anal. methods allow for the simultaneous detection of hundreds of metabolites, generating increasingly large and complex data sets. The anal. of metabolomics data is a multi-step process that involves data processing and normalization, followed by statistical anal. One of the biggest challenges in metabolomics is linking alterations in metabolite levels to specific biol. processes that are disrupted, contributing to the development of disease or reflecting the disease state. A common approach to accomplishing this goal involves pathway mapping and enrichment anal., which assesses the relative importance of predefined metabolic pathways or other biol. categories. However, traditional knowledge-based enrichment anal. has limitations when it comes to the anal. of metabolomics and lipidomics data. We present a Java-based, user-friendly bioinformatics tool named Filigree that provides a primarily data-driven alternative to the existing knowledge-based enrichment anal. methods. Filigree is based on our previously published differential network enrichment anal. (DNEA) methodol. To demonstrate the utility of the tool, we applied it to previously published studies analyzing the metabolome in the context of metabolic disorders (type 1 and 2 diabetes) and the maternal and infant lipidome during pregnancy.

Metabolites published new progress about Alditols, esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Ying-Jie; Yang, Hui-Rong; Wang, Hong-Feng; Zong, Min-Hua; Lou, Wen-Yong published the artcile< Immune enhancement activity of a novel polysaccharide produced by Dendrobium officinale endophytic fungus Fusarium solani DO7>, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Dendrobium Fusarium immunomodulatory activity.

A novel polysaccharide DG2 was obtained from the Dendrobium officinale endophytic fungus Fusarium solani DO7. The structural characterization and immunol. activity of DG2 were investigated. Results showed that DG2 with the mol. weight of 152.8 kDa was composed of Galp, Manp, Glcp and Araf at a molar ratio of 4.3:1.9:2.8: 1.0. The main linkage types of DG2 were (1 → )-β-D-Glc, (1 → 4)-β-D-Glc, (1 → 3,6)-β-D-Gal and (1 → 6)-β-D-Gal, which demonstrated DG2 was a novel galactoglucan and different from other fungal and botanic polysaccharide. Furthermore, DG2 did not contain deoxynivalenol, and showed no direct toxicity to human embryonic kidney cells and RAW 264.7 cells. Meanwhile, DG2 could increase the TNF-α, IL-6 and iNOs mRNA expression levels of RAW264.7 cells, and further promote the production of TNF-α, IL-6 and NO. These results suggested DG2 could enhance macrophage-mediated immune responses and have the potential to be an attractive functional food supplement candidate for the hypoimmunity therapies.

Journal of Functional Foods published new progress about Dendrobium catenatum. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Katagiri, Ryo; Uekusa, Yoshinori; Narukawa, Yuji; Kiuchi, Fumiyuki published the artcile< Synthesis of Methylophiopogonanone A>, SDS of cas: 4396-13-8, the main research area is methylophiopogonanone A preparation.

Here, methylophiopogonanone A I was synthesized, which was a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.

Heterocycles published new progress about Acylation. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, SDS of cas: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pakvojoud, Saeedeh; Hatefi Ardakani, Mehdi; Saeednia, Samira; Heydari-Bafrooei, Esmaeil published the artcile< Efficient, selective and mild oxidation of sulfides and oxidative coupling of thiols catalyzed by Pd(II)-isatin Schiff base complex immobilized into three-dimensional mesoporous silica KIT-6>, Name: 2-(Phenylthio)ethanol, the main research area is palladium isatin Schiff base silica sulfide thiol oxidation coupling.

In this study, a palladium(II)-isatin Schiff base complex immobilized into three-dimensional (3D) mesoporous silica KIT-6 (Pd-isatin Schiff base@KIT-6) was synthesized and characterized by various techniques including inductively coupled plasma (ICP) and Fourier transform IR (FT-IR) spectroscopies, X-ray diffraction (XRD), SEM (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET) technique and thermal gravimetric anal. (TGA). This new heterogeneous catalyst was successfully employed for the selective oxidation of sulfides to sulfoxides with tert-Bu hydroperoxide (tert-BuOOH) and oxidative coupling of thiols into corresponding disulfides using 30% H2O2 at room temperature The products were obtained in good to excellent yields and no over-oxidation of sulfoxides and disulfides was observed This catalytic system could also be applied for the chemo-selective oxidation of sulfides and thiols in the presence of other functional groups. The studied catalyst can be recovered easily by a simple filtration and reused five times in both oxidation reactions without a remarkable decrease in catalytic activity.

Journal of Sulfur Chemistry published new progress about Optimization. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts