Month: October 2022

Molina-Menor, Esther; Vidal-Verdu, Angela; Satari, Leila; Calonge-Garcia, Alba; Pascual, Javier; Pereto, Juli; Porcar, Manuel published the artcile< Belnapia mucosa sp. nov. and Belnapia arida sp. nov., isolated from desert biocrust>, Electric Literature of 87-73-0, the main research area is Belnapia desert biocrust fatty acid phylogeny; Alphaproteobacteria; Belnapia; Tabernas Desert; biocrust; novel species.

Two novel Gram-staining-neg., aerobic, cocci-shaped, non-motile, non-spore forming, pink-pigmented bacteria designated strains T6T and T18T, were isolated from a biocrust (biol. soil crust) sample from the vicinity of the Tabernas Desert (Spain). Both strains were catalase-pos. and oxidase-neg., and grew under mesophilic, neutrophilic and non-halophilic conditions. According to the 16S rRNA gene sequences, strains T6T and T18T showed similarities with Belnapia rosea CGMCC 1.10758T and Belnapia moabensis CP2CT (98.11 and 98.55% gene sequence similarity, resp.). The DNA G + C content was 69.80 and 68.96% for strains T6T and T18T, resp.; the average nucleotide identity by blast (ANIb) and digital DNA-DNA hybridization (dDDH) values confirmed their adscription to two novel species within the genus Belnapia. The predominant fatty acids were summed feature 8 (C18 : 1ω7c/C18 : 1ω6c), C16 : 0, C18 : 1 2-OH and summed feature 3 (C16 : 1ω7c/C16 : 1ω6c). According to he results of the polyphasic study, strains T6T and T18T represent two novel species in the genus Belnapia (which currently includes only three species), for which names Belnapia mucosa sp. nov. (type strain T6T = CECT 30228T = DSM 112073T) and Belnapia arida sp. nov. (type strain T18T = CECT 30229T = DSM 112074T) are proposed, resp.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Electric Literature of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Jieye; Oliver, Allen G.; Serianni, Anthony S. published the artcile< D-Mannosamine hydrochloride (2-amino-2-deoxy-D-mannose hydrochloride): ionic hydrogen bonding in saccharides involving chloride and aminium ions>, SDS of cas: 5505-63-5, the main research area is mannosamine hydrochloride ionic hydrogen bonding saccharide; 2-amino-2-deoxy-d-mannose hydrochloride; anomeric disorder; crystal structure; d-mannosamine hydrochloride; ionic hydrogen bonding.

D-Mannosamine hydrochloride (2-amino-2-deoxy-D-mannose hydrochloride), C6H14NO5+·Cl-, (I), crystallized from a methanol/ethyl acetate/n-hexane solvent mixture at room temperature in a 4C1 chair conformation that is slightly distorted towards the C3,O5B form. A comparison of the structural parameters of (I) with the corresponding parameters in α-D-glucosamine hydrochloride, (II), and β-D-galactosamine hydrochloride, (III)/(III’), was undertaken to evaluate the effects of ionic hydrogen bonding on structural properties. Three types of ionic hydrogen bonds are present in the crystals of (I)-(III)/(III’), i.e. N+-H···O, N+-H···Cl-, and O-H···Cl-. The exocyclic structural parameters in (I), (II), and (III)/(III’) appear to be most influenced by this bonding, especially the exocyclic hydroxy groups, which adopt eclipsed conformations enabled by ionic hydrogen bonding to the chloride anion. Anomeric disorder was observed in crystals of (I), with an α:β ratio of 37:63. However, anomeric configuration appears to exert minimal structural effects; i.e., bond lengths, bond angles, and torsion angles are essentially identical in both anomers. The observed disorder at the anomeric C atom of (I) appears to be caused by the presence of the chloride anion and atom O3 or O4 in proximal voids, which provide opportunities for hydrogen bonding to atom O1 in both axial and equatorial orientations.

Acta Crystallographica, Section C: Structural Chemistry published new progress about Crystallization. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, SDS of cas: 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Esquivel-Fajardo, Edgar A.; Martinez-Ascencio, Eduardo U.; Oseguera-Toledo, Miguel E.; Londono-Restrepo, Sandra M.; Rodriguez-Garcia, Mario E. published the artcile< Influence of physicochemical changes of the avocado starch throughout its pasting profile: Combined extraction>, Reference of 492-62-6, the main research area is Na calcium amylopectin potassium avocado behavior; C-type starch; Hexagonal and orthorhombic structures; Isolation process; Lamellae; Mineral composition.

This work focused on studying the effect of lamellae presence on the pasting profile of isolated avocado starch (C-type) obtained by a combined mech. and ultrasonic process. Inductively Couple Plasma indicates that this starch is rich in P, K, Na, and Ca. This starch exhibits the most cryst structure reported so far. The correlation between the morphol. and structural properties throughout its pasting profile explains its apparent viscosity behavior. Granules exhibit a non-conventional irregular morphol. with sizes ranging from 35 to 40μm in their long side. DSC reveals endothermal transitions at 68°C and 119°C associated with the nanocrystals solvation and amylose-lipid complex, respectivley. After gelatinization, the presence of lamellae originated from the partial fragmentation of the crystals. The pasting end exhibited a combined behavior between custard and hydrogel. This correlation could be considered a new methodol. to understand the pasting behaviors in any starch.

Carbohydrate Polymers published new progress about Avocado. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shimada, Kazuyo; Hasegawa, Shiori; Nakao, Satoshi; Mukai, Ririka; Matsumoto, Kiyoka; Tanaka, Mizuki; Uranishi, Hiroaki; Masuta, Mayuko; Nishida, Shohei; Shimizu, Shinya; Hayashi, Yuichi; Suzuki, Akio; Nakamura, Mitsuhiro published the artcile< Adverse event profiles of ifosfamide-induced encephalopathy analyzed using the Food and Drug Administration Adverse Event Reporting System and the Japanese Adverse Drug Event Report databases>, HPLC of Formula: 1492-18-8, the main research area is ifosfamide alkylating agent encephalopathy; Encephalopathy; FAERS; FDA Adverse Event Reporting System; Ifosfamide; JADER; Japanese Adverse Drug Event Report.

Ifosfamide is extensively used to treat several malignant conditions. Administration of ifosfamide can cause encephalopathy and other neurotoxic effects. The aim of this study was to obtain novel information on the onset profiles of ifosfamide-induced encephalopathy (IIE) considering other associated clin. factors using the US Food and Drug Administration Adverse Event Reporting System (FAERS) and the Japanese Adverse Drug Event Report (JADER) databases. We analyzed the reports of encephalopathy between 2004 and 2018 from the FAERS and JADER databases. To define IIE, we used the Medical Dictionary for Regulatory Activities (MedDRA) preferred terms and standardized queries. The reporting odds ratios (ROR) at 95% confidence interval (CI) was used to detect the signal for IIE and adjusted for covariates using a multivariate logistic regression technique. We evaluated the time-to-onset profile of IIE and used the association rule mining technique to discover undetected associations, such as potential risk factors. In the FAERS database, the ROR (CI) for encephalopathy (preferred term, PT) and encephalopathy (standardized MedDRA queries, SMQ) was 56.58 (51.69-61.93) and 1.57 (1.48-1.67), resp. In the JADER database, the ROR (95% CI) for encephalopathy (PT) and encephalopathy (SMQ) was 13.54 (9.91-18.50) and 1.24 (1.01-1.53), resp. The multivariate logistic regression anal. showed a significant contribution in IIE signal in the ≥ 60 yr group (p = 0.00094; vs. < 60 yr group) and ≥ 2000 mg/m2 dosage group (p = 0.00045; vs. < 2000 mg/m2 dosage group). The association rules of {ifosfamide, aprepitant} → {encephalopathy (SMQ)} demonstrated high lift values. The average dose of ifosfamide in patients with encephalopathy (PT) and without encephalopathy (PT) was 2022.8 ± 592.8 (mean ± standard deviation) and 1568.5 ± 703.2 mg/m2, resp. (p < 0.05). Encephalopathy within the first 7 days of ifosfamide administration was 94.1% for encephalopathy (PT) and 87.7% for encephalopathy (SMQ), resp. The present anal. demonstrated that the incidence of encephalopathy with ifosfamide should be closely monitored for a short onset (within 7 days). The patients who are administered a high dose of ifosfamide or co-administrated aprepitant should be carefully monitored for the development of encephalopathy. Cancer Chemotherapy and Pharmacology published new progress about Alkylating agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, HPLC of Formula: 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hassenrueck, Jessica; Wittmann, Valentin published the artcile< Cyclopropene derivatives of aminosugars for metabolic glycoengineering>, Quality Control of 5505-63-5, the main research area is cyclopropene aminosugar metabolic glycoengineering; bioorthogonal chemistry; carbohydrates; cyclopropenes; inverse electron-demand Diels–Alder reaction; metabolic engineering.

Cyclopropenes have been proven valuable chem. reporter groups for metabolic glycoengineering (MGE). They readily react with tetrazines in an inverse electron-demand Diels-Alder (DAinv) reaction, a prime example of a bioorthogonal ligation reaction, allowing their visualization in biol. systems. Here, we present a comparative study of six cyclopropene-modified hexosamine derivatives and their suitability for MGE. Three mannosamine derivatives in which the cyclopropene moiety is attached to the sugar by either an amide or a carbamate linkage and that differ by the presence or absence of a stabilizing Me group at the double bond have been examined We determined their DAinv reaction kinetics and their labeling intensities after metabolic incorporation. To determine the efficiencies by which the derivatives are metabolized to sialic acids, we synthesized and investigated the corresponding cyclopropane derivatives because cyclopropenes are not stable under the anal. conditions. From these experiments, it became obvious that N-(cycloprop-2-en-1-ylcarbonyl)-modified (Cp-modified) mannosamine has the highest metabolic acceptance. However, carbamate-linked N-(2-methylcycloprop-2-en-1-ylmethyloxycarbonyl)-modified (Cyoc-modified) mannosamine despite its lower metabolic acceptance results in the same cell-surface labeling intensity due to its superior reactivity in the DAinv reaction. Based on the high incorporation efficiency of the Cp derivative we synthesized and investigated two new Cp-modified glucosamine and galactosamine derivatives Both compounds lead to comparable, distinct cell-surface staining after MGE. We further found that the amide-linked Cp-modified glucosamine derivative but not the Cyoc-modified glucosamine is metabolically converted to the corresponding sialic acid.

Beilstein Journal of Organic Chemistry published new progress about Amino sugars Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Quality Control of 5505-63-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gvozdev, V. D.; Shavrin, K. N.; Nefedov, O. M. published the artcile< A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols>, Computed Properties of 45434-02-4, the main research area is arylmethylene pyrrolooxazine pyrrolooxazole pyrrolothiazole stereoselective preparation; bicyclic enaminal stereoselective preparation; base mediated cyclocondensation amino alc thiol alkynal.

4-Alkynals RCCCH2CR1R2CHO [R = Ph, 2-thienyl, 4-F3CC6H4; R1 = R2 = H, Me; R1R2 = (CH2)5] underwent base-mediated cyclocondensations with amino alcs. H2NCH2XCH2OH (X = bond, Me2C, 1,1-cyclopropanediyl) or 2-aminoethanethiol hydrochloride with KOH in DMSO to yield arylmethylene pyrrolooxazines, pyrrolooxazoles, and pyrrolothiazoles I [R = Ph, 2-thienyl, 4-F3CC6H4; R1 = R2 = H, Me; R1R2 = (CH2)5; X = bond, Me2C, 1,1-cyclopropanediyl; Y = O, S] (bicyclic enaminals) stereoselectively as the (E)-isomers in 30-82% yields.

Russian Chemical Bulletin published new progress about Alkynals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl). 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, Computed Properties of 45434-02-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dorosz, Urszula; Barteczko, Natalia; Latos, Piotr; Erfurt, Karol; Pankalla, Ewa; Chrobok, Anna published the artcile< Highly efficient biphasic system for the synthesis of alkyl lactates in the presence of acidic ionic liquids>, Related Products of 104-76-7, the main research area is alkyl lactate preparation green chem; lactic acid alc esterification ionic liquid catalyst.

Alkyl lactates such as 2-ethylhexyl lactate and Et lactate are produced from lactic acid via esterification, and used in the production of plastics, paints, solvents and detergents. In the pursuit of an inexpensive, industry-suitable catalyst for this reaction, the application of protic ionic liquids based on nitrogen base and sulfuric acid is proposed. The ionic liquid was synthesized via a simple reaction of triethylamine and a threefold molar excess of sulfuric acid. Water was added to remove the heat of reaction. Next, the reaction conditions for the model esterification of 2-ethylhexanol with lactic acid without addnl. solvent were optimized. Exceptionally mild conditions, i.e., a twofold molar excess of alc. to lactic acid with the addition of an ionic liquid in a catalytic amount (15 mol%) at 60°C, resulted in high yields of Et and 2-ethylhexyl lactates (96-97%). The driving force of this reaction is the production of a biphasic system with immiscible ester during the reaction. This phenomenon makes it possible to overcome the reaction equilibrium Using an inexpensive ionic liquid, which could be recycled up to five times without diminution in conversion or selectivity, leads to both a greener and a more economically-viable process.

Catalysts published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Related Products of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Ji-Hyun; Kim, Moo Song; Kim, Hyung Jun; Kim, Jong-Ryang; Ahn, Cheol-Hee published the artcile< Potentially biobased copolyesters comprising 1,3-butanediol, 1,4-cyclohexanedimethanol and dimethyl terephthalate and effect of different catalysts on polymerization behavior>, HPLC of Formula: 627-27-0, the main research area is butanediol cyclohexane dimethanol dimethylene terephthalate polyester thermomech property.

A new series of potentially biobased copolyesters, poly(1,3-butylene 1,4-cyclohexylenedimethylene terephthalate) (P13BCT) based on 1,3-butanediol (1,3-BD) with 1,4-cyclohexane dimethanol (CHDM) was synthesized. Dibutyltin oxide (DBTO) and titanium(IV) butoxide (TBT) catalysts were employed, and the resulting copolymers were analyzed to evaluate the efficacy of each catalyst on the copolymerization DBTO produced low mol. weight oligomers with Mn ranging from 2,000 to 2,500, whereas TBT produced high mol. weight copolymer Mn ranging from 8,700-21,900. GC-MS anal. was performed to identify the byproducts during the transesterification process, and side reactions such as dehydration were observed, which were in good agreement with previous results showing the same byproduct. The correlation spectroscopy (COSY), heteronuclear single-quantum correlation spectroscopy (HSQC), 1H and 13C NMR analyses revealed that the chain end of P13BCT_Sn was primarily composed of the vinyl end group rather than the hydroxyl group, which was a major contributor to the formation of low mol. weight polymers. The d. of P13BCT slightly increased with the addition of 1,3-BD. The Tg of P13BCT decreased with 1,3-BD contents from 74°C – 51°C due to the enhanced flexibility of the main chain. The thermal stability of the copolyesters was determined using TGA in a nitrogen atm. The copolyesters were stable up to 330-360°C, and the decomposition temperature decreased as the 1,3-BD content increased. Yield strength increased from 39.4 MPa to 43.6 MPa as 1,3-BD content increased; however, Young’s modulus and yield strength difference was not statistically significant.

Macromolecular Research published new progress about Crystallization enthalpy. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jiawei; Wang, Chuan published the artcile< Zinc-Catalyzed Hydroxyl-Directed Regioselective Ring Opening of Aziridines in SN2 Reaction Pathway>, Name: (2-Aminophenyl)methanol, the main research area is zinc catalyzed regioselective ring opening aziridinyl alc amine thiophenol.

In this protocol, a zinc-catalyzed catalytic regioselective ring opening of electronically and sterically unbiased 2,3-aziridinyl alcs. has been accomplished. The directing effect of the hydroxyl moiety enables the selective nucleophilic attack to the C-3 position of 2,3-aziridinyl alcs. with various aromatic amines and thiophenols as nucleophiles. This operationally simple reaction provides convenient access to a variety of amino alcs. and hydroxyl sulfides in excellent regiocontrol. Moreover, simple derivatization of the ring opening product establishes a general strategy to approach internal vicinal diamines in regioselective and diastereomerically pure form.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aziridine). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Shihua; Jia, Bing; Chen, Xiubin; Jiang, Xiaobo published the artcile< Liquid-Liquid Equilibrium for Ternary System of Water + 2-Methyl-3-buten-2-ol + (Methyl tert-butyl ether/Butyl acetate/4-Methyl-2-pentanone/2-Ethyl-1-hexanol) at 308.2 K>, Safety of 2-Ethylhexan-1-ol, the main research area is water methylbutenol methyltertbutylether butyl acetate methylpentanone ethylhexanol ternary system; ternary system liquid equilibrium.

For separation of the azeotropes of water + 2-methyl-3-buten-2-ol by liquid-liquid extraction, Me tert-Bu ether or Bu acetate or 4-methyl-2-pentanone or 2-ethyl-1-hexanol was selected as the extraction solvent. The liquid-liquid equilibrium (LLE) data for water + 2-methyl-3-buten-2-ol + (Me tert-Bu ether/butyl acetate/4-methyl-2-pentanone/2-ethyl-1-hexanol) ternary systems at 308.2 K under 101.3 kPa were determined The distribution coefficient and the separation factor were calculated to evaluate the extraction ability of different solvents. The Othmer-Tobias, Bachman, and Hand equations were applied to verify the reliability of the exptl. LLE data. Meanwhile, the exptl. LLE data were successfully correlated by the NRTL and UNIQUAC models with the root-mean-square deviations (RMSD) were less than 0.42%.

Journal of Solution Chemistry published new progress about Extraction. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts