Month: October 2022

Jeandet, Philippe; Sobarzo-Sanchez, Eduardo; Silva, Ana Sanches; Clement, Christophe; Nabavi, Seyed Fazel; Battino, Maurizio; Rasekhian, Mahsa; Belwal, Tarun; Habtemariam, Solomon; Koffas, Mattheos; Nabavi, Seyed Mohammad published the artcile< Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives>, Product Details of C14H12O3, the main research area is Biocatalysis; Enzymatic transformation; Green chemistry; Laccases; Peroxidases; Resveratrol; Resveratrol glucosides; Resveratrol oligomers; Stilbenes; Whole cell biocatalysis.

Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacol. effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathways and their biol. properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnol. may provide a competitive approach for the large-scale and low cost production of biol. active stilbenes. Addnl., one major limitation in the use of resveratrol and related aglycon derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacol. resveratrol derivatives in vivo by exploiting whole microorganisms, enzymic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biol. activity through glucosylation (β-D-glucosides vs. α-D-glucosides) and oligomerization methodologies of resveratrol including green chem. methods in organic solvent-free media are discussed as well.

Biotechnology Advances published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Product Details of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Monsen, Paige J.; Luzzio, Frederick A. published the artcile< Applicability of aluminum amalgam to the reduction of arylnitro groups>, COA of Formula: C7H9NO, the main research area is aryl amine preparation; arylnitro compound reduction; Aluminum amalgam; Arylnitro groups; Azides; Click chemistry; Reduction.

An array of arylnitro compounds RNO2 [R = 4-methylphenyl, naphthalen-1-yl, (morpholin-4-yl)carbonyl, etc.] with various functionality was treated with freshly-prepared aluminum amalgam in THF/water solution and resulted in the corresponding arylamines RNH2. The Al(Hg)-mediated reductions are relatively rapid with consumption of the amalgam and disappearance of starting material occurring over 20-30 min. The workup of the reductions involves only removal of the insoluble byproducts by filtration followed by concentration Only in some cases is chromatog. required to secure the pure product. The desired arylamines are furnished in quantities of 25-100 mg, which in some cases, could be taken on to the next reaction without further purification Reductions of 4-nitrobenzyl derivatives of carbohydrates or nucleosides, e.g., I were selective in affording the corresponding 4-aminobenzyl products. To show applicability in click chem., selected aminobenzyl products are directly azidated to yield products that were then used in click reactions to afford the corresponding 1,2,3-triazoles, e.g., II.

Tetrahedron Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zishan; Asghar, Azeem; Hou, Changjun; Ali, Imtiaz; Naqvi, Salman Raza; Wang, Ning; Zhu, Hui; Mehmood, Muhammad Aamer; Liu, Chen-Guang published the artcile< Co-pyrolysis of the Chinese liquor industry waste and bamboo waste, elucidation of the pyrolysis reaction chemistry, and TG-FTIR-MS based study of the evolved gases>, Reference of 627-27-0, the main research area is liquor industry bamboo waste pyrolysis thermogravimetry mass Spectrometry.

Chinese liquor and bamboo are the leading industrial enterprises in China which produce huge amounts of residual biomass. This study was aimed at assessing the potential of both residual biomasses to produce clean energy and biochems. via pyrolysis and co-pyrolysis. Both biomasses were pyrolyzed either alone (1:0 and 0:1) or co-pyrolyzed in three combinations (1:1, 1:3, and 3:1) using a thermogravimetric analyzer at five heating rates including 10°C min-1, 20°C min-1, 30°C min-1, 40°C min-1, and 50°C min-1. The data were interpreted through isoconversional models namely Ozawa-Wall-Flynn (OWF), Kissenger-Akahira-Sunose (KAS), and Friedman for the elucidation of pyrolysis reaction. It was shown to be a three-stage pyrolysis where major pyrolysis occurred during stage-II, between conversions (0.2-0.7), where 59-60% of the biomass was transformed to bioproducts within the temperature range of 180°C to 450°C, where 17-20% of the biomass was left as char. The average activation energies for the bamboo waste (labeled as B) and the liquor industry waste (labeled as D) were shown to be 151-160 kJ mol-1 for B:D = 1:0, 192-205 kJ mol-1 for B:D = 1:1, 193-202 kJ mol-1 for B:D = 1:3, 178-188 kJ mol-1 for B:D = 3:1, and 194-201 kJ mol-1 for B:D = 1:3 computed through OWF, KAS, and Friedman methods (R2 = 0.98-0.99). The values of activation energy, calorific values, Gibb’s free energy, enthalpy change, and pre-exponential factors indicated that the pyrolysis of bamboo waste was energy efficient when compared to the liquor industry waste, however, mixing both biomasses in the ratio of 3:1 was shown to be the most suitable co-pyrolysis scenario. The FTIR analyses of the evolved gases showed that these gases were dominated by the functional groups related to alcs., aromatic hydrocarbons, alkynes, aldehydes, halides, ketones, esters, phenols, and amines. While TG-FTIR-GC-MS analyses confirmed the presence of aforementioned compounds in the evolved gases indicating the substantial potential of both biomasses to produce syngas and biochems. In conclusion, the wastes from bamboo forests and liquor industry could be renewable and carbon neutral feedstocks to produce bioenergy and biochems. via pyrolysis and co-pyrolysis.

Fuel published new progress about Bamboo (waste). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Wenzhong; Wan, Baibai; Shi, Ran; Chen, Si; Li, Jiazhu; Wang, Fangzhen; Niu, Hexu; Xu, Xin-Ming; Wang, Wei-Li published the artcile< Catalyst-free one-pot cascade cyclization: An efficient synthesis of isoindolobenzoxazinones and isoindoloquinazolinones derivatives>, Category: alcohols-buliding-blocks, the main research area is isoindolobenzoxazinone isoindoloquinazolinone preparation one pot catalyst free; acylbenzoic acid amino alc diamine cascade cyclization.

A practical and efficient catalyst-free cascade cyclization reaction of 2-acylbenzoic acids with various amino alcs. or diamines was developed. This protocol provides a powerful and straightforward method for the one-pot synthesis of diverse isoindolobenzoxazinones, isoindoloquinazolinones and their derivatives The synthetic strategy evades the use of catalyst, shows a broad substrate scope and could be performed in gram-scale.

Tetrahedron published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bierwirth, S. Peter; Honorio, Gabriel; Gainaru, Catalin; Boehmer, Roland published the artcile< Linear and nonlinear shear studies reveal supramolecular responses in supercooled monohydroxy alcohols with faint dielectric signatures>, Category: alcohols-buliding-blocks, the main research area is supercooled monohydroxy alc dielec loss.

Monohydroxy alcs. (MAs) with Me and hydroxyl side groups attached to the same carbon atom in the alkyl backbone can display very weak structural and supramol. dielec. relaxation processes when probed in the regime of small elec. fields. This can render their separation and assignment difficult in the pure liquids When mixing with bromoalkanes, a faint Debye-like process can be resolved dielec. for 4-methyl-4-heptanol. To achieve a separation of structural and supramol. processes in pure 4-methyl-4-heptanol and 3-methyl-3-heptanol, mech. experiments are carried out in the linear-response regime as well as using medium-angle oscillatory shear amplitudes. It is demonstrated that first-order and third-order nonlinear mech. effects allow for a clear identification of supramol. viscoelastic modes even for alcs. in which they leave only a weak signature in the linear-response shear modulus. Addnl., the nonlinear rheol. behavior of 2-ethyl-1-hexanol is studied, revealing that its linearly detected terminal mode does not coincide with that revealed beyond the linear-response regime. This finding contrasts with those for the other MAs studied in this work. (c) 2019 American Institute of Physics.

Journal of Chemical Physics published new progress about Dielectric loss. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Jamie S.; Mamlouk, Omar; Selamet, Umut; Tchakarov, Amanda; Glass, William F.; Sheth, Rahul A.; Layman, Rachel M.; Dadu, Ramona; Abdelwahab, Noha; Abdelrahim, Maen; Diab, Adi; Yee, Cassian; Abudayyeh, Ala published the artcile< Infliximab for the treatment of patients with checkpoint inhibitor-associated acute tubular interstitial nephritis>, Application In Synthesis of 1492-18-8, the main research area is infliximab checkpoint inhibitor acute tubular interstitial nephritis patient treatment; Checkpoint inhibitors; acute interstitial nephritis; immune-related adverse event.

Acute tubular interstitial nephritis (ATIN) is the most frequently reported pathol. in patients with checkpoint inhibitor (CPI) induced acute kidney injury (AKI). Glucocorticoid (GC) therapy and discontinuation of CPI are the mainstay of treatment to prevent permanent renal dysfunction and dialysis. However, less than 50% of patients have complete kidney recovery and relapse of ATIN can occur. Infliximab is effective in treating other immune-related adverse events but its use for the treatment of CPI-ATIN is not well established. We report the first retrospective study examining the steroid-sparing potential of infliximab in achieving durable and complete renal recovery for patients with CPI-ATIN. Data were collected from medical records of patients diagnosed with CPI-AKI with a kidney biopsy or clin. diagnosis of ATIN that was managed with GC and infliximab. Infliximab-containing regimens were used to treat 10 patients with CPI-ATIN. Four patients relapsing after GC therapy achieved durable and complete renal recovery, four patients experienced partial renal recovery, and two patients showed no improvement in kidney function. This is the first study evaluating clin. outcomes using an infliximab-containing regimen for treatment of relapsed CPI-ATIN in patients or patients failing to achieve complete response after primary therapy. Our data suggest that infliximab may be a treatment option for achieving durable and complete renal recovery in this patient population and represents a potential steroid-sparing strategy in challenging cases of CPI-ATIN. Rigorous clin. studies are warranted to evaluate the risk-benefit anal. for infliximab usage in CPI-ATIN patients.

OncoImmunology published new progress about Acute kidney injury. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Application In Synthesis of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Ying-Jie; Yang, Hui-Rong; Wu, Xiao-Ling; Peng, Fei; Huang, Zhi; Pu, Lei; Zong, Min-Hua; Yang, Ji-Guo; Lou, Wen-Yong published the artcile< Structure and immunomodulatory activity of polysaccharides from Fusarium solani DO7 by solid-state fermentation>, Quality Control of 3458-28-4, the main research area is fermentation polysaccharide Fusarium solani; Polysaccharides from Fusarium solani DO7; Solid-state fermentation; Structure-activity relationship.

Two polysaccharides, DGS1 and DGS2, were obtained by solid-state fermentation (SSF) of Fusarium solani DO7, an endophytic fungus isolated from the orchid Dendrobium officinale. Structural characterizations revealed that DGS1 consisted of arabinose, glucose, mannose and galactose with a molar ratio of 2.9:13.4:3.0:1, resp., and contained (1 → 5)-Araf, (1 → 4)-Glcp, (1 → 6)-Glcp, (1 → 3)-Manp, (1 → 2,6)-Manp and (1 → 6)-Galp glycosidic linkages, while DGS2 was composed of arabinose, glucose, mannose and galactose in a molar ratio of 3.5:8.1:2.1:1, resp., and contained (1 → 5)-Araf, (1 → 4)-Glcp, (1 → 6)-Glcp, (1 → 3)-Manp and (1 → 6)-Galp glycosidic linkages. Neither polysaccharide was toxic to human embryonic kidney cells or mouse RAW 264.7 macrophage cells. An immunomodulatory activity assay indicated that both polysaccharides could significantly enhance the levels of TNF-α, IL-6 and NO by activating TNF-α, IL-6 and iNOs gene expression, resp., especially DGS2. Interestingly, DGS2 also possessed relatively high antioxidant activity. These results illustrate that, due to its cost-effectiveness and environmentally friendly features, SSF has significant potential as a com. competitive source of natural products, including fungal polysaccharides, with immunomodulatory activity.

International Journal of Biological Macromolecules published new progress about Fusarium solani. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Garlatti, Laura; Huet, Raphael; Alvarez, Karine published the artcile< Efficient access to 3'-deoxy-3'-(4-substituted-1,2,3-triazol-1-yl)-thymidine derivatives via ligand-promoted CuAAC>, Computed Properties of 10602-04-7, the main research area is click alkyne azide triazole cycloaddition catalyst preparation nucleoside.

Herein we describe an efficient and rapid access to 3′-deoxy-3′-(4-substituted-1,2,3-triazol-1-yl)-thymidine derivatives, e.g. I, using 1,3-dipolar cycloaddition reaction catalyzed by copper(I). Innovative conditions allow us to generate target compounds in a one-pot reaction mixing 3′-azido-3′-deoxythymidine, alkyne, copper sulfate pentahydrate, sodium ascorbate and tris(benzyltriazolylmethyl)amine in a water:tert-butanol solvent mixture Rapid treatment of the reaction and subsequent flash purification chromatog. afforded pure compounds in an overall yield of 71-100%. All eleven synthesized compounds were identified on the basis of their spectral data anal. (1H, 13C, 2D NMR and high-resolution mass spectra).

Tetrahedron published new progress about 1,3-Dipolar cycloaddition reaction. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Computed Properties of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nanyan, Pierre published the artcile< Fragrance Allergens in Hair Removal Cosmetic Products>, Formula: C10H18O, the main research area is fragrance allergen hair removal cosmetic product.

Background: Fragrances are the most common cause of contact allergy in cosmetics. Objective: The aim of this study was to identify fragrance allergens in hair removal products based on the list of ingredients. Methods: Hair removal products found in the French market were checked for the 26 allergens classified in accordance with Directive 2003/15/EC through information on the packages using the Web site of the manufacturer, vendor, or supermarket. Conclusions: A total of 662 hair removal products were checked. Fragrance allergens were present in 318 (48%) of the products, with an average of 4 allergens per product. Linalool and limonene were the most common fragrances present in 67% and 50.3%, resp. Strip and spray formulations contained significantly more allergens than cream/lotion or wax products. To prevent allergic contact dermatitis, the formulation of hair removal products should be considered, because fragrance allergens are more often present in strip and spray formulations.

Dermatitis published new progress about Allergens Role: ADV (Adverse Effect, Including Toxicity), BSU (Biological Study, Unclassified), BIOL (Biological Study). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miyazaki, Kanako; Nakata, Kenya published the artcile< Two-Step Kinetic Resolution of Racemic Secondary Benzylic Alcohols Using the Combination of Enantioselective Silylation and Acylation: One-Pot Procedure Catalyzed by Chiral Guanidine>, Synthetic Route of 403-41-8, the main research area is alc benzylic enantioselective preparation kinetic resolution; ester preparation enantioselective kinetic resolution benzylic alc; benzylic alc chiral guanidine catalyst silylation acylation kinetic resolution.

A novel two-step kinetic resolution of racemic secondary benzylic alcs. with practical enantiomeric ratios was achieved. The reactions were carried out via a one-pot operation by combining enantioselective silylation and acylation mediated by the same chiral guanidine catalyst.

Journal of Organic Chemistry published new progress about Acylation catalysts (stereoselective). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts