Month: October 2022

Jung, Mun Yhung; Lee, Da Eun; Baek, Sun Hye; Lim, Su Min; Chung, Ill-Min; Han, Jae-Gu; Kim, Seung-Hyun published the artcile< An unattended HS-SPME-GC-MS/MS combined with a novel sample preparation strategy for the reliable quantitation of C8 volatiles in mushrooms: A sample preparation strategy to fully control the volatile emission>, Safety of 2-Ethylhexan-1-ol, the main research area is mushroom volatile HSSPMEGCMS freeze drying rehydration; Automation; Beech; Button; C8 volatiles; Gas chromatography; Headspace-solid phasemicroextraction; Mass spectrometry; Mushrooms; Quantitative analysis; Shiitake.

Eight carbon (C8) compounds are the key characteristic flavors of mushrooms. The quant. anal. of the volatiles in mushrooms is challenging especially with the unattended HS-SPME-GC-MS. An unattended HS-SPME-GC-MS/MS in combination with novel sample preparation of the complete control of volatile emissions was developed for the quantitation of the C8 volatiles in mushrooms. The sample preparation strategy was composed of freeze-drying, rehydration, and the addition of a 15% citric acid solution With this strategy, the volatile emission from mushroom was fully controlled at a certain time point. This method was found to be highly reliable, sensitive, precise, and accurate. This method was successfully applied to measure the contents of the C8 volatiles in the beech, button, and shiitake mushrooms. 1-Octene-3-ol was the most predominant compound in the mushrooms, representing 62.4, 69.0, and 89.2% of the total C8 volatiles in the beech, button, and shiitake mushrooms, resp.

Food Chemistry published new progress about Acrylic polymers Role: ARG (Analytical Reagent Use), MOA (Modifier or Additive Use), ANST (Analytical Study), USES (Uses). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Docherty, Jamie H.; Nicholson, Kieran; Dominey, Andrew P.; Thomas, Stephen P. published the artcile< A Boron-Boron Double Transborylation Strategy for the Synthesis of gem-Diborylalkanes>, Product Details of C12H20O6, the main research area is gem alkyl diboronate preparation terminal alkyne borylation hydroborane catalyst; diborylation transborylation mechanism alkyne hydroborane catalyst preparation gem diboronate.

1,1-Diborylalkanes RCH2CH(Bpin)2 were prepared by double borylation of α-alkynes catalyzed by 9-borabicyclononane via transborylation pathway. Olefin hydroboration reactions provide efficient access to synthetically versatile and easily handled organoboronic esters. In this study, we demonstrate that the com. available organoborane reagent 9-borabicyclo[3.3.1]nonane (H-B-9-BBN) can serve as a catalyst for the sequential double hydroboration of alkynes using pinacolborane (HBpin). This strategy, which is effective for a wide range of terminal alkynes, is predicated upon a key C(sp3)-B/B-H transborylation reaction. Transition-state thermodn. parameters and 10-boron-isotopic labeling experiments are indicative of a σ-bond metathesis exchange pathway.

ACS Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Ying; Chen, Liuxi; Zhang, Ruonan; Chen, Bi; Xiang, Yu; Zhang, Mingming; Huang, Xingxing; Zhang, Wenzheng; Chen, Xiaying; Pan, Ting; Yan, Lili; Jin, Ting; Liu, Shuiping; Feng, Jiao; Duan, Ting; Xie, Tian; Lin, Shuang; Sui, Xinbing published the artcile< Efficacy and safety of elemene combined with chemotherapy in advanced gastric cancer: A Meta-analysis>, Quality Control of 1492-18-8, the main research area is elemene 5fluorouracil doxorubicin anticancer agent gastric cancer.

Elemene is a natural compound extracted from Zingiberaceae plants, and is used in various cancer. However, the efficacy and safety elemene combined with chemotherapy in advanced gastric cancer (GC) are lack of systematic assessment. We searched the PubMed, EMBASE, Web of Science, Cochrane Library, China Academic Journals (CNKI), Chinese Science and Technol. Journals (CQVIP) and Chinese Biomedical Literature databases. Randomized controlled trials (RCTs) comparing elemene plus chemotherapy with chemotherapy alone in participants with advanced GC and reporting at least one of the following outcomes were selected and assessed for inclusion. JADAD scale was used to assess the quality. Data was screened and extracted by two independent investigators. The primary clin. outcome was overall response rate (ORR); the secondary outcomes were quality of life (QOL) and adverse events (AEs). Anal. was performed using Review Manager 5.3. Sixteen RCTs matched the selection criteria, which reported on 969 subjects. Risk ratios (RR) and corresponding 95% confidence intervals (CIs) were pooled for ORR, life quality based on KPS, and risk of AEs. Compared to chemotherapy alone, elemene combined with chemotherapy in the treatment of GC may increase the efficiency of ORR(RR: 1.41; 95% CI: 1.23-1.60; P<.0001), improve their life quality based on KPS (RR: 1.84; 95% CI: 1.45-2.34; P<.00001), and reduce the adverse reactions, including leukopenia(RR: 0.73; 95% CI: 0.62-0.85; P<.00001), neutropenia (RR: 0.75; 95% CI: 0.60-0.95; P=.02), anemia (RR: 0.76; 95% CI: 0.60-0.95; P=.02), thrombocytopenia (RR: 0.56; 95% CI: 0.43-0.73; P<.00001). Nausea and vomiting (RR: 0.84; 95% CI: 0.84-1.07; P=.39), diarrhea (RR: 0.69; 95% CI: 0.41-1.15; P=.15), neurotoxicity (RR: 0.77; 95% CI: 0.59-1.00; P=.05) and hepatic dysfunction (RR: 0.95; 95% CI: 0.58-1.54; P=.83) were similar between two groups. Elemene may have the potential to improve the efficacy and reduce the AEs of chemotherapy for gastric cancer. However, the long-term, high-quality researches with a large sample size in different populations are required. Medicine (Philadelphia, PA, United States) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Quality Control of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Qingwei; Tang, Shaohu; Li, Jianqiu; Fan, Chunfen; Xing, Libo; Luo, Keming published the artcile< Integrative transcriptomic and metabolomic analyses provide insight into the long-term submergence response mechanisms of young Salix variegata stems>, Formula: C6H10O8, the main research area is Salix variegata stem submergence integrative transcriptomics metabolomics; Oxidative stress; Phytohormones; S. variegate; Stress signaling; Submergence tolerance.

Salix variegata Franch. is a riparian shrub species that can tolerate long-term complete submergence; however, the mol. mechanisms underlying this trait remain to be elucidated. In this study, we subjected S. variegata plants to complete submergence for 60 d and collected stems to perform transcriptomic and metabolomic analyses, as well as quant. reverse transcription-polymerase chain reaction (qRT-PCR) assays. Results revealed that photosynthesis and the response to light stimulus were inhibited during submergence and recovered after desubmergence. Ethylene and abscisic acid (ABA) signaling could be important for the long-term submergence tolerance of S. variegata. Jasmonic acid (JA) signaling also participated in the response to submergence. Raffinose family oligosaccharides, highly unsaturated fatty acids, and specific stress-related amino acids accumulated in response to submergence, indicating that they may protect plants from submergence damage, as they do in response to other abiotic stressors. Several organic acids were produced in S. variegata plants after submergence, which may facilitate coping with the toxicity induced by submergence. After long-term submergence, cell wall reorganization and phenylpropanoid metabolic processes (the synthesis of specific phenolics and flavonoids) were activated, which may contribute to long-term S. variegata submergence tolerance; however, the detailed mechanisms require further investigation. Several transcription factors (TFs), such as MYB, continuously responded to submergence, indicating that they may play important roles in the responses and adaptation to submergence. Genes related to oxidative stress tolerance were specifically expressed after desubmergence, potentially contributing to recovery of S. variegata plants within a short period of time.

Planta published new progress about Abscisic acid receptor PYL1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Formula: C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nelson, Hope; Richard, William; Brown, Hailee; Medlin, Abigail; Light, Christina; Heller, Stephen T. published the artcile< Practical Chemoselective Acylation: Organocatalytic Chemodivergent Esterification and Amidation of Amino Alcohols with N-Carbonylimidazoles>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is alc carbonylimidazole diazabicycloundecene catalyst chemoselective esterification; carboxylic ester preparation; carbonylimidazole aniline pyridinium chloride catalyst chemoselective amidation; aryl amide preparation; amidation; carbonylimidazoles; chemoselectivity; esterification; organocatalysis.

Here, the N-carbonylimidazoles enable catalytic chemodivergent aniline or alc. acylation in the presence of pyridinium ions or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), was reported. Both acylation reactions display high and broad chemoselectivity for the target group. Unprecedented levels of chemoselectivity were observed in the DBU-catalyzed esterification: A single esterification product was obtained from a mol. containing primary aniline, alc., phenol, secondary amide, and N-H indole groups. These acylation reactions are highly practical as they involve only readily available, inexpensive, and relatively safe reagents; can be performed on a multigram scale; and can be used on carboxylic acids directly by in situ formation of the acylimidazole electrophile.

Angewandte Chemie, International Edition published new progress about Acylation (chemoselective). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ying, Hanglu; Yao, Jie; Wu, Fan; Zhao, Yufen; Ni, Feng published the artcile< A mild and concise synthesis of aryloxy phosphoramidate prodrug of alcohols via transesterification reaction>, Recommanded Product: But-3-en-1-ol, the main research area is aryloxy phosphoramidate prodrug alc transesterification reaction.

A synthesis of aryloxy phosphoramidate prodrug of alcs. enabled by a transesterification strategy is described here. This reaction operates under mild conditions and thus has excellent functional group tolerance. This method provides an efficient and practical solution to the rapid construction of the aryloxy phosphoramidate prodrugs library for potential SAR studies.

RSC Advances published new progress about Alcohols Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Hang; Zhang, Yunjia; Shu, Linyi; Song, Guangyao; Ma, Huijuan published the artcile< Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro>, Electric Literature of 501-36-0 , the main research area is blood glucose; endoplasmic reticulum stress; insulin resistance; resveratrol.

Purpose: The aim of the study was to examine the effects of resveratrol upon hepatic endoplasmic reticulum stress (ERS) and insulin sensitivity in vivo and in vitro. Material and methods: C57BL/6J mice were fed a high-fat diet (HFD) for 8 wk, and insulin resistance was evaluated by the i.p. glucose tolerance test (IPGTT). Mice were then treated with resveratrol for 12 wk and blood and liver samples collected. Blood biochem. indicators were determined by kits, liver protein expression was determined by western blot, and morphol. changes were observed by histol. staining. Palmitic acid (PA)-induced insulin-resistant HepG2 cells were established. Cells were exposed to 100, 50 or 20 μM resveratrol for 24 h, and proliferation/cytotoxicity was determined Cells were divided into five groups: control, PA, PA + Rev (100 μM), PA + Rev (50 μM) and PA + Rev (20 μM) groups. After 24 h of treatment, cellular proteins were analyzed the same way as animal tissues. Results: The IPGTT confirmed that the insulin resistance model was established successfully. After resveratrol treatment, fasting blood glucose and cholesterol levels declined and the quant. insulin sensitivity check index increased. Western-blot results showed that resveratrol-treated HFD mice had reduced hepatic levels of p-PERK, ATF-4 and TRIB3, and increased the levels of ATF-6, p-AKT and p-GSK3β. In the cell model, resveratrol with 100 and 50 μM enhanced ERS and insulin resistance, whereas 20 μM had beneficial effects, similar to the animal model. Conclusion: Resveratrol reduced hepatic ERS, thereby improving insulin sensitivity and glucose levels. However, high doses of resveratrol had harmful effects on cells, elevating ERS and insulin resistance. The safe dose of resveratrol needs further investigation.

Drug Design, Development and Therapy published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yiyun; Xi, Yixin; Zhao, Jiulong; Zhao, Jiayan; Li, Jincan; Huang, Guoqi; Li, Junqiang; Fang, Fei; Gu, Lingling; Wang, Shige published the artcile< Preparation of therapeutic-laden konjac hydrogel for tumor combination therapy>, Related Products of 1492-18-8, the main research area is therapeutic laden konjac hydrogel tumor combination therapy.

Featured with three-dimensional network structure, polymer hydrogels have found tremendous applications in biomedical fields. In this study, therapeutic-laden Konjac glucomannan (KGM) hydrogel was prepared by injecting polydopamine (PDA)/5-fluorouracil (5-FU)/calcium folinate (CF)/KGM alk. solution to the target area, for the synergistic tumor photothermal and chemotherapy. In alk. solution, dopamine can be synchronously polymerized to form PDA, while KGM can be hydrolyzed and transformed into a thermally irreversible KGM hydrogel. Besides, the alk. condition can increase the solubility of 5-FU. The hydrogel matrix can control the release of 5-FU and cf. PDA renders the composite hydrogel excellent tumor photothermal therapy ability. Moreover, CF can be used as a synergist to enhance the tumor chemotherapy efficiency of 5-FU. With convenient handling, excellent photothermal conversion ability and high biocompatibility, the multifunctional hydrogel system is anticipated to find a promising translational potential in clin. therapeutic applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Hui-Hui; Peng, Fei; Ou, Xiao-Yang; Zeng, Ying-Jie; Zong, Min-Hua; Lou, Wen-Yong published the artcile< Combinatorial synthetic pathway fine-tuning and cofactor regeneration for metabolic engineering of Escherichia coli significantly improve production of D-glucaric acid>, Product Details of C6H10O8, the main research area is metabolic engineering Escherichia coli glucaric acid; Microbial fermentation; Platform chemical; RBS optimization; Self-sufficient; Systematic metabolic engineering.

D-glucaric acid (GA) has been identified as among promising biotechnol. alternatives to oil-based chems. GA and its derivatives are widely used in food additives, dietary supplements, drugs, detergents, corrosion inhibitors and biodegradable materials. The increasing availability of a GA market is improving the cost-effectiveness and efficiency of various biosynthetic pathways. In this study, an engineered Escherichia coli strain GA10 was constructed by systematic metabolic engineering. This involved redirecting metabolic flux into the GA biosynthetic pathways, blocking the conversion pathways of D-glucuronic acid (GlcA) and GA into byproducts, introducing an in situ NAD+ regeneration system and fine-tuning the activity of the key enzyme, myo-inositol oxygenase (Miox). Subsequently, the culture medium was optimized to achieve the best performance of the GA10 strain. GA was produced at 5.35 g/L (extracellular and intracellular), with a maximized yield of ∼0.46 mol/mol on D-glucose and glycerol, by batch fermentation This work demonstrates efficient biosynthetic pathways of GA in E. coli by metabolic engineering and should accelerate the application of GA biosynthetic pathways in industrial processes.

New Biotechnology published new progress about Escherichia coli. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Product Details of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Couteau, C.; Morin, T.; Diarra, H.; Coiffard, L. published the artcile< Influence of Cosmetic Type and Distribution Channel on the Presence of Regulated Fragrance Allergens: Study of 2044 Commercial Products>, Synthetic Route of 78-70-6, the main research area is contact dermatitis cosmetic distribution channel fragrance allergens; Allergens; Fragrance; Makeup; Personal care; Skin care.

Contact dermatitis linked to cosmetic products is a very common reason for visits to the dermatologist, and in more than half the cases, it is due to an allergic reaction. The aim of the study was to describe the common fragrance allergens in different categories of cosmetic products available on the European market. The influence that the product category and its distribution channel (retail stores and specialized stores such as beauty institutes or hairdressers and pharmacy) have on the prevalence of these allergens was evaluated. The Kruskal-Wallis test has been used for statistical data anal. There is a wide range of fragrance allergens, the most common being limonene (found in about 30% of products tested), linalool (just over a quarter of the products tested), and benzyl alc. (approx. 16% of the products tested). The average number of allergens found and their nature varies depending on the type of product in question (maximum number for shampoos and oral care with about 70 allergens and min. number for nail polish and makeup for eyes with fewer than 10 allergens). In the area of hygiene, deodorants and oral hygiene products are particularly noteworthy, the former for their significantly high number of allergens and the latter for their low number There is also a significant difference between the number of allergens found in eye makeup and foundations. Our results indicate that the number of regulated fragrance allergens is particularly influenced by the type of products.

Clinical Reviews in Allergy & Immunology published new progress about Allergens Role: COS (Cosmetic Use), BIOL (Biological Study), USES (Uses). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Synthetic Route of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts