Month: April 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called π-Electronic structure and electronic spectra of methylated 3,5-dicyanopyridines, published in 1977, which mentions a compound: 1195-58-0, mainly applied to methyldicyanopyridine UV MO; cyanopyridine UV MO; pyridine cyano UV MO, Formula: C7H3N3.

Quantum-chem. interpretation is given for the UV spectra of mono-, di-, and trimethylated title compounds using the limited-configuration-interaction method on the bases of Hueckel MO and SCF wave functions. Results of both procedures agree well with exptl. The modifications agree also in qualities of individual transitions and weights of configurations. The influence of Me-group on 3,5-dicyanopyridine skeleton was followed by the electron d. change.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 12080-32-9, is researched, Molecular C8H12Cl2Pt, about Novel tetranuclear PdII and PtII anticancer complexes derived from pyrene thiosemicarbazones, the main research direction is tetranuclear palladium platinum cyclometalated pyrene thiosemicarbazone preparation antitumor activity; crystal mol structure cyclometalated pyrene thiosemicarbazone platinum tetranuclear complex.HPLC of Formula: 12080-32-9.

Cyclometalated palladium(II) and platinum(II) pyrenyl-derived thiosemicarbazone (H2PrR) complexes of the type [M4(μ-S-PrR-κ3-C,N,S)4] (M = PdII, PtII; R = Et, cyclohexyl) have been synthesized in good yields and fully characterized. X-ray crystallog. showed that the tetranuclear complex [Pt4(μ-S-PrCh-κ3-C,N,S)4](CH3)2COCHCl3 contains an eight-membered ring of alternating M-S atoms. The Et derivatives [M4(μ-S-PrEt-κ3-C,N,S)4] exhibit potent antiproliferative activity towards A2780 human ovarian cancer cells, with IC50 values of 1.27μM (for M = PdII) and 0.37μM (for M = PtII), the latter being an order of magnitude more potent than the anticancer drug cisplatin (IC50 1.20μM). These promising complexes had low toxicity towards non-cancerous human MRC5 cells, which points towards an early indication of differential toxicity between cancer and normal cells. Experiments that investigated the effects of these tetranuclear complexes on the cell cycle, integrity of the cell membrane, and induction of apoptosis, suggested that their mechanism of action of does not involve DNA targeting, unlike cisplatin, and therefore could be promising for combating cisplatin resistance.

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Oh, Yoo Jin; Yum, Eul Kgun published an article about the compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate( cas:651780-02-8,SMILESS:CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12 ).COA of Formula: C12H13BrN2O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:651780-02-8) through the article.

Diverse mono or biaryl substituents were introduced to indazole moieties under microwave-assisted palladium-catalyzed coupling reactions with isomeric bromoindazoles and aryl boronic acids. 1,3-Disubstituted indazoles were also obtained by C=C or C-N coupling of monosubstituted indazoles with functionalized terminal alkenes and arylhalides. Facile introduction of diverse substituents to indazoles showed useful synthetic approach for creating indazole compound library to discover biol. active small mols.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 12080-32-9, is researched, Molecular C8H12Cl2Pt, about A Germylene Supported by Two 2-Pyrrolylphosphane Groups as Precursor to PGeP Pincer Square-Planar Group 10 Metal(II) and T-Shaped Gold(I) Complexes, the main research direction is pyrrolylphosphino germylene pincer platinum gold preparation crystal mol structure; planar T shaped gold pyrrolylphosphino germylene preparation crystal structure; nickel palladium pyrrolylphosphino germylene complex preparation mol structure; Group 10 elements; T-shaped gold; germylenes; phosphorus; pincer complexes.SDS of cas: 12080-32-9.

An efficient synthesis of 2-di-tert-butylphosphinomethylpyrrole (HpyrmPtBu2), by treating 2-dimethylaminomethylpyrrole (HpyrmNMe2) with tBu2PH at 135° in the absence of any solvent, has allowed the preparation of the new PGeP germylene Ge(pyrmPtBu2)2 (1), by treating [GeCl2(dioxane)] with LipyrmPtBu2, in which the Ge atom is stabilized by intramol. interactions with one (solid state) or both (solution) of its phosphine groups. Reactions of germylene 1 with Group 10 metal dichlorido complexes containing easily displaceable ligands have led to [MCl{κ3P,Ge,P-GeCl(pyrmPtBu2)2}] [M = Ni (2), Pd (3), Pt (4)], which have an unflawed square-planar metal environment. Treatment of germylene 1 with [AuCl(tht)] (tht = tetrahydrothiophene) rendered [Au{κ3P,Ge,P-GeCl(pyrmPtBu2)2}] (5), which is a rare case of a T-shaped gold(I) complex. The hydrolysis of 5 gave the linear gold(I) derivative [Au(κP-HpyrmPtBu2)2]Cl (6). Complexes 2-5 contain a PGeP pincer chloridogermyl ligand that arises from the insertion of the Ge atom of germylene 1 into a M-Cl bond of the corresponding metal reagent. The bonding in these mols. has been studied by DFT/NBO/QTAIM calculations These results demonstrate that the great flexibility of germylene 1 makes it a better precursor to PGeP pincer complexes than the previously known germylenes of this type.

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Fukunaga, Toshiya M.; Sawabe, Chizuru; Matsuno, Taisuke; Takeya, Jun; Okamoto, Toshihiro; Isobe, Hiroyuki published the article 《Manipulations of Chiroptical Properties in Belt-Persistent Cycloarylenes via Desymmetrization with Heteroatom Doping》. Keywords: cycloarylene preparation dipole moment fluorescence UV spectrum CD; chirality; circular dichroism; cylinders; macrocycles; nanotubes.They researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Category: alcohols-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12080-32-9) here.

A desymmetrization strategy has been devised in the design of mol. cylinders to maximize the dissymmetry factor relevant to circularly polarized light. Although the highest dissymmetry factor of organic mols. was previously achieved with a chiral belt-persistent cycloarylene having magnetic and elec. transition dipole moments in parallel, we noticed that an unbalanced magnitude of two moments was detrimental for higher dissymmetry factors. In this study, a mol. cylinder was desymmetrized by arraying doped and undoped panels via stereoselective cross-coupling macrocyclization. The desymmetrization succeeded in balancing two moments by reducing the elec. transition moment at the global min. but failed to maximize the dissymmetry factor. Structural studies revealed that the dissymmetry factor is sensitive to subtle structural fluctuations, while the rotatory strength is not affected. This study is important for the development of chiroptical materials.

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Computed Properties of C8H12Cl2Pt. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about An Antitumor Bis(N-Heterocyclic Carbene)Platinum(II) Complex That Engages Asparagine Synthetase as an Anticancer Target. Author is Hu, Di; Yang, Chen; Lok, Chun-Nam; Xing, Fangrong; Lee, Pui-Yan; Fung, Yi Man Eva; Jiang, Haibo; Che, Chi-Ming.

New anticancer platinum(II) compounds with distinctive modes of action are appealing alternatives to combat the drug resistance and improve the efficacy of clin. used platinum chemotherapy. Herein, we describe a rare example of an antitumor PtII complex targeting a tumor-associated protein, rather than DNA, under cellular conditions. Complex [(bis-NHC)Pt(bt)]PF6 (1a; Hbt=1-(3-hydroxybenzo[b]thiophen-2-yl)ethanone) overcomes cisplatin resistance in cancer cells and displays significant tumor growth inhibition in mice with higher tolerable doses compared to cisplatin. The cellular Pt species shows little association with DNA, and localizes in the cytoplasm as revealed by nanoscale secondary ion mass spectrometry. An unbiased thermal proteome profiling experiment identified asparagine synthetase (ASNS) as a mol. target of 1a. Accordingly, 1a treatment reduced the cellular asparagine levels and inhibited cancer cell proliferation, which could be reversed by asparagine supplementation. A bis-NHC-ligated Pt species generated from the hydrolysis of 1 a forms adducts with thiols and appears to target an active-site cysteine of ASNS.

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Name: Pyridine-3,5-dicarbonitrile. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Pyridine-3,5-dicarbonitrile, is researched, Molecular C7H3N3, CAS is 1195-58-0, about Sodium cyanoborohydride.

Properties and applications of sodium cyanoborohydride as a selective, mild reducing reagent for reductive aminations of aldehydes and ketones, reductions of imines, iminium ions, oximes and oxime derivatives, hydrazones, enamines, reductive deoxygenation of carbonyls via sulfonyl hydrazones, reductions of aldehydes and ketones, polarized alkenes, alkyl halides, epoxides, acetals and allylic ester groups were reviewed.

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Tan, Bryan Yong-Hao; Teo, Yong-Chua published the article 《Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water》. Keywords: aryl iodide aliphatic amide cross coupling cobalt catalyst water; arylamide flutamide preparation.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Related Products of 7661-33-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N’-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products I [R1 = Pr, i-Pr, Bu, etc; R2 = Ph, 2-F-C6H4, 4-Me-C6H4, etc.] were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Shook, Brian C.; Chakravarty, Devraj; Barbay, J. Kent; Wang, Aihua; Leonard, Kristi; Alford, Vernon; Powell, Mark T.; Rassnick, Stefanie; Scannevin, Robert H.; Carroll, Karen; Wallace, Nathaniel; Crooke, Jeffrey; Ault, Mark; Lampron, Lisa; Westover, Lori; Rhodes, Kenneth; Jackson, Paul F. researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).Recommanded Product: 1195-58-0.They published the article 《Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists》 about this compound( cas:1195-58-0 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: thienopyrimidine preparation adenosine A2A antagonist. We’ll tell you more about this compound (cas:1195-58-0).

A novel series of benzyl substituted thieno[2,3-d]pyrimidines, e.g. I, were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Dihydropyridines. V. Formation of the isomeric 1,2- and 1,4-dihydro derivatives in the reaction of methylmagnesinm iodide with 3,5-dicyanopyridine and 3,5-dicyano-2-methylpyridine》. Authors are Kuthan, J.; Janeckova, E.; Havel, M..The article about the compound:Pyridine-3,5-dicarbonitrilecas:1195-58-0,SMILESS:N#CC1=CC(C#N)=CN=C1).Quality Control of Pyridine-3,5-dicarbonitrile. Through the article, more information about this compound (cas:1195-58-0) is conveyed.

cf. CA 58, 5626a. MeMgI adds to 3,5-dicyanopyridine (I) to give 3,5-dicyano-2-methyl-1,2-dihydropyridine (II) and 3,5-dicyano-4-methyl-1,4-dihydropyridine (III). Similarly, 3,5-dicyano-2-methylpyridine (IV) forms 3,5-dicyano-2,6-dimethyl-1,2-dihydropyridine (V) and 3,5-dicyano-2,4-dimethyl-1,4-dihydropyridine (VI), resp. Nicotinoyl chloride-HCl (from 500 g. nicotinoic acid and 1400 ml. SOCl2) refluxed 35 hrs. with 500 ml. Br, the mixture evaporated on a steam bath, the residue dissolved in 1 l. absolute EtOH, and the solution heated 30 min. on a steam bath gave 81% HBr salt of Et 5-bromonicotinate, m. 147-7.5° (EtOH), from which 80% Et 5-bromonicotinate (VII), b0.5 86-92°, m. 42°, was obtained by treatment with Na2CO3. VII (50 g.) stirred with 30 g. CuCN in 50 ml. HCONMe2 2 hrs. at 160-75°, the mixt evaporated in vacuo, and the residue shaken with 500 ml. concentrated NH4OH and extracted successively with 800 ml. C6H6 and 200 ml. Et2O gave after evaporation 45% Et 5-cyanonicotinate (VIII), b16 143-5°, m. 89-90° (petr. ether). VIII (50 g.) in 1 l. absolute EtOH saturated with NH3 kept 7 days at room temperature gave 72% 5-cyanonicotinamide (IX), m. 220-1° (H2O, EtOH). A mixture of 14 g. IX and 40 ml. anhydrous C5H5N treated over 15 min. with 9 ml. POCl3, stirred 8 hrs., decomposed with ice, alkalized with NH4OH, and extracted with CHCl3 gave 64% I, m. 113-13.5° (dilute EtOH), sublimed 80-90°/10 mm. K salt of 2-hydroxy-3,5-dicyano-6-methylpyridine (6.07 g.) and 7 g. PCl5 treated with 10 ml. POCl3, and the mixture refluxed 30 min., evaporated in vacuo, decomposed with ice, and extracted with C6H6 gave 35% 3,5-dicyano-2-chloro-6-methylpyridine, m. 143-3.5°, which gave IV, m. 76-7°, on catalytic hydrogenation. Reaction of 1.04 g. I in 70 ml. Et2O with MeMgI (from 0.8 g. Mg, 2 ml. MeI, and 30 ml. Et2O) followed by chromatography on Al2O3 (activity II) gave 512 mg. yellow II, m. 114-15° (C6H6, dilute EtOH), and 240 mg. yellowish III, m. 180.5-81° (dilute EtOH). Similarly, 670 mg. IV with MeMgI (from 0.72 g. Mg, 1.9 ml. MeI, and 25 ml. Et2O) afforded 405 mg. yellow V, m. 152-3° (dilute MeOH), and 138 mg. yellowish VI, m. 129.5-30.5°. Dehydrogenation of II, III, V, and VI by heating with equal amounts 30% Pd-C 20 min. at 200-5° gave IV, 3,5-dicyano-4-methylpyridine, m. 84.5-85°, 3,5-dicyano-2,6-dimethylpyridine, m. 118-18.5°, and 3,5-dicyano-2,4-dimethylpyridine, m. 115-15.5°, resp. Ultraviolet and infrared data for II, III, V, and VI, and of some of the intermediates, are given.

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