Month: September 2021

Reference of 80379-31-3, Adding some certain compound to certain chemical reactions, such as: 80379-31-3, name is Ethyl 3-hydroxy-2H-chromene-4-carboxylate,molecular formula is C12H12O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 80379-31-3.

The mixture of 2a (44 mg, 0.2 mmol) and Ph2O (400 mg) was heated to 210 C under argon for 30 min. After cooling to the room temperature, the residue was purified on silica gel (PE/EtOAc, 30:1) to get the product as a colorless oil (25 mg, 84%). 1H NMR (400 MHz, CDCl3): delta 7.26-7.22 (m, 1H), 7.14-7.12 (m, 1H), 7.06 (d, J=7.6 Hz, 2H), 4.41 (s, 2H), 3.62 (s, 2H); 13C NMR (100 MHz, CDCl3): delta 207.74, 154.65, 129.08, 128.58, 123.45, 121.63, 117.80, 73.08, 41.03 ppm. The date of the compound is identical with the described date of the reference.16

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80379-31-3, Ethyl 3-hydroxy-2H-chromene-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Xiaolin; Lei, Mei; Zhang, Yi-Nan; Hu, Li-Hong; Tetrahedron; vol. 70; 21; (2014); p. 3400 – 3406;,
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Application of 4541-14-4 , The common heterocyclic compound, 4541-14-4, name is 4-(Benzyloxy)butan-1-ol, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

DMSO (9.8 mL, 138.8 mmol) was added at -78 C to a solution of oxalyl chloride (9.7 mL, 111.0 mmol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the mono benzylated alcohol 18 (10 g, 55.5 mmol) in CH2Cl2(50 mL), was added drop wise at -78 C over 30 min. After the solution had been stirred for an additional 30 min, Et3N (38.2 mL, 275.0 mmol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4 and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification.

The synthetic route of 4541-14-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Avuluri, Srilatha; Bujaranipalli, Sheshurao; Das, Saibal; Yadav; Tetrahedron Letters; vol. 59; 39; (2018); p. 3547 – 3549;,
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Adding a certain compound to certain chemical reactions, such as: 4415-82-1, Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4415-82-1, blongs to alcohols-buliding-blocks compound. name: Cyclobutylmethanol

Example 37: (E)-3-(cyclobutylmethylene)octan-2-one (Compound ID 19) Prepared as described in Example 35 in 50% yield from cyclobutanecarbaldehyde (obtained by PCC-oxidation of cyclobutanemethanol) and diethyl 2-oxooctan-3- ylphosphonate (obtained from hexyl iodide and triethyl phosphite via diethyl hexylphosphonate). Boiling point: 105C (0.07 mbar).13C-NMR (100MHz, CDCI3): £199.75 (s, C(2)), 147.99 (d, CH=C(3)), 140.66 (s, C(3)), 34.82 (Cf), 31.92 (Q, 29.33 (Q, 29.20 (t, 2 C), 25.66 (Q, 25.61 (q, C(I)), 22.50 (Q, 19.05 (Q, 13.97 t°, C(S)).MS (El): 194 (2), 179 (7), 166 (16), 151 (11), 137 (29), 123 (44), 109 (39), 95 (27), 81 (27), 79 (13), 77 (8), 67 (30), 55 (13), 43 (100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4415-82-1, its application will become more common.

Reference:
Patent; GIVAUDAN SA; WO2008/116338; (2008); A2;,
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Adding a certain compound to certain chemical reactions, such as: 110-73-6, 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 110-73-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C4H11NO

1-(tert-Butoxycarbonyl)-5-hydroxyindole (2.33 g, 10.0 mmol) and triphenylphosphine (5.25 g, 20.0 mmol) were dissolved in toluene (46.0 mL), and the solution was added with glycidol (1.32 mL, 20.0 mmol) and 40% DEAD-toluene solution (9.10 mL, 20 mmol) at room temperature, followed by stirring at 80C for 4 hours. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (hexane/ethyl acetate=4/1). A crude product (1.28 g) of 1-(tert-butoxycarbonyl)-5-hydroxyindole (1.28 g) was obtained. The obtained crude product was dissolved in N,N-dimethylacetoamide (20.0 mL), and the solution was added with 2- (ethylamino) ethanol (8.60 mL, 87.8 mmol), followed by stirring at 80C for 4 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (chloroform/methanol =9/1) to obtain 1-(tert-butoxycarbonyl)-5-{3-[N-ethyl(2-hydroxyethyl)amino]-2-hy droxypropoxy}indole (1.53 g, 40%). ESI-MS m/z: 379 [M+H]+; 1H-NMR (CDCl3)delta(ppm): 1.07 (t, J = 7.2 Hz, 3H), 1.66 (s, 9H), 2.61-2.80 (m, 6H), 3.61-3.68 (m, 2H), 3.99-4.14 (m, 3H), 6.48 (d, J = 3.9 Hz, 1H), 6.94 (dd, J = 2.6, 8.7 Hz, 1H), 7.04 (d, J = 2.6 Hz, 1H), 7.56 (d, J = 3.9 Hz, 1H), 8.01 (d, J = 8.7 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
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Application of 616-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 21A (7 g, 77.7 mmol), and di-tert-butyldicarbonate (35.6 g, 163 mmol) were stirred in methylene chloride (100 ml_) at25 C for 2 hr. Saturated aqueous NaCI (150 mL) was added. The aqueouslayer was extracted with CHaCfe (100 ml) twice. The organic phase waswashed with brine (100 mL), dried over Na2SO4. The solvent was removed byrotary evaporator to give compound 21B (17g, 76%) which was used withoutfurther purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Patent; SCHERING CORPORATION; WO2006/19768; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, molecular formula is C8H19NO4, molecular weight is 193.2408, as common compound, the synthetic route is as follows.Recommanded Product: 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol

Part A Preparation of 11-Benzyloxycarbonylamino-3,6,9-trioxaundecanol A solution of 11-amino-3,6,9-trioxaundecanol (6.56 g, 0.034 mol) and TEA (5.2 mL, 0.037 mol) in DCM (200 mL) was treated with benzyl chloroformate (5.1 mL, 0.036 mol) in one portion. After 18 h the solution was concentrated to a viscous oil and triturated with ether (3*100 mL). The combined triturants were concentrated to give an amber oil (9.4 g). Flash chromatoraphy on silica gel (6% MeOH/EtOAc) gave the title compound as a colorless viscous oil (7.0 g, 63%). 1H NMR (CDCl3): 7.36-7.25 (m, 5H), 6.04 (bs, 1H), 5.08 (s, 2H), 3.72-3.48 (m, 14H), 3.41-3.31 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Pharma Company; US6416733; (2002); B1;; ; Patent; Carpenter JR., Alan P.; US2003/3049; (2003); A1;; ; Patent; Barrett, John Andrew; Cheesman, Edward Hollister; Harris, Thomas David; Liu, Shuang; Rajopadhye, Milind; Sworin, Michael; US2003/124053; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1124-63-6, 3-Cyclohexylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1124-63-6, blongs to alcohols-buliding-blocks compound. Formula: C9H18O

3-Cyclohexylpropan-1-ol (10 mmol) was refluxed overnight with bromic acid (10 mmol). After adding ice water, the reaction mixture was extracted with ethyl acetate to obtain 3- (bromopropyl) cyclohexane. The crude mixture was reacted with phthalimide (15 mmol) in THF solution (20 ml) to obtain a white solid phthalimide derivative. This was filtered and then reacted with hydrazine (98%, 63 mmol) in anhydrous ethanol (15 ml) at 60 C for 10 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate to give a 3-cyclohexylpropylamine compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1124-63-6, its application will become more common.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6149-41-3, name is Methyl 3-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl 3-hydroxypropanoate

Example 16 This example describes the preparation of various alkyl acrylate esters by dehydrating 3-HP esters using various catalysts. A catalyst was placed in a 3-neck flask that was equipped with a temperature probe (in contact with the catalyst). A distillation column and receiving flask were attached so that the vapors formed during the reaction could be collected, and the catalyst was heated to the desired temperature. A solution of a 3-hydroxypropionic acid ester in the corresponding alcohol was added drop-wise directly onto the catalyst using a syringe. The liquid that distilled over was collected and analyzed by gas chromatography. The results, and corresponding experimental conditions are shown in the following table. Ester Catalyst Temperature Concentration Solvent Yield of Yield of (C) of Ester in Acrylic Acrylic Solvent ester (GC) acid (GC) – (%) (%) (%) Ethyl NaH2P04-Silica 275-EtOH 49 26 Ethyl NaH2PO4-Silica 250 35 EtOH 53 Ethyl NaH2PO4-Silica 250 50 EtOH 14 21 Ethyl NaH2PO4-Silica 180 40 EtOH 30 – Ethyl Copper-H3PO4 220 20 EtOH 50 50 Methyl NaH2PO4-Silica 280-MeOH 78 Methyl CuS04-Silica 280-MeOH 37 9 Methyl Cs2CO3-Silica 220 45 MeOH 49 – Butyl NaH2PO4-Silica 280 50 BuOH 40 Similar dehydration reactions were performed using 3-HP as the starting material and a flask containing heated catalyst in place of the GC: (a) Aqueous 3-HP was dehydrated to acrylic acid over NaH2PO4-Silica gel catalyst at 180C. Based on GC and HPLC analysis, the yield of acrylic acid was 90- 96%. (b) Aqueous 3-HP was dehydrated to acrylic acid over H3PO4-Silica gel catalyst at 180C. Based on GC and HPLC analysis, the yield of acrylic acid was 85-90%. (c) Aqueous 3-HP was dehydrated to acrylic acid over CuS04-Silica gel catalyst at 180C. Based on GC and HPLC analysis, the yield of acrylic acid was 73%. (d) Aqueous 3-HP was dehydrated to acrylic acid over Zeolite H-ss powder and 85% H3PO4 as the catalyst at 180C. Based on GC and HPLC analysis, the yield of acrylic acid was 71%. (e) Aqueous 3-hydroxyisobutyric acid was dehydrated to methacrylic acid over NaH2PO4-Silica gel catalyst at 270C. Based on GC analysis, the yield of methacrylic acid was 79%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6149-41-3, Methyl 3-hydroxypropanoate.

Reference:
Patent; CARGILL, INCORPORATED; WO2003/82795; (2003); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

To a solution of anhydrous CH2Cl2 (3 mL), 4 A mol. sieves (0.1 g), protected glycolicacid 6 (150 g, 0.91 mmol) and compound 5 (500 g, 0.91 mmol) was added, at 20 C under argon atmosphere, TMSOTf (15 muL, 0,075 mmol). Afterwards the reaction mixture was stirred at this temperature for 3 h until TLC showed full conversion (PE:EtOAc 7:3, Rf 0.3). Than the mixture wasquenched by the addition of Et3N, filtered and the residue washed with CH2Cl2 (100 mL). The organic layer was concentrated. Pd-C catalyst was added to a solution of the oily mixture obtained from the previous reaction in 75 mL of (1:1) THF-MeOH. Afterwards, under stirring, the reaction mixture was placed under an H2 gas atmosphere (atmospheric pressure) and the deprotection of the benzyl ester was continued overnight. When full conversion had taken place (TLC examination), the H2 flow was replaced by Argon and the reaction mixture was filtered and washed (MeOH, 200 mL) through a pad of Celite. Upon concentration of the filtrate, a white solid material was obtained, and added CH2Cl2 was evaporated to remove traces of MeOH to afford 7 as a white solid (274 g, 0.6 mmol, 65% yield).

The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ghidini, Alice; Steunenberg, Peter; Murtola, Merita; Stromberg, Roger; Molecules; vol. 19; 3; (2014); p. 3135 – 3148;,
Alcohol – Wikipedia,
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Related Products of 402-63-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 402-63-1, name is 1-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The catalyst solutionwas prepared by dissolving complex 3(36.1 mg,0.05mmol) in methanol (5.0 mL).Under a nitrogen atmosphere, the mixture of an alcohol substrate (2.0 mmol) and1.0 mL of the catalyst solution (0.01mmol) in 20mL acetone was stirred at 56 Cfor 10 minutes. tBuOK(22.4mg, 0.2 mmol)was then added to initiate the reaction.At the stated time, 0.1 mL of the reaction mixture was sampled and immediately diluted with 0.5 mL acetone pre-cooled-to-0 C for GC or NMR analysis. After the reaction was complete, the reaction mixture was condensed under reduced pressure and subject to purification by flash silica gel column chromatography to afford the corresponding ketone product, which was identified by comparison with the authentic sample through NMR and GC analysis.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 402-63-1, 1-(3-Fluorophenyl)ethanol.

Reference:
Article; Wang, Qingfu; Du, Wangming; Liu, Tingting; Chai, Huining; Yu, Zhengkun; Tetrahedron Letters; vol. 55; 9; (2014); p. 1585 – 1588;,
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