Month: September 2021

Related Products of 928-51-8 ,Some common heterocyclic compound, 928-51-8, molecular formula is C4H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of2b(6.52 g, 50.90 mmol) in pyridine (20 mL) was successively added toluene-4-sulfonylchloride (TsCl, 9.72 g, 50.90 mmol) under nitrogen atmosphere, the mixture was stirred at 0 C for 2 h. The resulting mixture was poured into water (110 mL), extracted with ethyl acetate (EA, 2 × 70 mL), The combined organic layers were washed with hydrochloric acid (2 M, 50 mL) and brine, dried over anhydrous Na2SO4and concentrated under vacuum to give3b(10.54 g, 79%) as a colorless oil, Rf(PE /EA, 5:1) = 0.21.1H NMR (CDCl3, 400 MHz) delta = 7.79 (d, J=8.2 Hz, 2H), 7.36 (d, J=8.2 Hz, 2H), 4.07 (t, J=5.6 Hz, 2H), 3.50 (t, J=5.7 Hz, 2H), 2.46 (s, 3H), 1.86-1.79(m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-51-8, its application will become more common.

Reference:
Article; Wei, Zhao; Liu, Yan-Qin; Zhou, Xin-Bo; Luo, Yuan; Huang, Chun-Qian; Wang, Yong-An; Zheng, Zhi-Bing; Li, Song; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5743 – 5748;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 112-27-6

j00524j A solution of triethylene glycol (30 g, 199.7 mmol) in THF (300 mL) wascooled to 0C and charged with NaOH (11.98 g, 299.7 mmol) and stirred for 15 mm. Thissolution was charged with tosyl chloride (38.07 g, 199.7 mmol) and stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo and the residue obtained was dilutedwith water (100 mL) and extracted with ethyl acetate (3 X 200 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo resulting in acrude compound which was purified by chromatography on silica gel, eluting with 2%methanol in DCM to give 18.5 g, 30% yield of the title compound as a colorless oil. ?H NMR(400 MHz, CDC13): oe = 7.78 (d, J= 8.3 Hz, 2H), 7.33 (d, J= 8.1 Hz, 2H), 4.25 -4.10 (m, 2H),3.75 – 3.60 (m, 6H), 3.63 – 3.52 (m, 4H), 2.43 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 112-27-6.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Application of 1113-21-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, molecular formula is C20H34O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The 5E, 9E, 13E-geranyl geranyl acetone (1) can be prepared by reacting 6E-10E-geranyl linalool (23) with diketene (24) catalyzed by DMAP in ethyl ether to give the ester 25. The ester 25 in the Carroll rearrangement using Al(OiPr)3 at elevated temperature can afford the desired 5E, 9E, 13E-geranyl geranyl acetone (1). In another approach, the GGA (1) can be prepared by treating geranyl linalool (23) with the Meldrum’s acid 26 in the Carroll rearrangement using Al(OiPr)3 at 160 C. Similarly, the use of tert-butyl acetoacetate (27) with geranyl linalool (23) in the Carroll rearrangement can also give the desired 5E,9E,13E-geranyl geranyl acetone (1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1113-21-9, 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; Look, Gary C.; US2015/133431; (2015); A1;,
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Electric Literature of 33420-52-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33420-52-9, name is 2,2-Difluoropropan-1-ol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of 5-chloro-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-l- yl)triazolo[4,5-d]pyrimidine (example 8, step a) (38.5 mg, 0.1 mmol), 2,2,2-Trifluoro- ethanol (99 mg, 1 mmol) and NaH (suspension in oil, 20 mg, 5 mmol) in DMF (1 mL) was stirred at 110 C for 6 h. After cooling to room temperature formic acid was added and the mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid. After evaporation of the product containing fractions 29.3 mg (65 %) of the title compound was isolated. MS(m/e): 449.2 (MH+). Example 53; 3-[(2-Chlorophenyl)methyl]-5-(2,2-difluoropropoxy)-7-(3,3-difluoropyrrolidin-l- yl)triazolo[4,5-d]pyrimidine; In analogy to the procedure described for the synthesis of 3-[(2-chlorophenyl)methyl]-7- (3,3-difluoropyrrolidin-l-yl)-5-(2,2,2-trifluoroethoxy)triazolo[4,5-d]pyrimidine (example 40) the title compound was prepared from 5-chloro-3-[(2-chlorophenyl)methyl]-7-(3,3- difluoropyrrolidin-l-yl)triazolo[4,5-d]pyrimidine and 2,2-difluoropropan-l-ol with the use of Cs2C03 instead of NaH. MS(m/e): 445.3 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33420-52-9, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ROEVER, Stephan; ROGERS-EVANS, Mark; NETTEKOVEN, Matthias; SCHMITT, Sebastien; GRETHER, Uwe; KIMBARA, Atsushi; WO2015/32769; (2015); A1;,
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Related Products of 5182-44-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5182-44-5, name is 2-(3-Chlorophenyl)ethanol, molecular formula is C8H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 63-Chloro-7-[2-(3-chloro-phenyl)-ethoxymethyl]-6H-pyrimido[4,5-c]pyridazin-5-one6.1 [2-(3-Chloro-phenyl)-ethoxy]-acetic acid methyl ester; To a solution of 2-(3-chloro-phenyl)-ethanol (1.96 g, 12.51 mmol) in THF (55 ml) was added n-BuLi (8.8 ml, 1.6 M solution in hexane, 13.77 mmol) at -78 C. Then sodium iodoacetate (2.6 g, 12.51 mmol) was added and the mixture was allowed to warm to ambient temperature and was stirred overnight. The THF was then removed and 1 N HCl was added to the remaining residue to adjust the pH to 1. This mixture was extracted two times with dichloromethane and the combined extracts were dried (Na2SO4) and evaporated. The remaining red liquid was dissolved in MeOH (60 ml) and thionylchloride (1.56 ml, 21.5 mmol) was added dropwise at -15 C. The reaction mixture was then stirred for 1.5 h at ambient temperature. Then water was added and the mixture was extracted three times with ether. The combined extracts were washed with brine, dried (Na2SO4) and evaporated. The remaining residue was then purified by column chromatography (silica gel, heptane/ethyl acetate 95:5 to 88:12) to give the title compound (2.161 g, 9.45 mmol; 76%) as orange liquid. MS: m/e=229.2 [M+H+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5182-44-5, 2-(3-Chlorophenyl)ethanol.

Reference:
Patent; Conte, Aurelia; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Kuehne, Holger; Narquizian, Robert; Panousis, Constantinos G.; Peters, Jens-Uwe; Ricklin, Fabienne; US2008/234277; (2008); A1;,
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Reference of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2.5.1 (1,1-Dimethyl-2-phenyl-ethoxy)-trimethylsilyl ether IR (neat): nu = 2950, 1450, 1255, 1095, 838, 740, 693 cm-1; 1H NMR (400 MHz, CDCl3): delta = 0.148 (s, 9H), 1.292 (s, 6H), 2.802 (s, 2H), 7.272-7.356 (m, 5H) ppm; MS (EI, 70 eV) m/z: 222 [M+], 207 [M+-CH3], 133 [M+-OTMS]; Anal. calcd for C13H22OSi: C, 70.27; H, 9.90. Found: C, 70.25; H, 9.87.

According to the analysis of related databases, 100-86-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shirini, Farhad; Khaligh, Nader Ghaffari; Akbari-Dadamahaleh, Somayeh; Journal of Molecular Catalysis A: Chemical; vol. 365; (2012); p. 15 – 23;,
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Adding a certain compound to certain chemical reactions, such as: 2277-23-8, 2,3-Dihydroxypropyl decanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2,3-Dihydroxypropyl decanoate, blongs to alcohols-buliding-blocks compound. Quality Control of 2,3-Dihydroxypropyl decanoate

Compound 1, 100 mg, compound 2, 76 mg,120 mg of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI)42 mg of 1-hydroxybenzotriazole (HOBt) was dissolved in 2 ml of THF,The reactants were mixed and replaced with nitrogen three times,After stirring at room temperature for 1 hour.TLC detection (DCM: MeOH = 5: 1), the remaining starting material,The system was concentrated directly and scraped into large plates (DCM: MeOH = 10: 1) to give 51 mg of a light yellow oil.

The synthetic route of 2277-23-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.; Yao Qingjia; Wu Simin; Xu Yangjun; (6 pag.)CN106749210; (2017); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C10H21BrO

To 2.00 g of 10-bromo-1-decanol in 15 mL of chloroform (CHCl3) was added dropwise 16.9 mmol of 3,4-dihydro-2H-pyran (DHP) and catalytic amounts of p-toluenesulphonic acid (pTSA). The reaction mixture was stirred for 24 h at room temperature. The organic layer was washed with water (2 .x. 20 mL), NaHCO3 (2 .x. 20 mL), CHCl3 (1 .x. 20 mL), and dried over MgSO4, filtered, and evaporated in vacuo. The crude product was purified using silica gel column chromatography eluting with hexane/ether (9:1). The pure product 2 (Banaszak et al., 2009) was obtained as a colorless oil 2.35 g (7.32 mmol) for a 100percent yield.

With the rapid development of chemical substances, we look forward to future research findings about 53463-68-6.

Reference:
Article; Carballeira, Ne?stor M.; Montano, Nashbly; Cintro?n, Gabriel A.; Ma?rquez, Carmary; Rubio, Celia Ferna?ndez; Prada, Christopher Ferna?ndez; Balan?a-Fouce, Rafael; Chemistry and Physics of Lipids; vol. 164; 2; (2011); p. 113 – 117;,
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Reference of 1454-85-9 , The common heterocyclic compound, 1454-85-9, name is Heptadecan-1-ol, molecular formula is C17H36O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 100 ml, 3 port reaction vessel equipped with a mechanical stirrer, mantle, thermowatch, short-column condenser, cow receiver, thermometers, and a nitrogen blanket, 27.68 grams of hydrophobe group containing compound and 4.34 grams of p-toluenesulfonic acid monohydrate were added. The reactants were heated to about 80° C. and 25 grams of the trithiocarbonate compound was added. A partial vacuum to 60 mmHg mercury was applied and the temperature was increased to about 110° C. for a period of five hours to produce the product shown above.

The synthetic route of 1454-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lai, John Ta-Yuan; Hsu, Shui-Jen Raymond; Tamareselvy, Krishnan; US2006/39939; (2006); A1;,
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Related Products of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1Reduction of Methyl Glycolate in Methanol to Ethylene Glycol The following example shows the positive effect of adding a promoter to the catalyst mixture. Run 1 in the table below is a comparative example. Runs 2-9 represent variants of the current invention.A 300-milliliter autoclave was charged with Ru(Acac)3 (0.10 mmole), TRIPHOS (0.50 mmole), and the promoter in the amount specified in the table. Methanol (32 milliliters) and methyl glycolate (0.156 mole) were added, and the reactor was sealed under N2. The reactor was pressurized to 250 psig (1.7 MPa) with H2 and heated to 200 C. Upon reaching 200 C., the H2 pressure was raised to 2000 psig (13.8 MPa). The autoclave was stirred and held at 200 C., 2000 psig (13.8 MPa) for a total of 3 hours. The autoclave was then cooled, excess gas vented, and the contents recovered. The contents were analyzed by the use of an internal standard gas chromatography method for the presence of methyl glycolate (?MG?) and ethylene glycol (?EG?). The results are shown in the table below. Catalyst Activity Rate Amount of Conversion of Selectivity to (moles EG per Promoter MG EG mole of Ru Run Promoter (mmole) (%) (%) per hr) 1 none none 39.5 88.4 205 2 Zn 0.25 49.3 88.9 228 Acetonylacetonate 3Me4NBF4 0.025 99.7 98.2 509 4Me4NBF4 0.001 96.8 98.2 394 5NH4PF6 0.025 100 96.9 504 6NH4OAc 0.150 67.8 94.8 334 7Ph4PBr 0.025 84.1 97.8 428 8NaPh4B 0.500 81.1 93.5 394 9BuN4PF6 0.025 97.8 95.8 487 Analysis of the run without a promoter showed a 39.5% conversion of the methyl glycolate with 88.4% selectivity to ethylene glycol. The catalyst activity rate for this experiment was 205 moles of EG per mole of ruthenium per hour. On the other hand, runs with a promoter showed MG conversions of 49-100%, EG selectivities of 89-98%, and catalyst activity rates of 230-510 moles of EG per mole of ruthenium per hour. This data show the positive effects of adding a promoter to the reaction mixture.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,96-35-5, its application will become more common.

Reference:
Patent; EASTMAN CHEMICAL COMPANY; US2009/143612; (2009); A1;,
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