Month: September 2021

Related Products of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

To a solution of 4-(methylsulfonamidomethyl)benzoic acid (0.4 g, 1.745 mmol) and benzyl 2-hydroxyacetate (0.290 g, 1.745 mmol) in a mixture of DCM and THF 1/1 (50 ml), EDC (0.334 g, 1.745 mmol) and DMAP (0.256 g, 2.094 mmol) were added in one portion. The reaction was stirred at RT for 3h. The solvent was removed under vacuum and the resulting crude was portioned between EtOAc and HC1 2N. The organic phase was separated, washed with brine and dried over Na2S04. The solvent was removed under vacuum affording 2-(benzyloxy)-2- oxoethyl 4-(methylsulfonamidomethyl) benzoate (0.4 g, 1.060 mmol, 60.7% yield, MS/ESr 377.9 [MH] +). This product was employed in the following step without any further purification.

The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria; WO2013/45280; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H5F9O

5.00 parts of a compound represented by the formula (I-1-b),Mix 20 parts of tetrahydrofuran and 8.98 parts of pyridine,After stirring for 30 minutes at 23 C., it was cooled at 5 C.In the resulting mixture, formula (I-7-a)9.74 parts of a compound represented byAfter stirring for 1 hour at 5 C.,Stir at 23 C. for 18 hours,Then, it cooled to 23 degreeC. In the reaction product obtained,50 parts and 10% ethyl acetateMix 30 parts of aqueous potassium carbonate solution and stir for 30 minutes atThe organic layer was obtained by liquid separation.In the collected organic layer,Mix 30 parts of deionized water and stir at 23 C. for 30 minutes,The organic layer was obtained by separation.After concentrating the obtained organic layer,The concentrated residue thus obtained was columned (silica gel 60 N (spherical, neutral) 100-210 mum; manufactured by Kanto Chemical Co.,Developing solvent: n-heptane / ethyl acetate = 1/3)By sorting,Compound Represented by Formula (I-7)I got 8.54 copies.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol.

Reference:
Patent; Sumitomo Chemical Co., Ltd.; Mashiyama, Tatsuro; Yasue, Takahiro Hamada; Ichikawa, Koji; (79 pag.)JP2019/52141; (2019); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 117284-59-0, name is 2-(2,2-Difluorocyclopropyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 117284-59-0

Methanesulfonyl chloride (1.35 mL) was added to a solution of 2- (2 , 2-difluorocyclopropyl) ethanol (1.42 g) and triethylamine (3.24 mL) in THF (20 mL) dropwise at 0 C. The mixture was stirred at room temperature overnight. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography(hexane/ethyl acetate) to give the title compound (1.31 g) as a pale yellow oil.XH NMR (300 MHz, DMSO-d6) delta 1.17-1.30 (1H, m) , 1.44-1.98 (4H, m) , 3.19 (3H,. s) , 4.16-4.36 (2H, m)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YASUMA, Tsuneo; KAMATA, Makoto; YAMASHITA, Tohru; HIROSE, Hideki; MURAKAMI, Masataka; KINA, Asato; YONEMORI, Kazuko; MIZOJIRI, Ryo; FUJIMORI, Ikuo; FUJIMOTO, Takuya; IKEDA, Zenichi; WO2012/74126; (2012); A1;,
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Reference of 115-20-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115-20-8, name is Trichloroethanol, molecular formula is C2H3Cl3O, molecular weight is 149.4, as common compound, the synthetic route is as follows.

A solution of 3-tert-butyl-5-methylsulfamoyl-benzoic acid (WO 2008/021388, which is incorporated herein by reference in its entirety, 400 mg, 1.47 mmol) in THF (10 ml) was treated with TEA (270 mu1, 1.91 mmol) and DPPA (412 mul, 1.91 mmol). The reaction mixture was stirred at RT for 1 hour and then 2,2,2-trichloro-ethanol (225 mul, 2.35 mmol) was added. The reaction mixture was heated at 70 C. for 18 hours and cooled at RT. The volatiles were removed under reduced pressure and the residue was partitioned between EtOAc and an aqueous 5% citric acid solution. The two phases were separated and the aqueous phase was extracted with EtOAc. The combined organic phases were washed with a saturated aqueous NaHCO3 solution and brine, dried with Na2SO4 and the solvent was removed under reduced pressure. Purification by FCC, eluting with 0-70% EtOAc/cyclohexane gave the title compound (429 mg, 70%). 1H NMR (300 MHz, CDCl3): 1.35 (9H, s), 2.69 (3H, d, J=5.4 Hz), 4.45 (1H, q, J=5.4 Hz), 4.84 (2H, s), 7.18 (1H, br s), 7.62 (1Ht, J=1.7 Hz), 7.66 (1H, br s), 7.81 (1H, br s).

Statistics shows that 115-20-8 is playing an increasingly important role. we look forward to future research findings about Trichloroethanol.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; CAPALDI, Carmelida; ARMANI, Elisabetta; JENNINGS, Andrew Steven Robert; HURLEY, Christopher; (82 pag.)US2017/183345; (2017); A1;,
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Synthetic Route of 23783-42-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol, molecular formula is C9H20O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2,5,8,1 1-Tetraoxatridecan-13-ol (5.0 g, 24.01 mmol) was dissolved in THF(20.01 ml). pyridine (5.83 ml, 72.0 mmol) was added to the mixture followed by 4-methylbenzene-1-sulfonyl chloride (5.49 g, 28.8 mmol). The mixture stirred at roomtemperature overnight. Mixture was concentrated by roto-vap. Residue was dissolved in dichloromethane. Material was washed twice with saturated aqueous sodium bicarbonate. Combined aqueous layers were back-extracted with dichloromethane. Combined organics were washed twice with iN hydrochloric acidand once with brine. Organics were dried MgSO4, filtered and then concentrated todryness to get 2,5,8,11-tetraoxatridecan-13-yl 4-methylbenzenesulfonate (4.12 g, 11.37 mmol, 47.3 % yield) which was used as is in the next step.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GILLMAN, Kevin W.; GOODRICH, Jason; BOY, Kenneth M.; ZHANG, Yunhui; MAPELLI, Claudio; POSS, Michael A.; SUN, Li-Qiang; ZHAO, Qian; MULL, Eric; GILLIS, Eric P.; SCOLA, Paul Michael; LANGLEY, David, R.; (683 pag.)WO2016/77518; (2016); A1;,
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Related Products of 4358-87-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4358-87-6, name is Methyl 2-hydroxy-2-phenylacetate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Entry 5: According to general procedure II (chapter 2.1.2) racemic methyl mandelate (rac-132, 336 mg, 2.00 mmol, 1.0 equiv), DMF (30.9 ilL, 29.2 mg, 0.40 mmol, 20 molpercent), dioxane (1 mL, 2 M)and 2-fluoro benzoyl chloride (372 ilL, 490 mg, 3.00 mmol, 1.5 equiv) were combined and allowed to react for 36 h at 80 C. Chromatographic purification of the crude material (540 mg, 232/332 86:14) on silica gel (mass of crude material/Si02 1:9) with Et20/nPen 5:95 gave rise of the chloride rac-232 ascolorless oil (227 mg, 1.23 mmol, 62percent).M (C9H9C102) = 184.62 g/mol; rf (Si02, Et20/nPen 5:95) = 0.37; [aID2° = +134.1 (c = 1.48 g/100 mL,CHCI3).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4358-87-6, Methyl 2-hydroxy-2-phenylacetate.

Reference:
Patent; UNIVERSITAET DES SAARLANDES; HUY, Peter Helmut; (208 pag.)WO2016/202894; (2016); A1;,
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Application of 869725-53-1 ,Some common heterocyclic compound, 869725-53-1, molecular formula is C8H6BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

STEP A: Preparation of (2-bromo-5-trifluoromethyl-benzyloxy)-tert-butyl-dimethyl-silane To a solution of (2-bromo-5-(trifluoromethyl)phenyl)methanol (from Preparation 2, 10 g, 39 mmol) in DMF (20 mL) was added imidazole (5.87 g, 86.3 mmol) followed by t-butyldimethylsilyl chloride (7.11 g, 47.2 mmol) and the reaction was stirred at room temperature for 16 hours. The mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by chromatography over 25+M Biotage silica column (eluted with 0-20% ethyl acetate in heptane) (5CV), 20% (1 CV) to afford a colorless oil (14 g, 97%) of the title compound. 1H NMR (400 MHz, CDCl3) delta ppm 0.15 (s, 6H) 0.98 (s, 9H) 4.75 (s, 2H) 7.36 (m, 1H) 7.60 (d, J=8.3 Hz, 1H) 7.84 (s, 1H)). GCMS: 311 (M-57, t-bu).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 869725-53-1, 2-Bromo-5-(trifluoromethyl)benzyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc; US2007/213371; (2007); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Benzyl 2-hydroxyacetate

General procedure: The suitable acid (1.1 equiv), DCC (1.1 equiv) and a catalytic amount of DMAP (0.1-0.2 equiv.) were added to a solution of the alcohol in anhydrous DCM, and stirred at room temperature for several hours. The solid was removed by filtration, and the filtrate was washed successively with a 1N aqueous acetic acid solution and water, dried over MgSO4, filtered, and concentrated under vacuum.The resulting residue was purified by silica gel chromatography to yield the expected compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Article; El Hilali, Mostafa; Reux, Bastien; Debiton, Eric; Leal, Fernand; Galmier, Marie-Josephe; Vivier, Magali; Chezal, Jean-Michel; Miot-Noirault, Elisabeth; Coudert, Pascal; Weber, Valerie; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5692 – 5708;,
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Adding a certain compound to certain chemical reactions, such as: 4249-72-3, 2-Phenoxy-1-phenylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Phenoxy-1-phenylethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-Phenoxy-1-phenylethanol

General procedure: In a typical reaction, 125 ML phosphate buffer (0.2 mol L-1, pH 7),90 ML distilled water, 265 ML AuNPs-GQDs18 (0.72 g L-1, 0.01 mg gold)were mixed. Then, 0.1 mg substrate in 50 ML ethanol was dried at 50 Cin an open bottle. The bottle was sealed after the AuNPs-GQDs18 solutionand 20 ML fresh H2O2 (30 g L-1) was injected into it. The reactionmixture was heated at 75 C for 4 h in a horizonal oscillator. The conversionand yield were determined by HPLC. The catalyst could be recoveredby dialysis (8000-140,000 Da) and reused for 2 times (seeTable S3).

The synthetic route of 4249-72-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Fangwei; Zhang, Jiali; Guo, Shouwu; Inorganic Chemistry Communications; vol. 104; (2019); p. 105 – 109;,
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Related Products of 13726-17-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13726-17-5, name is (4-Chloro-3-methoxyphenyl)methanol, molecular formula is C8H9ClO2, molecular weight is 172.61, as common compound, the synthetic route is as follows.

[00154] Step 2. A suspension of pyridinium chlorochromate (1.37 g, 6.34 mmol) in dichloromethane (35 mL) was treated with Celite (2.0 g) and stirred at rt. A solution of (4-chloro-3-methoxyphenyl)methanol (730 mg, 4.23 mmol) in dichloromethane (5 mL) was added in one portion, and the resulting mixture was stirred at rt for 3 h. After this time, the mixture was diluted with diethyl ether, and stirred vigorously. The mixture was then filtered through a pad of silica gel and the collected solids were rinsed with additional diethyl ether. The combined filtrates were concentrated under vacuum to provide 4-chloro-3-methoxybenzaldehyde as a pale tan-yellow solid (630 mg, 87%). 1H NMR (400 MHz, CDCl3) delta ppm 3.98 (s, 3 H) 7.41 (dd, J=I.9, 1.8 Hz, 1 H) 7.45 (d, J=2.0 Hz, 1 H) 7.55 (d, J=7.6 Hz, 1 H) 9.95 (s, I H).

The chemical industry reduces the impact on the environment during synthesis 13726-17-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BATT, Douglas, G.; WO2010/9069; (2010); A1;,
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