Month: August 2021

Related Products of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

A. To a solution of cyclobutanemethanol (4.00 g, 46.4 mmol) in dichloromethane (60 mL) was added pyridine (10mL), followed by the addition of p-toluenesulfuryl chloride (7.20 g, 37.8 mmol) at 0 C. The reaction mixture wasstirred for 23 h at ambient temperature, and then diluted with diethyl ether (350 mL), washed sequentially with water,1% aqueous HCl solution, water and brine. The organic layer was dried over Na2SO4 and concentrated in vacuoto give the product (9.00 g, 80.7%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; Xenon Pharmaceuticals Inc.; Abreo, Melwyn; Chafev, Mikhail; Chakka, Nagasree; Chowdhury, Sultan; Fu, Jian-Min; Gschwend, Heinz, W.; Holladay, Mark, W.; Hou, Duanjie; Kamboj, Rajender; Kodumuru, Vishnumurthy; Li, Wenbao; Liu, Shifeng; Raina, Vandna; Sun, Sengen; Sun, Shaoyi; Sviridov, Serguei; Tu, Chi; Winther, Michael, D.; Zhang, Zaihui; (94 pag.)EP2316827; (2016); B1;,
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Synthetic Route of 40571-86-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.40571-86-6, name is Trans-2-(benzylamino)cyclohexanol, molecular formula is C13H19NO, molecular weight is 205.2961, as common compound, the synthetic route is as follows.

General procedure: In a typical reaction, 90mL dry acetonitrile solution of tetrabutylammonium tetrafluoroborate(0.1 M) as the supporting electrolyte in an undivided cell fitted with a sacrificial magnesium rod as an anode and a stainless steel grid (20 cm2) as the cathode was subjected to electrolysis at a constant current density (I = 80 mA/cm?2). The cell was cooled to ?20°C by immersing in the Lauder refrigerating system. During the electrolysis, the system was maintained under an inert atmosphere by continuous bubbling of nitrogen. The electrolysis was stopped after the formationof two equivalents of cyanomethyl anion with respect to the beta-aminoalcohol derivatives(10 mmol, Q = 193 C). Then, 1.1 equivalent of carbon disulfide is added.The solution was removed from the cooling bath and was allowed to reach room temperature and kept under continuous stirring for 12 hours to ensure completion of the reaction. The excess of acetonitrile was removed using a rotatory evaporator, the residue was washed with water and the product was extracted three times with diethyl ether. The organic layer was washed with 20mL of water and dried over anhydrous magnesium sulfate. The solvent was removed and the residue was purified by column chromatography on silica gel 60 using a mixture of ethyl acetate/hexane (3:7) as the eluent. All the products were obtained as solids. They were characterized by 1H and 13C NMR spectroscopy, IR spectroscopy, EI mass spectrometry andelementary analysis.

The chemical industry reduces the impact on the environment during synthesis 40571-86-6, I believe this compound will play a more active role in future production and life.

Reference:
Article; Medini, Hayet; Mekni, Nejib Hussein; Boujlel, Khaled; Journal of Sulfur Chemistry; vol. 36; 6; (2015); p. 653 – 659;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29055-08-1, name is (2-(Methylamino)phenyl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 29055-08-1

General procedure: To a solution of 13 (500 mg, 1.86 mmol) in DMF (5.0 mL) were added N-methylaniline (241 muL, 2.23 mmol), 1-hydroxybenzotriazole (251 mg, 1.86 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (534 mg, 2.79 mmol) at room temperature. The reaction mixture was stirred at room temperature for 12 h. Water was then added, and the mixture was extracted with a mixture of toluene and EtOAc (1:1). The organic layer was washed with H2O and brine, and dried over anhydrous sodium sulfate. After filtration, the solvent was removed in vacuo, and the residue was purified by silica gel column chromatography using hexane/EtOAc (1:1, v/v) as eluent. The solvent was removed in vacuo, and the resulting solid was recrystallized from iPrOH to give 14 (547 mg, 82percent) as a white solid

With the rapid development of chemical substances, we look forward to future research findings about 29055-08-1.

Reference:
Article; Fukaya, Takayuki; Kodo, Toru; Ishiyama, Takeo; Kakuyama, Hiroyoshi; Nishikawa, Hiroyuki; Baba, Satoko; Masumoto, Shuji; Bioorganic and Medicinal Chemistry; vol. 20; 18; (2012); p. 5568 – 5582;,
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Synthetic Route of 10602-04-7 ,Some common heterocyclic compound, 10602-04-7, molecular formula is C9H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of (4-ethynylphenyl)methanol (1.66 g, 12.54 mmol) and imidazole (1.71 g, 25.08 mmol) in DMF (37mL) was added TBDMSCl (2.84 g, 18.81 mmol). This reaction mixture was stirred at ambient temperature for overnight. All the volatile solvent was removed under reduced pressure, and the residue was dissolved in DCM (10 ml). Water (10 mL) was added, and the aqueous layer was extracted with DCM (10 mL X 2). The combined organic layer was washed with brine (20 mL), dried over Na2SO4, and filtered. The organic layer was concentrated under reduced pressure and the residue was purified by silica gel chromatography, by column chromatography with hexane/ethyl acetate (10/1, v/v) to obtain the compound 59 as a brown solid (2.91 mg, 94percent yield): 1H NMR (400 MHz, CDCl3) _ 7.46 (d, J = 8.2 Hz, 2H), 7.28 (d, J = 8.8 Hz, 2H), 4.73 (s, 2H), 3.04 (s, 1H), 0.94 (s, 9H), 0.10 (s, 6H); 13C NMR (100 MHz, CDCl3) _ 142.5, 132.2, 126.0, 120.6, 83.9, 64.7, 26.1, 18.5, -5.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10602-04-7, (4-Ethynylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; DALBY, Kevin N.; EDUPUGANTI, Ramakrishna; TALIAFERRO, Juliana; LEE, Juhyeon; (0 pag.)WO2018/160967; (2018); A1;,
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Synthetic Route of 150192-39-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Preparative Example 91 Preparation of 5-methoxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 2-bromo-5-methoxybenzylalcohol (6.5 parts; 0.03M) was dissolved in dry THF (100 ml) and cooled to -78 C. n-Butyl-lithium (26.4 ml of a 2.5M solution in hexanes ex Aldrich, 0.066M) was added over 20 minutes with stirring under a nitrogen blanket and keeping the temperature below -60 C. After stirring for a further hour at -70 C. HPLC showed the reaction to be incomplete with 20% starting material remaining. A further aliquot of n-butyl-lithium in hexanes (5 ml; 0.0125M) was added and the reactants allowed to warm to -50 C. Tributylborate (17.8 ml; 0.066M) was then added at between -70 and -50 C. with stirring under a nitrogen blanket and the reactants allowed to warm to about 20 C. Water (20 ml) was added and the pH adjusted to 10 with hydrochloric acid. After washing with diethylether, the pH of the aqueous phase was adjusted to pH 1-2 with hydrochloric acid and washed with diethyl ether. The ether extract was washed with aqueous saturated brine, dried over anhydrous magnesium sulphate and the ether evaporated to leave the product as a pale oil (3.7 parts). This was slurried with water containing a little methanol whereupon a pinkish-white solid separated which was filtered, washed with water and dried (2.0 parts) mp=110-115 C. after recrystallisation from aqueous methanol.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150192-39-5, (2-Bromo-5-methoxyphenyl)methanol.

Reference:
Patent; Zeneca Limited; US5880188; (1999); A;,
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Synthetic Route of 1562-00-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, molecular weight is 148.1135, as common compound, the synthetic route is as follows.

EXAMPLE 1 14.8 g Isethionic acid-Na and 150 mg NaOH and 100 ml of benzyl alcohol were reacted in a 250 ml round bottom flask with a distillation bridge and heated slowly at 180 to 200 C for about 3 hours. At this temperature, about 1.8 g of water was distilled off. (0049) The reaction product was allowed to cool, forming crystals, and then filtered under suction. The very fine precipitate was dried. 18.7 g of a white substance at 78.6 % yield was recovered. IR confirmed that the reaction product was 99% pure.

Statistics shows that 1562-00-1 is playing an increasingly important role. we look forward to future research findings about Sodium isethionate.

Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (16 pag.)WO2017/175177; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1462-03-9, name is 1-Methylcyclopentanol. A new synthetic method of this compound is introduced below., Safety of 1-Methylcyclopentanol

500 mg (3.87 mmol) of ethyl isocyanatoacetate was dissolved in 5 ml of dichloromethane. 0.05 ml of 4 N hydrochloric acid / 1,4-dioxane solution was added to the obtained solution. 465 mg (4.64 mmol) of 1-methylcyclopentanol was added to the resultant mixture, and they were stirred for 3 hours 30 minutes. 10 ml of methanol and 12 ml of 1 N aqueous sodium hydroxide solution were added thereto and they were stirred for 15 minutes. The organic solvent was evaporated under reduced pressure. After extracting with dichloromethane twice, the aqueous layer was neutralized with 1 N aqueous hydrochloric acid solution. The product was extracted with dichloromethane 3 times and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound. The product was subjected to the next reaction without any purification. Yield: 43.0 mg (0.214 mmol), 5.5 %1H-NMR (CDCl3): (Only the main peaks are shown because the product contained impurities) 1.56 (3H, s), 5.22 (1H, d).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1462-03-9, 1-Methylcyclopentanol.

Reference:
Patent; Ajinomoto Co., Inc.; EP1481673; (2004); A1;,
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Adding a certain compound to certain chemical reactions, such as: 62058-03-1, trans-4-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 62058-03-1, blongs to alcohols-buliding-blocks compound. Quality Control of trans-4-Aminoadamantan-1-ol

General procedure: To a solution of ethyl 1-phenyl-5-(2-methyl-4-oxobutan-2-yl)-1H-pyrazole-4-carboxylate 14b (45 mg, 0.15 mmol) in CHCl3 (9 mL) was added trans-5-hydroxy-2-adamantylamine (25 mg, 0.15 mmol), acetic acid (0.025 mL, 0.45 mmol) and sodium triacetoxyborohydride (85 mg, 0.45 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl. The combined organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was dissolved in methanol (0.30 mL), and added 1.0 N NaOH (0.22 mL, 0.22 mmol) at room temperature. After stirring at ambient temperature for 16 hours, the solvent was removed under vacuum. The mixture of the residue in CHCl3 (1.5 mL) and DIPEA (0.078 mL, 0.45 mmol) and HBTU (35 mg, 0.15 mmol) was stirred at room temperature. After 16 hours, the reaction mixture was quenched with aq. NaHCO3, extracted with CHCl3, and washed with aq. NaCl., then purified with column chromatography (silica gel, eluting with CHCl3/methanol) to give the title compound as a white solid (0.025 g, 42 percent yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62058-03-1, its application will become more common.

Reference:
Article; Udagawa, Shuji; Sakami, Satoshi; Takemura, Takahiro; Sato, Mikiya; Arai, Takahiro; Nitta, Aiko; Aoki, Takumi; Kawai, Koji; Iwamura, Tomokatsu; Okazaki, Seiji; Takahashi, Takehiro; Kaino, Mie; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1617 – 1621;,
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Reference of 83647-43-2, Adding some certain compound to certain chemical reactions, such as: 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83647-43-2.

To a flask charged with (3-bromo-2-methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M trifluoroacetic acid solution of thallium trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 minutes to ensure complete removal of TFA. To the residue was then added palladium (II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and methanol (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a Celite pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford 5-bromo-4-methyl-2-benzofuran-l(3H)-one. ?-NMR (500 MHz, CDC13) delta ppm 7.71 (d, J= 8.0 Hz, 1H), 7.58 (d, J= 8.0 Hz, 1H), 5.25 (s, 2H), 2.37 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83647-43-2, (3-Bromo-2-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; PASTERNAK, Alexander; DEJESUS, Reynalda, K.; TANG, Haifeng; PIO, Barbara; SHAHRIPOUR, Aurash; BELYK, Kevin, M.; CHOBANIAN, Harry, R.; GUO, Yan; FRIE, Jessica, L.; SHI, Zhi-Cai; CHEN, Helen; BLIZZARD, Timothy, A.; CATO, Brian; WO2013/66714; (2013); A1;,
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Electric Literature of 79418-41-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one, molecular formula is C9H7NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Amino-7-hydroxy-2H-chromen-2-one (3) (0.56 g, 31 mmol) and O-(4-formylphenyl)dimethylcarbamothioate (0.65 g, 31 mmol) were dissolved in absoluteEtOH (10 mL) and refluxed for 2 h, during which time a precipitate formed.After cooling, the solid was collected and washed with an excess of hot EtOH:yellow solid, 0.85 g, 80 %. m.p. 240-242 C; 1H NMR (DMSO-d6): delta 8.59 (s, 1H, N=C-Ar), 7.94-7.92 (d, 1H, Ar-H, J = 8.6 Hz), 7.78 (s, 1H, =C-H),7.56-7.54 (d, 1H, Ar-H, J = 8.0 Hz),7.22-7.20 (d, 1H, Ar-H, J = 8.0 Hz),6.81 (dd, 1H, Ar-H, J = 8.0, 2.0 Hz),6.75(d, 1H, Ar-H, J = 2.0 Hz), 3.36(s, 3H, N(CH3)2), 3.32 (s, 3H, N(CH3)2);13C NMR (DMSO-d6):delta 39.1, 43.3, 102.3, 112.4, 114.0, 123.9, 130.0, 130.1, 132.3, 132.4, 133.8,154.0, 156.7, 158.5, 161.1, 161.8, 186.3; m/z obsd 369.0895; calcd for [M+H]+369.4143.

According to the analysis of related databases, 79418-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Garcia-Beltran, Olimpo; Rodriguez, Alejandra; Trujillo, Ariel; Canete, Alvaro; Aguirre, Pabla; Gallego-Quintero, Sebastian; Nunez, Marco T.; Aliaga, Margarita E.; Tetrahedron Letters; vol. 56; 42; (2015); p. 5761 – 5766;,
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