Month: July 2021

Application of 349-75-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 349-75-7 as follows.

Aniline (46.5 mg, 0.5 mmol),Cat.[Ir] (5.4 mg, 0.005 mmol, 1 mol%), cesium carbonate (49 mg, 0.15 mmol, 0.3 equiv.),3-trifluoromethylbenzyl alcohol (105.6 mg, 0.6 mmol) and t-amyl alcohol (1 ml) were sequentially added to 5 mLIn a round bottom flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.The solvent was removed by rotary evaporation, followed by column chromatography (developer: petroleum ether/ethyl acetate) to give the pure target compound. Yield: 86%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,349-75-7, its application will become more common.

Reference:
Patent; Nanjing University of Science and Technology; Fan Hongjun; Li Shun; Liu Pengcheng; Li Feng; (9 pag.)CN107778182; (2018); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, molecular weight is 146.23, as common compound, the synthetic route is as follows.Safety of 1,8-Octanediol

General procedure: A mixture of 1,n-diols 1a-d (1.0 mmol), DHP-hexane 3% (v/v) (1.96 mmol) and aqueous 5 M NaHSO4 (01 mL) was prepared. To 1,10-decanediol 1c and 1,12-dodecanediol 1d, 0.2 mL of DMSO were also added to the mixture at the beginning of the reaction. This mixture was stirred at 40 C for 16 h and then extracted with hexane (3 × 20 mL). The combined organic phases were dried (Na2SO4), filtered and then evaporated under reduced pressure. The residue obtained was chromatographed using silica gel using hexane/EtOAc (8:2) to yield pure Compounds 2a-d.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,629-41-4, 1,8-Octanediol, and friends who are interested can also refer to it.

Reference:
Article; Gonalves, Alessandra Mirtes Marques Neves; De Lima, Aline Brito; Da Silva Barbosa, Maria Cristina; De Camargos, Luiz Fernando; De Oliveira, Jlia Teixeira; De Souza Barbosa, Camila; Villar, Jos Augusto Ferreira Perez; Costa, Andr Carvalho; Da Silva, Isabella Viana Gomes; Silva, Luciana Maria; De Pilla Varotti, Fernando; Dos Santos, Fabio Vieira; Viana, Gustavo Henrique Ribeiro; Marine Drugs; vol. 12; 8; (2014); p. 4361 – 4378;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6920-22-5, name is Hexane-1,2-diol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H14O2

A 500 mL three-necked round-bottom flask equipped with mechanical stirrer, pressure equalizing addition funnel, and reflux condenser is charged with 1,2-hexanediol (6, 5.91 g, 50.0 mmol) and 50 mL of carbon tetrachloride. Upon dissolving of the 1,2-hexanediol, thionyl chloride (5.5 mL, 75 mmol) is added dropwise at room temperature, and the reaction is heated to 60 C. After 2 h, the reaction is cooled via ice bath. Water (50 mL) and acetonitrile (75 mL) are added. Ruthenium chloride hydrate (0.131 g, 0.50 mmol) and sodium periodate (21.4 g, 100 mmol) are added and the reaction mixture is stirred at room temperature for I h. The mixture is extracted with diethyl ether (4 x 175 mL), the organic layers are washed with water (5 x 100 mL), saturated sodium bicarbonate (3 x 100 mL), brine (2 x 100 mL), filtered through celite/silica gel, and dried over magnesium sulfate. The clear liquid is concentrated to give 7, a clear oil. The preparation is represented by the following reaction:

The synthetic route of 6920-22-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE PROCTER & GAMBLE COMPANY; EP1210332; (2006); B1;,
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Application of 7073-69-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7073-69-0, its application will become more common.

Reference:
Article; Della Ca, Nicola; Fontana, Marco; Xu, Di; Cremaschi, Mirko; Lucentini, Riccardo; Zhou, Zhi-Ming; Catellani, Marta; Motti, Elena; Tetrahedron; vol. 71; 37; (2015); p. 6389 – 6401;,
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Synthetic Route of 41175-50-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, molecular formula is C12H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 150 mL round bottom flask was added 40 mL of toluene, followed by the addition of 18.9 g (0.1 mol) of compound 3, phthalic anhydride14.8 g (0.1 mol), stirred and stirred. The mixture was refluxed for 5 hours to gradually form a solid. The solid was removed by suction filtration and recrystallized from methanol to give Dark red solid.

According to the analysis of related databases, 41175-50-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Xuchang University; Hou Xufeng; Xu Zhihong; Li Bolun; Zhan Qiangqiang; Cheng Zijie; (23 pag.)CN107090191; (2017); A;,
Alcohol – Wikipedia,
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Electric Literature of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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Electric Literature of 769-30-2, Adding some certain compound to certain chemical reactions, such as: 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol,molecular formula is C8H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 769-30-2.

General procedure: A mixture of corresponding alcohol (1, 1 mmol) and 3,4-dihydro-2H-pyran (2, 100 mg, 1.2 mmol) was stirred in the presence of zwitterionic-salt A (10 mg, 10 mol%) at 60-80 C (oil bath) for 10-12 h in a seal tube. After completion of the reaction (TLC), the reaction mixture was cooled to room temperature and diluted with water (10 mL) and extracted with ethyl acetate (20 mL). Organic layer was dried over anhydrous Na2SO4. After evaporation of solvent the crude product was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (4-5%) as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mahato, Sachinta; Chatterjee, Rana; Chakraborty Ghosal, Nirnita; Majee, Adinath; Synthetic Communications; vol. 47; 20; (2017); p. 1905 – 1915;,
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Related Products of 78573-45-2, Adding some certain compound to certain chemical reactions, such as: 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol,molecular formula is C10H11F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78573-45-2.

A solution of (R) -N- [1- (1-naphthyl) ethyl] -2-nitrobenzenesulfonamide in toluene (83 g pure)92 g of triphenylphosphine,72 g of 3- (3-trifluoromethylphenyl) propanol and 125 mL of toluene were added and stirred. Adjust the solution temperature to 50 ° C,DiisopropylazodicarboxylateA diluted solution obtained by adding 330 mL of toluene to 71 g was dropped. After the dripping end50 mL of toluene was added and stirred at 50 ° C. for 1 hour.After completion of the reaction, 133 g of anhydrous magnesium chloride and 42 mL of toluene were added. After stirring at 50 ° C. for 2 hours, the liquid temperature was cooled to 0 ° C.The reaction solution was filtered to remove insolubles, and then washed with 415 mL of toluene cooled to 0° 415 mL of tap water was added to the filtrate and stirred, and the aqueous layer was removed by liquid separation operation. The same operation was repeated twice, and the obtained organic layer was concentrated under reduced pressure at 55 ° C. to 1165 mL,(R) -N- [1- (1-naphthyl) ethyl] -3- [3- (trifluoromethyl) phenyl]Propane-2-nitrobenzenesulfonamide tolueneA solution was obtained (pure yield 127 g, pure yield 100percent, chemical purity 92percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Iwaki Pharmaceutical Co Ltd; Nagasaki, Atsushi; Fukushima, Koichi; (8 pag.)JP2019/14687; (2019); A;,
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Application of 599-67-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 599-67-7, name is 1,1-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solvent (5 mL) was placed in a 10 mL round bottom-flask equipped with a magnetic stirrerunder reflux, NXS (1.1 mmol) was then added and, after being dissolved, the substrate (1 mmol) wasadded and the solution was stirred for 4-24 h. The progress of the reaction mixture was monitoredby TLC, whilst the consumption of NXS was tested by KI (0.1 M). Upon completion of the reaction,the crude reaction mixture was cooled down at room temperature, diluted with EtOAc (15 mL),washed with aqueous Na2S2O3 (6 mL), NaHCO3 (6 mL), and water (10 mL), and dried over anhydrousNa2SO4. The solvent was evaporated under reduced pressure and the crude product obtained wasanalyzed by 1H-NMR. The pure final products were obtained after flash chromatography, columnchromatography or preparative thin layer chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 599-67-7, 1,1-Diphenylethanol.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Molecules; vol. 21; 10; (2016);,
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Application of 3391-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3391-86-4, name is Oct-1-en-3-ol, molecular formula is C8H16O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a sealed tube, under nitrogen atmosphere, the ruthenium complex [RuCl2( 6-C6H6)(PTA-Me)] (3a) (0.02-0.1 mmol; 0.5-2.5 mol% of Ru) and K2CO3 (0.05-0.25 mmol; 1.25-6.25 mol%) were added to a solution of the corresponding allylic alcohol 4a-o (4 mmol) in tetrahydrofuran (4 mL), and the resulting mixture stirred at 75 C for the indicated time (see Table 4 and Scheme 3). The course of the reaction was monitored by taking regularly samples of ca. 10 L which after dilution with dichloromethane (3 mL) were analyzed by GC. After the reaction was finished, the mixture was cooled to room temperature leading to the partial precipitation of 3a. The solid was separated by filtration and the reaction product isolated by solvent removal and chromatographic workup of the residue on silica-gel using a mixture of EtOAc-hexane (1:10) as eluent. The identity of the resulting carbonyl compounds 5a-o was assessed by comparison of their retention times with those of commercially available pure samples (Sigma-Aldrich or Acros Organics), by their fragmentation in GC/MS, and/or NMR spectroscopy.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3391-86-4, Oct-1-en-3-ol.

Reference:
Article; Menendez-Rodriguez, Lucia; Crochet, Pascale; Cadierno, Victorio; Journal of Molecular Catalysis A: Chemical; vol. 366; (2013); p. 390 – 399;,
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