Month: June 2021

Reference of 6920-22-5, Adding some certain compound to certain chemical reactions, such as: 6920-22-5, name is Hexane-1,2-diol,molecular formula is C6H14O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6920-22-5.

General procedure: Glycerol (0.3 mmol, 42 mg), NH4ReO4 (0.03 mmol, 8 mg), 2,4-dimethyl-3-pentanol (0.43-0.86 mmol, 60-120 muL), and 1 mL anhydrous toluene were added to a thick-walled Ace glass reactor tube. The Teflon seal was closed and the reactor was placed in a heating mantle connected with a Digi Troll (Glas-Col) digital temperature controller equipped with a thermocouple at 140-165 C for 5-48 h while stirring. After cooling to room temperature, the solution was filtered to remove the precipitated NH4ReO4 and analyzed with GC-MS

According to the analysis of related databases, 6920-22-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gossett, Justin; Srivastava, Radhey; Tetrahedron Letters; vol. 58; 39; (2017); p. 3760 – 3763;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

4-Methoxy-2,6-dimethylbenzenesulfonyl chloride (12 g, 51 mmol) is added to a solution of 2- (methylamino)ethanol (4.6 mL, 61 mmoi), diisopropyl ethyl amine (22 mL, 130 mmol), and CH2Cl2 (130 mL) under N2. The reaction vessel is sealed and left to stir for 21 h. The solution is washed with 1 :1 sat. aq. NH4C.: H2O (2 X 200 mL) and brine (200 mL). The aqueous layers are extracted with CH2Cl2 (200 mL). The combined organic layers are dried over Na2SO4, filtered, and concentrated to afford the title compound as a pale yellow oil. LC-MS m/? (M + Na~): 296.06 (§).

With the rapid development of chemical substances, we look forward to future research findings about 109-83-1.

Reference:
Patent; NEUROGEN CORPORATION; WO2007/140383; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.Computed Properties of C8H8O3

General procedure: In a typical reaction, the catalyst was weighed into a screw-capped glass pressure vessel containing a stir bar. The required amounts of alcohol (0.5 mmol) and amine (0.6 mmol), pre-dissolved in solvent (2 mL), were added and the vessel was filled with oxygen, sealed, and heated to the desired temperature in an oil bath with stirring. The products of the reaction were analyzed by gas chromatography (GC, Agilent 7890A) and GC-mass spectrometry (MS, Agilent 7890A/5975C).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Zhixin; Wang, Yehong; Wang, Min; Lue, Jianmin; Li, Lihua; Zhang, Zhe; Li, Mingrun; Jiang, Jingyang; Wang, Feng; Chinese Journal of Catalysis; vol. 36; 9; (2015); p. 1623 – 1630;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, the common compound, a new synthetic route is introduced below. Safety of Ethyl 4-chloro-3-hydroxybutanoate

(1) Ethyl S-4-chloro-3-hydroxybutyrate was stirred with 60percent by weight of DMSO and 1-fold by weight of sodium azide at 60 ° C for 5 hours, The solvent is DMF, n-propanol, isopropanol, n-butanol, tert-butanol, toluene or cyclopentanol and so on to get the intermediate I, and the reaction is complete, stop the reaction, direct concentration to remove the solvent,

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chongqing East Ze Pharmaceutical Technology Development Co., Ltd.; Yuan, Huajie; Dai, Liping; Xie, Lingling; Ye, Lei; (24 pag.)CN105330581; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62285-58-9, name is (2,6-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below., Application In Synthesis of (2,6-Dimethylphenyl)methanol

Step C: Preparation of 3-(3-(2,6-dimethylbenzyloxy)phenyl)propanenitrile: A solution of 3-(3-hydroxyphenyl)propanenitrile (Step B, 1.25 g, 8.5 mmol) and diisopropyl azodicarboxylate (DIAD, 1.87 g, 9.26 mmol) in dry THF (10 ml) was added drop wise to a solution of 2.6-Dimethylbenzyl alcohol (1.27 g, 9.3 mmol) and triphenylphosphine (TPP. 2.43 g, 9.26 mmol) in dry THF (30 ml) at 0C under argon. The reaction mixture was warmed to room temperature for 4 hours or until all the starting material is consumed, diluted with ether and washed with water (2X). The organic layer was dried over Na3SO4. filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 2:1) to give the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62285-58-9, (2,6-Dimethylphenyl)methanol.

Reference:
Patent; Wellstat Therapeutics Corporation; O’NEIL, James, Dennen; SHARMA, Shalini; ARUDCHANDRAN, Ramachandran; EP2282736; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.

10129] l3enzyl glycolate (30 g, 0.25 mol) and Hoc anhydride (39.1 g, 0.19 mol) were dissolved in 30 ml of dichloromethane. 5 ml of DMAP (4.62 g, 0.038 mol) in dichloromethane solution was added dropwise into the resultant reaction liquid at 80 C. Afier that, the reaction liquid was reacted at 15 C. for 0.5 h. Afier completion of the reaction, the reaction liquid was poured into ice water, extracted with ethyl acetate, the combined resultant organic phase was washed with water and saturated salt water successively. The organic phase was concentrated and recrystallized with petroleum ether/ethyl acetate in a ratio of 10:1 to give a white solid (32.5 g, 66%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Patent; JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD.; Zhou, Wei; Jing, Yunrong; Wang, Yongfeng; Wang, Guocheng; (81 pag.)US2016/340365; (2016); A1;,
Alcohol – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below., Product Details of 534-03-2

General procedure: Amine (1 mmol) and Fmoc-Cl (1.1 mmol) were placed in a glass tube under neat conditions and were sonicated for a suitable time (as indicated in Tables 1, 2 and 3). All reactions were performed in a water bath at room temperature. After completion of the reaction (as indicated by TLC), 5 cm3 of diethyl ether was added to the mixture. The N-Fmoc derivatives were crystallized and were obtained in good to excellent yields. Purification of the product was accomplished by recrystallization from diethyl ether.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Article; Mansouri, Rachida; Aouf, Zineb; Lakrout, Salah; Berredjem, Malika; Aouf, Nour-Eddine; Journal of the Brazilian Chemical Society; vol. 27; 3; (2016); p. 546 – 550;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, the common compound, a new synthetic route is introduced below. Safety of 2,6-Dichlorophenethyl alcohol

To a solution of 2-(2,6-dichlorophenyl)ethan- 1-ol (20 g, 104.68 mmol, 1.00 equiv) in pyridine (500 mL) was added sodium hydride (5.2 g,216.67 mmol, 1.25 equiv). The resulting solution was stirred at 0 C for 1 h. Then CuC1 (600 mg, 6.12 mmol, 0.05 equiv) was added. The resulting solution was stirred overnight at 115C. The resulting mixture was concentrated under vacuum. The reaction was then diluted with 500 mL of H20. The pH value of the solution was adjusted to 4 with HC1 (3 M). The solids were filtered out. The resulting solution was extracted with petroleum ether. And the organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum. The cmde product was purified by 5i02 chromatography, eluted with petroleum ether to afford 16 g (99%) of 4-chloro-2,3-dihydro-1-benzofuran as colorless oil.

The synthetic route of 30595-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; ZHANG, Chengzhi; CHAKMA, Justin; LAUFER, Ralph; (108 pag.)WO2016/109359; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 307353-32-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 307353-32-8, name is Methyl 3-bromo-5-(hydroxymethyl)benzoate. A new synthetic method of this compound is introduced below.

TBDPS-Cl (15.9 mL, 16.8 g, 61.21 mmol) was added to a solution of methyl 3-bromo-5-(hydroxymethyl)benzoate (10 g, 40.8 mmol) in CH2Cl2 (408 mL) at 23 C. and stirred for 1 h. The resultant heterogeneous reaction mixture was filtered and concentrated in vacuo. The residue was purified by flash chromatography (Combi-flash Rf, Hex/EtOAc=0-10% gradient) to afford the title compound (18.2 g, 37.6 mmol, 92%) as a white solid. 1H NMR (400 MHz, chloroform-d) delta 8.05 (s, 1H), 7.89 (s, 1H), 7.76-7.64 (m, 5H), 7.48-7.34 (m, 6H), 4.75 (s, 2H), 3.91 (s, 3H), 1.11 (s, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,307353-32-8, Methyl 3-bromo-5-(hydroxymethyl)benzoate, and friends who are interested can also refer to it.

Reference:
Patent; Vanderbilt University; Gogliotti, Rocco D.; Stauffer, Shaun R.; Jeon, KyuOk; Salovich, James M.; Macdonald, Jonathan D.; Mills, Jonathan J.; Meyers, Kenneth M.; Alvarado, Joseph R.; Han, Changho; Fesik, Stephen W.; Lee, Taekyu; (177 pag.)US2020/55824; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3250-73-5, Adding some certain compound to certain chemical reactions, such as: 3250-73-5, name is 2-(2-Ethoxyphenoxy)ethanol,molecular formula is C10H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3250-73-5.

To a solution of (ether)benzoxy alcohol 20A (501.2 mg, 2.751 mmol) in CH2Cl2 (20 mL) was added Et3N (509 mg, 5.03 mmol) and toluenesulfonyl chloride (623 mg, 3.27 mmol) at 5-10 C. After being stirred at 25 C for 30 min, the reaction mixture was quenched with saturated aqueous Na2CO3 (20 mL) and extracted with ethyl acetate (3 × 50 mL). The combined organic layers were dried over MgSO4(s), filtered, and concentrated under reduced pressure to obtain (ether)benzoxy tosylate 21A (853.5 mg, 2.539 mmol) as white solids in 92 % yield: mp (recrystallized from CH2Cl2 and CCl4) 82-83 C; 1H NMR (CDCl3, 300 MHz) delta 1.43 (t, J = 10.2 Hz, 3 H, OCH2CH3), 2.51 (s, 3 H, ArCH3), 4.04 (q, J = 10.2 Hz, 2 H, OCH2CH3), 4.36 (t, J = 6.9 Hz, 2 H, OCH2CH2), 4.59 (t, J = 6.9 Hz, 2 H, OCH2CH2), 6.86-6.97 (m, 4 H, ArH), 7.10-7.22 (m, 4 H, ArH); IR (neat) 3446 (br), 2982 (m), 2934 (m), 2884 (m), 1591 (s), 1558 (w), 1509 (s), 1478 (s), 1454 (s), 1407 (s), 1394 (s), 1371 (s), 1354 (s), 1279 (m), 1259 (s), 1247 (s), 1217 (s), 1178 (s), 1127 (s), 1066 (s), 1043 (s), 1031 (s), 977 (s), 929 (s), 905 (s), 809 (s), 776 (m), 749 (s), 776 (m) cm-1

According to the analysis of related databases, 3250-73-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Well-being Biochemical Corp.; Taiwan Biotech Co., Ltd.; EP1734036; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts