Month: June 2021

Reference of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example II-a-1 CH3 SO2 OCH2 COO-nC4 H9 27.8 g (0.2 mol) of n-butyl hydroxyacetate (95% pure by GC) and 20.2 g (0.2 mol) of triethylamine are first introduced into 300 ml of dichloromethane at -5 C. 34.4 g (0.3 mol) of methanesulfonyl chloride in 50 ml of dichloromethane are slowly added dropwise at 0 to 5 C. Stirring of the batch at 0 C. is continued overnight, ice water is added, the phases are separated, and the aqueous phase is extracted twice with dichloromethane. The combined organic phases are dried, and the solvent is removed on a rotary evaporator leaving a colorless oil which is subjected to incipient distillation in vacuo. n-Butyl methylsulfonyloxyacetate is isolated as an almost colorless oil (40.5 g, 96.3% of theory, GC content 91%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US5698735; (1997); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 30379-58-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 30379-58-9, name is Benzyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below.

To a tetrahydrofuran (40.0 mL) solution of the compound (3.68 g, 10.0 mmol)obtained in above Process 1 and benzyl glycolate (4.99 g, 30.0 mmol), potassium tertbutoxide (2.24 g, 20.0 mmol) was added at OC and stirred at room temperature for 15 minutes. The reaction solution was charged with ethyl acetate and water at OC and extracted with ethyl acetate and chloroform. The obtained organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure. The obtained residues were dissolved in dioxane (40.0 mL) and water (10.0 mL), charged with sodium hydrogen carbonate (1.01 g, 12.0 mmol) and 9-fluorenylmethyl chloroformate (2.59 g, 10.0 mmol), and stirred at room temperature for 2 hours. The reaction solution was charged with water and extracted with ethyl acetate. The obtained organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the obtained residues were purified by silica gel column chromatography [hexane: ethyl acetate = 100 : 0 (v/v) – 0: 1001 to yield the titled compound in colorless oily substance (1.88 g, 40%).1HNMR (400 MHz, CDC13) delta: 3.84 (2H, d, J = 5.5 Hz), 4.24 (3H, t, J = 6.5 Hz),4.49 (2H, d, J = 6.7 Hz), 4.88 (2H, d, J = 6.7 Hz), 5.15-5.27 (1H, m), 5.19 (2H, s), 6.74(1H, brs), 7.3 1-7.39 (7H, m), 7.43 (2H, t, J = 7.4 Hz), 7.61 (2H, d, J = 7.4 Hz), 7.79(2H, d, J = 7.4 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; HETTMANN, Thore; ABRAHAM, Reimar; BLUM, Sabine; UENO, Suguru; WO2015/155998; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Aminopropane-1,3-diol

To a solution of TBDMSCI (7.2 g, 48 mmol), A/,A/-diisopropylethylamine (5.0 mL, 29 mmol) and DMAP (50 mg) in dichloromethane (50.0 mL) was added 2-amino-1 ,3-propan-diol (2.0 g, 22 mmol), and the mixture was stirred overnight. Volatiles were removed under high vacuum to give a residue, which was subjected to flash silica gel column purification on ISCO companion (ethyl acetate/hexane, 50 -100% containing 2% triethylamine) to give 1.2 g (17%) of compound S76 as colorless oil. H NMR (500MHz, CDCI3): 53.70 (2H, dd, J 10.0, 5.5 Hz), 3.63 (2H, dd, J 10.0, 5.5 Hz), 3.04 (1 H, m), 0.90 (18H, s), 0.07 (12H, s)

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; ELTEPU, Laxman; KABAKIBI, Ayman; LAM, Son; LIU, Bin; LIU, Dingguo; MEADE, Bryan, R.; SAKAMURI, Sukumar; WO2015/69932; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 928-51-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 928-51-8, name is 4-Chlorobutan-1-ol. A new synthetic method of this compound is introduced below.

Step A: Preparation of 4-(Chlorobutoxy)-3,4,5,6-2H-tetrahydropyran A solution of 4-chlorobutanol (23.2 g, 0.2140 mol) and 2 drops of concentrated hydrochloric acid at 0 C. is treated with 3,4-dihydro-2H-pyran (15 g, 0.1783 mol). The reaction is allowed to warm to room temperature over 3 hours. The reaction mixture is purified by distillation (130 C., 20 mm) to give 18.07 g of 2-(4-chlorobutoxy)-3,4,5,6-2H-tetrahydropyran as a colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-51-8, its application will become more common.

Reference:
Patent; Warner-Lambert Co.; US5045550; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H11ClO

EXAMPLE 155 Preparation of 5-chloro-1-(2-furyl)-1-pentanol To a stirred suspension of 2-furyllithium [prepared from 0.53 moles of n-butyllithium and 39.5 g of furan by the procedure of J. Org. Chem., 27, 1216 (1962)] in 350 ml. of ether and with 200 ml. of hexane at -78° C is added a solution of 57.9 g of 5-chloropentanol [Chem. Abstr. 59, 7579F (1963)] in 80 ml. of ether during 25 minutes. The mixtures is warmed to 0° C. during 20 minutes, stirred at 0° C for 15 minutes, and treated with 140 ml. of saturated ammonium chloride. The ether phase is washed with water and brine, dried over magnesium sulfate and potassium carbonate mixture, and concentrated to give a liquid, pmr spectrum (CDCl3) delta 3.59 (triplet, CH2 Cl) and 4.70 (triplet, CH2 CHOH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Patent; American Cyanamid Company; US4131737; (1978); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 52244-70-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 52244-70-9 as follows.

4-Methylphenylsulfonic acid 4-(4-methoxyphenyl)butyl ester (I). Pyridine (15 mL) was added dropwise to a cooled (0° C.) solution of 4-(4-methoxyphenyl)butanol (10.0 g, 0.055 mol) and p-toluenesulfonyl chloride (13.6 g, 0.072 mol) in dry chloroform (100 mL) under stirring. The reaction mixture was stirred overnight at room temperature. After this time, the reaction was quenched with 10percent HCl (300 mL) and extracted with chloroform. The organic fraction was washed with saturated NaHCO3, water and dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue purified by flash chromatography (eluent: hexane, ethyl acetate=15:1) to provide 12.9 g (66percent) of I as clear oil. 1H NMR (360 MHZ, CDCl3) delta1.61 (m, 4H), 2.44 (s, 3H), 2.52 (m, 2H), 3.78 (s, 3H), 4.05 (m, 2H), 6.77 (d, J=12.5 Hz, 2H), 7.05 (d, J=12.5 Hz, 2H), 7.34 (d, J=10.5 Hz, 2H), 7.78 (d, J=10.5 Hz, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52244-70-9, its application will become more common.

Reference:
Patent; CYFI, INC.; US2003/195160; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 171623-29-3, (4-Cyclopentylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C12H16O, blongs to alcohols-buliding-blocks compound. COA of Formula: C12H16O

General procedure: Under nitrogen atmosphere, to a stirred mixture of thecorresponding alcohol 11b-am (1.0 eq.) in dry CH2Cl2 (5.0 mL), DMAP (0.1 eq.), and 2-DPC (1.2 eq.)were added. The reaction mixture was stirred at room temperature for 16 h, then diluted with CH2Cl2(20 mL) and sequentially washed with sat. NH4Cl solution (25 mL), sat. NaHCO3 solution (3 x 25 mL)and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated to dryness atlow pressure, as a mixture of alkyl-2-pyridyl carbonate 12b-am and alkyl-2-oxopyridine-1-carboxylate13b-am. The mixture of isomers was not separated and used in the next step without any furtherpurification.

The synthetic route of 171623-29-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nuzzi, Andrea; Fiasella, Annalisa; Ortega, Jose Antonio; Pagliuca, Chiara; Ponzano, Stefano; Pizzirani, Daniela; Bertozzi, Sine Mandrup; Ottonello, Giuliana; Tarozzo, Glauco; Reggiani, Angelo; Bandiera, Tiziano; Bertozzi, Fabio; Piomelli, Daniele; European Journal of Medicinal Chemistry; vol. 111; (2016); p. 138 – 159;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 261762-59-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 261762-59-8, name is 2-Chloro-5-fluorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

The solution of 2-chloro-5-fluoro-benzoic acid (4.00 g, 23.0 mmol) in THE (200 ml) was added triethylamine (4.14 ml, 29.9 mmol). At -30 C, the mixture was added ethyl chloroformate (2.62 ml, 27.8 mmol) and stirred for 10 min. The solution was added sodium borohydrate (2.60 g, 68.9 mmol) and stirred for 5 min. The mixture was added H2O (10 ml) and stirred for 20 min at room temperature. The solution was concentrated in vacuo and the residue was added CHCl3 and 1 N HClaq. The organic layer was washed with 1 N NaOHaq and dried over Na2SO4. The solution was removed in reduced pressure. The residue was washed with n-hexane to give alcohol as a colorless solid. To the CH2Cl2 suspention of dimethylsulfoxide (2.43 ml, 34.2 mmol) was added a solution of oxalyl chloride (1.47 ml, 17.1 mmol) in 50 ml of dry CH2Cl2 at -78 C, and the resulting mixture was stirred for 20 min. CH2Cl2 (15 ml) solution of the alcohol was added at -78 C. The mixture was allowed to warm to -40 C for 1 h. The mixture was added triethylamine (7.89 ml, 57.0 mmol), allowed to warm to room temperature, and was treated with 0.1 N HClaq. The organic layer was washed with saturated Na2CO3aq, dried over Na2SO4, and concentrated in vacuo to give the title compound (1.33 g, 37%) as a colorless solid after trituration with n-hexane. 1H NMR (400 MHz, CDCl3) delta 7.22-7.28 (1H, m), 7.41-7.47 (1H, m), 7.58-7.64 (1H, m), 10.42 (1H, d, J = 3.2 Hz). MS (EI) m/z 158 M+.

According to the analysis of related databases, 261762-59-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Sugita, Kazuyuki; Usui, Hiroyuki; Shimizu, Hironari; Suzuki, Makoto; Terayama, Koji; Kanda, Akira; Bioorganic and Medicinal Chemistry; vol. 19; 6; (2011); p. 1930 – 1949;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 59854-12-5 , The common heterocyclic compound, 59854-12-5, name is tert-Butyl 4-hydroxybutanoate, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Targeting tripodal tethers bearing easily removable protective groups in the side chains, we performed the synthesis of tether 10 (FIG. 13), where the malonic ester moieties are further elongated with C3 alkyl chains terminated by tert-butyl ester groups. In this case, selective hydrolysis of the ester moieties or focal deprotection (debenzylation) of the formed tris-adducts of C60 can give a facile access to structurally different derivatives. For this purpose, tert-butyl 4-hydroxybutyrate (8) was prepared (FIG. 13) and then subjected to a DCC monoesterification reaction with malonic acid to yield the mono-protected diacid 9. Three-fold esterification of trio 4 with acid 9 by using DCC and DMAP in CH2Cl2, afforded the tether 10 in 95% isolated yield.

The synthetic route of 59854-12-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hirsch, Andreas; Beuerle, Florian; Chronakis, Nikos; US2006/47167; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 111-46-6 ,Some common heterocyclic compound, 111-46-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Protocole 2 To a solution of diethylene glycol (31.83 g ; 300.0 mmol ; 7.0 eq) in CH2Cl2 (90 mL) was added Et3N (4.77 g ; 47.1 mmol ; 1.1 eq). The mixture was stirred vigorously. A solution of p-toluenesulfonyl chloride (8.17 g ; 42.8 mmol ; 1.0 eq) in CH2Cl2 (108 mL) was added dropwise. Following the addition, the reaction mixture was stirred for 24 h at room temperature. Then a 1.0 M solution of HCl (50 mL), water (50 mL) and saturated solution of brine (60 mL) were added. The resultant aqueous layers were further extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The product was purified by flash column chromatography on silica gel (99% CH2Cl2/MeOH) to give the desired compound 3b as a colorless oil in 67% yield (7.48 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-46-6, 2,2′-Oxybis(ethan-1-ol), other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ricco, Christophe; Abdmouleh, Fatma; Riccobono, Charlotte; Guenineche, Lena; Martin, Frederique; Goya-Jorge, Elizabeth; Lagarde, Nathalie; Liagre, Bertrand; Ali, Mamdouh Ben; Ferroud, Clotilde; Arbi, Mehdi El; Veitia, Maite Sylla-Iyarreta; Bioorganic Chemistry; vol. 96; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts